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| 1 | 蓼科蓼属植物化学成分及生物活性分析(英文)显示文摘蓼属(Polygonum)的主要化学成分是黄酮类,醌类,苯丙素类和萜类类化合物,具有抗癌,抗肿瘤,抗氧化,抗炎,镇痛,抗菌,杀虫等药理作用。本文总结了近15年来蓼属植物化学成分和药理作用的研究进展。 | 沈冰冰 杨玉佩 Sumera Yasamin 梁娜 苏维 陈胜璜 王晓娟 王炜 | 2018 | Digital Chinese Medicine2018，1，1： | 9 |
| 2 | Hepatic expression and cellular distribution of the glucose transporter family显示文摘Glucose and other carbohydrates are transported into cells using members of a family of integral membrane glucose transporter (GLUT) molecules. To date 14 members of this family, also called the solute carrier 2A proteins have been identified which are divided on the basis of transport characteristics and sequence similarities into several families (Classes 1 to 3). The expression of these different receptor subtypes varies between different species, tissues and cellular subtypes and each has differential sensitivities to stimuli such as insulin. The liver is a contributor to metabolic carbohydrate homeostasis and is a major site for synthesis, storage and redistribution of carbohydrates. Situations in which the balance of glucose homeostasis is upset such as diabetes or the metabolic syndrome can lead metabolic disturbances that drive chronic organ damage and failure, confirming the importance of understanding the molecular regulation of hepatic glucose homeostasis. There is a considerable literature describing the expression and function of receptors that regulate glucose uptake and release by hepatocytes, the most import cells in glucose regulation and glycogen storage. However there is less appreciation of the roles of GLUTs expressed by non parenchymal cell types within the liver, all of which require carbohydrate to function. A better understanding of the detailed cellular distribution of GLUTs in human liver tissue may shed light on mechanisms underlying disease pathogenesis. This review summarises the available literature on hepatocellular expression of GLUTs in health and disease and highlights areas where further investigation is required. | Sumera Karim David H Adams Patricia F Lalor | 2012 | World Journal of Gastroenterology2012，18，46： | 5 |
| 3 | Multi-temporal forest cover dynamics in Kashmir Himalayan region for assessing deforestation and forest degradation in the context of REDD+ policy显示文摘The role of forests is being actively considered under the agenda of REDD+(Reducing Emissions from Deforestation and Forest Degradation plus) aimed at reducing emissions related to changes in forest cover and forest quality. Forests in general have undergone negative changes in the past in the form of deforestation and degradation, while in some countries positive changes are reported in the form of conservation, sustainable management of forests and enhancement of carbon stock. The present study in the Kashmir Himalayan forests is an effort to assess historical forest cover changes that took place from 1980 to 2009 and to predict the same for 2030 on the basis of past trend using geospatial modeling approach. Landsat data(Multispectral Scanner(MSS),Thematic Mapper(TM) and Enhanced Thematic Mapper(ETM+)) was used for the years 1980, 1990 and(2001, 2009) respectively and change detection analysis between the dates was performed. The maps generated were validated through ground truthing. The study area(3375.62 km^2) from 1980-2009 has uffered deforestation and forest degradation of about 126 km^2 and 139.02 km^2 respectively which can be claimed under negative options of REDD+, while as the area that experienced no change(1514 