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| 1 | Geochemical-geomorphological Evidence for the Provenance of Aeolian Sands and Sedimentary Environments in the Hunshandake Sandy Land, Eastern Inner Mongolia, China显示文摘Identifying the provenance of aeolian sediments in the Hunshandake Sandy Land is of great importance for understanding the formation of the dune fields in the mid-latitudes and for deciphering information about desert's responses to global change. By determining the major and trace elements concentrations of aeolian sands in three grain size fractions from the central and western parts of the Hunshandake Sandy Land, we systematically study the provenance and the depositional history of aeolian sands in this desert environment. Our results show that aeolian sands from the Hunshandake Sandy Land are enriched in SiO2 and are depleted in many other elements compared to those of the Upper Continent Crust (UCC). Variations of the immobile elements ratios like Zr/Hf, La/Yb, Th/Nb, La/Nb,LaN/YbN , GdN/YbN are relatively large in the coarse and medium fractions but minor in the fine fractions. Eu anomalies are quite different in the coarse fractions, but mostly positive in the medium fractions and all negative in the fine fractions. Decreasing tendency of Zr concentrations from the west to the east in the Hunshandake Sandy Land is evident in the coarse sands but rather weak in the fine grain size fractions. Our geochemical data indicate that the sources for the coarse and medium fractions of aeolian sands are diverse, influenced by local geology and geomorphology, while the fine sand fractions are more homogenous due to intensive mixture mainly by aeolian processes. Various ratios of immobile elements suggest that these sands should be sourced primarily from the surrounding mountains by fluvial/alluvial processes rather than from any remote territories. Aeolian sands with Ce negative anomalies are widely distributed in the Hunshandake Sandy Land, indicating that aquatic environments have occurred extensively prior to the occurrence of the dune field. | LIU Ziting YANG Xiaoping | 2013 | Acta Geologica Sinica(English Edition)2013，87，3： | 13 |
| 2 | Improvements on radiation-hardened performance of static induction transistor显示文摘The radiation-hardened performances of static induction transistor (SIT) have been studied in depth in this paper. The effects of radiation of electron beam on the I-V characteristics, carrier distribution and potential distribution in the channel of SIT have been represented. A large number of electron-hole pairs are generated in the depletion region of reversely biased gate-channel PN junction. The radiation-generated electrons drift towards the drain region at high positive potential, while generated holes flow into gate region biased to the lowest potential. With the accumulation of holes in gate region, the gate potential is boosted, resulting in a decrease in the height of potential barrier in channel, and an increase in drain current. I-V characteristics of SIT in the presence of radiation have been theoretically derived, and compared with experimental results. With the increase in thickness of epitaxial layer, the radiation-hardened capability of SIT is continuously improved until the optimum thickness of 26 μm is reached. The optimum matching relationship among geometric, material and technological parameters has been represented to acquire excellent radiation-hardened performances of SIT. | WANG YongShun LUO XianLiang LI HaiRong WANG ZiTing WU Rong ZHANG CaiZhen LI SiYuan | 2010 | Science China(Information Sciences)2010，53，5： | 6 |
