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| 1 | Caspase-3 activation as a bifurcation point between plasticity and cell death显示文摘Death-mediating proteases such as caspases and caspase-3 in particular,have been implicated in neurodegenerative processes,aging and Alzheimer's disease.However,emerging evidence suggests that in addition to their classical role in cell death,caspases play a key role in modulating synaptic function.It is remarkable that active caspases-3,which can trigger widespread damage and degeneration,aggregates in structures as delicate as synapses and persists in neurons without causing acute cell death.Here,we evaluate this dichotomy,and discuss the hypothesis that caspase-3 may be a bifurcation point in cellular signaling,able to orient the neuronal response to stress down either pathological/apoptotic pathways or towards physiological cellular remodeling.We propose that temporal,spatial and other regulators of caspase activity are key determinants of the ultimate effect of caspase-3 activation in neurons.This concept has implications for differential roles of caspase-3 activation across the lifespan.Specifically,we propose that limited caspase-3 activation is critical for synaptic function in the healthy adult brain while chronic activation is involved in degenerative processes in the aging brain. | Shikha Snigdha Erica D Smith G Aleph Prieto Carl W Cotman | 2012 | Neuroscience Bulletin2012，28，1： | 91 |
| 2 | 标准·方案·指南——2014年美国癌症学会最新宫颈癌筛查指南及筛查中存在的问题显示文摘美国癌症学会(ACS)每年都会发布有关癌症早期检测、癌症筛查率数据与趋势报告及相关问题的指南,并会持续关注可能需要在癌症筛查指南中做出相应改变与更新的医学科学文献中出现的新证据以及需要传达给临床工作者与公众的筛查相关信息。在制定新指南的过程中,ACS至少每5年对指南更新1次,如有重要新证据出现,则更新间隔时间会更短。本期就2014年ACS关于宫颈癌筛查的最新指南报道如下。 | Robert A Smith Deana Manassaram-Baptiste Durado Brooks Vilma Cokkinides Mary Doroshenk Debbie Saslow Richard C Wender Otis W Brawley 王静 | 2014 | 中国全科医学2014，17，27： | 16 |
| 3 | MRI在腰骶神经根畸形诊断中的价值显示文摘目的确定MRI对腰骶神经根畸形(lumbosacralnerverootanomalies,LNRA)潜在的诊断价值。方法复习376例腰腿痛患者的腰椎MRI片。矢状面及水平面采用T1加权或T2加权成像,冠状面采用短TI反转回复序列成像。结果发现65例存在LNRA,其中分叉神经57例,尾侧起源7例,近邻根1例。手术患者术前诊断的畸形根,在术中显露到的均得到证实。结论MRI特别是短TI反转回复序列冠状面成像能够直观清晰地显示LNRA的起源、路径及大小等信息。 | 王海蛟 Douglas Wardlaw Francis W Smith | 2000 | 中华骨科杂志2000，20，3： | 15 |
| 4 | 1990—2017年中国伤害负担:2017年全球疾病负担研究结果(摘译)显示文摘伤害是全球性的公共卫生挑战,涉及各年龄组和不同性别的人群。过去三十年来,中国经济快速发展,人口老龄化趋势加重,社会呈现出城镇化、机动化和老龄化等特征。随着人们生活环境和生活方式的改变,伤害已跃居人群致死原因第五位,仅排在恶性肿瘤、心脑血管疾病、呼吸系统疾病和心肌梗死之后。据估计,中国每年在伤害方面消耗的直接医疗费用约为650亿元人民币. | 林泽婷(译) 吕来文(译) 黄晓晴(译) 李丽萍(审校) Duan Leilei Ye Pengpeng Juanita A Haagsma Jin Ye Wang Yuan Er Yuliang Deng Xiao Gao Xin Ji Cuirong Wang Linhong Marlena S Bannick W Cli Mountjoy-Venning Caitlin N Hawley Zichen Liu Mari Smith Spencer L James Theo Vos Christopher J L Murray | 2020 | 伤害医学(电子版)2020，9，2： | 15 |
| 5 | Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-1igase signaling effector DWARF3显示文摘 | Li-Hua Zhao X Edward Zhou Wei Yi Zhongshan Wu Yue Liu Yanyong Kang Li Hou Parker W de Waal Suling Li Yi Jiang Adrian Scaffidi Gavin R Flematti Steven M Smith Vinh Q Lam Patrick R Griffin YonghongWang Jiayang Li Karsten Melcher H Eric Xu | 2015 | Cell Research2015，25，11： | 7 |
| 6 | HIGH-ENERGY IONS PRODUCED IN EXPLOSIONS OF SUPERHEATED ATOMIC CLUSTERS显示文摘 | T Ditmire J W G Tisch E Springate M B Mason N Hay R A Smith J Marangos and M H R Hutchinson | | 0，，： | 4 |
| 7 | ACC/AHA guidelines for the management of patients with unstable angina and non–st-segment elevation myocardial infarction显示文摘 | Eugene Braunwald Elliott M Antman John W Beasley Robert M Califf Melvin D Cheitlin Judith S Hochman Robert H Jones Dean Kereiakes Joel Kupersmith Thomas N Levin Carl J Pepine John W Schaeffer Earl E Smith David E Steward Pierre Theroux Raymond J Gibbons J | 2000 | Journal of the American College of Cardiology2000，，3： | 4 |
