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| 1 | Empirical estimates of regional carbon budgets imply reduced global soil heterotrophic respiration显示文摘Resolving regional carbon budgets is critical for informing land-based mitigation policy.For nine regions covering nearly the whole globe,we collected inventory estimates of carbon-stock changes complemented by satellite estimates of biomass changes where inventory data are missing.The net land–atmospheric carbon exchange(NEE)was calculated by taking the sum of the carbon-stock change and lateral carbon fluxes from crop and wood trade,and riverine-carbon export to the ocean.Summing up NEE from all regions,we obtained a global‘bottom-up'NEE for net land anthropogenic CO_(2)uptake of–2.2±0.6 Pg C yr^(-1)consistent with the independent top-down NEE from the global atmospheric carbon budget during 2000–2009.This estimate is so far the most comprehensive global bottom-up carbon budget accounting,which set up an important milestone for global carbon-cycle studies.By decomposing NEE into component fluxes,we found that global soil heterotrophic respiration amounts to a source of CO_(2)of 39 Pg C yr^(-1)with an interquartile of 33–46 Pg C yr^(-1)—a much smaller portion of net primary productivity than previously reported. | Philippe Ciais Yitong Yao Thomas Gasser Alessandro Baccini Yilong Wang Ronny Lauerwald Shushi Peng Ana Bastos Wei Li Peter A.Raymond Josep G.Canadell Glen P.Peters Rob J.Andres Jinfeng Chang Chao Yue A.Johannes Dolman Vanessa Haverd Jens Hartmann Goulven Laruelle Alexandra G.Konings Anthony W.King Yi Liu Sebastiaan Luyssaert Fabienne Maignan Prabir K.Patra Anna Peregon Pierre Regnier Julia Pongratz Benjamin Poulter Anatoly Shvidenko Riccardo Valentini Rong Wang Grégoire Broquet Yi Yin Jakob Zscheischler Bertrand Guenet Daniel SGoll Ashley-P.Ballantyne Hui Yang Chunjing Qiu Dan Zhu | 2021 | National Science Review2021，8，2： | 3 |
| 2 | Golimumab in real-world practice in patients with ulcerative colitis:Twelve-month results显示文摘BACKGROUND The introduction of biologics has revolutionized the management of the chronic inflammatory bowel disease,ulcerative colitis(UC),with many patients experiencing significant improvements not only in their symptoms but in other outcomes relevant to individuals and society as a whole.In Germany,there are no prospective data>3 mo that assess the work productivity,daily activities and quality of life(QoL)of patients with moderate-to-severe UC treated with golimumab.AIM To assess change in work productivity,capacity for daily activities and QoL in UC patients treated with golimumab in Germany.METHODS The validated Work Productivity Activity Impairment(WPAI)Questionnaire was used to analyze the change in work productivity,the capacity for daily activities after three months(primary endpoint)and disease specific and health related QoL(HRQoL)up to 1 year(secondary endpoints).The changes in work productivity and activity impairment were evaluated every three months until month twelve compared to baseline.Disease-specific and health-related QoL were assessed with the inflammatory bowel disease questionnaire and with the short-form 12 health survey questionnaire(SF-12).RESULTS This prospective non-interventional study included 287 patients.The analysis population was comprised of 282 patients who had completed at least two visits.At baseline,61%of patients had moderate UC and 18%had severe UC.Furthermore,75%of patients worked full-time or part-time at baseline.A total of 212 patients who were employed at the start of the study(employed population)were evaluated for the primary endpoint.Golimumab significantly reduced all WPAI sub-scores compared to baseline after three,six,nine and twelve months after the start of treatment(P<0.0001).In addition,disease-specific QoL and HRQoL,as measured by the SF-12 questionnaire,improved significantly with golimumab at all evaluation times(P<0.0001 in each case vs baseline).CONCLUSION Treatment of moderate-to-severe UC with golimumab leads to significant improvements in patient´s work productivity,daily activity and QoL over twelve months. | Niels Teich Harald Grümmer Eric Jorgensen Thomas Liceni Frank Holtkamp-Endemann Tim Fischer Susanne Hohenberger | 2020 | World Journal of Gastroenterology2020，26，21： | 3 |
