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| 1 | Endoscopic submucosal dissection for the treatment of neoplastic lesions in the gastrointestinal tract显示文摘AIM: To investigate the indications, resection rate, and safety of endoscopic submucosal dissection (ESD) for neoplastic lesions in the gastrointestinal tract at a European referral center. METHODS: We carried out a retrospective analysis of the ESD procedures performed in our center for mucosal neoplastic and submucosal lesions of the gastrointestinal tract. The duration of the procedure, en bloc and complete (R0) resection rates, and complication rates were evaluated. Variables were reported as mean ± SD or simple proportions. Univariate analysis and comparisons of procedure times and resection rates were performed using Mann-Whitney U tests, or χ2 tests for dichotomous variables.RESULTS: Between 2007 and 2011, ESD was performed in a total of 103 patients (46.7% male, mean age 64.0 ± 12.7 years). The indications for the procedure were epithelial tumor (n = 54), submucosal tumor (n = 42), or other (n = 7). The total en bloc resection rate was 90.3% (93/103) and R0 resection rate 80.6% (83/103). The median speed of the procedure was 15.0 min/cm2 . The complete resection rate was lower for submucosal tumors arising from the muscle layer (68%, 15/22, P < 0.05). Resection speed was quicker for submucosal tumors localized in the submucosal layer than for lesions arising from the muscularis propria layer (8.1 min/cm 2 vs 17.9 min/cm 2 , P < 0.05). The R0 resection rate and speed were better in the last 24 mo (90.1%, 49/54 and 15.3 min/cm 2 ) compared to the first 3 years of treatment (73.5%, 36/49, P < 0.05 and 22.0 min/cm2 , P < 0.05). Complications occurred in 14.6% (n = 15) of patients, including perforation in 5.8% (n = 6), pneumoperitoneum in 3.9% (n = 4), delayed bleeding in 1.9% (n = 2), and other in 2.9% (n = 3). Only one patient with delayed perforation required surgical treatment. During the mean follow-up of 26 ± 15.3 mo, among patients with R0 resection, recurrence occurred in one patient (1.2%).CONCLUSION: ESD is an effective and safe method for resection of neoplastic lesions with low recurrence. Speed and the R0 resection rate increased after 50 procedures. | Andrzej Biaek Anna Wiechowska-Kozowska Jan Pertkiewicz Katarzyna Karpińska Wojciech Marlicz Piotr Milkiewicz Teresa Starzyńska | 2013 | World Journal of Gastroenterology2013，19，12： | 21 |
| 2 | Influence of silybin on biophysical properties of phospholipid bilayers显示文摘Aim:Silybin(silibinin)is major biologically active flavonolignan extracted frommilk thistle(Sylibum marianum).Its biological activities include hepato-protection,anticancer properties,and antioxidant-and membrane-stabilizing functions.Al-though membranes are postulated to be one of the cellular targets for silybin,littleis known about its interaction with phospholipid bilayers.Methods:In the presentwork,the interactions of silybin with phosphatidylcholine bilayers were studiedin detail using fluorescence spectroscopy,microcalorimetry and electron spinresonance techniques.Results:The results showed that silybin interacted withthe surface of lipid bilayers.It affected the generalized polarization of the fluores-cent probe Prodan,while not influencing the more deeply located Laurdan.Silybinlowered the main phospholipid phase transition temperature as judged bymicrocalorimetry,and caused the immobilization of spin probe Tempo-palmitatelocated on the surface of membranes.The mobility of spin probes 5-and 16-doxylstearic acid was not affected by silybin.Silybin-induced quenching of 1,6-diphe-nyl-1,3,5-hexatriene fluorescence indicated that some flavonoid molecules parti-tioned into the hydrophobic region of membranes,which did not change signifi-cantly the biophysical properties of the deeper membrane regions.Conclusion:Such a behavior of silybin in membranes is in accordance with its postulatedbiological functions and neglectable side effects of therapies using silybin. | OlgaWESO￡OWSKA Barbara￡ANIA-PIETRZAK MichaKU~-D~-A￡ KamilaSTAN~CZAK DanielaMOSI PiotrDOBRYSZYCKI AndrzejO~-YHAR Magorzata KOMOROWSKA AndrzejBHENDRICH KrystynaMICHALAK | 2007 | Acta Pharmacologica Sinica2007，28，2： | 11 |
