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| 1 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 2 | 加钼或未加钼的低铜日粮对牛的铜状态、生产性能和胴体品质的长期影响显示文摘用42头7月龄安格斯公牛进行试验,测定加钼或未加钼的低铜饲粮对牛的生产性能、胴体品质和铜状态的长期影响。断奶前28d给22头犊牛注射90mg铜,断奶后,饲粮中添加铜7.5mg/kg干物质,对照组不添加铜。在获得铜后第40d末,铜的添加量降低到5mg/kg干物质,施铜期后,每组1/2牛的日粮中添加钼5mg/kg干物质。生长期持续196d随后为49d的肥育期,饲喂高浓度饲粮。试验结果表明:注射铜提高了断奶时牛的血浆铜浓度(P<0.01)。从生长期开始补加铜的牛具有较高的血浆铜含量、血浆铜蓝蛋白活性、过氧化物歧化酶(SOD)活性和肝脏铜浓度(P<0.01)。补加钼降低了未添加铜组牛生长期和肥育期血浆铜含量、血浆铜蓝蛋白和过氧化物岐化酶活性,但对加铜组的牛无影响。添加铜提高了施铜期(P<0.05)和生长期(P<0.08)牛的干物质采食量(DMI)及肥育期牛的日增重量(ADG)和饲料转化效率(G/F)。补加铜的牛的背膘厚度较薄(P<0.06),肋部眼肌面积较大(P<0.09)。研究结果证明,饲粮铜浓度可能改变牛的生产性能和胴体品质。 | Ward J D Spears J W 郭艳丽 | 1999 | 国外畜牧学(草原与牧草)1999，0，3： | 3 |
| 3 | Interstitial cells of Cajal and electrical activity in ganglionic and aganglionic colons of mice显示文摘 | Ward S M G ershon M D Keef K | 2002 | Am J Physiol2002，283，2： | 2 |
| 4 | Quantitative X-ray powder diffraction analysis of clay minerals in Australian coals using Rietveld methods显示文摘 | RUAN C D WARD C R | 2002 | Appl Clay Sci2002，21，56： | 2 |
| 5 | Plants pass the salt显示文摘 | Ward J M Hirschi K D Sze H | 2003 | Trends Plant Sci2003，8，5： | 2 |
| 6 | Radar sea clutter显示文摘 | Ward K D | 1985 | Microwave Journal1985，，6： | 2 |
| 7 | Destructible surfactants based on a silicon-oxygen bond显示文摘 | Ward M D | 1982 | J Org Chem1982，47，11： | 1 |
| 8 | improved survival in patients with locally advanced prostate cancer treated with radiotherapy and goserelin 显示文摘 | Bolla M Gonzalez D Warde P | 1997 | N EngtJ Med1997，337，5： | 1 |
| 9 | Effect of culture conditions on growth and sporulation of Bacillus thuringiensis subsp israelensis and development of media for production of the protein Crystal endotoxin显示文摘 | PEARSON D WARD O P | 1988 | Biotechnology Letters1988，10，7： | 1 |
| 10 | Modulation of chaperone function and cochaperone interaction by novobiocin in the C- terminal domain of Hsp90 evidence that coumarin antibiotics disrupt Hsp90 dimerization显示文摘 | Allan R K Mok D Ward B K | 2006 | The Journal of Biology Chemistry2006，281，11： | 1 |
| 11 | Arrhythmogenic fight ventrieular dysplasia/cardiomyopathy associated with mutations in the desmosomal gene desmocollin-2显示文摘 | Syrris P Ward D Evans A | 2006 | Am J Hum Genet2006，79，5： | 1 |
| 12 | Rapid and sensitive colorimetric method for visualizing biotin-labeled DNA probes hybridized to DNA or RNA immobilized on nitrocellulose:bio-blots显示文摘 | Leary J L Brigati D J Ward D C | 1983 | Proc Natl Acad Sci USA1983，80，： | 1 |
| 13 | Environmental decision-making and lake management显示文摘 | Cough J D Ward J C | 1995 | Journal of Archaeological Science1995，44，1： | 1 |
| 14 | Characterization of the virB operon from an Agrobacterium tumefaciens Ti plasmid显示文摘 | Ward JE Akiyoshi DE regier D | 1988 | J Biol Chem1988，263，： | 1 |
| 15 | 3',5'-diiodothyronine to 3'-monoiodothyronine conversion in the fed and fasted rat:enzyme characteristic and evidence for two distinct 5' -deiodinases 显示文摘 | Smallridge R C Burman K D Ward K E | 1981 | Endocrinology1981，108，： | 1 |
| 16 | Brucellosis control in Tajikistan using Rev 1 vaccine: change in seroprevalence in small ruminants from 2004 to 2009显示文摘 | Ward D Jackson R Karomatullo H | 2012 | Vet Rec2012，170，4： | 1 |
| 17 | Harmful molecular mechanisms in sepsis显示文摘 | RITTIRSCH D FLIERL MA WARD PA | 2008 | Nat Rev Immunol2008，8，： | 1 |
| 18 | Does thoracic irradiation improve survival and local control in limited-stage small-cell carcinoma of the lung? A meta- analysis显示文摘 | Warde P Payne D | 1992 | J Clin Oncol1992，10，6： | 1 |
| 19 | Sudden productivity collapse associated with the triassic- jurassic boundary mass extinction显示文摘 | Ward P D Haggart J W Carter E S | 2001 | Science2001，292，： | 1 |
| 20 | The campaign to DNA barcode all fishes,FISH-BOL显示文摘 | WARD R D HANNER R HEBERT P D N | 2009 | Journal of Fish Biology2009，74，2： | 1 |
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