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| 1 | 乳腺囊内型乳头状癌显示文摘 | Collins L C Carlo V P Hwang H 魏兵(摘译) 步宏(审校) | 2006 | 临床与实验病理学杂志2006，22，5： | 38 |
| 2 | Molecular targets in the treatment of alcoholic hepatitis显示文摘Alcohol related costs to health and society are high. One of the most serious complications of alcohol misuse to the individual is the development of alcoholic hepatitis (AH), a clinical syndrome of jaundice and progressive inflammatory liver injury in patients with a history of recent heavy alcohol use. It has a poor outcome and few existing successful therapies. The use of glucocorticoids in patients with severe AH is still controversial and there remains a group of patients with glucocorticoid-resistant disease. However, as our understanding of the pathogenesis of the condition improves there are opportunities to develop new targeted therapies with specific actions to control liver inflammation without having a detrimental effect on the immune system as a whole. In this article we review the molecular mechanisms of AH concentrating on the activation of the innate and adaptive immune response. We consider existing treatments including glucocorticoids, anti-tumor necrosis factor therapy and pentoxifylline and their limitations. Using our knowledge of the disease pathogenesis we discuss possible novel therapeutic approaches. New targets include pro-inflammatory cytokines such as interleukin (IL)-17, chemokines and their receptors (for example IL-8, CXCL9 and CXCR3) and augmentation of anti-inflam- matory molecules such as IL-10 and IL-22. And there is also future potential to consider combination therapy to selectively modulate the immune response and gain control of disease. | Ashwin D Dhanda Richard WL Lee Peter L Collins C Anne McCune | 2012 | World Journal of Gastroenterology2012，18，39： | 9 |
| 3 | 藏药七十味珍珠丸对阿尔茨海默病小鼠模型脑组织Aβ表达的影响显示文摘目的观察藏药七十味珍珠丸(ratanasampil,RNSP)对阿尔茨海默病(AD)转基因鼠脑组织β-淀粉样蛋白(Aβ1-40和Aβ1-42)生成和改善认知功能的作用。方法利用Y-迷宫明暗分辨学习和旷场实验来观察23只13~14月龄雌性阿尔茨海默病转基因鼠(Tg2576)和同龄雌性BL6×SJL非转基因鼠(NTg)的学习记忆功能和焦虑水平。治疗组选取6只Tg2576鼠和5只NTg鼠给予七十味珍珠丸用针管灌胃1μl(0.14mg/d),每天1次,连续用药8周;对照组选取7只Tg2576鼠和5只NTg鼠用蒸馏水和芝麻油各0.5μl混匀后用针管灌胃1μl,每天1次,连续用药8周。用蛋白印迹法和酶标免疫吸附测试法联合测定鼠脑组织β淀粉样蛋白(Aβ1-40加和Aβ1-42)以及人鼠嵌合型跨膜蛋白淀粉样前体蛋白(β-amyloid precursor protein,APP)的蛋白含量,采用免疫组织化学法观察Aβ在鼠脑海马和大脑皮质的表达。结果通过Y-迷宫明暗分辨学习测试,Tg2576鼠治疗组达标所需要的训练时间(34.23±9.65)s,比Tg2576鼠对照组(52.35±12.50)s显著降低;t=5.871,P〈0.01。与Tg2576鼠对照组比较,旷场实验测定结果显示Tg2576鼠治疗组在中央格停留时间明显减低[(4.70±3.56)s和(12.91±9.02)s;t=3.465,P〈0.01],跨格次数和站立次数增加[(85.33±17.64)次和(56.25±13.86)次;(57.67±17.08)次和(20.63±17.39)次;t=8.200,3.093,P〈0.01,P〈0.05],粪便排泄次数也明显减少[(1.17±0.56)次和(3.38±0.86)次;t=2.231,P〈0.05]。两对照组比较,Tg2576鼠达标所需要的训练时间延长[(52.35±12.25)s和(37.03±8.98)s;t=3.131,P〈0.05],在中央格停留时间NTg较长,跨格次数和站立次数减少[(12.91±9.02)s和(5.24±5.88)s;(56.25±13.86)次和(82.75±22.54)次;(20.63±17.39)次和(53.50±13.94)次;P均〈0.05]。上述训练项目NTg鼠在治疗组和对照组之间差异均无统计学意义。蛋白印迹法和酶标免疫吸附测试法联合结果显示Tg2576治疗组的脑组织内Aβ1-40却和Aβ1-42含量均较对照组显著减低;通过RNSP治疗8周后Aβ42/Aβ40比率低于对照组(P〈0.05);但对Tg2576脑APP的表达未能减低。RNSP能够明显减少大脑皮质和海马周围老年淀粉样斑块的数目和面积。结论藏药七十味珍珠丸可能通过减少Tg2576转基因鼠脑内Aβ1-40和Aβ1-42越水平抑制老年斑的形成来改善转基因鼠学习空间记忆和探索运动能力,减少焦虑行为的发生。 | 朱爱琴 褚以德 LI Qiao-xin Collin L Masters | 2010 | 中华精神科杂志2010，43，2： | 9 |
