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| 1 | Clinicohistopathological implications of phosphoserine 9 glycogen synthase kinase-3β/β-catenin in urinary bladder cancer patients显示文摘BACKGROUND Aberrant activation of phosphorylated form of glycogen synthase kinase-3β[pS9 GSK-3β(Serine 9 phosphorylation)] is known to trigger Wnt/β-catenin signal cascade but its clinicohistopathological implications in bladder carcinogenesis remain unknown.AIM To investigate the diagnostic and prognostic relevance of expressions of pS9 GSK-3β, β-catenin and its target genes in the pathobiology of bladder cancer.METHODS Bladder tumor tissues from ninety patients were analyzed for quantitative expression and cellular localization of pS9 GSK-3β by immunohistochemical(IHC) staining. Real time-quantitative polymerase chain reaction and IHC were done to check the expression of β-catenin, Cyclin D1, Snail and Slug at transcriptome and protein level respectively. Clinicohistopathological variables were obtained from histology reports, follow up and OPD visits of patients.Expressions of the markers were statistically correlated with these variables to determine their significance in clinical setting. Results were analysed using SPSS20.0 software.RESULTS Aberrant(low or no membranous/high nuclear/high cytoplasmic) expression of pS9 GSK-3β was noted in 51% patients and found to be significantly associated with tumor stage and tumor grade(P = 0.01 and 0.04; Mann Whitney U test).Thirty one percent tumors exhibited aberrant co-expression of pS9 GSK-3β andβ–catenin proteins and showed strong statistical association with tumor stage,tumor type, smoking/tobacco chewing status(P = 0.01, 0.02 and 0.04, MannWhitney U test) and shorter overall survival probabilities of patients(P = 0.02;Kaplan Meier test). Nuclear immunostaining of Cyclin D1 in tumors with altered pS9 GSK-3β/β–catenin showed relevance with tumor stage, grade and type.CONCLUSIONβ–catenin and pS9 GSK-3β proteins are identified as markers of diagnostic/prognostic significance in disease pathogenesis. Observed histopathological association of Cyclin D1 identifies it as marker of potential relevance in tumors with altered pS9 GSK-3β/β-catenin. | Niharika Maurya Rinni Singh Apul Goel Atin Singhai Uday Pratap Singh Vinita Agrawal Minal Garg | 2019 | World Journal of Clinical Oncology2019，10，4： | 2 |
| 2 | Modeling hydrology and reactive transport in roads: the effect of cracks, the edge, and contaminant properties显示文摘 | Apul D S Gardner K H Eighmy T T | 2007 | Science Direct Waste Management2007，27，： | 1 |
| 3 | Probabilistic modeling of one-dimensional water movement and leaching from highway embankments containing secondary materials显示文摘 | Apul D S Gardner K H Eighmy T T | 2005 | Environmental Engineering Science2005，22，2： | 1 |
| 4 | Adsorption of aromatic organic contaminants by graphene nanosheets: Comparison with earbon nanotubes and activated carbon 显示文摘 | Apul 0 G Wang Q L Zhou Y | 2013 | Water Research2013，47，4： | 1 |
| 5 | Re: In Vivo Evaluation of the Third Generation Biodegradable Stent: A Novel Approach to Avoiding the Forgotten Stent Syndrome显示文摘 | Sagorika Paul Apul Goel Amit Kumar | 2013 | The Journal of Urology2013，，2： | 1 |
| 6 | Simultaneousapplication of dissolution/precipitation and surface complexation/surface precipitation modeling to contaminant leaching显示文摘 | Apul D S Gardne r K H Eighmy T T | 2005 | Environmental Science and Technolgy2005，39，15： | 1 |
| 7 | Adsorption of synthetic organic contaminants by carbon nanotubes: a critical review显示文摘 | APUL O G KARANFIL T | 2015 | Water Research2015，68，： | 1 |
| 8 | Comparing graphene, carbon nanotubes, and superfine powdered activated carbon as adsorptive coating materials for microfiltration membranes显示文摘 | Ellerie J R Apul O G Karanfil T | 2013 | Journal of Hazardous Materials2013，261，： | 1 |
| 9 | Minimally Invasive Retroperitoneoscopic Ureterolithotomy显示文摘 | A.K. HEMAL APUL GOEL RAJIV GOEL | 2003 | The Journal of Urology2003，，2： | 1 |
| 10 | Ultrasonic pretreatment and subsequent anaerobic digestion under different operational conditions显示文摘 | Onur Güven Apul F. Dilek Sanin | 2010 | Bioresource Technology2010，，23： | 1 |
| 11 | Re: Jason A. Efstathiou, Daphna Y. Spiegel, William U. Shipley, et al. Long-Term Outcomes of Selective Bladder Preservation by Combined-Modality Therapy for Invasive Bladder Cancer: The MGH Experience. Eur Urol 2012;61:705–11显示文摘 | Neeraj Kumar Goyal Manish Garg Apul Goel | 2012 | European Urology2012，，： | 1 |
| 12 | Minimally Invasive Retroperitoneoscopic Ureterolithotomy显示文摘 | A.K. HEMAL APUL GOEL RAJIV GOEL | 2003 | The Journal of Urology2003，，2： | 1 |
