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| 1 | Addition of statins to the standard treatment in patients with cirrhosis:Safety and efficacy显示文摘This review summarizes the safety and efficacy of statins in patients with cirrhosis.Due to concerns about the safety of statins in patients with impaired liver function,they have recently been investigated as a potential treatment option in cirrhosis.The most clinically significant adverse event is statin-related myopathy,and this may be related to the high serum statin concentrations in the setting of severely impaired liver function.Rhabdomyolysis is the most serious and potentially life-threatening manifestation.It has recently been demonstrated that the recommended dose of simvastatin in patients with decompensated cirrhosis would be 20 mg/d because higher values,such as 40 mg/d,are associated with many adverse events,especially muscle injury.Likewise,simvastatin should not be administered to patients with Model for End-stage Liver Disease score>12 and/or Child-Pugh class C because of the high risk of severe muscle injury.Due to the pleiotropic effects,the focus on statins has shifted from being considered harmful to something useful.Through these effects,statins could prevent liver-related morbidity and mortality in cirrhotic patients.Observational studies in large populations of patients with cirrhosis have shown that treatment with statins to decrease high cholesterol levels was associated with a reduced risk of hepatic decompensation,hepatocellular carcinoma development and death.The few randomized controlled trials in patients with cirrhosis and portal hypertension showed that statins lower portal pressure,quite likely through a reduction in hepatic resistance.Another large randomized controlled trial in patients with variceal bleeding showed that simvastatin in addition to standard of care did not prevent rebleeding but improved survival rate.Despite these encouraging outcomes,the quality of the evidence regarding the use of statins is low or very low due to the observational characteristics of most of the studies involved.Therefore,it is advisable to perform further randomized controlled trials on a large series of patients with hard clinical endpoints,using different statin types and varying doses.The objectives would be to prevent liver-related morbidity and mortality rather than treating cirrhosis complications to take additional information that makes it possible to add statins to the standard of care of these patients. | Alberto E Muñoz Florencia D Pollarsky Mónica Marino Mariano Cartier Horacio Vázquez Pablo Salgado Gustavo Romero | 2021 | World Journal of Gastroenterology2021，27，28： | 4 |
| 2 | Classification of hyperspectral images by using extended morphological attribute profiles and independent component analysis显示文摘 | Mauro D M Alberto V | 2011 | IEEE Trans Geosci Remote Sensing Lett2011，8，3： | 1 |
| 3 | Valsartan benefits left ventricular structure and function in heart failure: Val-HeFT echocardiographic study显示文摘 | Maylene Wong Lidia Staszewsky Roberto Latini Simona Barlera Alberto Volpi Yann-Tong Chiang Raymond L Benza Sidney O Gottlieb Thomas D Kleemann Franco Rosconi Pieter M Vandervoort Jay N Cohn | 2002 | Journal of the American College of Cardiology2002，，： | 1 |
| 4 | Upgrading heavy oil using slurry processes显示文摘 | ALBERTO D B NICOLETTA P MARIO M | 1995 | Chemtech1995，25，11： | 1 |
| 5 | Traditional and Innovative Paths towards Time-based Competition显示文摘 | ALBERTO D T ANTONELLA M | 2000 | International Journal of Production Economics2000，66，3： | 1 |
| 6 | Comparison of contact-force models for the simulation of collisions in DEM-based granular flow codes显示文摘 | ALBERTO D R FRANCESCO P D M | 2004 | Chemical Engineering Science2004，59，13： | 1 |
| 7 | Ant system:optimization by a colony of cooperating agents显示文摘 | Marco D Vittorio M Alberto C | 1996 | IEEE Transactions on Cybernetics1996，26，1： | 1 |
| 8 | Fiat:Open Innovation in a Downturn(1993-2003)显示文摘 | ALBERTO D M FEDERICO F ANDREA P | 2010 | California Management Review2010，52，3： | 1 |
| 9 | Preparation of ferrofluid from cyclodextrin and mag- netite显示文摘 | Alberto Bocanegra-Diaza N D S Mohallema M A Novakb | 2004 | Journal of Magnetism and Magnetic Materials2004，，： | 1 |
| 10 | An improved integral non-linear model for the contact of particle in distinct element simulations显示文摘 | ALBERTO D R FRANCESCO D M | 2005 | Chemical Engineering Science2005，60，1： | 1 |
| 11 | Antioxidant capacities,carotenoids and polyphenols evaluation of fresh and refrigerated peach and nectarine cultivars from Italy显示文摘 | Claudio D V Giulia G Luigi M Annunziata C Alberto R | | 0，，： | 1 |
| 12 | Upgrading heavy oil using slurry processes 显示文摘 | ALBERTO D B NICOLETTA P MARIO M | 1995 | Chemtech1995，25，11： | 1 |
| 13 | Comparison of contact-force models for the simulation of collisions in DEM-based granular flow codes 显示文摘 | ALBERTO D R FRANCESCO P D M | 2004 | Chemical En- gineering Science2004，59，3： | 1 |
| 14 | The ant system: optimization by a colony of cooperating agents 显示文摘 | MACRO D VITI'ORIO M ALBERTO C | 1996 | IEEE Transactions on Systems Man and Cybernetics1996，26，1： | 1 |
| 15 | Current controversies regarding the role of asbestos exposure in the causation of malignant mesothelioma: the need for an evidence-based approach to de- velop medicolegal guidelines 显示文摘 | ALBERTO M MARCHEVSKY M D MARK R WICK M D | 2003 | Annals of Diagnostic Pathology2003，7，： | 1 |
| 16 | Aneuploidies detection in miscarriages and fetal deaths using multiplex ligation-dependent probe amplification: an alternative for speeding up results?显示文摘 | Berta Carvalho Sofia Dória Carla Ramalho Otília Brand?o Mário Sousa Alexandra Matias Alberto Barros Filipa Carvalho | 2010 | European Journal of Obstetrics and Gynecology2010，，2： | 1 |
| 17 | The ant system:optimization by a colony of cooperating agent显示文摘 | MARCO D VITTORIO M ALBERTO C | 1996 | IEEE Transactions on Systems Man and Cybernetics Part B:Cybernetics1996，26，1： | 1 |
| 18 | Chitosan:A versatile biopolymer for orthopaedic tissue-engineering显示文摘 | Alberto D M Michael S Makarand V R | 2005 | Biomaterials2005，26，30： | 1 |
| 19 | Comparison of contact-force models for the simulation of collisions in DEM-based granular flow codes显示文摘 | Renzo D Alberto D M | 2004 | Chemical Engineering Science2004，59，3： | 1 |
| 20 | Effect of glu- cose oxidase, transglutaminase, and pentosanase on wheat proteins: Relationship with dough properties and bread - making quality 显示文摘 | Steffolani M E Ribotta P D Alberto E L | 2010 | Journal of Cereal Science2010，51，： | 1 |
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