| 3 | Oxidative stress factors in Parkinson's disease显示文摘Parkinson's disease(PD) is the second most common cause of neurodegeneration.Over the last two decades, various hypotheses have been proposed to explain the etiology of PD.Among these is the oxidant-antioxidant theory, which asserts that local and systemic oxidative damage triggered by reactive oxygen species and other free radicals may promote dopaminergic neuron degeneration.Excessive reactive oxygen species formation, one of the underlying causes of pathology in the course of PD has been evidenced by various studies showing that oxidized macromolecules including lipids, proteins, and nucleic acids accumulate in brain tissues of PD patients.DNA oxidation may produce various lesions in the course of PD.Mutations incurred as a result of DNA oxidation may further enhance reactive oxygen species production in the brains of PD patients, exacerbating neuronal loss due to defects in the mitochondrial electron transport chain, antioxidant depletion, and exposure to toxic oxidized dopamine.The protein products of SNCA, PRKN, PINK1, DJ1, and LRRK2 genes are associated with disrupted oxidoreductive homeostasis in PD.SNCA is the first gene linked with familial PD and is currently known to be affected by six mutations correlated with the disorder: A53T, A30P, E46K, G51D, H50Q and A53E.PRKN encodes Parkin, an E3 ubiquitin ligase which mediates the proteasome degradation of redundant and disordered proteins such as glycosylated α-synuclein.Over 100 mutations have been found among the 12 exons of PRKN.PINK1, a mitochondrial kinase highly expressed in the brain, may undergo loss of function mutations which constitute approximately 1–8% of early onset PD cases.More than 50 PD-promoting mutations have been found in PINK1.Mutations in DJ-1, a neuroprotective protein, are a rare cause of early onset PD and constitute only 1% of cases.Around 20 mutations have been found in DJ1 among PD patients thus far.Mutations in the LRRK2 gene are the most common known cause of familial autosomal dominant PD and sporadic PD.Treatment of PD patients, especially in the advanced stages of the disease, is very difficult.The first step in managing progressive PD is to optimize dopaminergic therapy by increasing the doses of dopamine agonists and L-dopa.The next step is the introduction of advanced therapies, such as deep brain stimulation.Genetic factors may influence the response to L-dopa and deep brain stimulation therapy and the regulation of oxidative stress.Consequently, research into minimally invasive surgical interventions, as well as therapies that target the underlying etiology of PD is warranted. | Jolanta Dorszewska Marta Kowalska Michał Prendecki Thomas Piekut Joanna Kozłowska Wojciech Kozubski | 2021 | Neural Regeneration Research2021，16，7： | 7 |
| 4 | Factors associated with irritable bowel syndrome symptoms in hemodialysis patients显示文摘AIM: To investigate clinical characteristics associated with the presence of irritable bowel syndrome (IBS) symptoms in hemodialysis (HD) patients.METHODS: This was a cross-sectional study. A questionnaire based on the Bowel Disease Questionnaire that records gastrointestinal symptoms was given to 294 patients in 4 dialysis centers. A total of 196 (67%) subjects returned the survey. A multivariable logistic regression model was used to identify factors significantly associated with IBS symptoms. RESULTS: Symptoms compatible with IBS