| 13 | Mutational analysis of Ras hotspots in patients with urothelial carcinoma of the bladder显示文摘BACKGROUND Mutational activation of Ras genes is established as a prognostic factor for the genesis of a constitutively active RAS-mitogen activated protein kinase pathway that leads to cancer.Heterogeneity among the distribution of the most frequent mutations in Ras isoforms is reported in different patient populations with urothelial carcinoma of the bladder(UCB).AIM To determine the presence/absence of mutations in Ras isoforms in patients with UCB in order to predict disease outcome.METHODS This study was performed to determine the mutational spectrum at the hotspot regions of H-Ras,K-Ras and N-Ras genes by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP)and DNA sequencing followed by their clinical impact(if any)by examining the relationship of mutational spectrum with clinical histopathological variables in 87 UCB patients.RESULTS None of the 87 UCB patients showed point mutations in codon 12 of H-Ras gene;codon 61 of N-Ras gene and codons 12,13 of K-Ras gene by PCR-RFLP.Direct DNA sequencing of tumor and normal control bladder mucosal specimens followed by Blastn alignment with the reference wild-type sequences failed to identify even one nucleotide difference in the coding exons 1 and 2 of H-Ras,NRas and K-Ras genes in the tumor and control bladder mucosal specimens.CONCLUSION Our findings on the lack of mutations in H-Ras,K-Ras and N-Ras genes could be explained on the basis of different etiological mechanisms involved in tumor development/progression,inherent genetic susceptibility,tissue specificity or alternative Ras dysfunction such as gene amplification and/or overexpression in a given cohort of patients. | Kiran Tripathi Apul Goel Atin Singhai Minal Garg | 2020 | World Journal of Clinical Oncology2020，11，8： | 1 |
| 14 | Simultaneous application of dissolution/precipitation and surface complexation/ surface precipitation modeling to contaminant leaching 显示文摘 | Apul D S Gardner K H Eighmy T T | 2005 | Environmental Science & Technology2005，39，15： | 1 |
| 15 | Malignant paraganglioma of the urinary bladder. A case report显示文摘 | M.S. Ansari Apul Goel Saroj Goel L.N. Durairajan Amlesh Seth | 2001 | International Urology and Nephrology2001，，2： | 1 |
| 16 | Simultaneous application of dissolution/precipitation and surface complexation/surface precipitation modeling to contaminant leaching 显示文摘 | Apul D S Gardner K H Eighmy T T | 2005 | Environmental Science & Technology2005，39，15： | 1 |
| 17 | Adsorption of synthetic organic contaminants by carbon nanotubes:a critical review显示文摘 | Apul O G Karanfil T | 2015 | Water Research2015，，68： | 1 |
| 18 | Utility of trans-vaginal ultrasound in diagnosis and follow-up of non-pregnant sexually active females with lower ureteric calculi显示文摘objective:To assess the utility of trans-vaginal ultrasonography in evaluation of non-pregnant sexually active female patients with lower ureteric calculi.Methods:A prospective study was done from January 2015 to December 2017 including non-pregnant sexually active females with suspected ureteric calculus.Trans-abdominal ultrasound was initially done in all patients.In those patients in whom trans-abdominal ultrasound was inconclusive or there was indirect evidence of lower ureteric calculus in form of ureteral dila-tion but no calculus was evident,trans-vaginal ultrasound was done.The patients with ureteric calculi detected on trans-vaginal ultrasound and kept on conservative management were also followed up with trans-vaginal ultrasound.Non-contrast computed tomography was done in patients with inconclusive trans-vaginal ultrasound.Results:As per the study protocol,156 out of the total 468 patients evaluated by trans-abdominal ultrasound were eligible for trans-vaginal ultrasound.Trans-vaginal ultrasound was done in 149 patients,as seven patients did not give consent.Seventy-nine patients were detected with a lower ureteric calculus on trans-vaginal ultrasound and 27 patients had gyne-cologic or other cause for their symptoms.Forty-three patients had an inconclusive trans-vaginal ultrasound of which 36 underwent non-contrast computed tomography,among them only one patient had a lower ureteric calculus.Stone free status could be easily demonstrated on follow-up trans-vaginal ultrasound. | Siddharth Pandey Tanica Pandey Apul Goel Ajay Aggarwal Deepanshu Sharma Tushar Pandey Satya sankhwar Gaurav Garg | 2020 | Asian Journal of Urology2020，7，1： | 1 |
| 19 | 显示文摘 | Apul Goel A. Hemal N. Gupta | 2002 | World Journal of Urology2002，，4： | 1 |
| 20 | Simultaneous application of dissolution/precipitation and surface complexation/ surface precipitation modeling to contaminant leaching 显示文摘 | Apul D S Gardner K H Eighmy T T | 2005 | Environmental Science and Technolgy2005，39，15： | 1 |
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