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| 1 | 皮质下小血管病诊断的共识声明显示文摘血管性认知损害是用于描述一组涉及大血管和小血管的散发性和遗传性异质性疾病的诊断术语。皮质下小血管病可导致腔隙性梗死和进行性白质损害。被称为宾斯旺格病(Binswanger's disease, BD)的进行性白质损害患者构成了从单纯血管性疾病到合并神经变性病变的疾病谱。BD患者是一个相对同质性的亚组,存在缺氧缺血、腔隙性梗死和炎症,它们协同作用破坏血脑屏障和髓鞘。通过临床、脑脊液、神经心理学和影像学检查获得的多模式疾病标记物能促进该亚组患者的鉴别。本共识声明确定了一系列基于基础病理学改变的潜在生物学标记物,这将有助于诊断以及将来协作性治疗试验的患者选择。 | Gary A Rosenberg Anders Wallin Joanna M Wardlaw Hugh S Markus Joan Montaner Leslie Wolfson Costantino Iadecola Berislav V Zlokovic Anne Joutel Martin Dichgans Marco Duering Reinhold Schmidt Amos D Korczyn Lea T Grinberg Helena C Chui Vladimir Hachinski 王训师 张劼 陈涵丰 俞娅美 徐子奇 罗本燕 | 2016 | 国际脑血管病杂志2016，24，6： | 18 |
| 2 | 中国城市地区成年人二手烟暴露水平及相关知识和态度调查显示文摘目的 了解中国城市地区成年人二手烟暴露水平及其相关知识态度.方法 利用全球成人烟草调查中国调查(GATS)、国际烟草控制政策评估项目中国调查(ITC)中有关二手烟暴露、禁烟规定、二手烟相关知识态度的变量,使用SAS软件计算率及其95%CI.结果 2项调查中调查对象报告的工作场所室内全面禁烟的比例均低于40%.调查对象报告在餐厅看到吸烟现象比例在各类场所中最高(83.4% ~ 95.6%),其次为工作场所(53.3% ~ 84.0%),在医疗卫生机构、学校、公共交通工具看到吸烟现象的比例较低.GATS调查中60.6%的吸烟者和68.5%的非吸烟者知晓二手烟导致肺癌,但只有三分之一的调查对象知晓二手烟导致成年人心脏病.ITC调查对象对二手烟危害的知晓率高于GATS,但知晓二手烟导致成年人心脏病的比例仅有58.2%.ITC调查对象对学校、出租车、医院、政府机构全面禁烟的支持率较高(>70%),但对工作场所全面禁烟的支持率仅有50.9%和60.9%.结论 中国城市地区室内工作场所全面禁烟的比例较低,二手烟暴露情况严重,公众对二手烟危害的认识以及对工作场所全面禁烟的支持率有待提高. | 冯国泽 姜垣 Zhao Luhua Meng Gang Wu Changbao Anne CK Quah Geoffrey T Fong | 2014 | 中华流行病学杂志2014，35，9： | 18 |
| 3 | Panitumumab and irinotecan versus irinotecan alone for patients with KRAS wild-type, fluorouracil-resistant advanced colorectal cancer (PICCOLO): a prospectively stratified randomised trial显示文摘 | Matthew T Seymour Sarah R Brown Gary Middleton Timothy Maughan Susan Richman Stephen Gwyther Catherine Lowe Jennifer F Seligmann Jonathan Wadsley Nick Maisey Ian Chau Mark Hill Lesley Dawson Stephen Falk Ann O’Callaghan Kim Benstead Philip Chambers Alfred | 2013 | Lancet Oncology2013，，8： | 6 |
| 4 | Impact of enclosure management on soil properties and microbial biomass in a restored semi-arid rangeland, Kenya显示文摘Rangeland degradation is a serious problem throughout sub-Saharan Africa and its restoration is a challenge for the management of arid and semi-arid areas. In Lake Baringo Basin of Kenya, communities and individual farmers are restoring indigenous vegetation inside enclosures in an effort to combat severe land degradation and address their livelihood problems. This study evaluated the impact of enclosure management on soil properties and microbial biomass, being key indicators of soil ecosystem health. Six reseeded communal enclosures using soil embankments as water-harvesting structures and strictly regulated access were selected, varying in age from 13 to 23 years. In six private enclosures, ranging from 3 to 17 years in age, individual farmers emulated the communal enclosure strategy and restored areas for their exclusive use. Significant decreases in bulk density, and increases in the soil organic carbon, total nitrogen and microbial biomass contents and stocks were found in the enclosures as compared with the degraded open rangeland. In the private enclosures, the impact of rehabilitation on the soil quality was variable, and soil quality was in general lower than that obtained under communal management. The significant increase of absolute stocks of carbon, nitrogen and microbial biomass compared to the degraded open rangeland indicates the potential for the restoration of soil quality through range rehabilitation. Over-sowing with indigenous legume fodder species could improve total nitrogen content in the soil and nutritional value of the pastures as well. | Stephen M MUREITHI Ann VERDOODT Charles KK GACHENE Jesse T NJOKA Vivian O WASONGA Stefaan De NEVE Elizabeth MEYERHOFF Eric Van RANST | 2014 | Journal of Arid Land2014，6，5： | 3 |