| 4 | The hypoxia-inducible factor-1α activates ectopic production of fibroblast growth factor 23 in tumor-induced osteomalacia显示文摘Tumor-induced osteomalacia(TIO) is a rare paraneoplastic syndrome in which ectopic production of fibroblast growth factor 23(FGF23) by non-malignant mesenchymal tumors causes phosphate wasting and bone fractures. Recent studies have implicated the hypoxia-inducible factor-1α(HIF-1α) in other phosphate wasting disorders caused by elevated FGF23, including X-linked hypophosphatemic rickets and autosomal dominant hypophosphatemia. Here we provide evidence that HIF-1α mediates aberrant FGF23 in TIO by transcriptionally activating its promoter. Immunohistochemical studies in phosphaturic mesenchymal tumors resected from patients with documented TIO showed that HIF-1α and FGF23 were co-localized in spindleshaped cells adjacent to blood vessels. Cultured tumor tissue produced high levels of intact FGF23 and demonstrated increased expression of HIF-1α protein. Transfection of MC3T3-E1 and Saos-2 cells with a HIF-1α expression construct induced the activity of a FGF23 reporter construct. Prior treatment of tumor organ cultures with HIF-1α inhibitors decreased HIF-1α and FGF23 protein accumulation and inhibited HIF-1α-induced luciferase reporter activity in transfected cells. Chromatin immunoprecipitation assays confirmed binding to a HIF-1α consensus sequence within the proximal FGF23 promoter, which was eliminated by treatment with a HIF-1α inhibitor. These results show for the first time that HIF-1α is a direct transcriptional activator of FGF23 and suggest that upregulation of HIF-1α activity in TIO contributes to the aberrant FGF23 production in these patients. | Qian Zhang Michele Doucet Ryan E Tomlinson Xiaobin Han L Darryl Quarles Michael T Collins Thomas L Clemens | 2016 | Bone Research2016，4，2： | 6 |
| 5 | Interpreting sedimentation dynamics at Longxi catchment in the Three Gorges Area,China,using Cs-137 activity,particle size and rainfall erosivity显示文摘Reservoir sedimentation dynamics were interpreted using Cs-137 activity,particle size and rainfall erosivity analysis in conjunction with sediment profile coring.Two sediment cores were retrieved from the Changshou reservoir of Chongqing,which was dammed in 1956 at the outlet of Longxi catchment in the Three Gorges Area using a gravity corer equipped with an acrylic tube with an inner diameter of 6 cm.The extracted cores were sectioned at 2 cm intervals.All sediment core samples were dried,sieved(<2 mm) and weighed.137 Cs activity was measured by γ-ray spectrometry.The particle size of the core samples was measured using laser particlesize granulometry.Rainfall erosivity was calculated using daily rainfall data from meteorological records and information on soil conservation history was collated to help interpret temporal sedimentation trends.The peak fallout of 137 Cs