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| 1 | 酵母细胞壁在家禽营养中的作用显示文摘 | Peter Spring | 2001 | 饲料工业2001，22，12： | 11 |
| 2 | 卵圆孔未闭超声心动图及右心声学造影临床操作规范显示文摘近几年卵圆孔未闭(patent foramen ovale,PFO)相关疾病越来越得到临床的重视,如何准确检出并综合评估PFO变得越来越重要。操作规范对经胸超声心动图、经食管超声心动图及右心声学造影诊断PFO的操作技巧、技术要领和检查结果解读进行规范化说明,以指导最佳地执行检查操作和全面综合评估PFO,更好地为临床提供有价值信息。 | 李贺智 何亚峰 王琦光 胡海波 周强 张文琪 刘煜昊 陈伟斌 徐吉喆 沈群山 张宏伟 费洪文 陈晓彬 李元十 王仲朝 张刚成 李越 张曹进 SPRING研究项目组 | 2022 | 中国实用内科杂志2022，42，5： | 10 |
| 3 | Trends in Extremes of Surface Humidity, Temperature, and Summertime Heat Stress in China显示文摘In the past half century, the mean summertime temperature in China has increased, with nights warm- ing more than days. Using surface station observations, we show that the frequency of extreme heat-stress events in China, caused by extremely hot and humid days as well as by heatwaves lasting for a few days, has increased over the period from 1951 to 1994 When humidity is high, hot weather can cause heat stress in humans. The increased heatrstress trend may pose a public health | Julian X.L. Wang and Dian J. Gaffen NOAA/ Air Resources Laboratory, Silver Spring, MD, 20910, USA | 2001 | Advances in Atmospheric Sciences2001，18，5： | 6 |
| 4 | 汽油车前氧传感器响应性能主动诊断策略研究显示文摘本文提出一种基于频率和振幅的汽油车前氧传感器电压信号响应性能主动诊断策略。通过在特定工况下主动快速调整闭环燃油调节因子的波动幅度,以快速改变排气系统废气成分,并在合理的采样区间内计算氧传感器电压跳变频率与跳变振幅,测试氧传感器电压信号响应性能。以氧电压跳变频率对主动燃油调节过程进行监控,以氧电压跳变振幅作为故障诊断指标。实车试验验证的结果表明,所提出的诊断方法能有效诊断氧传感器从浓到稀迟滞、从稀到浓迟滞和双向迟滞等典型响应故障,具有良好的实用性。 | 漆正刚 曾广智 Gary Spring 许匀峰 王聪 詹迅 | 2015 | 汽车工程2015，37，10： | 5 |
| 5 | 酵母细胞壁在家禽营养中的作用显示文摘 | Peter Spring | 2001 | 饲料工业2001，22，11： | 5 |
| 6 | Nitrite-derived nitric oxide by xanthine oxidoreductase protects the liver against ischemia- reperfusion injury显示文摘It was demonstrated that xanthine oxidoreductase (XOR), during ischemia, catalyzes the formation of nitric oxide (NO) from nitrite (NO2-) and this NO2--derived NO protects the isolated perfused rat heart against the damaging effects of ischemia-reperfusion (I/R) when conventional nitric oxide synthase (NOS) -dependent NO production is impaired. Liver is one of the organs with the highest XOR concentration. This study was designed to determine whether NO2--derived NO by XOR protects liver against I/R injury in vivo. For its minute amounts and active reactivity, NO can not be detected directly in real time in vivo by this time. We have to prove the above hypothesis indirectly. METHODS:Wistar rats were pretreated with saline, NOS inhibitor L-NAME (10 mg/kg intravenously), XOR inhibitor allopurinol (1.5 mg/kg orally), L-NAME +allopurinol and NO scavenger carboxy-PTIO (0.6 mg/kg intravenously) respectively (12 animals per group). And then, they were subjected to total liver ischemia for 40 minutes followed by reperfusion. Blood samples and liver tissues were obtained for analysis after 3 hours of reperfusion. Survival was also investigated. RESULTS:Allopurinol-treated animals exhibited further increased serum alanine aminotransferase (ALT) levels and liver myeloperoxidase (MPO) activities, but further decreased liver adenosine triphosphate (ATP) stores after I/R compared to saline-treated counterparts (830.5±108.3 U/L, 56.5±11.0 U/mg protein and 1.93±0.47 μmol/g vs. 505.8± 184.2 U/L, 41.5±10.2 U/mg protein and 3.05±0.55 μmol/g respectively, P<0.01, P<0.05 and P<0.01 respectively). The hepatocyte injury was further exacerbated and the overall survival rate was significantly decreased after I/R in animals given by allopurinol compared to those pretreated by saline (P<0.05). L-NAME and allopurinol co-treated animals exhibited more severe liver injury (P<0.05 and P<0.01) and a further decreased overall survival rate (P<0.05) compared to L-NAME or allopurinol alone-treated counterparts, but they were not different from carboxy-PTIO treated animals (P>0.05). CONCLUSION:NO2--derived NO by XOR in the hypoxic and acidic environment induced by hepatic I/R protects the liver against I/R injury in vivo. | Department of General Surgery ( Lu P, Wang CY and Chen DD), and Department of Radiology (Liu F), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China Cold Spring Harbor Laboratory, New York 11724, USA ( Yao Z) General Surgery Laboratory, Union Hospital, Tongji Medical College , Huazhong University of Science and Technology, Wuhan 430022 , China (Tian Y, Zhang JH and Wu YH) | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 4 |
| 7 | 放疗联合免疫检查点抑制剂治疗非小细胞肺癌研究进展显示文摘肺癌是世界上常见的致死性癌症之一,其中85%的肺癌为非小细胞肺癌(non-small cell lung cancer,NSCLC)。目前放疗是NSCLC主要的治疗手段之一。随着免疫治疗的发展,免疫检查点抑制剂(immune checkpoint inhibitors,ICIs)已成为部分晚期NSCLC患者的一线治疗。研究发现放疗与免疫治疗具有协同效应,能够改善NSCLC患者的生存。众多研究探索了放疗联合ICIs治疗NSCLC的安全性及有效性,本文就放疗联合ICIs治疗NSCLC的研究进展做一综述。 | 刘晓丽 李莉 袁双虎 Feng-Ming(Spring)Kong 于金明 | 2019 | 肿瘤综合治疗电子杂志2019，5，4： | 4 |
| 8 | 糖类在微生物中的作用显示文摘 | Peter Spring | 2006 | 中国畜牧兽医2006，33，5： | 3 |
| 9 | High Prevalence of Sessile Serrated Adenomas With BRAF Mutations: A Prospective Study of Patients Undergoing Colonoscopy显示文摘 | Kevin J. Spring Zhen Zhen Zhao Rozemary Karamatic Michael D. Walsh Vicki L.J. Whitehall Tanya Pike Lisa A. Simms Joanne Young Michael James Grant W. Montgomery Mark Appleyard David Hewett Kazutomo Togashi Jeremy R. Jass Barbara A. Leggett | 2006 | Gastroenterology2006，，5： | 3 |
| 10 | Screening for Pancreatic Cancer in a High-Risk Cohort: An Eight-Year Experience显示文摘 | Wigdan Al-Sukhni Ayelet Borgida Heidi Rothenmund Spring Holter Kara Semotiuk Robert Grant Stephanie Wilson Malcolm Moore Steven Narod Kartik Jhaveri Masoom Haider Steven Gallinger | 2012 | Journal of Gastrointestinal Surgery2012，，4： | 3 |
| 11 | Cytotoxic CD8+ T cells and tissue resident memory cells in colorectal cancer based on microsatellite instability and BRAF status显示文摘BACKGROUND Recent studies in non-colorectal malignancy have associated T resident memory(T_(RM)) cells with improved patient survival. It is unknown if T_(RM) plays a role in colorectal cancer(CRC).AIM To examine the potential role of T_(RM) cells in providing immunogenicity in CRC stratified by microsatellite instability(MSI) and BRAF status.METHODS Patients with known MSI and BRAF mutation status were eligible for inclusion in this study. CRC tumour sections stained with haematoxylin and eosin were microscopically reviewed and the images scanned prior to assessment for location of invading edge and core of tumour. Sequential sections were prepared for quantitative multiplex immunohistochemistry(IHC) staining. Opal Multiplex IHC staining was performed with appropriate positive and negative controls and imaged using a standard fluorescent microscope fitted with a spectral scanning camera(Mantra) in conjunction with Mantra snap software. Images were unmixed and annotated in in Form 2.2.0. Statistical analysis was performed using Graphpad Prism Version 7 and Stata Version 15.RESULTS Seventy-two patients with known MSI and BRAF status were included in the study. All patients were assessed for MSI by IHC and high resolution capillary electrophoresis testing and 44 of these