| 5 | Cholangiocarcinoma, gone without the Wnt?显示文摘Cholangiocarcinoma(CCA) is a relatively rare malignancy of the intra- or extra-hepatic bile ducts that is classified according to its anatomical localization as intrahepatic, perihilar or distal. Overall, CCA has a dismal prognosis due to typical presentation at an advanced irresectable stage, lack of effective non-surgical treatments, and a high rate of disease recurrence. CCA frequently arises on a background of chronic liver inflammation and cholestasis. Chronic inflammation is accompanied by enhanced cell turnover with generation of additional inflammatory stimuli, and a microenvironment rich in pro-inflammatory mediators and proliferative factors that enable accumulation of mutations, transformation and expansion of mutated cells. A recent study by Boulter et al implicates the Wnt signaling cascade in cholangiocarcinogenesis. Wnt ligands Wnt7 B and Wnt10 A were found to be highly overexpressed in human CCA tissue. Wnt7 B protein was present throughout the tumor stroma, and often co-localized with a subset of CD68+ macrophages. To address in a direct manner whether Wnt signaling is engaged in development of CCA, Boulter et al explored the Wnt signaling pathway in an experimental model that recapitulates the multi-stage progression of human CCA.Wnt ligands found to be elevated in human CCA were also upregulated during the course of CCA development following thioacetamide treatment. Wnt10 a increased during the(pre-cancerous) regenerative phase, while Wnt7 b induction paralleled tumor growth. Along with upregulation of target genes, the findings demonstrate that the canonical Wnt pathway is progressively activated during cholangio-carcinogenesis. Macrophage depletion,eliminating a major source of Wnt7 b, prevented activation of the canonical Wnt cascade, and resulted in reduced number and volume of tumors in this model. Moreover,specific inhibitors of the canonical Wnt pathway(ICG-001 and C-59) caused reduction of tumor area and number,in xenograft and thioacetamide models of CCA. The aggregated findings show that experimental, and presumably human CCA, is a Wnt-driven tumor. Modulation of Wnt signaling, alone or in combination with surgicalor chemotherapy approaches, holds promise in the management of this fatal malignancy. | Anne T R Noll Thorsten Cramer Steven W M Olde Damink Frank G Schaap | 2016 | World Journal of Hepatology2016，8，26： | 3 |
| 6 | Lumican is increased in experimental and clinical heart failure, and its production by cardiac fibroblasts is induced by mechanical and proinflammatory stimuli显示文摘 | Kristin V. T. Engebretsen Ida G. Lunde Mari E. Strand Anne Waehre Ivar Sjaastad Henriette S. Marstein Biljana Skrbic Christen P. Dahl Erik T. Askevold Geir Christensen Johannes L. Bj?rnstad Theis T?nnessen | 2013 | FEBS J2013，，10： | 2 |
| 7 | Emergency medical services use and its association with acute ischaemic stroke evaluation and treatment in Singapore显示文摘Background Emergency medical services(EMS)is a critical link in the chain of stroke survival.We aimed to assess EMS use for stroke in Singapore,identify characteristics associated with EMS use and the association of EMS use with stroke evaluation and treatment.Methods The Singapore Stroke Registry combines nationwide EMS and public hospital data for stroke cases in Singapore.Multivariate regressions with the generalised estimating equations were performed to examine the association between EMS use and timely stroke evaluation and treatment.results Of 3555 acute ischaemic patients with symptom onset within 24 hours admitted to all five public hospitals between 2015 and 2016,68%arrived via EMS.Patients who used EMS were older,were