in 1963 appeared at a depth of 84 cm in core A and 56 cm in core B.The peaks of sand contents were related to the peaks of rainfall erosivity which were recorded in 1982,1989,1998 and 2005,respectively.Sedimentation rates were calculated according to the sediment profile chronological controls of 1956,1963,1982,1989,1998 and 2005.The highest sedimentation rate was around 2.0 cm?a^(-1) between 1982 and 1988 when the Chinese national reform and the Household Responsibility System were implemented,leading to accelerated soil erosion in the Longxi catchment.Since 1990 s,andparticularly since 2005,sedimentation rates clearly decreased,since a number of soil conservation programs have been carried out in the catchment.The combined use of 137 Cs chronology,particle size and rainfall erosivity provided a simple basis for reconstructing reservoir sedimentation dynamics in the context of both physical processes and soil restoration.Its advantages include avoiding the need for full blown sediment yield reconstruction and the concomitant consideration of core correlation and corrections for autochthonous inputs and reservoir trap efficiency. | GAO Jin-zhang LONG Yi ZHANG Xin-bao Collins Adrian L HE Xiu-bin ZHANG Yun-qi SHI Zhong-lin | 2016 | Journal of Mountain Science2016，13，5： | 6 |
| 6 | 针对患者利益的机器学习和人工智能研究:在透明性、可重复性、伦理和有效性等方面的20个关键问题显示文摘机器学习(ML)、人工智能(AI)和其他现代统计方法正为利用先前尚未开发且极速增长的数据资源提供新的机会,以期让患者获益。尽管目前正在进行许多有前景的研究,特别是在图像方面,但就文献整体而言还缺乏透明度、对可重复性清晰的阐述、对潜在伦理问题的探究,以及对有效性的明确验证。这些问题的存在有许多原因,其中最重要的一点(为此我们提供了初步解决方案)就是当前缺乏针对ML和AI的最佳实践指南。我们认为从事研究的跨学科团队和应用ML/AI影响健康的项目,将因解决有关透明度、可重复性、伦理和有效性(TREE)的一系列问题而受益。这里提出的20个关键问题为研究团队提供了一个研究设计、实施和报告框架;帮助编辑和同行评审专家评估文献的贡献;让患者、临床医生和政策制定者评估新发现可能会给患者带来的获益。 | Sebastian Vollmer Bilal A Mateen Gergo Bohner Franz J Kirdly Rayid Ghani Pall Jonsson Sarah Cumbers Adrian Jonas Katherine S L McAllister Puja Myles David Granger Mark Birse Richard Branson Karel G M Moons Gary S Collins John P A Chris Holmes Harry Hemingwayp 李峰(译) 徐磊(校) 赵邑(校) | 2020 | 英国医学杂志中文版2020，23，9： | 5 |
| 7 | Is liver biopsy necessary in the management of alcoholic hepatitis?显示文摘Acute alcoholic hepatitis(AAH)is characterised by deep jaundice in patients with a history of heavy alcohol use,which can progress to liver failure.A clinical diagnosis of AAH can be challenging to make in patients without a clear alcohol history or in the presence of risk factors for other causes of acute liver failure.Other causes of acute on chronic liver failure such as sepsis or variceal haemorrhage should be considered.Liver biopsy remains the only reliable method to make an accurate diagnosis.However,there is controversy surrounding the use of liver biopsy in patients with AAH because of the risks of performing a percutaneous biopsy and limitations in access to transjugular biopsy.We review the existing literature and find there are few studies directly comparing clinical and histological diagnosis of AAH.In the small number of studies that have been conducted the correlation between a clinical and histological diagnosis of AAH