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| 1 | Association of extraintestinal manifestations of inflammatory bowel disease in a province of western Hungary with disease phenotype:Results of a 25-year follow-up study显示文摘IBD is a systemic disease associated with a large number of extraintestinal manifestations (EIMs). Our aim was to determine the prevalence of EIMs in a large IBD cohort in Veszprem Province in a 25-year follow-up study.METHODS: Eight hundred and seventy-three IBD patients were enrolled (ulcerative colitis/UC/: 619, m/f: 317/302,mean age at presentation: 38.3 years, average disease duration: 11.2 years; Crohn's disease/CD/: 254, m/f: 125/129,mean age at presentation: 32.5 years, average disease duration: 9.2 years). Intestinal, extraintestinal signs and laboratory tests were monitored regularly. Any alteration suggesting an EIMs was investigated by a specialist.RESULTS: A total of 21.3% of patients with IBD had EIM (UC: 15.0%, CD: 36.6%). Age at presentation did not affect the likelihood of EIM. Prevalence of EIMs was higher in women and in CD, ocular complications and primary sclerosing cholangitis (PSC) were more frequent in UC. In UC there was an increased tendency of EIM in patients with a more extensive disease.Joint complications were more frequent in CD (22.4% VS UC 10.2%, P<0.01). In UC positive family history increased the risk of joint complications (OR:3.63). In CD the frequency of type-1 peripheral arthritis was increased in patients with penetrating disease (P=0.028). PSC was present in 1.6% in UC and 0.8% in CD. Dermatological complications were present in 3.8% in UC and 10.2% in CD, the rate of ocular complications was around 3% in both diseases. Rare complications were glomerulonephritis, autoimmune hemolytic anaemia and celiac disease.CONCLUSION: Prevalence of EIM in Hungarian IBD patients is in concordance with data from Western countries. The high number of EIM supports a role for complex follow-up in these patients.ACKNOWLEDGEMENTDr. Zsuzsanna Erdelyi, Dr. Agnes Horvath, Dr Gabor Mester (Veszprem), Dr. Sandor Meszaros (Ajka), Dr. Csaba Molnar help in data collection and to Gabriella Demenyi for technical assistance. | Laszlo Lakatos Tunde Pandur Gyula David Zsuzsanna Balogh Pal Kuronya Arpad Tollas Peter Laszlo Lakatos | 2003 | World Journal of Gastroenterology2003，9，10： | 25 |
| 2 | 生物湿法冶金的现状和未来的挑战显示文摘在湿法冶金中应用生物工艺学的原理,对选矿工业提出了新的机遇与挑战。在五十年代和六十年代,成功地采用了有细菌参与的堆浸工艺,处理矿山废料和复杂的矿石资源,尤其是用于铜和铀的生产。细菌浸出在经济上的活力,使得它在矿业中得到了世界范围的承认。在七十年代,该工艺更趋完善,被称为“生物湿法冶金”。目前,细菌浸出技术即将得到实际应用。除了铜和铀外,它还用于从各种矿石中提取钴、镍、锌、金和银、并可用于某些煤的脱硫。在可以预见的将来,生物湿法冶金工艺也可能用天然的以及遗传工程化的微生物处理高品位的矿石和精矿。 | Arpad E. Torma 李纪归 | 1990 | 国外金属矿选矿1990，27，10： | 21 |
| 3 | Successful use of adalimumab for treating fistulizing Crohn's disease with pyoderma gangrenosum:Two birds with one stone显示文摘Crohn's disease(CD) is a chronic relapsing and remitting autoinflammatory disorder of the gastrointestinal tract that has many intestinal and extraintestinal complications.The purpose of treatment is long-term remission,reduction of complications,and improvement of patients' quality of life.In many cases,this can be quite challenging and it is necessary to have a well thought out management strategy.We present the case of a 38-year-old woman with fistulizing CD that manifested as diffuse abdominal pain and bloody diarrhea accompanied by arthralgia.In addition,there were ulcerative lesions surrounded by cutaneous inflammation and erythema on her extremities,indicative of pyoderma gangrenosum.The patient was treated with high doses of parenteral methylprednisolone without any improvement and was started on adalimumab.A positive response to adalimumab therapy was observed:after 2 mo of therapy,the ulcerative skin lesion healed completely and the enterogastric fistula was closed after 5 mo adalimumab treatment.Adalimumab might be a suitable initial as well as maintenance therapy in patients with complicated CD. | Eva Zold Arpad Nagy Katalin Devenyi Margit Zeher Zsolt Barta | 2009 | World Journal of Gastroenterology2009，15，18： | 4 |
