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| 1 | Plant-derived anticancer agents: A green anticancer approach显示文摘Cancer is a frightful disease and represents one of the biggest health-care issues for the human race and demands a proactive strategy for cure. Plants are reservoirs for novel chemical entities and provide a promising line for research on cancer. Hitherto, being effective, chemotherapy is accompanied by certain unbearable side effects. Nevertheless,plants and plant derived products is a revolutionizing field as these are Simple, safer, ecofriendly, low-cost, fast, and less toxic as compared with conventional treatment methods.Phytochemicals are selective in their functions and acts specifically on tumor cells without affecting normal cells. Carcinogenesis is complex phenomena that involves many signaling cascades. Phytochemicals are considered suitable candidates for anticancer drug development due to their pleiotropic actions on target events with multiple manners. The research is in progress for developing potential candidates(those can block or slow down the growth of cancer cells without any side effects) from these phytochemicals. Many phytochemicals and their derived analogs have been identified as potential candidates for anticancer therapy. Effort has been made through this comprehensive review to highlight the recent developments and milestones achieved in cancer therapies using phytomolecules with their mechanism of action on nuclear and cellular factors. Furthermore, drugs for cancer treatment and their limitations have also been discussed. | Javed Iqbal Banzeer Ahsan Abbasi Tariq Mahmood Sobia Kanwal Barkat Ali Sayed Afzal Shah Ali Talha Khalil | 2017 | Asian Pacific Journal of Tropical Biomedicine2017，7，12： | 8 |
| 2 | Role of dietary phytochemicals in modulation of miRNA expression:Natural swords combating breast cancer显示文摘The National Cancer Institute had projected breast cancer(BC) as one of the topmost prevalent malignancies around the globe.In many cases,BC becomes resistant to chemotherapy,radiation and hormonal therapies.Traditional BC therapies are associated with adverse side effects,drug resistance and recurrence.Extensive research work has shown that these dietary phytochemicals(DPs) may exert therapeutic effects by regulating the miRNA expression.A large number of DPs have been researched as miRNA regulatory agents against BC and some other DPs have not yet been tested against BC.We have discussed the effects of curcumin,diallyl disulphide,3,3′ diindolylmethane,ellagic acid,genistein,indole-3-carbinol,quercetin,resveratrol,and sulforaphane on regulation of expression of BC miRNAs in a wide range of in vitro and in vivo models.We have also shown some of the possible DPs(Oleanolic acid,capsaicin,benzyl isothiocyanate,epigallocatechin gallate,phenethyl isothiocyanate and ursolic acid) that have shown miRNA regulatory activities and have not yet been tested against BC miRNAs.Finally,current limitations,challenges,future perspectives of DPs and BC research are also critically discussed. | Banzeer Ahsan Abbasi Javed Iqbal Tariq Mahmood Ali Talha Khalil Barkat Ali Sobia Kanwal Sayed Afzal Shah Riaz Ahmad | 2018 | Asian Pacific Journal of Tropical Medicine2018，11，9： | 3 |
| 3 | Why more research needs to be done on echinococcosis in Pakistan显示文摘Background:Echinococcosis has a worldwide geographical distribution with endemic foci on every inhabited continent.Due to the frequent outbreaks in different parts of Pakistan in the recent past,echinococcosis is being described as a neglected tropical disease and is considered one of the most neglected parasitic diseases in the country.In endemic regions,predominantly settings with limited resources,there are high numbers of echinococcosis patients,as these communities do not have access to appropriate treatment.In Pakistan,there are limited reports on echinococcosis.The disease is prevalent in human and livestock,but this has not been sufficiently explored yet.Pakistan is an agricultural country and due to the disease’s zoonotic mode of transmission,there is a dire need of future research on it.The present paper is an effort to highlight the importance of echinococcosis in Pakistan.Discussion:There is a dire need for future research on echinococcosis in Pakistan as very few investigations had been carried out on this topic thus far.The prevalence of the disease in neighbouring countries highlights that Pakistan might be at severe risk of this zoonotic infection and further supports the need for more research.In Pakistan,the majority of the population lives in rural areas with limited acess to proper hygienic/sanitary facilities.These conditions favour the outbreak of diseases such as echinococcosis.The limited available data could result in higher outbreaks in the future,and thus cause