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| 1 | Abnormal β-catenin gene expression with invasiveness of primary hepatocellular carcinoma in China显示文摘AIM To study the abnormal expression of β-catenin gene and its relationship with invasiveness of primary hepatocellular carcinoma among Chinese people.METHODS Thirty-four hepatocellular carcinoma (HCC) specimens and adjacent para-cancerous tissues, 4 normal liver tissues were immunohistochemically stained to study subcellular distribution of β-catenin. Semiquantitive analysis of expression of β-catenin gene exon 3 mRNA was examined by RT-PCR and in situ hybridization. The relationship between expressions of both β-catenin protein, mRNA and clinicopathological characteristics of HCC was also analyzed.RESULTS Immunohistochemistry showed that all normal liver tissues and para-cancerous tissues examined displayed membranous type staining for β-catenin protein,occasionally with weak expression in the cytoplasm.While 21 cases (61.8%) of HCC examined showed accumulated type in cytoplasms or nuclei. The accumuled type Labling Index (LI) of cancer tissue and paracancarous tissue was (59.9 ± 26.3) and (18.3 ± 9.7)respectively (P<0.01). Higher accumulated type LI was closely related with invasiveness of HCC. Results of RTPCR showed the β-catenin gene exon 3 mRNA Expression Index (El) of 34 HCCs was higher than that of paracancerous tissue and normal liver tissue. Using in situ hybridization, the signal corresponding to β-catenin gene exon 3 mRNA was particularly strong in cytoplasm of HCC when compared with those of para-cancerous and normal liver tissues. Over expression of β-catenin exon 3 was also found to be correlated with high metastatic potential of HCC.CONCLUSION Abnormal expression of β-catenin gene may contribute importantly to the invasiveness of HCC among Chinese people. | Maija H Zile | 2001 | World Journal of Gastroenterology2001，7，4： | 22 |
| 2 | 3D printing of bone tissue engineering scaffolds显示文摘Tissue engineering is promising in realizing successful treatments of human body tissue loss that current methods cannot treat well or achieve satisfactory clinical outcomes.In scaffold-based bone tissue engineering,a high performance scaffold underpins the success of a bone tissue engineering strategy and a major direction in the field is to produce bone tissue engineering scaffolds with desirable shape,structural,physical,chemical and biological features for enhanced biological performance and for regenerating complex bone tissues.Three-dimensional(3D)printing can produce customized scaffolds that are highly desirable for bone tissue engineering.The enormous interest in 3D printing and 3D printed objects by the science,engineering and medical communities has led to various developments of the 3D printing technology and wide investigations of 3D printed products in many industries,including biomedical engineering,over the past decade.It is now possible to create novel bone tissue engineering scaffolds with customized shape,architecture,favorable macro-micro structure,wettability,mechanical strength and cellular responses.This article provides a concise review of recent advances in the R&D of 3D printing of bone tissue engineering scaffolds.It also presents our philosophy and research in the designing and fabrication of bone tissue engineering scaffolds through 3D printing. | Chong Wang Wei Huang Yu Zhou Libing He Zhi He Ziling Chen Xiao He Shuo Tian Jiaming Liao Bingheng Lu Yen Wei Min Wang | 2020 | Bioactive Materials2020，5，1： | 20 |
| 3 | Malus-metasurface-assisted polarization multiplexing显示文摘Polarization optics plays a pivotal role in diffractive,refractive,and emerging flat optics,and has been widely employed in contemporary optical industries and daily life.Advanced polarization manipulation leads to robust control of the polarization direction of light.Nevertheless,polarization control has been studied largely independent of the phase or intensity of light.Here,we propose and experimentally validate a Malus-metasurface-assisted paradigm to enable simultaneous and independent control of the intensity and phase properties of light simply by polarization modulation.The orientation degeneracy of the classical Malus’s law implies a new degree of freedom and enables us to establish a one-to-many mapping strategy for designing anisotropic plasmonic nanostructures to engineer the Pancharatnam–Berry phase profile,while keeping the continuous intensity