| 3 | Superior in vitro anticancer effect of biomimetic paclitaxel and triptolide co-delivery system in gastric cancer显示文摘As a well-known anticancer drug,paclitaxel(PTX),a first-line chemotherapeutic agent,remains unsatisfactory for gastric cancer therapy.It is reported that triptolide(TPL)could enhance the anti-gastric cancer effect of PTX.Considering the poor solubility of both drugs,we developed a red blood cell membrane-biomimetic nanosystem,an emerging tool in drug delivery,to co-load paclitaxel and triptolide(red blood cell membrane coated PTX and TPL co-loaded poly(lactic-co-glycolic acid)[PLGA]nanoparticles,RP(P/T)).The successful preparation was confirmed in terms of particle size,morphology,and surface markers assays.This biomimetic system could prolong circulation and escape immune surveillance.And these properties were verified by stability,in vitro drug release,and cellular uptake assays.Moreover,the MTT and colony formation assays demonstrated the superior anti-proliferation effect of the RP(P/T)to free drugs.The enhanced antitumor effects of RP(P/T)on migration and invasion were also evaluated by wound-healing and transwell assays.Overall,the bionic co-delivery nanoplatform with improved efficacy in vitro is a promising therapy for gastric cancer. | Siwan Wang Hui Jiang Jia Wang Haisi Wu Ting Wu Mengnan Ni Qianqian Zhao You Ji Ziting Zhang Chunming Tang Huae Xu | 2021 | The Journal of Biomedical Research2021，35，4： | 5 |
| 4 | Injectable baicalin/F127 hydrogel with antioxidant activity for enhanced wound healing显示文摘Baicalin,extracted from traditional Chinese medicine Scutellaria baicalensis Georg,possesses multiple pharmacological activities and has great potential for chronic skin wound repair.However,the poor solubility and lack of suitable vehicles greatly limit its further application.Herein,we proposed a convenient and robust strategy,employing PBS solution as solvent,to enhance the solubility of baicalin.Furthermore,we constructed injectable baicalin/F127 hydrogels to study their application in skin wound treatment.The composition and temperature sensitivity of baicalin/Pluronic®F-127 hydrogels were confirmed by FTIR and rheological testing,respectively.In vitro release measurement indicated that the first order model was best fitted with the release profile of baicalin from hydrogel matrix.Besides,MTT assay,AO/EO staining assay as well as hemolytic activity test revealed the excellent cytocompatibility of baicalin/F127 hydrogels.Antioxidant activity assay demonstrated the cytoprotective activity of baicalin/F127 hydrogels against reactive oxygen species(ROS).Furthermore,the in vivo experiments exhibited the ability of baicalin/F127 hydrogel to accelerate wound healing.In conclusion,this novel injectable baicalin/F127 hydrogel should have bright application for chronic wound treatment. | Guiting Liu Ziting Bao Jun Wu | 2020 | Chinese Chemical Letters2020，31，7： | 4 |
| 5 | Spatial patterns and effects of air pollution and meteorological factors on hospitalization for chronic lung diseases in Beijing, China显示文摘Chronic obstructive pulmonary disease(COPD), lung cancer(LC) and tuberculosis(TB) are common chronic lung diseases that generate a large disease burden and significant health care resource use in China. The aim of this study was to quantify spatial patterns and effects of air pollution and meteorological factors on hospitalization of COPD, LC and TB in Beijing. Daily counts of hospitalization for 2010 were obtained from the Beijing Urban Employees Basic Medical Insurance(UEBMI) system.Bayesian hierarchical Poisson regression models were applied to identify spatial patterns of hospitalization for COPD, LC and TB at the district level and explore associations with inhalable particulate matter(aerodynamic diameter <10 μm, PM10), sulfur dioxide(SO2), nitrogen dioxide(NO2), mean temperature and relative humidity. There were 18,882, 14,295 and 2,940 counts of hospitalizations for COPD, LC and TB respectively, in Beijing in 2010. Clusters of high relative risk were in different locations for the three diseases. The effect of relative humidity on COPD hospitalization was most significant with a relative risk(RR) of 1.070(95%CI: 1.054, 1.086) per one percent increase. For lung cancer hospitalization, exposure to ambient SO2 was associated with a RR of 1.034(95%CI: 1.011, 1.058) per μg m–3 increase. For tuberculosis, the effect of mean temperature was significant with a RR of 1.107(95%CI: 1.038, 1.180) per °C increase. Risk factors and spatial patterns were different for hospitalization of non-infectious and infectious chronic lung disease in Beijing. Even over a short time period(one year), associations were apparent with air pollution and meteorological factors. | Lin Tian Chuan Yang Zijun Zhou Ziting Wu Xiaochuan Pan Archie C. A. Clements | 2019 | Science China(Life Sciences)2019，62，10： | 3 |
