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| 1 | AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells显示文摘The current coronavirus disease 2019(COVID-19)pandemic presents a global public health challenge.The viral pathogen responsible,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),binds to the host receptor ACE2 through its spike(S)glycoprotein,which mediates membrane fusion and viral entry.Although the role of ACE2 as a receptor for SARS-CoV-2 is clear,studies have shown that ACE2 expression is extremely low in various human tissues,especially in the respiratory tract.Thus,other host receptors and/or co-receptors that promote the entry of SARS-CoV-2 into cells of the respiratory system may exist.In this study,we found that the tyrosine-protein kinase receptor UFO(AXL)specifically interacts with the N-terminal domain of SARS-CoV-2 S.Using both a SARS-CoV-2 virus pseudotype and authentic SARS-CoV-2,we found that overexpression of AXL in HEK293T cells promotes SARS-CoV-2 entry as efficiently as overexpression of ACE2,while knocking out AXL significantly reduces SARS-CoV-2 infection in HI 299 pulmonary cells and in human primary lung epithelial cells.Soluble human recombinant AXL blocks SARS-CoV-2 infection in cells expressing high levels of AXL.The AXL expression level is well correlated with SARS-CoV-2 S level in bronchoalveolar lavage fluid cells from COVID-19 patients.Taken together,our findings suggest that AXL is a novel candidate receptor for SARS-CoV-2 which may play an important role in promoting viral infection of the human respiratory system and indicate that it is a potential target for future clinical intervention strategies. | Shuai Wang Zongyang Qiu Yingnan Hou Xiya Deng Wei Xu Tingting Zheng Peihan Wu Shaofang Xie Weixiang Bian Chong Zhang Zewei Sun Kunpeng Liu Chao Shan Aifu Lin Shibo Jiang Youhua Xie Qiang Zhou Lu Lu Jing Huang Xu Li | 2021 | Cell Research2021，31，2： | 39 |
| 2 | A simple way to make pre-stressed ceramics with high strength显示文摘A pre-stressing design and a simple fabrication technology to substantially improve the strength of ceramic components are presented.Residual surface compressive stress is generated in ceramic components by pressureless sintering of a green bulk coated with a thin layer of low coefficient of thermal expansion(CTE).The stress level can be controlled by changing the cross-section area ratio,Young's modulus ratio and CTE ratio of the coating.Pre-stressed ZrO_(2) ceramics coated with Al_(2)O_(3) can achieve a flexural strength of 1330±52MPa,45% higher than their uncoated counterpart.Similarly,the flexural strength of building porcelain tiles is increased by 70%,from 67±3 MPa to 114±5MPa.The damage tolerance of pre-stressed ZrO_(2) ceramics is excellent with a high residual strength of ~1200 MPa in a thermal shock test at 325℃.This simple technique can improve the mechanical performance of ceramic components with no limitation of size and shape. | Yiwang Bao Fenghua Kuang Yi Sun Yueming Li Detian Wan Zongyang Shen Delong Ma Lingfeng He | 2019 | Journal of Materiomics2019，5，4： | 7 |
| 3 | Low-altitude small-sized object detection using lightweight feature-enhanced convolutional neural network显示文摘Unauthorized operations referred to as“black flights”of unmanned aerial vehicles(UAVs)pose a significant danger to public safety,and existing low-attitude object detection algorithms encounter difficulties in balancing detection precision and speed.Additionally,their accuracy is insufficient,particularly for small objects in complex environments.To solve these problems,we propose a lightweight feature-enhanced convolutional neural network able to perform detection with high precision detection for low-attitude flying objects in real time to provide guidance information to suppress black-flying UAVs.The proposed network consists of three modules.A lightweight and stable feature extraction module is used to reduce the computational load and stably extract more low-level feature,an enhanced feature processing module significantly improves the feature extraction ability of the model,and an accurate detection module