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| 1 | Improvements on radiation-hardened performance of static induction transistor显示文摘The radiation-hardened performances of static induction transistor (SIT) have been studied in depth in this paper. The effects of radiation of electron beam on the I-V characteristics, carrier distribution and potential distribution in the channel of SIT have been represented. A large number of electron-hole pairs are generated in the depletion region of reversely biased gate-channel PN junction. The radiation-generated electrons drift towards the drain region at high positive potential, while generated holes flow into gate region biased to the lowest potential. With the accumulation of holes in gate region, the gate potential is boosted, resulting in a decrease in the height of potential barrier in channel, and an increase in drain current. I-V characteristics of SIT in the presence of radiation have been theoretically derived, and compared with experimental results. With the increase in thickness of epitaxial layer, the radiation-hardened capability of SIT is continuously improved until the optimum thickness of 26 μm is reached. The optimum matching relationship among geometric, material and technological parameters has been represented to acquire excellent radiation-hardened performances of SIT. | WANG YongShun LUO XianLiang LI HaiRong WANG ZiTing WU Rong ZHANG CaiZhen LI SiYuan | 2010 | Science China(Information Sciences)2010，53，5： | 6 |
| 2 | Influence of reclaimed water discharge on the dissemination and relationships of sulfonamide, sulfonamide resistance genes along the Chaobai River, Beijing显示文摘Reclaimed water represents an important source of antibiotics and antibiotic resistance genes, threatening the ecological safety of receiving environments, while alleviating water resource shortages. This study investigated the dissemination of sulfonamide (SAs), sulfonamide resistance genes (SRGs), and class one integrons (intl1) in the surface water of the recharging area of the Chaobai River. The three antibiotics sulfamethoxazole, trimethoprim, and sulfadiazine had the highest abundance. The highest absolute abundances were 2.91×10^6, 6.94×10^6, and 2.18×10^4 copies/mL for sul1, sul2, and intl 1 at the recharge point, respectively. SRGs and intl1 were widespread and had high abundance not only at the recharging point, but also in remote areas up to 8 km away. Seasonal variations of SRGs abundance followed the order of summer>autumn>spring>winter. Significant correlations were found between SRGs and intl1 (a = 0.887 and 0.786, p<0.01), indicating the potential risk of SRGs dissemination. Strong correlations between the abundance of SRGs and environmental factors were also found, suggesting that appropriate environmental conditions favor the spread of SRGs. The obtained results indicate that recharging with reclaimed water causes dissemination and enrichment of SAs and SRGs in the receiving river. Further research is required for the risk assessment and scientific management of reclaimed water. | Ning Zhang Xiang Liu Rui Liu Tao Zhang Miao Li Zhuoran Zhang Zitao Qu Ziting Yuan Hechun Yu | 2019 | Frontiers of Environmental Science & Engineering2019，13，1： | 2 |
| 3 | The research advance of micrometastasis in patients with cervical carcinoma 显示文摘 | CHENG XI CAI SHUMO LI ZITING | 2005 | Foreign Med Sci Oncol Sect2005，32，9： | 1 |
| 4 | Associations Between Specific Diets, Dietary Diversity, and Cognitive Frailty in Older Adults — China, 2002–2018显示文摘Summary What is already known about this topic?The relationship between specific dietary patterns and dietary diversity with cognitive frailty continues to be a subject of ambiguity.What is added by this report?This research revealed that regular consumption of fruit,meat,bean products,garlic,and tea was connected to a decreased risk of cognitive frailty.Compared to participants with dietary diversity score(DDS)≤6 points,those with DDS of 9–10,11–12,and≥12 had a lower risk of cognitive frailty. | Qingmei Huang Wenfang Zhong Ziting Chen Zhihao Li Peidong Zhang Yujie Zhang Peiliang Chen Qi Fu Weiqi Song Yuebin Lyu Xiaoming Shi Chen Mao | 2023 | China CDC weekly2023，5，39： | 1 |