the already weak healthcare system to overburden.The country has a meagre annual budget for health,which is being spent on known infections such as polio,dengue fever and hepatic viral infections.A proper surveillance system for echinococcosis is required across the country as treatment is usually expensive,complicated and may require extensive surgery and/or prolonged drug therapy.Development of new/novel drugs and other treatment modalities receives very little,if any,attention.Prognostic awareness programmes against this infection involve deworming of the infected animals,improved food inspection and slaughterhouse hygiene,and public education campaigns.Conclusion:Future research on echinococcosis is anticipated to demonstrate whether the epidemiology,diagnosis and recombinant vaccines/antibodies relating to echinococcosis can meet the quality standards(purity,potency,safety and efficacy)defined by the World Health Organization.Research work should be carried out on the epidemiology and serodiagnosis of echinocossis in the different areas of Pakistan,which will be useful for the proper eradication of echinococcosis in this region.The health department should implement awareness-raising campaigns for the general public in order to reduce the burden of disease. | Haroon Ahmed Shahzad Ali Muhammad Sohail Afzal Abid Ali Khan Hamid Raza Zaheer Hussain Shah Sami Simsek | 2017 | Infectious Diseases of Poverty2017，6，1： | 2 |
| 4 | Anxiolytic potential of ursolic acid derivative-a stearoyl glucoside isolated from Lantana camara L.(verbanaceae)显示文摘Objective:To investigate the anxiolytic activity of newly isolated compound by our lab called ursolic acid stearoyl glucoside(UASG) from the leaves of Lantana camam(L camam).Methods: Column chromatography was used to isolate UASG.Anxiolytic potential was experimentally proved and demonstrated through Elevated plus-maze,Open field and light and dark test. Results:The UASG showed marked increased in time spent(%) and number of frequent movements made by animals in open arm of elevated plus-maze apparatus.In light and dark model,UASG produced marked increase in time spent by animal,number of crossing and reduced duration of immobility in light box.Conclusions:UASG showed significant increase in number of rearing,assisted rearing and number of square crossed in open field established test model.UASG showed its anxiolytic effect in dose dependent manner. | Imran Kazmi Muhammad Afzal Babar Ali Zoheir A.Damanhouri Aftab Ahmaol Firoz Anwar | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，6： | 2 |
| 5 | Garlic and Onions: their Effect on Eicosanoid Metablism and Its Clinical Relevance显示文摘 | Ali M Thomson M Afzal M | 2000 | Prostaglan- dins leukot Essent Fatty Acids2000，62，2： | 1 |
| 6 | Kinetics of oxidation of acetophenones by diperiodatonickelate(Ⅳ) in the presense and absense of asmium(Ⅷ)显示文摘 | M AFZAL ALI SIDDIQUI SUDHEER KUMAR C H CHANDDRAIAH U | 1991 | Indian Journal of Chemistry1991，30，10： | 1 |
| 7 | Environmental consequences of cattle feedlot manure on saline soils显示文摘 | Shahzad Afzal M. Ilyas Tariq Mohammad Younas Zahid Sarwar Karamat Ali | 2000 | International Journal of Environmental Studies2000，，6： | 1 |
| 8 | Chiral separation of β-adrenergic blockers on CelluCoat column by HPLC显示文摘 | Imran Ali Vinay D. Gaitonde Hassan Y. Aboul-Enein Afzal Hussain | 2008 | Talanta2008，，2： | 1 |
| 9 | Garlic and Onions:their Effect on Eicosanoid Metablism and Its Clinical Relevance显示文摘 | Ali M Thomson M Afzal M | 2000 | Prostaglandins leukot Essent Fatty Acids2000，62，2： | 1 |
| 10 | CVD Diamond: Controlling Structure and Morphology显示文摘 | Ahmed W Rego C A Cherry R Afzal A Ali N Hassan I U | 2000 | Vacuum2000，56，： | 1 |
| 11 | Knowledge-based queryconstruction using the CDSS knowledge base for efficient ev-idence retrieval 显示文摘 | Afzal M Hussain M Ali T | 2015 | Sensors ( Basel )2015，15，21： | 1 |
| 12 | Sustainable use of low lime fly ashes in geotechnical and geoenvironmental applications 显示文摘 | Moghal Arif Ali Baig Moghal Afzal Ali Baig | 2012 | Geo Congress2012，，： | 1 |
| 13 | Numerical Simulation and Experimental Verification of CMOD in SENT Specimen: Application on FCGR of Welded Tool Steel显示文摘Single-edged notched tension (SENT) specimen is used to study the fatigue crack growth rate (FCGR) behavior of AISI 50100 steel using MTS 810. Calibration tests are run to get plots of crack mouth opening displacement (CMOD) vs. load and CMOD vs. crack length-to-width ratio with the known crack lengths. Numerical simulation is also done to try to establish a relation between crack length and CMOD. FCGR of welded and un-welded specimens are plotted against stress intensity factor range to show the effect of welding on fatigue crack growth rate of AISI 50100 steel. The experimentally obtained CMOD values are compared with values obtained by numerical simulation using ABAQUS/StandardTM software package. Results show that numerical values are in good agreement with experimental data for small crack lengths and lower values of applied load. | Amir SULTAN Riffat Asim PASHA Mifrah ALI Muhammad Zubair KHAN Muhammad Afzal KHAN Naeem Ullah DAR Masood SHAH | 2013 | Acta Metallurgica Sinica(English Letters)2013，26，1： | 1 |