modulation unchanged.The proposed Malus metadevice can thus generate a near-field greyscale pattern,and project an independent far-field holographic image using an ultrathin and single-sized metasurface.This concept opens up distinct dimensions for conventional polarization optics,which allows one to merge the functionality of phase manipulation into an amplitudemanipulation-assisted optical component to form a multifunctional nano-optical device without increasing the complexity of the nanostructures.It can empower advanced applications in information multiplexing and encryption,anti-counterfeiting,dual-channel display for virtual/augmented reality,and many other related fields. | Liangui Deng Juan Deng Zhiqiang Guan Jin Tao Yang Chen Yan Yang Daxiao Zhang Jibo Tang Zhongyang Li Zile Li Shaohua Yu Guoxing Zheng Hongxing Xu Cheng-Wei Qiu Shuang Zhang | 2020 | Light(Science & Applications)2020，9，1： | 7 |
| 4 | Full-space Cloud of Random Points with a Scrambling Metasurface显示文摘With the rapid progress in computer science,including artificial intelligence,big data and cloud computing,full-space spot generation can be pivotal to many practical applications,such as facial recognition,motion detection,augmented reality,etc.These opportunities may be achieved by using diffractive optical elements(DOEs)or light detection and ranging(LIDAR).However,DOEs suffer from intrinsic limitations,such as demanding depth-controlled fabrication techniques,large thicknesses(more than the wavelength),Lambertian operation only in half space,etc.LIDAR nevertheless relies on complex and bulky scanning systems,which hinders the miniaturization of the spot generator.Here,inspired by a Lambertian scatterer,we report a Hermitian-conjugate metasurface scrambling the incident light to a cloud of random points in full space with compressed information density,functioning in both transmission and reflection spaces.Over 4044 random spots are experimentally observed in the entire space,covering angles at nearly 90°.Our scrambling metasurface is made of amorphous silicon with a uniform subwavelength height,a nearly continuous phase coverage,a lightweight,flexible design,and low-heat dissipation.Thus,it may be mass produced by and integrated into existing semiconductor foundry designs.Our work opens important directions for emerging 3D recognition sensors,such as motion sensing,facial recognition,and other applications. | Zile Li Qi Dai Muhammad Q.Mehmood Guangwei Hu Boris Luk’yanchuk Jin Tao Chenglong Hao Inki Kim Heonyeong Jeong Guoxing Zheng Shaohua Yu Andrea Alù Junsuk Rho Cheng-Wei Qiu | 2018 | Light(Science & Applications)2018，7，1： | 6 |
| 5 | Zero-order-free meta-holograms in a broadband visible range显示文摘The unwanted zero-order light accompanied by the birth of diffractive optical elements and caused mainly by fabrication errors and wavelength variations is a key factor that deteriorates the performance of diffraction-related optical devices such as holograms,gratings,beam shapers,beam splitters,optical diffusers,and diffractive microlenses.Here,inspired by the unique characteristic of nano-polarizer-based metasurfaces for both positive and negative amplitude modulation of incident light,we propose a general design paradigm to eliminate zero-order diffraction without burdening the metasurface design and fabrication.The experimentally demonstrated metahologram,which projects a holographic image with a wide angle of 70°×70°in the for field,presents a very low zero-order intensity(only 0.7%of the total energy of the reconstructed image).More importantly,the zero-orderfree meta-hologram has a large tolerance limit for wavelength variations(under a broadband illumination from520 to 660 nm),which brings important technical advances.The strategy proposed could significantly relieve the fabrication difficulty of metasurfaces and be viable for various diffractive-optics-related applications includingholography,laser beam shaping,optical data storage,vortex beam generation,and so on. | RAO FU LIANGUI DENG ZHIQIANG GUAN SHENG CHANG JIN TAO ZILE LI GUOXING ZHENG | 2020 | Photonics Research2020，8，5： | 5 |