patients successfully underwent quantitative multiplex IHC staining. Overall, there was a statistically significant increase in CD8+ T_(RM) cells in the MSI(BRAF mutant and wild type) group over the microsatellite stable(MSS) group. There was a statistically significant difference in CD8+ T_(RM) between high level MSI(MSI-H):BRAF mutant [22.57, 95% confidence interval(CI): 14.31-30.84] vs MSS [8.031(95%CI: 4.698-11.36)], P = 0.0076 and MSI-H:BRAF wild type [16.18(95%CI: 10.44-21.93)] vs MSS [8.031(95%CI: 4.698-11.36)], P = 0.0279. There was no statistically significant difference in CD8 T cells(both CD8+CD103-and CD8+CD103+T_(RM)) between MSI-H: BRAF mutant and wild type CRC.CONCLUSION This study has shown that CD8+ T_(RM) are found in greater abundance in MSI-H CRC, both BRAF mutant and MSI-H:BRAF wild type, when compared with their MSS counterpart. CD8+ T_(RM) may play a role in the immunogenicity in MSI-H CRC(BRAF mutant and BRAF wild type). Further studies should focus on the potential immunogenic qualities of T_(RM) cells and investigate potential immunotherapeutic approaches to improve treatment and survival associated with CRC. | James Wei Tatt Toh Angela L Ferguson Kevin J Spring Hema Mahajan Umaimainthan Palendira | 2021 | World Journal of Clinical Oncology2021，12，4： | 2 |
| 12 | 霉菌毒素--水产养殖中需要关注的问题显示文摘目前,水产养殖业在全球的食品生产中正扮演着越来越重要的角色,世界上几乎50%的食用鱼类由水产养殖业提供。据世界粮农组织(FAO)估计,随着海洋捕捞量下降,大多数区域都满负荷开采甚至过度开发,预计到2030年,人类对水产品的需求将增加4000万t,而最终这些需求将由水产养殖产业来满足。 | 敖志刚 John Sweetman Peter Spring | 2008 | 中国畜牧杂志2008，44，18： | 2 |
| 13 | Factors associated with overall survival in 1706 patients with nasopharyngeal carcinoma: Significance of intensive neoadjuvant chemotherapy and radiation break显示文摘 | Luying Xu Jianji Pan Junxin Wu Caizhu Pan Yu Zhang Shaojun Lin Ling Yang Chuanben Chen Chun Zhang Wei Zheng Senan Lin Xiaolei Ni Feng-Ming (Spring) Kong | 2010 | Radiotherapy and Oncology2010，，1： | 2 |
| 14 | Colorectal carcinogenesis:Road maps to cancer显示文摘 | Daniel L Worthley Vicki L Whitehall Kevin J Spring Barbara A Leggett | 2007 | World Journal of Gastroenterology2007，，28： | 2 |
| 15 | The network weather service:A distributed resource performance forecasting service for metacomputing显示文摘 | Wolski R Spring N Hayes J | 1999 | Journal of Future Generation Computing Systems1999，15，5： | 2 |
| 16 | Non-redundant roles of the Gabl and Gab2 scaffolding adapters in VEGF-mediated signalling, migration, and survival of endothelial cells显示文摘 | Caron C Spring K Laramee M | 2009 | Cell Signal2009，21，6： | 1 |
| 17 | A test of four plant species to reduce total nitrogen and total phosphorus from soil leachate in subsurface wetland microcosms显示文摘 | Lauchlan H Fraser Spring M Carty David Steer | 2004 | Bioresour Technol2004，94，： | 1 |
| 18 | Comribution of rpoB mutations to development of rifamycin cross-resistance in Mycobacterium tuberculosis显示文摘 | Willams DL Spring K Collins L | 1998 | Antimicrob Agents Chemother1998，42，： | 1 |
| 19 | Changes in the expression and localization of hepatocellular transporters and radixin in primary biliary cirrhosis显示文摘 | Hideyuki Kojima Anne T Nies J?rg K?nig Wolfgang Hagmann Herbert Spring Masahito Uemura Hiroshi Fukui Dietrich Keppler | 2003 | Journal of Hepatology2003，，5： | 1 |
| 20 | High prevalence of sessile serrated adenomas with BRAF mutations:a prospective study of patients undergoing colonoscopy显示文摘 | Spring KJ Zhao ZZ Karamatic R | | 0，，05： | 1 |
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