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| 1 | High-resolution multimodal flexible coherent Raman endoscope显示文摘Coherent Raman scattering microscopy is a fast,label-free,and chemically specific imaging technique that shows high potential for future in vivo optical histology.However,the imaging depth in tissues is limited to the sub-millimeter range because of absorption and scattering.Realization of coherent Raman imaging using a fiber endoscope system is a crucial step towards imaging deep inside living tissues and providing information that is inaccessible with current microscopy tools.Until now,the development of coherent Raman endoscopy has been hampered by several issues,mainly related to the fiber delivery of the excitation pulses and signal collection.Here,we present a flexible,compact,coherent Raman,and multimodal nonlinear endoscope(4.2mm outer diameter,71mm rigid length)based on a resonantly scanned hollow-core Kagomé-lattice double-clad fiber.The fiber design enables distortion-less,background-free delivery of femtosecond excitation pulses and back-collection of nonlinear signals through the same fiber.Sub-micrometer spatial resolution over a large field of view is obtained by combination of a miniature objective lens with a silica microsphere lens inserted into the fiber core.We demonstrate high-resolution,high-contrast coherent anti-Stokes Raman scattering,and second harmonic generation endoscopic imaging of biological tissues over a field of view of 320μm at a rate of 0.8 frames per second.These results pave the way for intraoperative label-free imaging applied to real-time histopathology diagnosis and surgery guidance. | Alberto Lombardini Vasyl Mytskaniuk Siddharth Sivankutty Esben Ravn Andresen Xueqin Chen Jérôme Wenger Marc Fabert Nicolas Joly Frédéric Louradour Alexandre Kudlinski Hervé Rigneault | 2018 | Light(Science & Applications)2018，7，1： | 6 |
| 2 | Comparison of contact-force models for the simulation of collisions in DEM-based granular flow codes显示文摘 | ALBERTO D R FRANCESCO P D M | 2004 | Chemical Engineering Science2004，59，13： | 1 |
| 3 | Comorbidity of obsessivecompulsive disorders and personality disorders:a Brazilian controlled study显示文摘 | ALBINA R T PORTO D ALBERTO J | 1995 | Psychopathology1995，28，6： | 1 |
| 4 | The staling of bread: an X-ray diffraction study显示文摘 | PABLO D R SILVIA C ALBERTO E | 2004 | European Food Research and Technology2004，218，： | 1 |
| 5 | An improved integral non-linear model for the contact of particle in distinct element simulations显示文摘 | ALBERTO D R FRANCESCO D M | 2005 | Chemical Engineering Science2005，60，1： | 1 |
| 6 | Antioxidant capacities,carotenoids and polyphenols evaluation of fresh and refrigerated peach and nectarine cultivars from Italy显示文摘 | Claudio D V Giulia G Luigi M Annunziata C Alberto R | | 0，，： | 1 |
| 7 | Comparison of contact-force models for the simulation of collisions in DEM-based granular flow codes 显示文摘 | ALBERTO D R FRANCESCO P D M | 2004 | Chemical En- gineering Science2004，59，3： | 1 |
| 8 | Current controversies regarding the role of asbestos exposure in the causation of malignant mesothelioma: the need for an evidence-based approach to de- velop medicolegal guidelines 显示文摘 | ALBERTO M MARCHEVSKY M D MARK R WICK M D | 2003 | Annals of Diagnostic Pathology2003，7，： | 1 |
| 9 | Chitosan:A versatile biopolymer for orthopaedic tissue-engineering显示文摘 | Alberto D M Michael S Makarand V R | 2005 | Biomaterials2005，26，30： | 1 |
| 10 | Cost and schedule monitoring of industrial building projects:case study显示文摘 | Alberto D M Diego B Cafele R | 2009 | Journal of Construction Engineering and Management2009，139，9： | 1 |
| 11 | Disappearance of azoxystrobin,pyrimethanil, cyprodinil, and fludioxonil on tomatoes in a greenhouse显示文摘 | VINCENZO L G ALBERTO A ANA A D R I | 2002 | Journal of Agricultural and Food Chemistry2002，50，： | 1 |
| 12 | Minimum entropy deconvolution with frequency - domain constraints 显示文摘 | Mauricio D Sacchi Danilo R Velis Alberto H Cominguez | 1994 | Geophysics1994，59，6： | 1 |
| 13 | Case study on quantifying the impact of political risks on demand and prieing in a power project显示文摘 | TILLMANN S ALBERTO D R ROBERT L K T | 2008 | The Journal of Structured Finance2008，，： | 1 |
| 14 | Influence of bioparticle size on the degradation of partially soluble wastewater in an anaerobic sequencing batch biofilm reactor (ASBBR) with mechanical stirring显示文摘 | Samantha C P Suzana M R Jose Alberto D R | 2005 | Bioresource Technology2005，96，6： | 1 |
| 15 | Comorbidity of obsessive--eompulsive disorders and personality disorders:a Brazilian eontrolled study显示文摘 | ALBINA R T PORTO D ALBERTO J | 1995 | Psyehopathology1995，28，6： | 1 |
| 16 | Internet traffic modeling by means of hidden Markov models 显示文摘 | ALBERTO D ANTONIO P PIERLUIGI S R et at | 2008 | Computer Networks2008，52，14： | 1 |
| 17 | Influence of gluten-free flours and their mixtures on batter properties and bread quality显示文摘 | LORENA S S PABLO D R ALBERTO E L | | 0，，04： | 1 |
| 18 | Re tricarbonyl complexes with ligands containing P, N, N and P, N, O donor atom sets : Synthesis and structural characterization 显示文摘 | Correia J D G Domingos A Santos I Alberto R Ortner K | 2001 | Inorg Chem2001，40，： | 1 |
| 19 | Comparison of contact-force models for the simulation of collisions in DEM-based granular flow codes显示文摘 | Alberto D R Francesco P D M | 2004 | Chemical Engineering Science2004，59，13： | 1 |
| 20 | Chitosan:a versatile biopolymer for orthopaedic tissue-engineering显示文摘 | Alberto D M Michael S Makarand V R | 2005 | Biomaterials2005，26，30： | 1 |
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