| 5 | Efficient sampling methods for characterizing POIs on maps based on road networks显示文摘 | Ziting ZHOU Pengpeng ZHAO Victor S. SHENG Jiajie XU Zhixu LI Jian WU Zhiming CUI | 2018 | Frontiers of Computer Science2018，12，3： | 1 |
| 6 | Radical abdominal trachelectomy for cervical malignancies: Surgical, oncological and fertility outcomes in 62 patients显示文摘 | Jin Li Ziting Li Huaying Wang Rongyu Zang Yuqi Zhou Xingzhu Ju Guihao Ke Xiaohua Wu | 2011 | Gynecologic Oncology2011，，3： | 1 |
| 7 | Quaternary environmental changes in the drylands of China – A critical review显示文摘 | Xiaoping Yang Louis Scuderi Philippe Paillou Ziting Liu Hongwei Li Xiaozong Ren | 2011 | Quaternary Science Reviews2011，，23： | 1 |
| 8 | Aqueous Two-Phase Interfacial Assembly of COF Membranes for Water Desalination显示文摘Aqueous two-phase system features with ultralow interfacial tension and thick interfacial region,affording unique confined space for membrane assembly.Here,for the first time,an aqueous two-phase interfacial assembly method is proposed to fabricate covalent organic framework(COF)membranes.The aqueous solution containing polyethylene glycol and dextran undergoes segregated phase separation into two water-rich phases.By respectively distributing aldehyde and amine monomers into two aqueous phases,a series of COF membranes are fabricated at water-water interface.The resultant membranes exhibit high NaCl rejection of 93.0-93.6% and water permeance reaching 1.7-3.7 L m^(−2) h^(−1) bar^(−1),superior to most water desalination membranes.Interestingly,the interfacial tension is found to have pronounced effect on membrane structures.The appropriate interfacial tension range(0.1-1.0 mN m^(−1))leads to the tight and intact COF membranes.Furthermore,the method is extended to the fabrication of other COF and metal-organic polymer membranes.This work is the first exploitation of fabricating membranes in all-aqueous system,confering a green and generic method for advanced membrane manufacturing. | Hongjian Wang Jiashuai Zhao Yang Li Yu Cao Ziting Zhu Meidi Wang Runnan Zhang Fusheng Pan Zhongyi Jiang | 2022 | Nano-Micro Letters2022，14，12： | 1 |
| 9 | Improvements on high voltage performance of power static induction transistors显示文摘 | Wang Yongshun Li Hairong Wang Ziting | 2009 | Chinese Journal of Semiconductors2009，30，10： | 1 |
| 10 | Enlarged DNA unwinding by Nme2Cas9 permits a broadened base editing window beyond the protospacer显示文摘Dear Editor,Base editing has been developed to be one of the effective CRISPR-based gene editing techniques(Rees and Liu,2018).Base editors(BEs)take advantage of DNAmodifying enzymes fused with a catalytically impaired CRISPR protein to install base mutations.In BE,DNA-modifying enzymes often process nontarget singlestranded DNA(NTS)generated by Cas proteins. | Ziting Chen Xiangyang Li Qian Zhang Wenjun Sun Xiaoxuan Song Xia Zhang Xingxu Huang Bo Sun | 2024 | Science China(Life Sciences)2024，67，2： | 0 |
| 11 | Real-world outcomes of niraparib treatment in patients with ovarian cancer:amulticenter non-interventional study in China显示文摘Dear Editor,Ovarian cancer remains the deadliest among all gynecological cancers.Although most patients at advanced stage respond to initial treatment,the majority experience recurrence[1].It was estimated that 55,342 new cases and 37,519 deaths from ovarian cancer occurred in China annually[2].Contemporarily,the treatment landscape has changed rapidly since the role of poly(adenosine diphosphate-ribose)polymerase inhibitors(PARPi)in ovarian cancer treatmentwas explored.Based on data from the PRIMA/ENGOT-OV26/GOG-3012[3]and ENGOTOV16/NOVA trials[4],niraparib has been approved globally as maintenance therapy for newly diagnosed and platinum-sensitive recurrent ovarian cancer.The indication of niraparib for salvage treatment was based on the results of the QUADRA(NCT02354586)trial[5].Although niraparib has been tested in prospective randomized clinical trials(RCTs),no multicenter study on its real-world application in China had been conducted.Considering the differences in population,accessibility and affordability of drugs,the results of the real-world settings may differ from those of RCTs.Therefore,we conducted this multicenter,non-interventional study at 8 hospitals. | Jin Li Jianhua Yang Huafeng Shou Lin Zhang Xiaohong Huang Xuedong Tang Fei Zheng Fang Liu Hao Wen Huijuan Yang Huaying Wang Ziting Li Xiaojun Chen Xingzhu Ju Xi Cheng Jie Tang Meiqin Zhang Xiaohua Wu | 2023 | Cancer Communications2023，43，6： | 0 |