integrates low-level and advanced features to improve the multiscale detection accuracy in complex environments,particularly for small objects.The proposed method achieves a detection speed of 147 frames per second(FPS)and a mean average precision(mAP)of 90.97%for a dataset composed of flying objects,indicating its potential for low-altitude object detection.Furthermore,evaluation results based on microsoft common objects in context(MS COCO)indicate that the proposed method is also applicable to object detection in general. | YE Tao ZHAO Zongyang ZHANG Jun CHAI Xinghua ZHOU Fuqiang | 2021 | Journal of Systems Engineering and Electronics2021，32，4： | 5 |
| 4 | Interaction of rice bZIP protein REB with the 5'-upstream region of both rice sbe1 gene and waxy gene显示文摘Rice starch branching enzyme 1 (SBE1) and granule-bound starch synthase (GBSS) catalyzed the bio-synthesis of amylopectin and amylose in rice developing en-dosperm respectively, and the genes encoding these two en-zymes, sbe1 and waxy, are mainly expressed in the en-dosperm. Within the 5 ’-upstream region of rice sbel gene, we identified a 53 bp fragment C53 which could interact with the nuclear proteins extracted from rice endosperm. We also found that fragment Ha-2 in the 5 ’-upstream region of rice waxy gene could compete with C53 for its interaction. Fur-ther experiments demonstrated that rice bZIP protein REB could interact with two ACGT elements (G-box and Hex) in the fragment C53 as well as three ACGT elements (WG1, WG2, and WG3) in the fragment Ha-2. The WG1 element could compete well with Hex element for its interaction with REB. These results suggested that the expression of sbel and waxy gene in rice developing endosperm may be coordinately regulated by REB-like bZIP transcriptional factors. | CAI Yi, XIE Donglu, WANG Zongyang & HONG MengminState Key Laboratory of Plant Molecular Genetics, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032, China | 2002 | Chinese Science Bulletin2002，47，4： | 5 |
| 5 | Introduction of antisense waxy gene into main parent lines of indica hybrid rice显示文摘Amylose content in rice endosperm is one of the key determinants of rice eating and cooking quality, and the poor quality of indica hybrid rice is closely related to the high amylose level in rice grains. In order to improve the grain quality of the indica hybrid rice by genetic engineering, an antisense fragment of rice waxy gene, driven by the 5’-franking sequences of the rice waxy gene, was successfully introduced into three major parent lines of indica hybrid rice, all contain a high amylose level in the grains, via Agrobacte-rium, and more than 100 hygromycin-resistant plants were regenerated. The analysis of PCR amplification and Southern blots indicated that the T-DNA containing the antisense waxy gene had been integrated into the genome of transgenic rice plants. Most of the primary transgenic rice plants grew normally, and the mature seeds from these transgenic plants were performed for analysis of the amylose content. The results showed that the amylose content in the endosperm of some grains | CHEN Xiuhua LIU Qiaoquan WANG Zongyang WANG Xingwen CAI Xiuling ZHANG Jingliu GU Minghong | 2002 | Chinese Science Bulletin2002，47，14： | 5 |
| 6 | Crystal structure and nucleotide selectivity of human IFIT5/ISG58显示文摘 | Feng Feng LingminYuan Yao E Wang Christopher Crowley Zongyang Lv Jingjing Li Yingfang Liu Genhong Cheng Su Zeng Huanhuan Liang | 2013 | Cell Research2013，23，8： | 4 |
| 7 | Design, optimization, and measurement of closed-loop Hall effect current sensor显示文摘A kind of closed-loop Hall effect sensor is designed and fabricated by considering several factors such as iron core material,Hall device,as well as selected integrated circuit.Through studying the effect of the iron material and structures of current sensor,a kind of optimal Hall effect current sensor is found.The experimental results show that the presented closed-loop Hall effect current sensor achieves 1 mA/A sensitivity.And its linearity and accuracy are 0.1%and 0.35%FS,respectively,at currents ranging from 0 to 50 A. | CHENG XingGuo LI FuAn ZHANG ZongYang LIU Sheng | 2014 | Science China(Technological Sciences)2014，57，9： | 3 |