is poor.Due to this lack of agreement together with difficulties in accessing transjugular liver biopsy outside tertiary referral centres and research institutions,we cannot advocate universal biopsy for AAH but there remains a definite role for liver biopsy where there is clinical diagnostic doubt or dual pathology.Italso adds value in a clinical trial context to ensure a homogeneous trial population and to further our understanding of the disease pathology.Further prospective studies are required to determine whether non-invasive markers can be used to accurately diagnose AAH. | Ashwin D Dhanda Peter L Collins C Anne McCune | 2013 | World Journal of Gastroenterology2013，19，44： | 4 |
| 8 | PrP^C-related signal transduction is influenced by copper, membrane integrity and the alpha cleavage site显示文摘铜绑定,抛锚膜的、细胞的 prion 蛋白质(PrPC ) 有二个组成的劈开地点生产不同 N 终端和 C 终端碎片(N1/C1 和 N2/C2 ) 。用表示也人的 PrPC,鼠标 PrPC 或鼠标 PrPC 的 RK13 房间带 3F4 epitope,这研究在 endoproteolytic 劈开和一个通常认为的 PrPC 函数上探索了 PrPC 主要顺序的影响,地图 kinase 信号 transduction,响应外长的铜与或没有使不安的膜环境。PrPC 主要顺序,特别在 N1/C1 劈开地点附近,看起来在这个地点和细胞外的调整信号的 kinase 1/2 (ERK1/2 ) phosphorylation 影响解朊作用的基础层次,与处理激活增加与基础 ERK1/2 表明一种反的关系。人的 PrPC 独自响应铜显示出增加的 N1/C1 劈开,由特定的 p38 和 JNK/SAPK phosphorylation 伴随了。到加扣押胆固醇的抗菌素 filipin 的铜的联合暴露导致了一只老鼠信号蛋白质 phosphorylation 的 PrPC 特定的实质的增加,由 N1/C1 劈开的增加伴随了。怀有人的 N1/C1 劈开地点的老鼠 PrPC 基础地并且响应铜假定更似人类的侧面并且改变了膜环境。我们的结果证明在 N1/C1 劈开地点附近的 PrPC 主要顺序影响在这个地点处理的 endoproteolytic,它显得连接了基础地并且响应铜印射 kinase 信号 transduction。进一步,主要顺序看起来响应外长的刺激在 PrPC 相关的信号 transduction 的忠实上授与 N1/C1 劈开和膜完整的相互的依赖。 | Cathryn L Haigh | 2009 | Cell Research2009，19，9： | 4 |
| 9 | FK506对实验性卒中疗效的系统评价和Meta分析显示文摘FK506是治疗急性卒中的一种候选用药。决定一种药物是否可以用于临床试验,应当以全面的、无偏倚的动物实验数据的评估为依据,同时还应考虑到这些数据的局限性。这种评估不但应包括药物疗效,而且也应包括药效在体内的特征和局限性。本研究应用系统评价和Meta分析的方法对FK506在卒中动物模型中保护作用的证据进行评价。总共纳入了29个描述了实验步骤的研究,包括1759只动物。结果显示,FK506疗效的点估计值(结局指标的改善)是31.3%[95%CI(0.272-0.354)]。在采用氯胺酮麻醉和短暂性脑缺血的动物实验中,FK506的疗效更高,在使用大鼠,合并其他疾病的动物及仅以梗死面积为疗效指标的实验中,FK506疗效较低。已发表的实验研究质量均接近临床试验标准,但在高质量的研究中,FK506的疗效较低。FK506在实验性脑卒中的研究中,虽然显示出有明显的疗效,但是应注意由于研究质量和可能的发表偏倚等冈素的影响,FK506的疗效可能被过高估计。 | Malcolm R Macleod Tori O’Collins Laura L Horky David W Howells Geoffrey A Donnan 段建钢 | 2006 | 中国循证医学杂志2006，6，6： | 3 |
| 10 | Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors显示文摘 | Li M Lee KF Lu Y Clarke I Shih D Eberhart C Collins VP Van Meter T Picard D Zhou L Boutros PC Modena P Liang ML Scherer SW Bouffet E Rutka JT Pomeroy SL Lau CC Taylor MD Gajjar A Dirks PB Hawkins CE Huang A. | 2009 | 中国神经肿瘤杂志2009，7，4： | 3 |
| 11 | Blood classical monocytes phenotype is not altered in primary non-small cell lung cancer显示文摘AIM: To evaluate the M1 and M2 monocyte phenotype in patients with non-small cell lung cancer(NSCLC) compared to controls. Also, to examine the expression of Th1 and Th2 cytokines in plasma of NSCLC vs controls. METHODS: Freshly prepared peripheral blood mononuclear cells samples were obtained from patients with NSCLC(lung adenocarcinoma and squamous cell lung carcinoma) and from non-cancer controls. Flow cytometry was performed to investigate M1 