| 14 | Antidiabetic potential of triterpenoid saponin isolated from Primula denticulate显示文摘 | Sanjay Singh Mamta Farswan Sadat Ali Muhamad Afzal Fahad A. Al-Abbasi Imran Kazmi Firoz Anwar | 2014 | Pharmaceutical Biology2014，，6： | 1 |
| 15 | Human Behavior Classification Using Geometrical Features of Skeleton and Support Vector Machines显示文摘Classification of human actions under video surveillance is gaining a lot of attention from computer vision researchers.In this paper,we have presented methodology to recognize human behavior in thin crowd which may be very helpful in surveillance.Research have mostly focused the problem of human detection in thin crowd,overall behavior of the crowd and actions of individuals in video sequences.Vision based Human behavior modeling is a complex task as it involves human detection,tracking,classifying normal and abnormal behavior.The proposed methodology takes input video and applies Gaussian based segmentation technique followed by post processing through presenting hole filling algorithm i.e.,fill hole inside objects algorithm.Human detection is performed by presenting human detection algorithm and then geometrical features from human skeleton are extracted using feature extraction algorithm.The classification task is achieved using binary and multi class support vector machines.The proposed technique is validated through accuracy,precision,recall and F-measure metrics. | Syed Muhammad Saqlain Shah Tahir Afzal Malik Robina khatoon SyedSaqlain Hassan Faiz Ali Shah | 2019 | Computers, Materials & Continua2019，，8： | 1 |
| 16 | New bioactive natural products from Launaea nudicaulis显示文摘 | Muhammad Saleem Shehla Parveen Naheed Riaz Muhammad Nawaz Tahir Muhammad Ashraf Iftikhar Afzal Muhammad Shaiq Ali Abdul Malik Abdul Jabbar | 2012 | Phytochemistry Letters2012，，4： | 1 |
| 17 | Genotyping of HCV RNA Reveals That 3a Is the Most Prevalent Genotype in Mardan, Pakistan显示文摘 | Sajid Ali Ayaz Ahmad Raham Sher Khan Sanaullah Khan Muhammad Hamayun Sumera Afzal Khan Amjad Iqbal Abid Ali Khan Abdul Wadood Taj Ur Rahman Ali Hydar Baig Jay C. Brown | 2014 | Advances in Virology2014，，： | 1 |
| 18 | Pathogenicity of avian influenza virus H5N1 2007 isolates from Pakistan显示文摘 | Farhan Afzal Ali Saeed Muhammad Azhar Sharif Najma Ayub Shamsul Hassan | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，，1： | 1 |
| 19 | Nationwide Outcomes of Non Variceal Upper Gastrointestinal Hemorrhage in Patients With END Stage Renal Disease显示文摘 | Ahmad S Ali M Afzal U | 2011 | Gastroenterology2011，140，5： | 1 |
| 20 | Thoracic impalement injury: A survivor with large metallic object in-situ显示文摘Impalement injuries, is a severe form of trauma, which are not common in civilian life. These injuries rarely occurs in major accidents. Abdomen, chest, limbs and perineum are often involved due to their large surface area. Thoracic impalement injury is usually a fatal injury, due to location of major vessels and heart in the thoracic cavity. These injuries are horrifying to site, but the patients who are lucky enough to make it to hospital, usually survive. Chances of survival are larger in right sided impalement injuries while central injuries are always died at the scene.Our patient, 25 years old male, was brought to the emergency room (ER) with large impaled metallic bar (about 2.5 feet long) in situ, in right sided chest. The patient was immediately shifted to operation room (OR) and was operated, his recovery was uneventful without any sequelae.Such patients should be treated and resuscitated according to advanced trauma life support (ATLS) protocols and operated without any delay for further investigations. Such operations are carried out by the most experienced surgeon team available. The impaled objects should not be processed if not necessary to avoid major hemorrhage and damage to vital structures, until the patient is in operation room. Large size and unusual position of impaled objects, makes the job difficult for surgeons/anesthetists.Although horrifying at scene, patients with thoracic impalement injuries are mostly young and healthy, and those who survive the pre-hospital phase are potentially manageable with proper resuscitation. Usually these patients make recovery without any further complications. | Randhawa Muhammad Afzal Muhammad Armughan Muhammad Waqas Javed Usman Ali Rizvi Sajida Naseem | 2018 | Chinese Journal of Traumatology2018，21，6： | 1 |
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