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| 1 | Fulminant myocarditis in adults: a narrative review显示文摘Fulminant myocarditis(FM)is an uncommon syndrome characterized by sudden and severe hemodynamic compromise secondary to acute myocardial inflammation,often presenting as profound cardiogenic shock,life-threatening ventricular arrhythmias and/or electrical storm.FM may be refractory to conventional therapies and require mechanical circulatory support(MCS).The immune system has been recognized as playing a pivotal role in the pathophysiology of myocarditis,leading to an increased focus on immunosuppressive treatment strategies.Recent data have highlighted not only the fact that FM has significantly worse outcomes than non-FM,but that prognosis and management strategies of FM are heavily dependent on histological subtype,placing greater emphasis on the role of endomyocardial biopsy in diagnosis.The impact of subtype on severity and prognosis will likewise influence how aggressively the myocarditis is managed,including whether MCS is warranted.Many patients with refractory cardiogenic shock secondary to FM end up requiring MCS,with venoarterial extracorporeal membrane oxygenation demonstrating favorable survival rates,particularly when initiated prior to the development of multiorgan failure.Among the challenges facing the field are the need to more precisely identify immunopathophysiological pathways in order to develop targeted therapies,and the need to better optimize the timing and management of MCS to minimize complications and maximize outcomes. | Santiago Montero Darryl Abrams Enrico Ammirati Florent Huang Dirk WDonker Guillaume Hekimian Cosme García-García Antoni Bayes-Genis Alain Combes Matthieu Schmidt | 2022 | Journal of Geriatric Cardiology2022，19，2： | 3 |
| 2 | Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial显示文摘 | Robert J Motzer Bernard Escudier Stéphane Oudard Thomas E Hutson Camillo Porta Sergio Bracarda Viktor Grünwald John A Thompson Robert A Figlin Norbert Hollaender Gladys Urbanowitz William J Berg Andrea Kay David Lebwohl Alain Ravaud | 2008 | The Lancet2008，，9637： | 2 |
| 3 | Contribution of myeloid cell subsets to liver fibrosis in parasite infection显示文摘 | Alain Beschin Patrick De Baetselier Jo A Van Ginderachter | 2012 | J. Pathol2012，，： | 2 |
| 4 | Adjuvant vinorelbine plus cisplatin versus observation in patients with completely resected stage IB–IIIA non-small-cell lung cancer (Adjuvant Navelbine International Trialist Association [ANITA]): a randomised controlled trial显示文摘 | Jean-Yves Douillard Rafael Rosell Mario De Lena Francesco Carpagnano Rodryg Ramlau Jose Luis Gonzáles-Larriba Tomasz Grodzki Jose Rodrigues Pereira Alain Le Groumellec Vito Lorusso Claude Clary Antonio J Torres Jabrail Dahabreh Pierre-Jean Souquet Julio A | 2006 | Lancet Oncology2006，，9： | 2 |
| 5 | Concurrent use of aromatase inhibitors and hypofractionated radiation therapy显示文摘AIM: To retrospectively assess the acute and long-term toxicity using aromatase inhibitors (AI) therapy concurrently with hypofractionated radiotherapy (HFRT) in breast cancer patients. METHODS: From November 1999 to October 2007, 66 patients were treated with breast HFRT and concurrent AI. In 63 patients (95.5%), HFRT delivered a total dose of 32.5 Gy to the whole breast within 5 wk (five fractions, one fraction per week). Other fractionations were chosen in three patients for the patients' personal convenience. A subsequent boost to the tumor bed was delivered in 35 patients (53.0%). Acute toxicities were scored according to the Common Toxicity Criteria for Adverse Events