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| 1 | NAFLD fibrosis score:A prognostic predictor for mortality and liver complications among NAFLD patients显示文摘AIM:To study whether the severity of liver fibrosis estimated by the nonalcoholic fatty liver disease(NAFLD) fibrosis score can predict all-cause mortality,cardiac complications,and/or liver complications of patients with NAFLD over long-term follow-up.METHODS:A cohort of well-characterized patients with NAFLD diagnosed during the period of 1980-2000 was identified through the Rochester Epidemiology Project.The NAFLD fibrosis score(NFS) was used to separate NAFLD patients with and without advanced liver fibrosis.We used the NFS score to classify the probability of fibrosis as <-1.5 for low probability,>-1.5 to < 0.67 for intermediate probability,and > 0.67 for high probability.Primary endpoints included allcause death and cardiovascular-and/or liver-related mortality.From the 479 patients with NAFLD assessed,302 patients(63%) greater than 18 years old were included.All patients were followed,and medical charts were reviewed until August 31,2009 or the date when the first primary endpoint occurred.By using a standardized case record form,we recorded a detailed history and physical examination and the use of statins and metformin during the follow-up period.RESULTS:A total of 302/479(63%) NAFLD patients(mean age:47 ± 13 year) were included with a followup period of 12.0 ± 3.9 year.A low probability of advanced fibrosis(NFS <-1.5 at baseline) was found in 181 patients(60%),while an intermediate or high probability of advanced fibrosis(NSF >-1.5) was found in 121 patients(40%).At the end of the follow-up period,55 patients(18%) developed primary endpoints.A total of 39 patients(13%) died during the follow-up.The leading causes of death were non-hepatic malignancy(n = 13/39;33.3%),coronary heart disease(CHD)(n = 8/39;20.5%),and liver-related mortality(n = 5/39;12.8%).Thirty patients had new-onset CHD,whereas 8 of 30 patients(27%) died from CHD-related causes during the follow-up.In a multivariate analysis,a higher NFS at baseline and the presence of new-onset CHD were significantly predictive of death(OR = 2.6 and 9.2,respectively;P < 0.0001).Our study showed a significant,graded relationship between the NFS,as classified into 3 subgroups(low,intermediate and high probability of liver fibrosis),and the occurrence of primary endpoints.The use of metformin or simvastatin for at least 3 mo during the follow-up was associated with fewer deaths in patients with NAFLD(OR = 0.2 and 0.03,respectively;P < 0.05).Additionally,the rate of annual NFS change in patients with an intermediate or high probability of advanced liver fibrosis was significantly lower than those patients with a low probability of advanced liver fibrosis(0.06 vs 0.09,P = 0.004).The annual NFS change in patients who died was significantly higher than those in patients who survived(0.14 vs 0.07,P = 0.03).At the end of the follow-up,we classified the patients into 3 subgroups according to the progression pattern of liver fibrosis by comparing the NFS at baseline to the NFS at the end of the followup period.Most patients were in the stable-fibrosis(60%) and progressive-fibrosis(37%) groups,whereas only 3% were in the regressive fibrosis.CONCLUSION:A higher NAFLD fibrosis score at baseline and a new onset of CHD were significantly predictive of death in patients with NAFLD. | Sombat Treeprasertsuk Einar Bjrnsson Felicity Enders Sompongse Suwanwalaikorn Keith D Lindor | 2013 | World Journal of Gastroenterology2013，19，8： | 13 |
| 2 | 骨原发Rosai-Dorfman病:15例临床病理分析显示文摘 | Demicco E G Rosenberg A E Bjrnsson J 郎志强 | 2010 | 临床与实验病理学杂志2010，26，5： | 10 |