| 12 | Overexpression of maize GOLDEN2 in rice and maize calli improves regeneration by activating chloroplast development显示文摘Golden2(G2), a member of the GARP transcription factor superfamily, regulates several biological processes and phytohormone signaling pathways in plants. In this study, we used a rice codon-optimized maize G2 gene(rZmG2) to improve the regeneration efficiency of rice and maize calli for genetic transformation. We isolated a promoter driving strong and callus-specific expression from rice to drive rZmG2 transcription from a transgene after transformation of two indica and two japonica rice cultivars. The resulting rZmG2 transgenic calli turned green in advance at the differentiation stage, thus significantly raising the regeneration rates of the transgenic indica and japonica rice plants relative to control transformations. Similar effect of this gene on improving maize transformation was also observed. Transcriptome sequencing and RT-qPCR analyses showed that many rice genes related to chloroplast development and phytohormones are upregulated in rZmG2-transgenic calli. These results demonstrate that rZmG2 can promote embryogenic callus differentiation and improve regeneration efficiency by activating chloroplast development and phytohormone pathways. We also established a heat-inducible Cre/loxP-based gene-excision system to remove rZmG2 and the antibiotic selectable gene after obtaining the transgenic plants. This study provides a useful tool for functional genomics work and biotechnology in plants. | Wanni Luo Jiantao Tan Tie Li Ziting Feng Zhi Ding Xianrong Xie Yuanling Chen Letian Chen Yao-Guang Liu Qinlong Zhu Jinxing Guo | 2023 | Science China(Life Sciences)2023，66，2： | 0 |
| 13 | Pegylated Liposomal Doxorubicin as a Single Agent or as Combination Therapy with Carboplatin in Patients with Recurrent or Refractory Epithelial Ovarian Cancer显示文摘OBJECTIVE Pegylated liposomal doxorubicin (PLD;CAELYX^(?)), a novel formulation of doxorubicin with enhancedtherapeutic efficacy and reduced toxicity, has demonstratedimproved progression-free survival in recurrent or refractoryovarian cancer. The objective of this open-label, noncomparative,observational study was to determine the efficacyand safety of PLD monotherapy or combination therapy withcarboplatin for patients with recurrent or refractory ovariancancer.METHODS Sixty-two patients with recurrent or refractoryovarian cancer who completed a platinum-based chemotherapyregimen and demonstrated platinum sensitivity for first-linetreatment at least 6 months prior to study entry were enrolledin 20 centers in China. PLD was given as monotherapy (50mg/m^2 infused over 60 minutes) or as combination therapy(30 mg/m^2 1-hour infusion) with carboplatin (area under thecurve 5 mg.min/mL 1-hour infusion) on day 1 every 28 daysfor 4 cycles. The primary endpoint was objective response (OR)rate or CA-125 level. Secondary endpoints included time toresponse, time-to-progression, health-related quality of life, andsafety.RESULTS Overall, 48% of the 62 evaluable patients achieveda confirmed OR. More patients receiving PLD and carboplatinachieved an OR vs the PLD monotherapy group (63% vs. 37%).The median time to response and disease progression was58.5 days and 56.0 days, respectively. Overall and drug-relatedadverse events were reported for 39% and 34%, respectively.The most commonly reported adverse events were stomatitis(22.6%) and palmar-plantar erythroderma (9.7%). Two deathswere reported.CONCLUSION PLD is an effective and well tolerated agentin women with recurrent or refractory epithelial ovarian cancer. | Beihua Kong Yunong Gao Lingying Wu Ziting Li Yile Chen Mengda Li Yongliang Gao Ding ga Zhilan Peng KengShen | 2009 | Clinical oncology and cancer resexreh2009，6，6： | 0 |