| 6 | Progress on intelligent hydrogels based on RAFT polymerization:Design strategy, fabrication and the applications for controlled drug delivery显示文摘Although intelligent hydrogels have shown bright potential application in biomedical fields,they were prepared by conventional methods and still face many serious challenges,such as uncontrollable stimulus-response and low response sensitivity.Recently,RAFT polymerization provides a versatile strategy for the fabrication of intelligent hydrogels with improved stimulus-response properties,owing to the ability to efficiently construct hydrogel precursors with well-defined structure,such as block copolymer,graft copolymer,star copolymer.In this review,we summarized the recent progress on intelligent hydrogels based on RAFT polymerization with emphasis on their fabrication strategies and applications for controlled drug delivery. | Caihong Xian Qijuan Yuan Ziting Bao Guiting Liu Jun Wu | 2020 | Chinese Chemical Letters2020，31，1： | 3 |
| 7 | Formation and evolution of sand deserts in Xinjiang, Northwest China: I. Provenances of desert sands显示文摘沙的荒芜的风景处于自然条件是干旱气候和丰富的沙材料供应的一个地质的产品,因此沙的沙漠的形成是为理解在地球系统的各种各样的 stratigraphic/epigenetic 范围之间的相互作用的一个理想的学习目标。直到现在,然而,这些的起源和形成的知识在 Xinjiang 抛弃,中亚多样、不一致,系统的评论是必要的。在在包围 Xinjiang 沙漠的新生代阶层的这些沙漠和他们的成双的灰尘存款的内部区域的古老的风神的沙沉积是反映沙漠的沙材料和形成和进化的起源的直接、间接的线索。在外部区域基于 geochemical,荒芜的沙的矿物学、同位素的证据和相关存款,这篇论文在 Xinjiang 在沙的沙漠的发展考察研究进步,西北中国。许多证明建议在 Xinjiang 的荒芜的沙主要从古老的雨、冲积、河的沉积被采购并且因为本地沙供应,最后被完成。它指出在 Xinjiang 的构造结构的设置在 Tarim 盆和被地区性的水文学系统极大地影响的 Junggar 盆使沉积成为了两个,风神的进程从行星的风系统发源西,东方亚洲冬季季风和地形学的山脉山谷弯屈。然而,交通路径的方向在水文学动力学和风神的动力学之间是不同的,分别地,它被盆 tectonics 和地区性的大气的发行量线路的倾斜的结构决定并且决定了不同代理人交付的这些沉积的运输小径的 anisotropies。这在二大盆导致由岩屑形成的沉积交通的一个地质的周期并且大部分因此增加沉积混合的度,引申并且在沙起源的更年轻、更旧的沉积来源,以及复杂性和差异之间再循环。 | ZHU Bingqi YU Jingjie QIN Xiaoguang Patrick RIOUAL LIU Ziting XIONG Heigang | 2014 | Journal of Geographical Sciences2014，24，1： | 2 |
| 8 | Improvements on voltage-resistant performance of bipolar static induction transistor (BSIT) with buried gate structure显示文摘The breakdown mechanism of power bipolar static induction transistor (BSIT) with buried gate structure is analyzed in depth.A power BSIT sample with high voltage-resistant capability has been designed and fabricated in this paper.The technological methods for improving high voltage performances are represented.The active region of BSIT is surrounded with a deep trench to avoid any probable influences of various defects on device performances.Two field-limiting ring-shape junctions and one channel termination ring-shape junction are arranged around the gate region to reduce the electric field intensity.The gate-source breakdown voltage BV GS of power BSIT has been increased to 110 V from previous value of 50-60 V,and its blocking voltage is increased to 1700 V.The optimal geometrical dimensions for achieving the maximum breakdown voltage BV GS and blocking voltage V block are also represented in the paper. | WANG YongShun FENG JingJing LIU ChunJuan WANG ZiTing WANG ZaiXing ZHANG CaiZhen | 2012 | Science China(Information Sciences)2012，55，4： | 2 |
| 9 | Highly Sensitive and Fast Hydrogen Detection Based on Light-Induced Thermoelastic Spectroscopy显示文摘As a new energy source,hydrogen(H_(2))detection is a hot topic in recent years.Because of the weak absorption characteristic,laser spectroscopy-based H_(2)detection is challenging.In this paper,a highly sensitive H_(2)sensor based on light-induced thermoelastic spectroscopy(LITES)technique is demonstrated for the first time.A continuous-wave,distributed feedback diode laser with emission in the 2.1μm region was adopted as the excitation source to target the strongest H_(2)absorption line of 4,712.90 cm^(−1).A Herriott multipass cell with an optical length of 10.1 m was chosen to further improve the H_(2)absorption.With the feature of processing the raw input data without data preprocessing and extracting the desired features automatically,the robust shallow neural network(SNN)fitting algorithm was brought in to denoise the sensor.For the LITES-based