| 3 | Effect of Annealing Temperature on Film Morphology of Organic–Inorganic Hybrid Pervoskite Solid‐State Solar Cells显示文摘 | Amalie Dualeh Nicolas Tétreault Thomas Moehl Peng Gao Mohammad Khaja Nazeeruddin Michael Gr?tzel | 2014 | Adv. Funct. Mater2014，，21： | 2 |
| 4 | Gap filling strategies for long term energy flux data sets显示文摘 | Eva Falge Dennis Baldocchi Richard Olson Peter Anthoni Marc Aubinet Christian Bernhofer George Burba Reinhart Ceulemans Robert Clement Han Dolman André Granier Patrick Gross Thomas Grünwald David Hollinger Niels-Otto Jensen Gabriel Katul Petri Keronen And | 2001 | Agricultural and Forest Meteorology2001，，1： | 2 |
| 5 | Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial显示文摘 | Robert J Motzer Bernard Escudier Stéphane Oudard Thomas E Hutson Camillo Porta Sergio Bracarda Viktor Grünwald John A Thompson Robert A Figlin Norbert Hollaender Gladys Urbanowitz William J Berg Andrea Kay David Lebwohl Alain Ravaud | 2008 | The Lancet2008，，9637： | 2 |
| 6 | The wilson disease gene is a putative copper transporting P- type ATPase similar to the Menkes gene 显示文摘 | Thomas GR Rommens JM | 1993 | Nature Genet1993，5，12： | 1 |
| 7 | Discovery of a high molecular weight complex of calcium,phosphate,fetuin and matrix gamma-carboxyglutamic acid protein in the serum of etidronatetreated rats显示文摘 | Price PA Thomas GR Pardini AW | 2002 | J Biol Chem2002，277，6： | 1 |
| 8 | Huganir RLRibosomal S6 kinase 2 interacts with and phosphorylates PDZ domain-containing proteins and regulates AMPA receptor transmission 显示文摘 | Thomas GM Rumbaugh GR Harrar DB | 2005 | Proc Natl Acad Sci USA2005，102，15： | 1 |
| 9 | Pelvic and lower extremity anerial imaging:diagnostic performance of three-dimensional contrast-enhanced MR angiography显示文摘 | Stefan GR Thomas FH Thomas P | 2000 | AJR2000，174，4： | 1 |
| 10 | The Wilson disease geneis a putative copper transporting P-type ATPase similar to theMenkes gene显示文摘 | Bull PC Thomas GR Rommens JM | 1993 | Nature Gene1993，5，12： | 1 |
| 11 | Age and gender differences in self- directed learning readiness: adevelopmental perspective 显示文摘 | Thomas GR Ward D | 2013 | International Journal of Self- Directed Learning2013，8，3： | 1 |
| 12 | The Wilson disease gene is a putative copper transporting P-type ATPase similar to the Menkes gene显示文摘 | Bull PC Thomas GR Rommens JM | 1993 | Nat Genet1993，5，4： | 1 |
| 13 | The Wilson disease gene is a putative copper transporting P - type ATPase similar to the Menkes gene 显示文摘 | Bull PC Thomas GR Rommens JM | 1993 | Nat Genet1993，5，： | 1 |
| 14 | Once daily therapy with isosorbide-5-mononitrate causes endothelial dysfunction in humans: evidence of a free radical mediated mechanism显示文摘 | Thomas GR DiFabio JM Tommaso T | 2007 | J Am Coll Cardiol2007，49，： | 1 |
| 15 | The Wilson disease gene:spectrum ofmutations and their consequences显示文摘 | Thomas GR Forbes JR Roberts EA | | 0，，06： | 1 |
| 16 | The Wilson disease gene is a putative coppertransporting P-type ATPase similar to the menkes gene显示文摘 | Bull PC Thomas GR Rommens JM | 1993 | Nature Genet1993，5，： | 1 |
| 17 | Gastrectomy with isoperistaltic jejunal parallel pouch in a 15-year-old adolescent boy with gastric adenocarcinoma and autosomal recessive agammaglobulinemia显示文摘 | Jan E. Slotta Sabine Heine Anne Kauffels Thomas Krenn Frank Grünhage Mathias Wagner Norbert Graf Martin K. Schilling Jochen Schuld | 2011 | Journal of Pediatric Surgery2011，，9： | 1 |
| 18 | EWS differentially activates transcription of the Bm-3a long and short isoform mRNAs from distinct promoters显示文摘 | Fanlkes DJ Gascoyne D | 2004 | Biochem Biophys Res Commun2004，318，4： | 1 |
| 19 | Content-Based Image Retrieval in Medicine: Retrospective Assessment, State of the Art, and Future Directions 显示文摘 | LR Long S Antani TM Desemo GR Thomas M | 2009 | International Journal of Heahheare Information Systems and Informaties2009，4，1： | 1 |
| 20 | The Wilson disease gene: spectrum of mutation and their consequences显示文摘 | Thomas GR Forbes JR Roberts EA | 1995 | Nature Genet1995，9，： | 1 |
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