| 6 | Materials Experiment on Tiangong-2 Space Laboratory显示文摘During the China's Tiangong-2(TG-2) flight mission, the experiments of 18 kinds of material samples were conducted in space by using a Multiple Materials Processing Furnace(MMPF) mounted in the orbital module of the TG-2 space laboratory. After the experiments of 12 kinds of samples of the first and second batches were completed successfully, astronauts packed and brought them back to the ground by ShenzhouII spacecraft. By studying processing and formation on semiconductor and optoelectronics materials, metal alloys and metastable materials, functional single-crystal, micro-and nano-composite materials encapsulated in sample ampoules both in space and on Earth, we expect to explore some physical and chemical processes and mechanism of the materials formation that are normally obscured and therefore are difficult to study quantitatively on the ground due to the gravity-induced convection, to obtain the processing and synthesis technology for preparing high quality materials, and lead to the improvement and development of materials processing techniques on Earth, and also develop the experiment device and comprehensive ability for materials experiment in microgravity environment. This report briefly introduces the main points of each research work and preliminary comparative analysis results of 12 samples carried out by scientists undertaking research task. | LI Xiangyang LU Ye MENG Xiangjian WANG Jianlu WANG Reng CHEN Lidong HUA Zile LI Xiaoya SHI Jianlin LIU Jinfeng XU Guisheng WEI Bingbo XIE Wenjun YIN Zhigang ZHANG Xingwang JIANG Hongxiang LI Hong LUO Xinghong ZHANG Haifeng ZHAO Jiuzhou WANG Binbin PAN Mingxiang | 2018 | 空间科学学报2018，38，5： | 4 |
| 7 | The angiotensin receptor neprilysin inhibitor LCZ696 in heart failure with preserved ejection fraction: a phase 2 double-blind randomised controlled trial显示文摘 | Scott D Solomon Michael Zile Burkert Pieske Adriaan Voors Amil Shah Elisabeth Kraigher-Krainer Victor Shi Toni Bransford Madoka Takeuchi Jianjian Gong Martin Lefkowitz Milton Packer John JV McMurray | 2012 | 2012 (9851)2012，，9851： | 3 |
| 8 | Ipsilateral dislocation of the radial head associated with fracture of distal end of the radius: a case report and review of the literature显示文摘在成年人的光线的头的脱臼是不平常的。光线的头的同时的脱臼和 ipsilateral 的骨折没有另外的联系损害的半径的远侧的结束是极其稀罕的。根据我们知道,在损害的一个不平常的模式以后的如此的损害很少在英语文学被报导了。没有任何联系损害或 comorbidity,我们报导如此的一个案例。关上的减小在损害以后在二个小时以内被执行,结果是令人满意的。Immobilisation 被继续 3 个星期。渐渐的动员在 physiotherapist 的管理下面在灰浆的移动以后被开始。在 6 months’后续病人没有剩余疼痛非常近与完整的屈曲与扩展。有限制的几乎完整的旋后上次,内转的 10 度被完成。没有肘的不稳定性的证据。 | Vinay Gupta Zile Singh Kundu Maneet Kaur Pradeep Kamboj Jitesh Gawande | 2013 | Chinese Journal of Traumatology2013，16，3： | 3 |
| 9 | Interference management in 6G space and terrestrial integrated networks: Challenges and approaches显示文摘The Space-Terrestrial Integrated Network(STIN)is considered to be a promising paradigm for realizing worldwide wireless connectivity in sixth-Generation(6G)wireless communication systems.Unfortunately,excessive interference in the STIN degrades the wireless links and leads to poor performance,which is a bottleneck that prevents its commercial deployment.In this article,the crucial features and challenges of STIN-based interference are comprehensively investigated,and some candidate solutions for Interference Management(IM)are summarized.As traditional IM techniques are designed for single-application scenarios or specific types of interference,they cannot meet the requirements of the STIN architecture.To address this issue,we propose a self-adaptation IM method that reaps the potential benefits of STIN and is applicable to both rural and urban areas.A number of open issues and potential challenges for IM are discussed,which provide insights regarding future research directions related to STIN. | Shi Yan Xueyan Cao Zile Liu Xiqing Liu | 2020 | Intelligent and Converged Networks2020，1，3： | 3 |
| 10 | Directional Electromagnetic Interference Shielding Based on Step-Wise Asymmetric Conductive Networks显示文摘Some precision electronics such as signal transmitters need to not only emit effective signal but also be protected from the external electromagnetic(EM)waves.Thus,directional electromagnetic interference(EMI)shielding materials(i.e.,when the EM wave is incident from different sides of the sample,the EMI shielding effectiveness(SE)is rather different)are strongly required;unfortunately,no comprehensive literature report is available on this research field.Herein,Nicoated melamine foams(Ni@MF)were obtained by a facile electroless plating process,and multiwalled carbon nanotube(CNT)papers were prepared via a simple vacuum-assisted self-assembly approach.Then,step-wise asymmetric poly(butylene adipate-co-terephthalate)(PBAT)composites consisting of loose Ni@MF