less likely to be female,had higher stroke severity by National Institute of Health Stroke Scale and had a higher prevalence of atrial fibrillation or peripheral arterial disease.Patients transported by EMS were more likely to receive rapid evaluation(door-to imaging time≤25 min 34.3%vs 11.1%,OR=2.74(95%CI 1.40 to 5.38))and were more likely to receive intravenous tissue plasminogen activator(tPA,22.8%vs 4.6%,OR=4.61(95%CI 3.52 to 6.03)).Among patients treated with tPA,patients who arrived via EMS were more likely to receive timely treatment than self-transported patients(door-to needle time≤60 min 52.6%vs 29.4%,OR=2.58(95%CI 1.35 to 4.92)).Conclusions EMS use is associated with timely stroke evaluation and treatment in Singapore.Seamless EMS-Hospital stroke pathways and targeted public campaigns to advocate for appropriate EMS use have the potential to improve acute stroke care. | Hanzhang Xu Ying Xian Fung Peng Woon Janet Prvu Bettger Daniel T Laskowitz Yih Yng Ng Marcus Eng Hock Ong David Bruce Matchar Deidre Anne De Silva | 2020 | Stroke & Vascular Neurology2020，5，2： | 2 |
| 8 | Selegiline potentiates the effects of EGb761 in response to ischemic brain injury显示文摘 | Kwon YS Ann HS Nabeshima T | 2004 | Neurochem Int2004，45，1： | 1 |
| 9 | Magnetic manipulation of copper-tin nanowires capped with nickel ends显示文摘 | ANNE K B JEREMY S T ARTHUR B E WENDY C C | 2004 | Nano Letters2004，4，3： | 1 |
| 10 | Changes in the expression and localization of hepatocellular transporters and radixin in primary biliary cirrhosis显示文摘 | Hideyuki Kojima Anne T Nies J?rg K?nig Wolfgang Hagmann Herbert Spring Masahito Uemura Hiroshi Fukui Dietrich Keppler | 2003 | Journal of Hepatology2003，，5： | 1 |
| 11 | Enhancement of mechanical properties of TiN/AlN multilayers by modb lying the number and the quality of interfaces显示文摘 | ANNE T CHRISTOPHE R CHRISTINE C | 2000 | Surface and Coatings Technology2000，124，： | 1 |
| 12 | Types and characteristics of ramp-related motor vehicle crashes on urban interstate roadways in Northern Virginia显示文摘 | Anne T McCartta Veronika Shabanova Northrup Richard A.Retting | | 0，，35： | 1 |
| 13 | Light interception,nitrogen and leaf mass distribution in a multilayer plant community显示文摘 | KULL O ANN A SOELSEPP T | 1995 | Function Ecology1995，9，： | 1 |
| 14 | Outpatient laparoscopic extraperitoneal aortic nodal dissection for locally advanced cervical carcinom a显示文摘 | LOW E M P TILLM ANNS T | 2008 | Gynecol Oncol2008，111，2： | 1 |
| 15 | Pl&tetet &lloimmuniz&tion &fter transf- usion显示文摘 | Ellen T Anne CS Erik H et &l | 1977 | Vox 9&ng1977，72，： | 1 |
| 16 | Reaction time of facial affect recognition in Asperger's disorder for cartoon and real,static and moving faces显示文摘 | Motohide M Anne B Masatsugu T | | 0，，： | 1 |
| 17 | On-site sorting of con- struction and demolition waste in Hong Kong显示文摘 | Poon C S Ann T W Ng L H | 2001 | Re- sources Conservation and Recycling2001，32，2： | 1 |
| 18 | Loop electrosurgical excision of the cervix and the subsequent risk of preterm delivery显示文摘 | Bugge N Ann T Kirsten F | 2007 | Obstetrical Gynecological Survey2007，62，8： | 1 |
| 19 | Glucosidases and exo-glucanases显示文摘 | Elwyn T Reese Anne H Maguire Frederick W Parrish | 1968 | Canadian Journal ofBiochemistry1968，46，1： | 1 |
| 20 | Microencapsulated cell-mediated treatment of inoperable pancreatic carcinoma显示文摘 | Matthias L?hr Anne Hoffmeyer Jens-Christian Kr?ger Mathias Freund Johannes Hain Albrecht Holle Peter Karle Wolfram T Kn?fel Stefan Liebe Petra Müller Horst Nizze Matthias Renner Robert M Saller Thomas Wagner Karlheinz Hauenstein Walter H Günzburg Brian Sa | 2001 | The Lancet2001，，9268： | 1 |
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