| 14 | In-situ imaging of strain-induced enhancement of hydrogen evolution activity on the extruded MoO_(2)sheets显示文摘Strain engineering is a useful strategy for modifying the catalytic activity of electrocatalysts.However,in-situ visual characterization of the strain effect on the catalytic activity at nanoscale remains a huge challenge.Herein,we performed in-situ electrochemical scanning tunneling microscopy(EC-STM)imaging measurements at the local strained regions of extruded singlecrystal molybdenum dioxide(MoO_(2))sheets with combination of current noise analysis(n-EC-STM).The intensity-enhanced noise was observed at the local strained region compared to the unstrained regions in the same frame,which reveals the positive effect of compressive strain on the hydrogen evolution reaction(HER)activity of MoO_(2)provided that the intensity of noise is positively correlated with catalytic HER Faradic current.Therefore,we clearly“see”the strain-induced enhancement of HER activity of MoO_(2)at nanoscale by means of noise visualization.This work extends the visual characterization of strain engineering in electrocatalysis and related fields. | Mansheng Liao Qiaomei Zhu Shuhua Li Qiongqiong Li Ziting Tao Yongchun Fu | 2023 | Nano Research2023，16，4： | 0 |
| 15 | Ferroptosis-induced anticancer effect of resveratrol with a biomimetic nano-delivery system in colorectal cancer treatment显示文摘Ferroptosis is a novel form of programmed cell death impelled by iron-dependent lipid peroxidation,which may be a potential strategy for cancer therapy.Here we demonstrated for the first time that Resveratrol(RSV),a traditional Chinese medicine(TCM)chemical monomer,could effectually inhibit the growth of colon cancer cells through the ROS-dependent ferroptosis pathway.Mechanistically,RSV evoked the increase of reactive oxygen species and lipid peroxidation in colorectal cancer cells,and eventually lead to ferroptosis.Furthermore,RSV could promote ferroptosis by downregulating the expression of the channel protein solute carrier family 7 member 11(SLC7A11)and glutathione peroxidase 4(GPX4).To improve the delivery efficiency of RSV,a biomimetic nanocarrier was developed by coating RSV-loaded poly(ε-caprolactone)-poly(ethylene glycol)(PCL-PEG)nanoparticles with erythrocyte membrane(RSV-NPs@RBCm).The RSV-NPs@RBCm provide the possibility to escape macrophage phagocytosis and have a long circulation effect.In addition,when coupled with a tumor-penetrating peptide iRGD,which could trigger enhanced tissue penetration tumor-specifically,the delivery of RSV-NPs@RBCm into tumors would be significantly improved results from the in vivo study demonstrated an excellent treatment efficacy for CRC.Altogether,our study highlighted the therapeutic potential of RSV as a ferroptosis-inducing anticancer agent and when loaded into a biomimetic nanoplatform,it might pave the way for the application of RSV loaded nanosystems for colorectal cancer treatment. | Ziting Zhang You Ji Nan Hu Qinqi Yu Xinrui Zhang Jie Li Fenglei Wu Huae Xu Qiyun Tang Xiaolin Li | 2022 | Asian Journal of Pharmaceutical Sciences2022，17，5： | 0 |
| 16 | Spatial light modulation for femtosecond laser manufacturing:Current developments and challenges显示文摘Since the invention of lasers,spatial-light-modulated laser processing has become a powerful tool for various applications.It enables multidimensional and dynamic modulation of the laser beam,which significantly improves the processing efficiency,accuracy,and flexibility,and presents wider prospects over traditional mechanical technologies for machining three-dimensional,hard,brittle,or transparent materials.In this review,we introduce:(1)The role of spatial light modulation technology in the development of femtosecond laser manufacturing;(2)the structured light generated by spatial light modulation and its generation methods;and(3)representative applications of spatial-light-modulated femtosecond laser manufacturing,including aberration correction,parallel processing,focal field engineering,and polarization control.Finally,we summarize the present challenges in the field and possible future research. | ZANG Xue LIU ZiTing XU YiShi WANG Yi WANG Qing LI ZhenZe WANG Lei | 2024 | Science China(Technological Sciences)2024，67，1： | 0 |