layer and compact CNT layer were successfully fabricated via a facile solution encapsulation approach.The step-wise asymmetric structures and electrical conductivity endow the Ni@MF/CNT/PBAT composites with unprecedented directional EMI shielding performances.When the EM wave is incident from Ni@MF layer or CNT layer,Ni@MF-5/CNT-75/PBAT exhibits the total EMI SE(SET)of 38.3 and 29.5 dB,respectively,which illustrates theΔSET of 8.8 dB.This work opens a new research window for directional EMI shielding composites with step-wise asymmetric structures,which has promising applications in portable electronics and next-generation communication technologies. | Bai Xue Yi Li Ziling Cheng Shengdu Yang Lan Xie Shuhao Qin Qiang Zheng | 2022 | Nano-Micro Letters2022，14，1： | 3 |
| 11 | A Multi-granularity Decomposition Mechanism of Complex Tasks Based on Density Peaks显示文摘There are many algorithms for solving complex problems in supervised manner. However, unsupervised tasks are more common in real scenarios. Inspired by the idea of granular computing and the characteristics of human cognitive process, this paper proposes a complex tasks decomposition mechanism based on Density Peaks Clustering(DPC) to address complex tasks with an unsupervised process, which simulates the multi-granular observation and analysis of human being. Firstly, the DPC algorithm is modified to nullify its essential defects such as the difficulty of locating correct clustering centers and classifying them accurately. Then, the improved DPC algorithm is used to construct the initial decomposition solving space with multi-granularity theory. We also define subtask centers set and the granulation rules to guide the multi-granularity decomposing procedure. These rules are further used to decompose the solving space from coarse granules to the optimal fine granules with a convergent and automated process. Furthermore, comprehensive experiments are presented to verify the applicability and veracity of our proposed method in community-detection tasks with several benchmark complex social networks.The results show that our method outperforms other four state-of-the-art approaches. | Ziling Pang Guoyin Wang Jie Yang | 2018 | Big Data Mining and Analytics2018，1，3： | 3 |
| 12 | Optogenetics in neuroscience:what we gain from studies in mammals显示文摘Optogenetics is a newly-introduced technology in the life sciences and is gaining increasing attention.It refers to the combination of optical technologies and genetic methods to control the activity of specific cell groups in living tissue,during which high-resolution spatial and temporal manipulation of cells is achieved.Optogenetics has been applied to numerous regions,including cerebral cortex,hippocampus,ventral tegmental area,nucleus accumbens,striatum,spinal cord,and retina,and has revealed new directions of research in neuroscience and the treatment of related diseases.Since optogenetic tools are controllable at high spatial and temporal resolution,we discuss its applications in these regions in detail and the recent understanding of higher brain functions,such as reward-seeking,learning and memory,and sleep.Further,the possibilities of improved utility of this newly-emerging technology are discussed.We intend to provide a paradigm of the latest advances in neuroscience using optogenetics. | Quanhui Chen Ziling Zeng Zhian Hu | 2012 | Neuroscience Bulletin2012，28，4： | 2 |
| 13 | Revolution of vitamin E production by starting from microbial fermented farnesene to isophytol显示文摘Vitamin E is one of the most widely used vitamins.In the classical commercial synthesis of vitamin E(a-tocopherol),the chemical synthesis of isophytol is the key technical barrier.Here,we establish a new process for isophytol synthesis from microbial fermented farnesene.To achieve an efficient pathway for farnesene production,Saccharomyces cerevisiae was selected as the host strain.First,b-farnesene synthase genes from different sources were screened,and through protein engineering and system metabolic engineering. | Ziling Ye Bin Shi Yanglei Huang Tian Ma Zilei Xiang Ben Hu Zhaolin Kuang Man Huang Xiaoying Lin Zhu Tian Zixin Deng Kun Shen Tiangang Liu | 2022 | The Innovation2022，3，3： | 2 |
| 14 | Effects of Digoxin on Morbidity and Mortality in Diastolic Heart Failure: The Ancillary Digitalis Investigation Group Trial显示文摘 | Ali Ahmed Michael W. Rich Jerome L. Fleg Michael R. Zile James B. Young Dalane W. Kitzman Thomas E. Love Wilbert S. Aronow Kirkwood F. Adams Mihai Gheorghiade | 2006 | Circulation2006，，5： | 2 |