| 3 | Nitrite,a novel method to decrease ischemia/reperfusion injury in the rat liver显示文摘AIM:To investigate whether nitrite administered prior to ischemia/reperfusion(I/R)reduces liver injury.METHODS:Thirty-six male Sprague-Dawley rats were randomized to 3 groups,including sham operated(n=8),45-min segmental ischemia of the left liver lobe(IR,n=14)and ischemia/reperfusion(I/R)preceded by the administration of 480 nmol of nitrite(n=14).Serum transaminases were measured after 4 h of reperfusion.Liver microdialysate(MD)was sampled in 30-min intervals and analyzed for glucose,lactate,pyruvate and glycerol as well as the total nitrite and nitrate(NOx).The NOx was measured in serum.RESULTS:Aspartate aminotransferase(AST)at the end of reperfusion was higher in the IR group than in the nitrite group(40±6.8μkat/L vs 22±2.6μkat/L,P=0.022).Similarly,alanine aminotransferase(ALT)was also higher in the I/R group than in the nitrite group(34±6μkat vs 14±1.5μkat,P=0.0045).The NOx in MD was significantly higher in the nitrite group than in the I/R group(10.1±2.9μmol/L vs 3.2±0.9μmol/L,P=0.031)after the administration of nitrite.During ischemia,the levels decreased in both groups and then increased again during reperfusion.At the end of reperfusion,there was a tendency towards a higher NOx in the I/R group than in the nitrite group(11.6±0.7μmol/L vs 9.2±1.1μmol/L,P=0.067).Lactate in MD was significantly higher in the IR group than in the nitrite group(3.37±0.18 mmol/L vs 2.8±0.12 mmol/L,P=0.01)during ischemia and the first 30 min of reperfusion.During the same period,glycerol was also higher in the IRI group than in the nitrite group(464±38μmol/L vs 367±31μmol/L,P=0.049).With respect to histology,there were more signs of tissue damage in the I/R group than in the nitrite group,and29%of the animals in the I/R group exhibited necrosis compared with none in the nitrite group.Inducible nitric oxide synthase transcription increased between early ischemia(t=15)and the end of reperfusion in both groups.CONCLUSION:Nitrite administered before liver ischemia in the rat liver reduces anaerobic metabolism and cell necrosis,which could be important in the clinical setting. | Bergthor Bjrnsson Linda Bojmar Hans Olsson Tommy Sundqvist Per Sandstrm | 2015 | World Journal of Gastroenterology2015，21，6： | 8 |
| 4 | Hepatic encephalopathy in patients with liver cirrhosis:Is there a role of malnutrition?显示文摘Hepatic encephalopathy(HE) is a common complica-tion in patients with liver cirrhosis but its pathogenesis remains incompletely understood.Malnutrition is com-monly encountered in patients with liver cirrhosis and it has been reported to affect the quality of life of this group of patients.Experimental studies suggest that low energy intake and poor nutritional status may facil-itate the development of HE but there are scarce data on the potential role of malnutrition in HE in patients with liver cirrhosis.Two recently published studies have evaluated the potential role of malnutrition in the development of HE in cirrhotic patients with conflicting results.In this letter to the editor we briefly present the results of the two studies as well as potential rea-sons for the conflicting results reported. | Evangelos Kalaitzakis Einar Bjrnsson | 2008 | World Journal of Gastroenterology2008，14，21： | 7 |
| 5 | Incidence, Presentation, and Outcomes in Patients With Drug-Induced Liver Injury in the General Population of Iceland显示文摘 | Einar S. Bj?rnsson Ottar M. Bergmann Helgi K. Bj?rnsson Runar B. Kvaran Sigurdur Olafsson | 2013 | Gastroenterology2013，，7： | 4 |
| 6 | 严重药物性肝病的后果及其预后指标 | Bjrnsson E. Olsson R. 徐瑞 | 2005 | 世界核心医学期刊文摘(胃肠病学分册)2005，0，11： | 4 |
| 7 | 北美和欧洲树线:影响其位置的外部因子和内在过程显示文摘本文对过去所提出的控制欧洲和北美树线位置的因子和植物过程进行了评价。有人认为是由于环境灾害造成的,另一种则认为是树木物质递增受到限制造成的,实际上二者是相辅相成的。这是因为植物所受的伤害、加之物质获取的不利条件及较少的可用物质源最终会导致生物量增加难以维持,而并非立刻死亡。树线达到平衡的位置随气候而变化,但灾难性的事件和人类活动削弱了树线与气候的相关关系,增加了预测其将来位置的难度。在树线或树线以下的多个地理位置开展多树种条件下的野外调控实验对总结解释和预测的一般结论是必须的。 | Bjartmar Sveinbjrnsson 石培礼 | 2000 | AMBIO-人类环境杂志2000，29，7： | 3 |
| 8 | Risk Factors for Idiosyncratic Drug-Induced Liver Injury显示文摘 | Naga Chalasani Einar Bj?rnsson | 2010 | Gastroenterology2010，，7： | 2 |
