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| 1 | Mzb1 protects against myocardial infarction injury in mice via modulating mitochondrial function and alleviating inflammation显示文摘Myocardial infarction(MI)leads to the loss of cardiomyocytes,left ventricle dilation and cardiac dysfunction,eventually developing into heart failure.Mzb1(Marginal zone B and B1 cell specific protein 1)is a B-cell-specific and endoplasmic reticulum-localized protein.Mzb1 is an inflammation-associated factor that participates a series of inflammatory processes,including chronic periodontitis and several cancers.In this study we investigated the role of Mzb1 in experimental models of MI.MI was induced in mice by ligation of the left descending anterior coronary artery,and in neonatal mouse ventricular cardiomyocytes(NMVCs)by H2O_(2)treatment in vitro.We showed that Mzb1 expression was markedly reduced in the border zone of the infarct myocardium of MI mice and in H2O_(2)-treated NMVCs.In H2O_(2)-treated cardiomyocytes,knockdown of Mzb1 decreased mitochondrial membrane potential,impaired mitochondrial function and promoted apoptosis.On contrary,overexpression of Mzb1 improved mitochondrial membrane potential,ATP levels and mitochondrial oxygen consumption rate(OCR),and inhibited apoptosis.Direct injection of lentiviral vector carrying Len-Mzb1 into the myocardial tissue significantly improved cardiac function and alleviated apoptosis in MI mice.We showed that Mzb1 overexpression significantly decreased the levels of Bax/Bcl-2 and cytochrome c and improved mitochondrial function in MI mice via activating the AMPK-PGC1αpathway.In addition,we demonstrated that Mzb1 recruited the macrophages and alleviated inflammation in MI mice.We conclude that Mzb1 is a crucial regulator of cardiomyocytes after MI by improving mitochondrial function and reducing inflammatory signaling pathways,implying a promising therapeutic target in ischemic cardiomyopathy. | Lu Zhang Yi-ning Wang Jia-ming Ju Azaliia Shabanova Yue Li Ruo-nan Fang Jia-bin Sun Ying-ying Guo Tong-zhu Jin Yan-yan Liu Tian-yu Li Hong-li Shan Hai-hai Liang Bao-feng Yang | 2021 | Acta Pharmacologica Sinica2021，42，5： | 3 |
| 2 | Types and characteristics of ramp-related motor vehicle crashes on urban interstate roadways in Northern Virginia显示文摘 | Anne T McCartta Veronika Shabanova Northrup Richard A.Retting | | 0，，35： | 1 |
| 3 | Ovarian function and disease activity in patients with systemic lupus erythematosus 显示文摘 | Shabanova SS Ananieva LP Alekberova ZS | 2008 | Clin Exp Rheumato12008，26，3： | 1 |
| 4 | Selection of internal standard for determination of boron and phosphorus by ICP-MS in silicon photovoltaic materials显示文摘 | VASILYEVA I E SHABANOVA E V SOKOLNIKOVA Y V PROYDAKOVA O A LOZHKIN V I | 1999 | J Anal At Spectrom1999，14，9： | 1 |
| 5 | New muhifunctional additive for lubricants 显示文摘 | Borshchevskii S B Shabanova E V Fufaev A A | 1991 | Chemistry and Technology of Fuels and Oils1991，27，4： | 1 |
| 6 | Electronic structure of Fe +X alloys (X = Si, Ge, Co)显示文摘 | SHABANOVA I N TEREBOVA N S | 2000 | J Struct Chem2000，41，： | 1 |
| 7 | The effect of hemosorption on the immunological status of patients with acute destractive pancreatitis显示文摘 | Shugave AI Shabanova LF | 2000 | Vestn Khir2000，150，34： | 1 |
| 8 | Temperature dependence of electromechanical properties of LGS crystal显示文摘 | Ilyaev A B Umarov B S Shabanova L A | 1986 | Phys Stat Sol(A)1986，98，： | 1 |
| 9 | Neonatal sepsis 2004- 2013:the rise and fall of eoagulase-negative staphylococci显示文摘 | Bizzan'o M J Shabanova V Baltimore RS | 2015 | J Pedi- atr2015，166，5： | 1 |
| 10 | Clinical and Laboratory Factors That Predict Death in Very Low Birth Weight Infants Presenting With Late-onset Sepsis显示文摘 | Orly Levit Vineet Bhandari Fang-Yong Li Veronika Shabanova Patrick G. Gallagher Matthew J. Bizzarro | 2014 | The Pediatric Infectious Disease Journal2014，，2： | 1 |
| 11 | The effect of hemosorption on the immunological status of patients with acute destructive panereatitis显示文摘 | Shugaev AI Shabanova LF | 1993 | Vestn Khir Ⅱ Grek1993，，： | 1 |
| 12 | Temperature dependence of electronmechanical properties of LGS crystals 显示文摘 | Umarov B S Shabanova L A | 1998 | Phys Stas Sol(a)1998，，1： | 1 |
| 13 | Slow glitches in the pulsar B1822-09显示文摘 | Tatiana V. Shabanova | 2007 | Astrophysics and Space Science (-)2007，，1： | 1 |
| 14 | Driving experience, crashes and traffic citations of teenage beginning drivers显示文摘 | MCCARTT A T SHABANOVA V I LEAF W A | 2003 | Accident Analysis and Prevention2003，35，3： | 1 |
| 15 | A study of microstructures responsible for the emergence of the invar and permalloy effects in Fe–Ni alloys显示文摘 | Y. Ustinovshikov I. Shabanova | 2013 | Journal of Alloys and Compounds2013，，： | 1 |
| 16 | Effect of vitamin D-binding protein genotype on the develop- ment of asthma in children显示文摘 | NAVAS-NAZARIO A LI F Y SHABANOVA V | 2014 | Ann Allergy Asthma Immu no12014，112，6： | 1 |
| 17 | The effect of hemosorption on the immunological status of patients with acute destractive pancreatitis 显示文摘 | Shugave AI Shabanova LF | 2000 | Vestn Khir2000，150，324： | 1 |
| 18 | Monocyte CD64 does not enhance neutrophil CD64 as a diagnostic marker in neonatal sepsis显示文摘 | Li FY Shabanova V Wang C | 2014 | Pediatr Infect Dis J2014，33，10： | 1 |
| 19 | Neonatal sepsis 2004-2013: the rise and fall of coagulasenegative staphylococci显示文摘 | Bizzarro MJ Shabanova V Baltimore RS | 2015 | J Pediatr2015，166，5： | 1 |
| 20 | A Study of Microstructures Re- sponsible for the Emergence of the Invar and Permalloy Effects in Fe-Ni Alloys 显示文摘 | Ustinovshikov Y Shabanova I | 2013 | Journal of Alloys and Compounds2013，578，： | 1 |
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