| 4 | Life threatening bleeding from duodenal ulcer after Roux-en-Y gastric bypass: Case report and review of the literature显示文摘Acute upper gastrointestinal bleeding is a rare, but serious complication of gastric bypass surgery. The inaccessibility of the excluded stomach restrains postoperative examination and treatment of the gastric remnant and duodenum, and represents a major challenge, especially in the emergency setting. A 59-year-old patient with previous history of peptic ulcer disease had an upper gastrointestinal bleeding from a duodenal ulcer two years after having a gastric bypass procedure for morbid obesity. After negative upper endoscopy finding, he was urgently evaluated for gastrointestinal bleeding. At emergency laparotomy, the bleeding duodenal ulcer was identified by intraoperative endoscopy through gastrotomy. The patient recovered well after surgical hemostasis, excision of the duodenal ulcer and completion of the remnant gastrectomy. Every general practitioner, gastroenterologist and general surgeon should be aware of growing incidenceof bariatric operations and coherently possible complications after such procedures, which modify patient's anatomy and physiology. | Arpad Ivanecz Marko Sremec Davorin erani Stojan Potr Pavel Skok | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，12： | 2 |
| 5 | Hypokalemic myopathy in a patient with gluten-sensitive enteropathy and dermatitis herpetiformis Duhring: A case report显示文摘The case of a 22-year-old patient with symptomatic hypokalemia caused by rhabdomyolysis is presented as a rarely reported complication of gluten-sensitive enteropathy (GSE) and dermatitis herpetiformis Duhring. The patient's myopathy ceased on potassium supplementation and her other complaints resolved while on gluten-free diet.Recovery was otherwise uneventful with a rapid decline in serum CPK level. At the time of her last follow-up a few months later, she was free of symptoms and CPK remained stable. Patients with GSE may present with hypokalemia in association with diarrhea and emesis, and if potassium loss is rapid, rhabdomyolysis may occur. | Zsolt Barta Zsofia Miltenyi Laszlo Toth Arpad Illes | 2005 | World Journal of Gastroenterology2005，11，13： | 2 |
| 6 | Metabolic changes in the lower esophageal sphincter influencing the result of anti-reflux surgical interventions in chronic gastroesophageal reflux disease显示文摘AIM: With the availability of a minimally invasive approach, anti-reflux surgery has recently experienced a renaissance as a cost-effective alternative to life-long medical treatment in patients with gastroesophageal reflux disease (GERD). We are not aware of the fact whether reflux episodes causing complaints for a long time i.e., at least for one year are associated with metabolic changes in the lower esophageal sphincter, and if so,whether these may influence functional results achieved after anti-reflux surgery.METHODS: Between 1 January 2001 and 31 December 2002 we performed anti-reflux surgery on 79 patients.Muscle samples were taken from the lower esophageal sphincter (LES) in 33 patients during anti-reflux surgery.Inclusion criteria were: LES resting pressure below 10 mmHg and a marked, pH proven acid exposure to the esophagus of at least one year's duration, causing subjective complaints and requiring continuous proton pump inhibitor treatment. Control samples were obtained from muscle tissue in the gastroesophageal junction that had been removed from 17 patients undergoing gastric or esophageal resection. Metabolic and lysosomal enzyme activities and special protein concentrations 16 parameters in total were evaluated in tissue taken from control specimens and tissue taken from patients with GERD. The biochemical parameters of these intra-operative biopsies were used to correlate the results of anti-reflux operations (Visick I and II-III).RESULTS: In the reflux-type muscle, we found a significant increase of the energy-enzyme activities e.g., creatine kinase, lactate dehydrogenase, β-hydroxybutyrate