| 8 | Multiple sgRNAs facilitate base editingmediated i-stop to induce complete and precise gene disruption显示文摘Dear Editor,Gene editing is a process to introduce desired changes into targeted loci of genomic DNA.Recently,type II clustered regularly in terspaced short palindromic repeats-associated Cas9 endonuclease(CRISPR/Cas9)system has been demonstrated as a versatile tool for engineering eukaryote genome(Hsu et al.,2014),such as in mice(Zuo et al.,2017). | Kun Jia Zongyang Lu Fei Zhou Zhiqi Xiong Rui Zhang Zhiwei Liu Yu'e Ma Lei He Cong Li Zhen Zhu Dejing Pan Zhengxing Lian | 2019 | Protein & Cell2019，10，11： | 3 |
| 9 | Exploration and functionalization of M1-macrophage extracellular vesicles for effective accumulation in glioblastoma and strong synergistic therapeutic effects显示文摘Glioblastoma multiforme(GBM)is a highly aggressive brain tumor with an extremely low survival rate.New and effective approaches for treatment are therefore urgently needed.Here,we successfully developed M1-like macrophage-derived extracellular vesicles(M1EVs)that overcome multiple challenges via guidance from two macrophage-related observations in clinical specimens from GBM patients:enrichment of M2 macrophages in GBM;and origination of a majority of infiltrating macrophage from peripheral blood.To maximize the synergistic effect,we further functionalized the membranes of M1EVs with two hydrophobic agents(the chemical excitation source CPPO(C)and the photosensitizer Ce6(C))and loaded the hydrophilic hypoxiaactivated prodrug AQ4N(A)into the inner core of the M1EVs.After intravenous injection,the inherent nature of M1-derived extracellular vesicles CCA-M1EVs allowed for blood-brain barrier penetration,and modulated the immunosuppressive tumor microenvironment via M2-to-M1 polarization,which increased hydrogen peroxide(H_(2)O_(2))levels.Furthermore,the reaction between H_(2)O_(2) and CPPO produced chemical energy,which could be used for Ce6 activation to generate large amounts of reactive oxygen species to achieve chemiexcited photodynamic therapy(CDT).As this reaction consumed oxygen,the aggravation of tumor hypoxia also led to the conversion of non-toxic AQ4N into toxic AQ4 for chemotherapy.Therefore,CCA-M1EVs achieved synergistic immunomodulation,CDT,and hypoxia-activated chemotherapy in GBM to exert a potent therapeutic effect.Finally,we demonstrated the excellent effect of CCA-M1EVs against GBM in cell-derived xenograft and patient-derived xenograft models,underscoring the strong potential of our highly flexible M1EVs system to support multi-modal therapies for difficult-to-treat GBM. | Xiaojun Wang Hui Ding Zongyang Li Yaonan Peng Hui Tan Changlong Wang Guodong Huang Weiping Li Guanghui Ma Wei Wei | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 3 |
| 10 | Generation of isogenic single and multiplex gene knockout mice by base editing-induced STOP显示文摘Although CRISPR/Cas9 has been widely used to generate knockout mice, two major limitations remain:the founders usually carry a mixture of genotypes, and mosaicism harboring multiple genotypes.Therefore, it takes a long time to get homozygous mutants. Recently developed base editing(BE) system,which introduces C-to-T conversion without double strand DNA cleavage, has been used to introduce artificial stop codons(i-STOP) to prematurely terminate translation, providing a cleaner strategy for genome engineering. Using this strategy, we generated CD160 KO and VISTA/CD160 double KO mice by microinjection of a single sg RNA targeting CD160 and a mixture of sg RNAs targeting VISTA and CD160,respectively. The BE system induced STOP efficiently in mouse embryos and consequently in founder mice without detectable off-target. Most interestingly, the majority of the mutants harbor same genetic modifications, indicating we generated isogenic single and multiplex gene mutant mice by BE-induced STOP. We also obtained homozygous mutant mouse in F1 mice, demonstrating the accelerated strategy in generating animal models. | Guang Yang Tianyu Zhu Zongyang Lu Guanglei Li Hao Zhang Songjie Feng Yajing Liu Jianan Li Yu Zhang Jia Chen Xuejiang Guo Xingxu Huang | 2018 | Science Bulletin2018，63，17： | 2 |