and M2 phenotypes in peripheral monocytes(classical monocytes CD14+, CD45+ and CD16-) using conventional surface markers. Th1 and Th2 cytokine production was alsoanalysed in the plasma using cytometric bead array technique. RESULTS: There were no significant difference in expression of M1(HLA-DR) and/or M2 markers(CD163 and CD36) markers on classical monocytes in patients with NSCLC compared to non-cancer controls. Expression of CD11 b, CD11 c, CD71 and CD44 was also shown to be similar in patients with NSCLC compared to noncancer controls. Th1 and Th2 cytokines [interleukin(IL)-1β, IL-2, IL-4, IL-5, IL-8, IL-10, IL-12(p70), tumor necrosis factor(TNF)-α, TNF-β, and interferon-γ] analysis revealed no significant difference between patients with NSCLC and non-cancer controls. CONCLUSION: This study shows no alteration in peripheral monocyte phenotype in circulating classical monocytes in patients with NSCLC compared to noncancer controls. No difference in Th1 and Th2 cytokine levels were noted in the plasma of these patients. | Saleh A Almatroodi Christine F Mc Donald Allison L Collins I an A Darby Dodie S Pouniotis | 2014 | World Journal of Clinical Oncology2014，5，5： | 2 |
| 12 | Oxidative DNA damage in human cells; the influence of antioxidants and DNA repairs 显示文摘 | Collins AR Duthie SJ Fillion L | 1997 | Biochem Soc Trans1997，25，1： | 2 |
| 13 | Intra - institutional factors that influence accounting research productivity 显示文摘 | Bucheit S Collins A B Collins D L | 2001 | The Journal of Applied Business Research2001，17，2： | 1 |
| 14 | Groundwater vulnerability assessment using a composite model combining DRASTIC with extensive agricultural land use in Israels Sharon region显示文摘 | Secunda S Collin M L Melloul A J | 1998 | Journal of Environmental Management1998，54，1： | 1 |
| 15 | Species diversity on-hances ecosystem functioning through interspecific facilitation 显示文摘 | Cardinale B J Palmer M A Collins S L | 2002 | Nature2002，415，6870： | 1 |
| 16 | Results from the National School-Based 1991 youth risk behvior survey and progress to-ward achieving related health objectives for the nation 显示文摘 | Kann L Wrren W Collins JL | 1993 | Public Health Reports1993，，： | 1 |
| 17 | Estrus synchronization and artificial insemination of hair sheep ewes in the tropics显示文摘 | Godfrey R W Collins J R Hensley E L | 1999 | Theriogenology1999，51，： | 1 |
| 18 | Comribution of rpoB mutations to development of rifamycin cross-resistance in Mycobacterium tuberculosis显示文摘 | Willams DL Spring K Collins L | 1998 | Antimicrob Agents Chemother1998，42，： | 1 |
| 19 | Surficial sediments of the Great Australian Bight:Facies dynamics and oceanography on a vast cool-water carbonate shelf显示文摘 | James N P Bone Y Collins L B | 2001 | Journal of Sedimentary Research2001，71，： | 1 |
| 20 | Do new roles contribute to job satisfaction and retention of staff in nursing and professions allied to medicine显示文摘 | Collins K Jones M L McDonnell A | 2000 | J Nurs Manag2000，8，1： | 1 |
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