| 15 | The angiotensin receptor neprilysin inhibitor LCZ696 in heart failure with preserved ejection fraction: a phase 2 double-blind randomised controlled trial显示文摘 | Scott D Solomon Michael Zile Burkert Pieske Adriaan Voors Amil Shah Elisabeth Kraigher-Krainer Victor Shi Toni Bransford Madoka Takeuchi Jianjian Gong Martin Lefkowitz Milton Packer John JV McMurray | 2012 | The Lancet2012，，9851： | 2 |
| 16 | Characterization of a Lacustrine Shale Reservoir and the Evolution of its Nanopores: A Case Study of the Upper Cretaceous Qingshankou Formation in the Songliao Basin, Northeastern China显示文摘The Songliao Basin is one of the most important petroliferous basins in northern China. With a recent gradual decline in conventional oil production in the basin, the exploration and development of unconventional resources are becoming increasingly urgent. The Qingshankou Formation consists of typical Upper Cretaceous continental strata, and represents a promising and practical replacement resource for shale oil in the Songliao Basin. Previous studies have shown that low-mature to mature Qingshankou shale mainly preserves type Ⅰ and type Ⅱ1 organic matter, with relatively high total organic carbon(TOC) content. It is estimated that there is a great potential to explore for shale oil resources in the Qingshankou Formation in this basin. However, not enough systematic research has been conducted on pore characteristics and their main controlling factors in this lacustrine shale reservoir. In this study, 19 Qingshankou shales from two wells drilled in the study area were tested and analyzed for mineral composition, pore distribution and feature evolution using Xray diffraction(XRD), scanning electron microscopy(SEM), low-pressure nitrogen gas adsorption(N2-GA), and thermal simulation experiments. The XRD results show that clay, quartz, and feldspar are the dominant mineral constituents of Qingshankou shale. The clay minerals are mostly illite/smectite mixed layers with a mean content of 83.5%, followed by illite, chlorite, and kaolinite. There are abundant deposits of clay-rich shale in the Qingshankou Formation in the study area, within which many mineral and organic matter pores were observed using SEM. Mineral pores contribute the most to shale porosity;specifically, clay mineral pores and carbonate pores comprise most of the mineral pores in the shale. Among the three types of organic matter pores, type B is more dominant the other two. Pores with diameters greater than 10 nm supply the main pore volume;most are half-open slits and wedge-shaped pores. The total pore volume had no obvious linear relationship with TOC content, but had some degree of positive correlation with the content of quartz + feldspar and clay minerals respectively. However, it was negatively correlated with carbonate mineral content. The specific surface area of the pores is negatively related to TOC content, average pore diameter, and carbonate mineral content. Moreover, it had a somewhat positive correlation with clay mineral content and no clear linear relationship with the content of quartz + feldspar. With increases in maturity, there was also an increase in the number of carbonate mineral dissolution pores and organic matter pores, average pore diameter, and pore volume, whereas there was a decrease in specific surface area of the pores. Generally, the Qingshankou shale is at a low-mature to mature stage with a TOC content of more than 1.0%, and could be as thick as 250 m in the study area. Pores with diameters of more than 10 nm are well-developed in the shale. This research illustrates that there are favorable conditions for shale oil occurrence and enrichment in the Qingshankou shale in the study area. | ZHANG Xu LIU Chenglin LI Bing WU Linqiang GUI Herong WANG Ziling ZHANG Zhihui LIANG Dexiu | 2020 | Acta Geologica Sinica(English Edition)2020，94，2： | 2 |