| 11 | 盐酸羟考酮控释片治疗晚期癌症疼痛的临床应用(英文)显示文摘Objective: The aim of this study was to evaluate the efficacy and adverse reactions of OxyContin hydrochloride controlled release tablets in the treatment of moderate or severe pain in patients with terminal cancer and to observe any improvement on the cancer patients' quality of life. Methods: Sixty-eight patients with moderate or severe cancer pain were treated with OxyContin hydrochloride controlled release tablets. The initial dose was 5 mg/12h, or 1/2 that of the standard morphine regimen. During the course of treatment, the dosage was adjusted according to the patients' condition until the pain completely disappeared or nearly did so. Each patient received a treatment for at least 15 days. At the same time, adverse reactions, the quality of life and scores for the intensity of pain were observed and recorded [1]. Results: The final titrated dosage of OxyContin was as follows: the patients in 30 cases (44.1%) received a dosage of ≤ 30 mg/d, those in 16 cases (23.5%) received a dosage of 31 to 60 mg/d, those in 18 cases (26.5%) received a dosage of 61 to 120 mg/d and those in 4 cases (5.9%) received a dosage of ≥ 120 mg/d. The overall rate of relief from pain was 95.6%, among which the rates of excellent, effective and moderate relief were respectively 39.7%, 48.5% and 7.4%. OxyContin had mild adverse reactions and patients' quality of life was markedly improved. Conclusion: OxyContin is effective in treatment of moderate and severe cancer pain. The adverse reactions of OxyContin are mild, and the drug can significantly improve the quality of life of patients with cancer pain. | Wenwu Wang Xuenong OuYang Zongyang Yu Zhangshu Chen | 2012 | The Chinese-German Journal of Clinical Oncology2012，11，7： | 2 |
| 12 | Adaptive Attitude Control for a Coaxial Tilt-Rotor UAV via Immersion and Invariance Methodology显示文摘Dear Editor,This letter is concerned with the attitude control for a novel tiltrotor unmanned aerial vehicle with two pairs of tiltable coaxial rotors and one rear rotor.An immersion and invariance-based adaptive attitude controller for the tilt-rotor unmanned aerial vehicle is proposed.In the proposed control strategy,an adaptive update law is specially designed to compensate for the uncertainties of damping coefficients.The stability of the resulting closed-loop coaxial tiltrotor unmanned aerial vehicle(CTRUAV)system is proved by the Lyapunov methodology and LaSalle’s invariance theory.Finally。 | Longlong Chen Zongyang Lv Xiangyu Shen Yuhu Wu Xi-Ming Sun | 2022 | IEEE/CAA Journal of Automatica Sinica2022，9，9： | 2 |
| 13 | Engineering of Co_(3O)_(4)@Ni_(2)P heterostructure as trifunctional electrocatalysts for rechargeable zinc-air battery and self-powered overall water splitting显示文摘Rational design of highly efficient,robust and nonprecious electrocatalysts for the oxygen reduction reaction(ORR),oxygen evolution reaction(OER)and hydrogen evolution reaction(HER)is highly demanded and challenging.Here,heterostructural Co_(3O)_(4)@Ni_(2)P arrays with numerous reaction sites,unique interfacial electronic structure and fast charge transfer kinetics are developed as electrocatalysts for rechargeable Zn-air batteries and overall water splitting.Both density functional theory calculation and X-ray absorption fine structure analysis manifest that the synergistic structural and abundant electronic modulations interfaces are formed,thus simultaneously promoting the electrocatalytic kinetics,activities and stabilities.Specifically,it can achieve an ultralow overpotential of 270 m V and 28 m V at 10 m A cm^(-2) for OER and HER,respectively.The water electrolyzer delivers a current density of 10 m A cm^(-2) at 1.563 V;furthermore,rechargeable Zn-air batteries triggered by this heterostructure can achieve excellent cyclic stability of 177 h(2 h per cycle)at 10 m A cm^(-2);both devices are superior to the Pt/C+Ir/C.This work not only designs an efficient trifunctional electrocatalyst but also paves an avenue to understand the heterostructure engineering for catalysts development and disclose the underlying relationship of interfacial electronic structures and catalytic properties. | Xiaolin Hu Tongxin Yang Zuguang Yang Zongyang Li Ronghua Wang Meng Li Guangsheng Huang Bin Jiang Chaohe Xu Fusheng Pan | 2022 | Journal of Materials Science & Technology2022，，20： | 1 |
