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| 1 | Noni(Morinda citrifolia L.) fruit juice delays immunosenescence in the lymphocytes in lymph nodes of old F344 rats显示文摘Objective: Aging is associated with the development of diseases because of immunosuppression and altered functioning of the neuroendocrine system. The medicinal properties of Morinda citrifolia L. have been widely exploited for the treatment of age-associated diseases. This study aims to investigate the in vitro and in vivo effects of noni(M. citrifolia) fruit juice(NFJ) on neuro-immunomodulation in the lymph node lymphocytes of F344 rats.Methods: Lymphocytes isolated from axillary and inguinal lymph nodes of young(3–4 months) and old(18–21 months) rats were treated in vitro with different concentrations(0.0001%, 0.01%, and 1%) of NFJ for a period of 24 h. In the in vivo study, old(16–17 months) male F344 rats were treated with 5 mL/kg body weight of 5%, 10% and 20% of NFJ, twice a day, by oral gavage, and lymph node lymphocytes were isolated after 60 d. Concanavalin A(Con A)-induced lymphocyte proliferation, interleukin-2(IL-2)and interferon-γ(IFN-γ) production and expression of intracellular markers, such as phosphoextracellular signal-regulated kinase(p-ERK1/2), phospho-γ AMP response element-binding protein,phospho-protein kinase B(p-Akt), phospho-tyrosine hydroxylase(p-TH), phospho-nuclear factor of κ light polypeptide gene enhancer in B-cells inhibitor-α(p-IκB-α) and phospho-nuclear factor-κB(p-NF-κB p65 and p50) were examined in the lymphocytes of lymph nodes.Results: NFJ increased Con A-induced lymphocyte proliferation, IL-2 and IFN-γ production, and p-ERK1/2 expression both in vitro and in vivo. In in vivo NFJ-treated old rats, lymph node lymphocytes showed increased expression of p-TH and Akt, nitric oxide production and decreased expression of p-NF-κB p65 and p50.Conclusion: These results suggest that the immunostimulatory properties of NFJ are facilitated through intracellular signaling pathways involving ERK1/2, Akt and NF-κB. | Uday P.Pratap Hannah P.Priyanka Karthik R.Ramanathan Vishak Raman Lalgi Hima Srinivasan Thyagarajan | 2018 | Journal of Integrative Medicine2018，16，3： | 5 |
| 2 | Reflected solutions of backward stochastic differential equations driven by G-Brownian motion显示文摘In this paper, we study the reflected solutions of one-dimensional backward stochastic differential equations driven by G-Brownian motion. The reflection keeps the solution above a given stochastic process. In order to derive the uniqueness of reflected G-BSDEs, we apply a 'martingale condition' instead of the Skorohod condition. Similar to the classical case, we prove the existence by approximation via penalization. We then give some applications including a generalized Feynman-Kac formula of an obstacle problem for fully nonlinear partial differential equation and option pricing of American types under volatility uncertainty. | Hanwu Li Shige Peng Abdoulaye Soumana Hima | 2018 | Science China Mathematics2018，61，1： | 2 |
| 3 | Minimally invasive(laparoscopic)surgery显示文摘 | Hima Hs | 2002 | Surg Endose2002，16，12： | 1 |
| 4 | Numerical study on the spontaneous ignition of pressurized hydrogen release through a tube into air显示文摘 | XU B P HIMA L E L WEN J X | 2007 | Journal of Loss Prevention in the Process Industries2007，21，2： | 1 |
| 5 | Isolation of endophytic bacteria producing the anti-cancer alkaloid camptothecine from Miquelia dentata Bedd. (Icacinaceae)显示文摘 | S. Shweta J. Hima Bindu J. Raghu H.K. Suma B.L. Manjunatha P. Mohana Kumara G. Ravikanth K.N. Nataraja K.N. Ganeshaiah R. Uma Shaanker | 2013 | Phytomedicine2013，，10： | 1 |
| 6 | An active pep- tide purified from gastrointestinal enzyme hydrolysate of Pa- cific cod skin gelatin attenuates angiotensin-1 converting en- zyme ( ACE ) activity and cellular oxidative stress 显示文摘 | Hima ya S W A Ngo D Ryu B Kim S | 2012 | Food Chemistry2012，132，： | 1 |
| 7 | An association between fetal arrhythmias and maternal use of cocoa butter显示文摘 | Hima T T Dennis W Samuel G | 2006 | American Journal of Obstetrics and Gynecology2006，195，6： | 1 |
| 8 | Facile synthesis and catalytic properties of nickel-based mixed-metal oxides with mesopore networks from a novel hybrid composite precursor 显示文摘 | Xiang X Hima H I Wang H | 2008 | Chem Mater2008，20，： | 1 |
| 9 | Differential diagnosis of primary benign and malignant retroperitoneal tumors 显示文摘 | Nakas hima J Ueno M Nakamura K | 1997 | Int J Urol1997，4，5： | 1 |
| 10 | Mutation of epidermal growth factor receptor is associat- ed with MIG6 expression 显示文摘 | Nagas hima T Ushikoshi-Nakayama R Suenaga A | 2009 | FEBS J2009，276，18： | 1 |
| 11 | Age-related changes in speed of walking显示文摘 | Hima n]E | | 0，，： | 1 |
| 12 | 查看详情显示文摘 | Xiang X Hima H I Wang H | | 0，，03： | 1 |
| 13 | 显示文摘 | Hima S Joshi Yitzhak Tor | 2001 | Chem Commun2001，1，6： | 1 |
| 14 | Hydrogen absorption by Mg2 Ni prepared by polyol reduction 显示文摘 | Hima K L Viswanathan B Srinivasa M S | 2008 | J Alloys Compd2008，461，： | 1 |
| 15 | Vascular endothelial growth fact or reduced and connect -ive tissue growth fact or induced by triamcinol one in ARPE19 cells under oxidative s tress显示文摘 | Matsuda S Gomi F Os hima Y | | 0，，03： | 1 |
| 16 | Muttional analysis of p73 and p55 in human cancer cell lines 显示文摘 | Yoshikaws H Nagss hima M Khan MA | 1999 | Oncogene1999，18，22： | 1 |
| 17 | Removal of H2S from hot gas in the presence of Cu-containing sorbents 显示文摘 | KYOTANI T KAWAS HIMA H | 1989 | Fuel1989，68，1： | 1 |
| 18 | Hydrogen absorption by Mg 2 Ni prepared by polyol reduction显示文摘 | L. Hima Kumar B. Viswanathan S. Srinivasa Murthy | 2007 | Journal of Alloys and Compounds2007，，1： | 1 |
| 19 | Influence of de- creasing water temperature and shortening of the light phase on macronutrient self-selection by rainbow troutOneorhynehus mykiss and common cax CypHnus earpio 显示文摘 | Yamamoto T S hima T Furuita H | 2001 | Fish Sci2001，67，： | 1 |
| 20 | Enhancement of activity of 1 alpha,25-dihydroxyvitamin D3 for growth inhibition and differentiation induction of human myelomonocytic leukemia cells by tretinoin tocoferil,an alpha-tocopherol ester of all-rams retinoic acid显示文摘 | Hima M Kanatani Y Yamamoto-yamaguchi Y | | 0，，08： | 1 |
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