| 17 | Nonperturbative generation of above-threshold harmonics from pre-excited argon atoms in intense mid-infrared laser fields显示文摘We experimentally investigate the generation of above-threshold harmonics completely from argon atoms on an excited state using mid-infrared femtosecond laser pulses. The highly nonlinear dependences of the observed signal on the pulse energy and polarization of the probe laser pulses indicate its nonperturbative characteristic. | Guihua Li Hongqiang Xie Ziting Li Jinping Yao Wei Chu Ya Cheng | 2017 | High Power Laser Science and Engineering2017，5，4： | 0 |
| 18 | Sodium vanadium oxides:From nanostructured design to high-performance energy storage materials显示文摘Developing high-capacity and low-cost cathode materials for metal-ion rechargeable batteries is the mainstream trend and is also the key to providing breakthroughs in making high-energy rechargeable batteries.Vanadium has a variety of valence states and can form a variety of vanadate structures.As a typical positive electrode material,vanadate has abundant ion adsorption sites,a unique“pillar”framework,and a typical layered structure.Therefore,it has the advantages of high specific capacity and excellent rate performance,possessing the prospect of being a large-capacity energy storage material.In this review,we focus on applications of sodium vanadium oxides(NVO)in electrical energy storage(EES)devices and summarize sodium vanadate materials from three aspects,including crystal structure,electrochemical performance,and energy storage mechanism.The recent progress of NVO-based highperformance energy storage materials along with nanostructured design strategies was provided and discussed as well.This review is intended to serve as general guidance for researchers to develop desirable sodium vanadate materials. | Yifan Dong Shuolei Deng Ziting Ma Ge Yin Changgang Li Xunlong Yuan Huiyun Tan Jing Pan Liqiang Mai Fan Xia | 2022 | Journal of Materials Science & Technology2022，，26： | 0 |
| 19 | Janus hydrogel with dual antibacterial and angiogenesis functions for enhanced diabetic wound healing显示文摘Anti-infection and neovascularization at the wound site are two vital factors that accelerate diabetic wound healing. However, for a wound healing dressing, the two functions need to work at different sites(inner and outer), giving big challenges for dressing design. In this study, we fabricated a novel sodium alginate/chitosan(SA/CS) Janus hydrogel dressing by the assembly of SA hydrogel loaded with silver nanoparticles(Ag NPs) and CS hydrogel impregnated with L-arginine loaded sodium alginate microspheres(Arg MSs) based on electrostatic interactions to combine the two functions. The outer SA-Ag NP hydrogel could prevent infection while avoiding the deposition of Ag NPs in the wound site, and the inner CS-Arg MS hydrogel on the wound surface could realize the sustained release of L-arginine and promote vascular regeneration. The composition, morphology and swelling/degradation of the SA-Ag NP/CS-Arg MS hydrogel were characterized systematically. L-Arginine release behavior has been tested and SA-Ag NP/CSArg MS hydrogel has been confirmed for excellent biocompatibility. Antibacterial and angiogenesis assays demonstrated the antibacterial and angiogenesis characteristics of the SA-Ag NP/CS-Arg MS hydrogel. Finally, in vivo diabetic wound healing assay demonstrated that the SA-Ag NP/CS-Arg MS hydrogel could significantly accelerate re-epithelialization, granulation tissue formation, collagen deposition and angiogenesis, thereby resulting in enhanced diabetic wound healing。 | Guiting Liu Yuan Zhou Zejun Xu Ziting Bao Li Zheng Jun Wu | 2023 | Chinese Chemical Letters2023，34，4： | 0 |
| 20 | Gypenosides ameliorate morphine-induced immunosuppression with an increased proportion of thymic T lymphocyte subsets and are involved in the regulation of the cAMP-CREM/CREB-IL-2 pathway显示文摘Opioid abuse can suppress the lymphatic system function,and produce severe immunosuppression that poses a significant risk of opportunistic infections such as methicillinresistant Staphylococcus aureus(MRSA)pneumonia.^(1,2)Gypenosides(Gps)are the most important immunomodulator components in the Chinese herbal medicine Gynostemma pentaphyllum. | Hui Wang Zhonghao Li Qisheng Wang Weixin Lin Ziting Zhou Xinru Mu Yongwei Jiang Shengfeng Lu Shaodong Chen Zhigang Lu | 2024 | Genes & Diseases2024，11，3： | 0 |
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