km^2) can be claimed under conservation. A small area(23.31 km^2) observed as positive change can be claimed under positive options. The projected estimates of forest cover for 2030 showed increased deforestation and forest degradation on the basis of trend analysis using Cellular Automata(CA) Markov modeling. Despite the fact that country as a whole has registered a net positive change in the past few decades, but there are regions like Kashmir region of western Himalaya which have constantly undergoing deforestation as well as degradation in the past few decades. | Akhlaq Amin WANI Pawan Kumar JOSHI Ombir SINGH Sumera SHAFI | 2016 | Journal of Mountain Science2016，13，8： | 2 |
| 4 | Germa-γ-lactones as novel inhibitors of bacterial urease activity显示文摘 | ZAREEN A CRISTIAN F SUMERA M | 2007 | Biochemical and Biophysical Research Comunications2007，，2： | 1 |
| 5 | Old-growth forest canopy structure and its relationship to throughfall interception显示文摘 | NADKARNI N M SUMERA M M | 2004 | Forest Science2004，50，3： | 1 |
| 6 | Rhizobium,Bradyrhizobium and Agrobacterium strains isolated from cultivated legumes显示文摘 | SOHAIL H SUMERA Y KAUSER A M | 2004 | Biology and Fertility of Soils2004，39，3： | 1 |
| 7 | A comparative study of macrophytes influence on wastewater treatment through subsurface flow hybrid constructed wetland显示文摘 | Sehar S Sumera Naeem S | 2015 | Ecological Engineering2015，81，： | 1 |
| 8 | Sareomatoid Renal Cell Carcinoma 显示文摘 | Mahera Roohi Imrana Tanvir Sumera Qazi | 2012 | International Journal of Pathology2012，10，1： | 1 |
| 9 | Characterization of Polypropylene and Ethylene-Propylene Copolymer Blends for Industrial Applications 显示文摘 | Bedia EL Sudarisman A Sumera F | 2000 | Applied Polymer Science2000，78，： | 1 |
| 10 | Hafeez Rhizobium, Bradyrhizobium and Agrobacterium Strains Isolated from Cultivated Legumes显示文摘 | SUMERA S H KAUSER A Y | 2004 | Biol Fertil Soils2004，39，： | 1 |
| 11 | Review: Beta- thalassemia and molecular chaperones 显示文摘 | Sumera A Radhakrishnan A Baba AA | 2015 | Blood Cells Mol Dis2015，54，4： | 1 |
| 12 | Genotyping of HCV RNA Reveals That 3a Is the Most Prevalent Genotype in Mardan, Pakistan显示文摘 | Sajid Ali Ayaz Ahmad Raham Sher Khan Sanaullah Khan Muhammad Hamayun Sumera Afzal Khan Amjad Iqbal Abid Ali Khan Abdul Wadood Taj Ur Rahman Ali Hydar Baig Jay C. Brown | 2014 | Advances in Virology2014，，： | 1 |
| 13 | Pulmonary hypertension and leading factors in patients undergoing dialysis 显示文摘 | Shoukat Rehman IU Sumera | 2014 | J Coil Physicians Surg Pak2014，24，11： | 1 |
| 14 | Gibberellitt production by pure cultures of a new strain of Aspergillus fumigates显示文摘 | Hamayun M Sumera A K Mir A K | 2009 | World J Microbiol Biotechnol2009，25，10： | 1 |
| 15 | Video-assisted thoraco- scopic surgery or transsternal thymectomy in the treat- ment of myasthenia gravis显示文摘 | Imran Zahida Sumera Sharifa | 2011 | Interactive CardioVascular and Thoracic Surgery2011，，22： | 1 |
| 16 | Germa-r-lactones as novel inhibitors of bacterial urease activity显示文摘 | ZARREN AMTUL CRISTIAN FOLLMER SUMERA MAHBOOB | 2007 | Biochemical and Biophysical Research Communications2007，，2： | 1 |
| 17 | Hafeez Rhizobium, Bradyrhizobium and Agrobacterium Strains Isolated from Cultivated Legumes 显示文摘 | SUMERA S H KAUSER A Y | 2004 | Biol Fertil Soils2004，39，： | 1 |