| 9 | How should liver hypertrophy be stimulated?A comparison of upfront associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)and portal vein embolization(PVE)with rescue possibility显示文摘Background:The role of associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)in comparison to portal vein embolization(PVE)is debated.The aim of this study was to compare successful resection rates(RR)with upfront ALPPS vs.PVE with rescue ALPPS on demand and to compare the hypertrophy of the liver between ALPPS and PVE plus subsequent rescue ALPPS.Methods:A retrospective analysis of all patients treated with PVE for colorectal liver metastasis(CRLM)or ALPPS(any diagnosis,rescue ALPPS included)at five Scandinavian university hospitals during the years 2013-2016 was conducted.A Chi-square test and a Mann-Whitney U test were used to assess the difference between the groups.A successful RR was defined as liver resection without a 90-day mortality.Results:A total of 189 patients were included.Successful RR was in 84.5%of the patients with ALPPS upfront and in 73.3%of the patients with PVE and rescue ALPPS on demand(P=0.080).The hypertrophy of the future liver remnants(FLRs)with ALPPS upfront was 71%(48-97%)compared to 96%(82-113%)after PVE and rescue ALPPS(P=0.010).Conclusions:Upfront ALPPS offers a somewhat higher successful RR than PVE with rescue ALPPS on demand.The sequential combination of PVE and ALPPS leads to a higher overall degree of hypertrophy than upfront ALPPS. | Ernesto Sparrelid Kristina Hasselgren Bård Ingvald Røsok Peter Nørgaard Larsen Nicolai Aagaard Schultz Ulrik Carling Eva Fallentin Stefan Gilg Per Sandström Gert Lindell Bergthor Björnsson | 2021 | Hepatobiliary Surgery and Nutrition2021，10，1： | 2 |
| 10 | Gastrointestinal symptoms in patients with cirrhosis: a longitudinal study before and after liver transplantation显示文摘 | Evangelos Kalaitzakis Axel Josefsson Maria Castedal Pia Henfridsson Maria Bengtsson Bengt Andersson Einar Bjö rnsson | 2013 | Scandinavian Journal of Gastroenterology2013，，11： | 2 |
| 11 | Long-term effects of hypnotherapy in patients with refractory irritable bowel syndrome显示文摘 | Perjohan Lindfors Peter Unge Henry Nyhlin Brjánn Ljótsson Einar S. Bj?rnsson Hasse Abrahamsson Magnus Simrén | 2012 | Scandinavian Journal of Gastroenterology2012，，4： | 2 |
| 12 | Effects of temperature and body weight on growth rate and feed conversion ratio in turbot ( Scophthalmus maximus )显示文摘 | Tómas árnason Bj?rn Bj?rnsson Agnar Steinarsson Matthías Oddgeirsson | 2009 | Aquaculture2009，，3： | 2 |
| 13 | Hepatotoxicity associated with statins:Reports of idiosyncratic liver injury post-marketing显示文摘 | Bj?rnsson E Jacobsen EI Kalaitzakis E | | 0，，： | 1 |
| 14 | Non-alcoholic fatty liver disease显示文摘 | Einar Bj?rnsson Paul Angulo | 2007 | Scandinavian Journal of Gastroenterology2007，，9： | 1 |
| 15 | Hepatic and extrahepatic malignancies in autoimmune hepatitis. A long-term follow-up in 473 Swedish patients显示文摘 | M?rten Werner Sven Almer Hanne Prytz Stefan Lindgren Sven Wallerstedt Einar Bj?rnsson Annika Bergquist Hanna Sandberg-Gertzén Rolf Hultcrantz Per Sangfelt Ola Weiland ?ke Danielsson | 2008 | Journal of Hepatology2008，，2： | 1 |
| 16 | Improved exercise performance and increased aerobic capacity after endurance training of patients with stable polymyositis and dermatomyositis显示文摘 | Alemo Munters L Dastmalchi M Katz A Esbj?rnsson M Loell I Hanna B | 2013 | Arthritis Res Ther2013，，： | 1 |
| 17 | Drug-induced liver injury:Hy's rule revisited显示文摘 | Einar Bj(o)rnsson | 2006 | Clin Pharmacol Ther2006，79，6： | 1 |
| 18 | Abrupt onset of the Little Ice Age triggered by volcanism and sustained by sea-ice/ocean feedbacks显示文摘 | Miller G.H Geirsdóttir (A) Zhong Y Larsen D.J Otto-Bliesner B.L Holland M.M Bailey D.A Refsnider K.A Lehman S.J Southon J.R Anderson C Bj(o)rnsson H Thordarson T | | 0，，： | 1 |
| 19 | Discontinuation of proton pump inhibitors in patients on longterm therapy:a double-blind,placebo-controlled trial显示文摘 | Bj?rnsson E Abrahamsson H Simrén M | 2006 | Aliment Pharmacol Ther2006，24，6： | 1 |
| 20 | Hydrological characteristics of the drainage sys- tem beneath a surging glacier 显示文摘 | Bj rnsson H | 1998 | Nature1998，395，22： | 1 |
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