dehydrogenase, and aspartate aminotransaminase-. The concentration of the structural protein S-100 and the myofibrillar protein troponin I were also significantly increased. Among lysosomal enzymes, we found that the activities of cathepsin B, tripeptidyl-peptidase I, dipeptidylpeptidase II, β-hexosaminidase B, β-mannosidase and β-galactosidase were significantly decreased as compared to the control LES muscles. By analyzing the activity values of the 9 patients in Visick groups Ⅱ and Ⅲ at two months post-surgery, we found a significant increase in the activity of the so-called energy-enzyme values and in the concentration of structural and myofibrillar proteins as compared to the rest of the reflux patients.CONCLUSION: Our results call attention to the metabolic changes that occurred in the LES muscles of reflux patients. The developing hypertrophy-like changes of LES muscles may be a reason for complaints after anti-reflux surgery, which consisted mainly of reports of persisting dysphagia. | Aron Altorjay Arpad Juhasz Viola Kellner Gellert Sohar Matyas Fekete Istvan Sonar | 2005 | World Journal of Gastroenterology2005，11，11： | 2 |
| 7 | Impaired mitochondrial respiratory chain and bioenergetics during chagasic cardiomyopathy development显示文摘 | Galina Vyatkina Vandanajay Bhatia Arpad Gerstner John Papaconstantinou Nisha Garg | 2004 | BBA - Molecular Basis of Disease2004，，2： | 1 |
| 8 | Comparison of life-cycle energy and emissions footprints of passenger transportation in metropolitan regioons显示文摘 | Chester Mikhail V Horvath Arpad Madanat Samer | | 0，，08： | 1 |
| 9 | Molecular shape, dimensions, and shape selective catalysis 显示文摘 | GYULA T ISTVAN P ARPAD M | 2003 | Journal of Molecular Structure: Theochem2003，，666667： | 1 |
| 10 | Inverse design and optimization of a return channel for a multistage centrifugal compressor显示文摘 | Arpad Veress Rene Van den Braembussche | 2004 | ASME Journal of Fluid Engineering2004，126，3： | 1 |
| 11 | Experiment-driven electrochemical modeling and systematic parameterization for a lithium-ion battery cell显示文摘 | Schmidt Alexander P Bitzer Matthias Imre Arpad W | 2010 | Journal of Power Sources2010，195，15： | 1 |
| 12 | Bilateral lung transplantation with intra- and postoperatively prolonged ECMO support in patients with pulmonary hypertension显示文摘 | Arpad Pereszlenyi Georg Lang Heinz Steltzer Hubert Hetz Alfred Kocher Petra Neuhauser Wilfried Wisser Walter Klepetko | 2002 | European Journal of Cardio-Thoracic Surgery2002，，5： | 1 |
| 13 | High- resolution impedance manometry findings in patients with nutcrack- er esophagus显示文摘 | Masato Hoshino Abhishek Sundaram Arpad Juhasz | 2012 | J Gastroenterology and Hepatology2012，27，3： | 1 |
| 14 | New catalytic materials from amorphous metal alloys显示文摘 | Arpad Molnaar Smith G V Mibaly Bartok | 1989 | Advances in Catalysis1989，36，32： | 1 |
| 15 | Systemic nitroglycerin increases nNOS levels in rat trigeminal nucleus caudalis显示文摘 | Arpad K | 2000 | Neuroreport2000，14，28： | 1 |
| 16 | Impaired mitochondrial respiratory chain and bioenergetics during chagasic cardiomyopathy development显示文摘 | GALINA VYATLINA VANDANAJAY BHATIA ARPAD GERSTNER | 2004 | Bioch Biophysica Acta2004，，1689： | 1 |
| 17 | Remodeling of Hippocampal Spine Synapses in the Rat Learned Helplessness Model of Depression显示文摘 | Tibor Hajszan Antonia Dow Jennifer L. Warner-Schmidt Klara Szigeti-Buck Nermin L. Sallam Arpad Parducz Csaba Leranth Ronald S. Duman | 2009 | Biological Psychiatry2009，，5： | 1 |
| 18 | Assessing the Benefits of Design for Recycling for Plastics in Electronics: a Case Study of Computer Enclosures 显示文摘 | MASANET Eric HORVATI4 Arpad | 2007 | Materials and Design2007，28，6： | 1 |
| 19 | Silica-supported Pd catalysts for Heck coupling reactions 显示文摘 | Vivek P Arpad M | 2007 | Tetrahedron2007，63，30： | 1 |
| 20 | The role of the vanilloid and related receptors in nociceptor function and neuroimmune regulation显示文摘 | Daniel N Cortright Arpad Szallasi | 2009 | Neuro Immune Biology2009，8，： | 1 |
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