| 18 | Inhibition of vascular adhesion protein-1 modifies hepatic steatosis in vitro and in vivo显示文摘BACKGROUND Non-alcoholic fatty liver disease(NAFLD)is associated with obesity,insulin resistance and dyslipidaemia and currently is estimated to affect up to a third of all individuals in developed countries.Current standard of care for patients varies according to disease stage,but includes lifestyle interventions common insulin sensitizers,antioxidants and lipid modifiers.However,to date specific therapies have shown little histological or fibrosis stage improvement in large clinical trials,and there is still no licensed therapy for NAFLD.Given the high prevalence,limited treatment options and significant screening costs for the general population,new treatments are urgently required.AIM To assess the potential for inhibition of the amine oxidase enzyme vascular adhesion protein-1(VAP-1)to modify hepatic lipid accumulation in NAFLD.METHODS We have used immunochemical and qPCR analysis to document expression of VAP-1 and key functional proteins and transporters across the NAFLD spectrum.We then utilised hepatocytes in culture and human precision cut liver slices in concert with selective enzyme activity inhibitors to test the effects of activating the semicarbazide-sensitive amine oxidase activity of VAP-1 on hepatic lipid uptake and triglyceride export.A murine model of NAFLD was also used to determine the consequences of VAP-1 knockout and gene expression arrays were used to quantify the effects of VAP-1 activity on key lipid modifying and proinflammatory gene expression.RESULTS We confirmed that increasing severity of NAFLD and progression to cirrhosis was associated with a significant increase in hepatocellular VAP-1 expression.Hepatocytes in vitro exposed to recombinant VAP-1 and its substrate methylamine showed increased lipid accumulation as determined by quantification of Oil Red O uptake.This was recapitulated using hydrogen peroxide,and lipid accumulation was accompanied by changes in expression of the lipid transporter molecules FABP3,FATP6,insulin receptor subunits and PPARα.Human liver tissue exposed to recombinant VAP-1 or substrates for endo/exogenous VAP-1 produced less triglyceride than untreated tissue and demonstrated an increase in steatosis.This response could be inhibited by using bromoethylamine to inhibit the SSAO activity of VAP-1,and mice deficient in VAP-1/AOC3 also demonstrated reduced steatosis on high fat diet.Exposure of human liver tissue to methylamine to activate VAP-1 resulted in increased expression of FABP2 and 4,FATP3-5,caveolin-1,VLDLR,PPARGC1 and genes associated with the inflammatory response.CONCLUSION Our data confirm that the elevations in hepatic VAP-1 expression reported in nonalcoholic steatohepatitis can contribute to steatosis,metabolic disturbance and inflammation.This suggests that targeting the semicarbazide sensitive amine oxidase capacity of VAP-1 may represent a useful adjunct to other therapeutic strategies in NAFLD. | Emma L Shepherd Sumera Karim Philip N Newsome Patricia F Lalor | 2020 | World Journal of Hepatology2020，12，11： | 0 |
| 19 | Antifungal Potential of Chenopodium album L. against Chickpea Blight显示文摘 | Khajista Jabeen Aqsa Zahid Sherazi Sumera Iqbal | 2014 | Journal of Agricultural Science and Technology(A)2014，4，1： | 0 |
| 20 | 水稻二化螟诱导表达基因OsSABATH启动子的克隆与缺失体构建显示文摘Northern杂交结果表明,OsSABATH基因受二化螟(Chilo suppressalis)为害诱导表达,但却不受机械损伤诱导。利用该基因序列和水稻基因组数据库相应序列设计引物,扩增到该基因编码区5′上游2050bp的启动子序列。用PLACE软件分析顺式作用元件,发现该基因起始密码子上游1.4kb的区域内存在几个可能与该基因表达调控相关的顺式作用元件,如W盒、DOF结合序列、GT-1、BIHD1结合序列等。将该基因启动子区域及其5′部分缺失构件与GUS报告基因相连,并克隆进pCAMBIA1391载体中,用于分析启动子活性及虫伤诱导特异性相关的顺式作用元件。 | 李冉 Sumera AFSHEEN 周国鑫 任楠 娄永根 | 2008 | 中国水稻科学2008，22，5： | 0 |
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