H_(2)sensor,the concentration response was tested,and an excellent linear response to H_(2)concentration levels was achieved.A minimum detection limit(MDL)of~80 ppm was obtained.On the basis of implementation of the H_(2)-LITES sensor,a heterodyne H_(2)-LITES sensor was further constructed to realize a fast measurement of resonance frequency of quartz tuning fork and H_(2)concentration simultaneously.The resonance frequency can be retrieved in several hundred milliseconds with the measurement accuracy of±0.2 Hz,and the result of 30,713.76 Hz is exactly same as the experimentally determined value of 30,713.69 Hz.After the SNN algorithm was applied,an MDL of~45 ppm was achieved for this heterodyne H_(2)-LITES sensor. | Yufei Ma Tiantian Liang Shunda Qiao Xiaonan Liu Ziting Lang | 2023 | Ultrafast Science2023，3，3： | 2 |
| 10 | Forecasting the volatility of EUA futures with economic policy uncertainty using the GARCH‑MIDAS model显示文摘This study investigates the impact of economic policy uncertainty(EPU)on the volatility of European Union(EU)carbon futures prices and whether it has predictive power for the volatility of carbon futures prices.The GARCH-MIDAS model is applied for evaluating the impact of different EPU indexes on the price volatility of European Union Allowance(EUA)futures.We then compare the predictive power for the volatility of the two GARCH-MIDAS models based on different EPU indexes and six GARCH-type models.Our empirical results show that the GARCH-MIDAS models,which exhibit superior out-of-sample predictive ability,outperform GARCH-type models.The results also indicate that EPU has noticeable effect on the volatility of EUA futures.Specifically,the forecast accuracy of the EU EPU index is significantly higher than that of the global EPU index.Robustness checks further confirm that the EPU index(especially the EPU index of the EU)has strong predictive power for EUA futures prices.Additionally,using the volatility forecasting methods that GARCH-MIDAS models combine with the EPU index,investors can construct their portfolios to realize economic returns. | Jian Liu Ziting Zhang Lizhao Yan Fenghua Wen | 2021 | Financial Innovation2021，7，1： | 2 |
| 11 | Influence of reclaimed water discharge on the dissemination and relationships of sulfonamide, sulfonamide resistance genes along the Chaobai River, Beijing显示文摘Reclaimed water represents an important source of antibiotics and antibiotic resistance genes, threatening the ecological safety of receiving environments, while alleviating water resource shortages. This study investigated the dissemination of sulfonamide (SAs), sulfonamide resistance genes (SRGs), and class one integrons (intl1) in the surface water of the recharging area of the Chaobai River. The three antibiotics sulfamethoxazole, trimethoprim, and sulfadiazine had the highest abundance. The highest absolute abundances were 2.91×10^6, 6.94×10^6, and 2.18×10^4 copies/mL for sul1, sul2, and intl 1 at the recharge point, respectively. SRGs and intl1 were widespread and had high abundance not only at the recharging point, but also in remote areas up to 8 km away. Seasonal variations of SRGs abundance followed the order of summer>autumn>spring>winter. Significant correlations were found between SRGs and intl1 (a = 0.887 and 0.786, p<0.01), indicating the potential risk of SRGs dissemination. Strong correlations between the abundance of SRGs and environmental factors were also found, suggesting that appropriate environmental conditions favor the spread of SRGs. The obtained results indicate that recharging with reclaimed water causes dissemination and enrichment of SAs and SRGs in the receiving river. Further research is required for the risk assessment and scientific management of reclaimed water. | Ning Zhang Xiang Liu Rui Liu Tao Zhang Miao Li Zhuoran Zhang Zitao Qu Ziting Yuan Hechun Yu | 2019 | Frontiers of Environmental Science & Engineering2019，13，1： | 2 |
| 12 | Molar cornual ectopic pregnancy 显示文摘 | Zite NB Lipscomb GH Merrill K | 2002 | Obstet Gynecol2002，99，52： | 1 |