| 14 | Combined effects of Li content and sintering temperature on polymorphic phase boundary and electrical properties of Li/Ta co-doped (Na, K)NbO3 lead-free piezo- ceramics 显示文摘 | SHEN Zongyang WANG Ke LI Jingfeng | 2009 | Appl Phy A2009，97，： | 1 |
| 15 | The effect of periosteal injury and masticatory micromovement on the healing of a mandibular distraction osteogenesis site显示文摘 | Zongyang Sun Susan W Herring | 2009 | Arch Oral Biol2009，54，3： | 1 |
| 16 | Prediction analysis of long-term memory effect for calamity gray series显示文摘It is adequate to use the gray theory for modeling and forecasting short-term calamity series. The forecast of calamity gray series is equivalent to predicting an extraordinary event in nature. In order to look for the regularity, the calamity date series, created from the threshold for a fixed time-interval series, are studied. In this paper, the Hurst exponent is applied to defining the long-term memory effect of the simulated calamity series, and is tested for the feasibility of using it as pre-requisite information before the gray modeling and forecasting. Based on the fractional Brownian motion (fBm) model, the time series with a definite length or quantity of data are derived assuming that various kinds of memory effect exist. Different threshold values are defined to yield or to analogize the calamity date series that are required in the prediction of the gray calamity events. After case study, both of the simulated and real seismic data show that the Hurst exponents are greater than 0.5 and, therefore, indicate that the long-term memory ef-fect exists. The correlation between the Hurst exponent and the gray modeling parameter, a, provides criteria for the classification of the forecast. | CHEN Zhaonan (CHEN Chaonan)1 & LI Zongyang (LEE Tzongyeang)2 1. Department of Earth Sciences, National Cheng Kung University, 1 Ta-Hsueh Road, Tainan 70101, Taiwan, China 2. Department of Information Management, Leader University, No. 188, Sec 5, Au-Chung Road, Tainan 70901, Taiwan, China | 2004 | Science China Earth Sciences2004，47，3： | 1 |
| 17 | 显示文摘 | ZhangJia(张佳) ZongYang(宗阳) YuanGuangyin(袁广银)etal | | 中国有色金属学报0，，： | 1 |
| 18 | Paleomagnetism and paleoclimate change in the South China Sea since the late Pleistocene显示文摘Signal processing techniques of cross-correlation, power spectral analysis and cross-power spectral analysis are used to determine the relationships between paleomagnetic properties and the oxygen isotope record of the South China Sea during the late Pleistocene. On the basis of correlation tests between the δ18O time series of cores V3 and A15 with the paleomagnetic properties of core SCS01, five events of susceptibility and intensity of natural remanent magnetization are identified as glacial events corresponding to δ18O positive events. The magnetic properties of the sediments which are independent of the geomagnetic field are sensitive climatic indicators which have frequencies corresponding to the Milankovitch orbital parameters. | Xidong Chen, Douglas F. Williams, Yuan Youren, Wang Baogui, Tang Xianzan, Fan Shiqing and Liu Zongyang 1. University of South Carolina, USA2. South China Sea Institute of Oceanology, Academia Sinica, Guangzhou 510301, China | 1992 | Acta Oceanologica Sinica1992，11，4： | 1 |
| 19 | Influence of sintering temperature on grain growth and phase structure of compositionally optimized high-performance Li/Ta-modified (Na,K)NbO3 ceramies 显示文摘 | SHEN Zongyang ZHEN Yuhua WANG Ke | 2009 | J Am Ceram Soc2009，92，8： | 1 |
| 20 | Fabrication and electromechanical properties of microscale 1-3-type piezoelectric composites using (Na,K)NbO3-based Pb-free piezoceramics 显示文摘 | SHEN Zongyang XU Ying LI Jingfeng | 2009 | J Appl Phys2009，105，10： | 1 |
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