| 8 | Muscle force and movement variability before and after total knee arthroplasty: A review显示文摘Variability in muscle force output and movement variability are important aspects of identifying individuals with mobility deficits, central nervous system impairments, and future risk of falling. This has been investigated in elderly healthy and impaired adults, as well as in adults with osteoarthritis(OA), but the question of whether the same correlations also apply to those who have undergone a surgical intervention such as total knee arthroplasty(TKA) is still being investigated. While there is a growing body of literature identifying potential rehabilitation targets for individuals who have undergone TKA, it is important to first understand the underlying post-operative impairments to more efficiently target functional deficits that may lead to improvedlong-term outcomes. The purpose of this article is to review the potential role of muscle force output and movement variability in TKA recipients. The narrative review relies on existing literature in elderly healthy and impaired individuals, as well as in those with OA before and following TKA. The variables that may predict longterm functional abilities and deficits are discussed in the context of existing literature in healthy older adults and older adults with OA and following TKA, as well as the role future research in this field may play in providing evidence-based data for improved rehabilitation targets. | Jessica W Smith Jesse C Christensen Robin L Marcus Paul C LaStayo | 2014 | World Journal of Orthopedics2014，5，2： | 3 |
| 9 | Improvements to NOAA’s Historical Merged Land-Ocean Surface Temperature Analysis (1880-2006)显示文摘 | Smith Thomas M Reynolds Richard W Peterson Thomas C Lawrimore Jay | | Journal of Climate0，，： | 3 |
| 10 | Selection of new banana varieties for the cool subtropics in Australia显示文摘 | SMITH M K HAMILL S D LANGDON P W | 1998 | Acta Hort1998，490，： | 2 |
| 11 | Pentoxifylline treatment and penile calcifications in men Nith Peyronie's disease显示文摘 | James F Smith Alan W Shindel Yun-Ching Huang Raul I Clavijo Lawrence Flechner Benjamin N Breyer Michael L Eisenberg Tom F Lue | 2011 | Asian Journal of Andrology2011，13，2： | 2 |
| 12 | Endocytosis and immunoglobulin transport across the small intestine of the new-born pig显示文摘 | Burton K A Smith M W | 1977 | Journal of Physiology1977，270，2： | 1 |
| 13 | On the application of a model of condition-based maintenance 显示文摘 | W Wang P A Scarf M A J Smith | 2000 | Journal of the Operational Research Society (S0160-5682)2000，，51： | 1 |
| 14 | Introduction and audit of intravenous paracetamol at a tertiary paediatric teaching hospital 显示文摘 | Palmer GM Chen SP Smith KR Hardikar W | 2007 | Anaesth Intensive Care2007，35，5： | 1 |
| 15 | Novel 1xN and NxN Integrated Optical Switches Using Self-lmaging Multimode GaAs/Al-GaAs Waveguides显示文摘 | Jenkins R M Heaton J M Wright D R Parker J T Birbeck J C H Smith G W Hilton K P | 1994 | Appl Phys Lett 71994，64，： | 1 |
| 16 | Hyperspectral remote sensing of atmospheric profiles from satellite and aircraft 显示文摘 | Smith W L | 2001 | Proc SPIE2001，4151，： | 1 |
| 17 | Predicting rainfall erosion losses: a guide to conservation planning显示文摘 | Wischmeier W H Smith D D | 1978 | US Department of Agriculture Agriculture Handbook1978，537，： | 1 |
| 18 | The Maturity Structure of Corporate Debt 显示文摘 | Barclay M J Smith C W | 1995 | The Journal of Finance1995，50，2： | 1 |
| 19 | Scavenger receptor-BI inhibits ATP-binding cassette transporter 1-mediated choles-terol efflux in macrophages显示文摘 | CHEN W SILVER D L SMITH J D | 2000 | J Biol Chem2000，275，30： | 1 |
| 20 | 显示文摘 | Smith R | 1998 | Transactions of International Chemical Engineering(Part A)1998，76，： | 1 |
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