were present in 27 (13.8%) subjects and independently associated with low post-dialysis serum potassium [OR = 0.258, 95% CI (0.075-0.891), P = 0.032], paracetamol use [OR = 3.159, 95% CI (1.214-8.220), P = 0.018], and Kidney Disease Quality of Life (KDQOL) cognitive function score [OR = 0.977, 95% CI (0.956-0.999), P = 0.042]. Univariate regressions were also performed and the reported significance is for multivariate analysis. No association was detected for age, gender, depressed mood, smoking (present or past), body mass index, albumin level, Kt/V, sodium preor post-dialysis level, change in potassium level during HD, proton pump inhibitor or H2 blocker use, aspirin use, residual diuresis, hepatitis B or C infection, diabetes mellitus, marital status and education level. CONCLUSION: This study examined potential risk factors for symptoms compatible with IBS in HD patients and identified an association with paracetamol use, post-dialysis potassium level and KDQOL-cognitive function score. | Bartosz Fiderkiewicz Alicja Rydzewska-Rosoowska Micha Myliwiec Magdalena Birecka Bozenna Kaczanowska Grazyna Rydzewska Andrzej Rydzewski | 2011 | World Journal of Gastroenterology2011，17，15： | 5 |
| 5 | Acute liver failure caused by concurrent autoimmune hepatitis and hepatitis B in a 16-year old girl显示文摘A 16 year-old girl was admitted to hospital because of fatigue and somnolence,nausea,epistaxis and jaund ice.Physical examination revealed jaundice,an enlarged liver and tenderness of upper right abdom en.Laboratory tests revealed an increased level of acute liver failure,bilirubin,bile acids,GGTP and a decreased prot hrombin ratio,with elevated gamma-globulin and IgG levels,and the presence of anti-mitochondrial M2 antibodies and HBV infection markers.The patient was diagnosed with liver failure resulting from chronic hepatitis B with an autoimmune component.The treatment consisted of steroids,azathioprine,vitam in K,low-protein diet and lactulose enemas.After undergoing a molecular test(HBV DNA 3.23 × 105 IU/mL and mutations 204 and 80),the treatment was mo tient was discharged in good clinical condition,with the recommendation of continued entecavir,prednisone and azathioprine.In subsequent months,no clinical deter ioration or abnormal biochemical liver function test results were found,despite the discontinuation of immunos up pressive therapy after 10 mo.The patient cont inues entecavir therapy. | Ma■gorzata Paw■owska Waldemar Halota | 2010 | World Journal of Hepatology2010，2，10： | 3 |
| 6 | Interrelationship between soil depth and soil properties of Pieniny National Park forest(Poland)显示文摘The purpose of this research was to investigate the relationship between soil biota such as microbial activity,soil fauna(e.g.,earthworms and enchytraeids),and soil physical and chemical properties.The study area was located in Pieniny National Park(PNP)in the Carpathian Mountains in southern Poland.Soil samples were collected from six forest monitoring areas of PNP from two soil layers(at 0–15 cm and 15–30 cm down,respectively).The investigated soils were classified to eutric cambisols and had silt or silt loam soil texture.Upon analysis,soil aggregate stability index was connected with other physical,chemical,and biological soil properties.It was noted that the stability index of 3 mm to 5 mm soil aggregates influenced pH and dissolved organic carbon.The stability index of 2 mm to 3 mm soil aggregates was positively correlated with dissolved organic carbon,soil moisture,microbial biomass carbon,total organic carbon,total nitrogen,and enchytraeid density,and negatively correlated with bulk density,particle density,porosity,and permanent wilting point.The stability index of 1 mm to 2 mm soil aggregates was positively correlated with total nitrogen,enchytraeid and earthworm density and negatively correlated with particle density,porosity,and permanent wilting point.The study has shown what factors create a stable soil structure in the forest soils of PNP. | Justyna SOKO?OWSKA Agnieszka JóZEFOWSKA Karolina WO?NICA Tomasz ZALESKI | 2019 | Journal of Mountain Science2019，16，7： | 2 |