v3. Late toxicity was defined as any toxicity occurring more than 6 mo after completion of HFRT and was scored according to the Late Effects Normal Tissue Task Force-Subjective, Objective, Management and Analytic scale. RESULTS: At the end of the HFRT course, 19 patients (28.8%) had no irradiation-related toxicity. Acute grade 1-2 epithelitis was observed in 46 patients (69.7%). One grade 3 toxicity (1.5%) was observed. With a median follow-up of 34 mo (range: 12-94 mo), 31 patients (47%) had no toxicity, and 35 patients (53%) presented with grade 1-2 fibrosis. No grade 3 or greater delayed toxicity was observed. CONCLUSION: We found that AI was well tolerated when given concurrently with HFRT. All toxicities were mild to moderate, and no treatment disruption was necessary. Further prospective assessment is warranted. | Cyrus Chargari Pablo Castro-Pena Ivan Toledano Marc A Bollet Alexia Savignoni Paul Cottu Fatima Laki Franois Campana Patricia De Cremoux Alain Fourquet Youlia M Kirova | 2012 | World Journal of Radiology2012，4，7： | 2 |
| 6 | A novel colorimetric test to study the susceptibility of human cytomegalovirus DNA polymerase to foscarnet显示文摘 | Alain S Scieux C | 2005 | Pathol Biol2005，53，8： | 1 |
| 7 | Molecular mecha- nisms of pancreatitis : Current opinion 显示文摘 | Alain V Jeremy S W Minoti V A | 2008 | 2I Gastroen- terol Hepatol2008，23，9： | 1 |
| 8 | Genetic and post - genetic molecular and isotopic fractionations in natural gases 显示文摘 | Prinzhofer A Alain Y Huc | 1995 | Chemical Geology1995，126，3： | 1 |
| 9 | 显示文摘 | ALAIN M MICHEL B MICHEL A | 1986 | J Chem Edu1986，63，4： | 1 |
| 10 | Early and lateonset ventilator associated pneumonia acquired in the intensive careunit:comparison of risk factors显示文摘 | Marine G Alain L Bernard A | | 0，，01： | 1 |
| 11 | Partitioning of ethoxylated alkylphenol surfactants in microemulsion-oil-water Systems显示文摘 | Nelson M Raquel A Alain G | 1995 | Colloids and Surfaces A: Physicochemical and Engineering Aspects1995，100，25： | 1 |
| 12 | Evolution of nanoporosity in dealloying显示文摘 | Jonah E Michael J A Alain K | 2001 | Nature2001，410，： | 1 |
| 13 | Review of recent research into cellulosic whiskers,their properties and their application in nanocomposite field显示文摘 | Azizi S Fannie A Alain D | | 0，，02： | 1 |
| 14 | Ischemic injury to rat forebrain mitochondria and cellular calcium homeostasis显示文摘 | Michele A S Jhon Z Alain Y F | 1992 | Biochim Biophys Acta1992，1134，： | 1 |
| 15 | Colloidal crystals as templates for macroporous carbon electrodes of controlled thick- ness显示文摘 | Stephane R Beatrice A Alain D | 2007 | Electroanalysis2007，19，23： | 1 |
| 16 | Engineering of a Xylose Metabolic Pathway in Corynebacterium glutamicum显示文摘 | Hideo Kawaguchi Alain A Vertes Shohei Okino | 2006 | Applied and Environmental Microbiology2006，72，5： | 1 |
| 17 | How to illustrate ligand - protein binding in a class experiment:An elementary fluorescent assay 显示文摘 | Alain M Michel B Michel A | 1986 | J Chem Edu1986，63，4： | 1 |
| 18 | Induction of tumor necrosis factor a and interleukin-8 gene expression in bronchial epithelial cells by toxic shock syndrome toxin 1显示文摘 | VINCENT A DOMINIK S ALAIN S | 2000 | Infection and Immunity2000，68，1： | 1 |
| 19 | Early and late-onset ventilator-associated pneumonia acquired in the intensive care unit:comparison of risk factors显示文摘 | Marine G Alain L Bernard A | | 0，，01： | 1 |
| 20 | Methylbenzene chemistry on zeolite H-beta: multiple insights into methanol-to-olefin catalysis 显示文摘 | Alain Sassi Mark A Wildman Hee Jung Ahn | 2002 | J Phys Chem B2002，106，9： | 1 |
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