| 13 | Progress in non-viral localized delivery of siRNA therapeutics for pulmonary diseases显示文摘Emerging therapies based on localized delivery of siRNA to lungs have opened up exciting possibilities for treatment of different lung diseases.Localized delivery of siRNA to lungs has shown to result in severalfold higher lung accumulation than systemic route,while minimizing non-specific distribution in other organs.However,to date,only 2 clinical trials have explored localized delivery of siRNA for pulmonary diseases.Here we systematically reviewed recent advances in the field of pulmonary delivery of siRNA using non-viral approaches.We firstly introduce the routes of local administration and analyze the anatomical and physiological barriers towards effective local delivery of siRNA in lungs.We then discuss current progress in pulmonary delivery of siRNA for respiratory tract infections,chronic obstructive pulmonary diseases,acute lung injury,and lung cancer,list outstanding questions,and highlight directions for future research.We expect this review to provide a comprehensive understanding of current advances in pulmonary delivery of siRNA. | Jingjing Gao Ziting Xia Dilrasbonu Vohidova John Joseph James N.Luo Nitin Joshi | 2023 | Acta Pharmaceutica Sinica B2023，13，4： | 1 |
| 14 | HCG in ectopic pregnancy 显示文摘 | Visconti K Zite N | 2012 | Clin Obstet Gynecol2012，55，2： | 1 |
| 15 | The research advance of micrometastasis in patients with cervical carcinoma 显示文摘 | CHENG XI CAI SHUMO LI ZITING | 2005 | Foreign Med Sci Oncol Sect2005，32，9： | 1 |
| 16 | hCG in Ectopic Pregnancy显示文摘 | KEVIN VISCONTI NIKKI ZITE | 2012 | Clinical Obstetrics and Gynecology2012，，2： | 1 |
| 17 | Associations Between Specific Diets, Dietary Diversity, and Cognitive Frailty in Older Adults — China, 2002–2018显示文摘Summary What is already known about this topic?The relationship between specific dietary patterns and dietary diversity with cognitive frailty continues to be a subject of ambiguity.What is added by this report?This research revealed that regular consumption of fruit,meat,bean products,garlic,and tea was connected to a decreased risk of cognitive frailty.Compared to participants with dietary diversity score(DDS)≤6 points,those with DDS of 9–10,11–12,and≥12 had a lower risk of cognitive frailty. | Qingmei Huang Wenfang Zhong Ziting Chen Zhihao Li Peidong Zhang Yujie Zhang Peiliang Chen Qi Fu Weiqi Song Yuebin Lyu Xiaoming Shi Chen Mao | 2023 | China CDC weekly2023，5，39： | 1 |
| 18 | Isolation and functional analysis of two thioredoxin peroxidases (peroxiredoxins) from Plasmodium falciparum 显示文摘 | Walter RD Muller S | 2001 | Mol Biochern Parasitol2001，113，： | 1 |
| 19 | Molecular mechanisms of Streptococcus pyogenes Cas9:a single-molecule perspective显示文摘Cas9 is an RNA-guided endonuclease from the type II CRISPR-Cas system that employs RNA–DNA base pairing to target and cleave foreign DNA in bacteria.Due to its robust and programmable activity,Cas9 has been repurposed as a revolutionary technology for wide-ranging biological and medical applications.A comprehensive understanding of Cas9 mechanisms at the molecular level would aid in its better usage as a genome tool.Over the past few years,single-molecule techniques,such as fluorescence resonance energy transfer,DNA curtains,magnetic tweezers,and optical tweezers,have been extensively applied to characterize the detailed molecular mechanisms of Cas9 proteins.These techniques allow researchers to monitor molecular dynamics and conformational changes,probe essential DNA–protein interactions,detect intermediate states,and distinguish heterogeneity along the reaction pathway,thus providing enriched functional and mechanistic perspectives.This review outlines the single-molecule techniques that have been utilized for the investigation of Cas9 proteins and discusses insights into the mechanisms of the widely used Streptococcus pyogenes(Sp)Cas9 revealed through these techniques. | Qian Zhang Ziting Chen Bo Sun | 2021 | Biophysics Reports2021，7，6： | 1 |
| 20 | Efficient sampling methods for characterizing POIs on maps based on road networks显示文摘 | Ziting ZHOU Pengpeng ZHAO Victor S. SHENG Jiajie XU Zhixu LI Jian WU Zhiming CUI | 2018 | Frontiers of Computer Science2018，12，3： | 1 |
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