| 7 | Assessment of OPG/RANK/RANKL Gene Expression Levels in Peripheral Blood Mononuclear Cells (PBMC) After Treatment With Strontium Ranelate and Ibandronate in Patients With Postmenopausal Osteoporosis显示文摘 | Micha? Stuss Piotr Rieske Agnieszka Ceg?owska Wioletta Stêpień-K?os Pawe? P. Liberski Ewa Brzeziańska Ewa Sewerynek | 2013 | The Journal of Clinical Endocrinology & Metabolism2013，，： | 2 |
| 8 | L-carnitine and cancer cachexia. I. L-carnitine distribution and metabolicdisorders in cancer cachexia显示文摘 | Jaros?aw Szefel Wies?aw Kruszewski Maciej Ciesielski Mariusz Szajewski Krzysztof Kawecki Ewa Aleksandrowicz?Wrona Jerzy Jankun Wies?awa ?ysiak-Szyd?owska | 2012 | Oncology Reports2012，，1： | 2 |
| 9 | Impact of IL-28B polymorphisms on pegylated interferon plus ribavirin treatment response in children and adolescents infected with HCV genotypes 1 and 4显示文摘 | K. Domagalski M. Paw?owska A. Tretyn W. Halota M. Pilarczyk E. Smukalska K. Linkowska T. Grzybowski | 2013 | European Journal of Clinical Microbiology & Infectious Diseases2013，，6： | 1 |
| 10 | Influence of serotonin 5-HT(7)receptor blockade on the behavioral and neurochemical effects of imipramine in rats显示文摘 | Wesoowska A Kowalska M | 2008 | Pharmacol Rep2008，60，： | 1 |
| 11 | Binding of transition metal ions to albumin: Sites, affinities and rates显示文摘 | Wojciech Bal Magdalena Soko?owska Ewa Kurowska Peter Faller | 2013 | BBA - General Subjects2013，，12： | 1 |
| 12 | Biodegradation of the outer silicone insulation of endocardial leads 显示文摘 | Kotodzifiska A Kutarski A Koz~owska M | 2013 | Circ Arrhythm Electrophysiol2013，6，2： | 1 |
| 13 | Binding of transition metal ions to albumin: Sites, affinities and rates显示文摘 | Wojciech Bal Magdalena Soko?owska Ewa Kurowska Peter Faller | 2013 | BBA - General Subjects2013，，： | 1 |
| 14 | The effect of tri- (1-chloro-3-etoxy-propane-2-ol),borate on the properties of rigid polyurethane-polyisocyanurate foams显示文摘 | Czuprynski B Paciorek-Sadowska J Liszk Owska J | | 0，，10： | 1 |
| 15 | Assessment of knee function and biochemical parameters of articular fluid and peripheral blood in gonarthrosis patients following intra-articular administration of hyaluronic acid显示文摘 | Ostaowska AB Nowak D Swichowicz S | 2013 | Pol Orthop Traumatol2013，78，： | 1 |
| 16 | Thermal decomposition of some chemical compounds used as food preservatives and kinetic parameters of this process显示文摘 | Mas覥owska J Wi誰d覥ocha M | 2000 | Journal of Thermal Analysis and Calorimetry2000，60，： | 1 |
| 17 | Effect of Mg and Mn oxide additions on structural and adsorptive properties of Cu/ZnO/ZrO2 catalysts for the methanol synthesis from CO2显示文摘 | S(1)OCZYńSKI J GRABOWSKI R KOZOWSKA A | 2003 | Appl Catal: A2003，249，1： | 1 |
| 18 | Urine metabolomics anal-ysis for adrenal incidentaloma activity detection and biomarker dis-covery显示文摘 | Kotowska A Sworczak K Stepnowski P | 2011 | J Chromatogr B Analyt Technol Biomed Life Sci2011，879，56： | 1 |
| 19 | Transformations in housing construction in rural areas of Poland\'s Lublin region-Influence on the spatial settlement structure and landscape aesthetics显示文摘 | Bański J Weso?owska M | 2010 | Landscape and Urban Planning2010，94，2： | 1 |
| 20 | Propionyl-L-Carnitine Improves Hemodynamics and Metabolic Markers of Cardiac Perfusion during Coronary Surgery in Diabetic Patients显示文摘 | Romuald Lango MD PhD Ryszard T. Smoleński Jan Rogowski Janusz Siebert Maria Wujtewicz Ewa M. S?omińska Wies?awa ?ysiak-Szyd?owska Magdi H. Yacoub | 2005 | Cardiovascular Drugs and Therapy2005，，4： | 1 |
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