| 17 | Reactivities of d^0 transition metal complexes toward oxygen:Synthetic and mechanistic studies显示文摘Transition metals such as Fe in porphyrin complexes are known to bind or react with O2,and such reactions are critical to many biological functions and catalytic oxidation using O2.The transition metals in these reactions often contain valence d electrons,and oxidation of metals is an important step.In recent years,reactions of O2 with d0 transition metal complexes such as Hf(NR2)4(R=alkyl) have been used to make metal oxide thin films as insulating gate materials in new microelectronic devices.This feature article discusses our recent studies of such reactions and the formation of TiO2 thin films.In contrast to the reactions of many dn complexes where metals are often oxidized,reactions of d0 complexes such as Hf(NMe2)4 and Ta(NMe2)4(SiR3) with O2 usually lead to the oxidation of ligands,forming,e.g.,-ONMe2 and -OSiR3 from-NMe2 and-SiR3 ligands,respectively.Mechanistic and theoretical studies of these reactions have revealed pathways in the formation of the metal oxide thin films as microelectronic materials. | CHEN ShuJian ZHANG XinHao LIN ZhenYang WU YunDong XUE ZiLing | 2009 | Science China Chemistry2009，52，11： | 2 |
| 18 | Global antimicrobial resistance:a system-wide comprehensive investigation using the Global One Health Index显示文摘Background:Antimicrobial resistance(AMR)is one of the top ten global public health challenges.However,given the lack of a comprehensive assessment of worldwide AMR status,our objective is to develop a One Health-based system-wide evaluation tool on global AMR.Methods:We have further developed the three-hierarchical Global One Health Index(GOHI)-AMR indicator scheme,which consists of five key indicators,17 indicators,and 49 sub-indicators,by incorporating 146 countries'data from diverse authoritative databases,including WHO's Global Antimicrobial Resistance and Use Surveillance System(GLASS)and the European CDC.We investigated the overall-or sub-rankings of GOHI-AMR at the international/regional/national levels for data preprocessing and score calculation utilizing the existing GOHI methodology.Additionally,a correlation analysis was conducted between the GOHI-AMR and other socioeconomic factors.Results:The average GOHI-AMR score for 146 countries is 38.45.As expected,high-income countries(HICs)outperform the other three income groups on overall rankings and all five key indicators of GOHI-AMR,whereas lowincome countries unexpectedly outperform upper-middle-income countries and lower-middle-income countries on the antibiotics-resistant key indicator(ARR)and ARR-subordinate indicators,including carbapenem-,β-lactam-,and quinolone resistance,and even HICs on aminoglycoside resistance.There were no significant differences among the four groups on the environmental-monitoring indicator(P>0.05).GOHI-AMR was positively correlated with gross domestic product,life expectancy,and AMR-related publications,but negatively with natural growth rate and chronic respiratory disease.In contrast to Cyprus,the remarkably lower prevalence of'ESKAPE pathogens'in high-scoring Sweden and Denmark highlights Europe's huge gaps.China and Russia outperformed the other three BRICS countries on all key indicators,particularly India's ARR and Brazil's AMR laboratory network and coordination capacity.Furthermore,significant internal disparities in carbapenem-resistant Klebsiella pneumoniae(CRKP)and methicillin-resistant Staphylococcus aureus(MRSA)prevalence were observed between China and the USA,with MRSA prevalence both gradually declining,whereas CRKP prevalence has been declining in the USA but increasing in China,consistent with higher carbapenems-related indicator'performance in USA.Conclusions:GOHI-AMR is the most comprehensive tool currently available for the assessment of AMR status worldwide.We discovered unique features impacting AMR in each country and offered precise recommendations to improve the capacity to tackle AMR in low-ranking countries. | Nan Zhou Zile Cheng Xiaoxi Zhang Chao Lv Chaoyi Guo Haodong Liu Ke Dong Yan Zhang Chang Liu Yunfu Chang Sheng Chen Xiaokui Guo Xiao-Nong Zhou Min Li Yongzhang Zhu | 2022 | Infectious Diseases of Poverty2022，11，4： | 2 |
| 19 | Synthesis and characterization of poly(pyrazolyl)borate tantalum amide complexes and their reactivities toward oxygen显示文摘Reaction of TaCl(NMe2)4 (1) with KTp* [Tp* = tris(3,5-dimethylpyrazolyl)borohydride] yields two products: Tp*Ta(NMe2)4 (2), in which one N atom of the Tp* ligand binds to Ta, and [Tp*Ta(NMe2)4]· 2KTp* (3) where three N atoms of the Tp* ligand in [Tp*Ta(NMe2)4] (2a) bind to Ta. Addition of excess 1 to 3 did not exclude KTp*. Further reaction of 2 with oxygen affords Tp*BH(NMe2) (4). TpTa(NMe2)4 (5) has been synthesized by a similar procedure through the reaction of 1 with TpK [Tp=tris(pyrazolyl)borohydride]. Reactions of 3 and 5 with oxygen were also studied. 2, 4, and 5 were characterized by NMR, EA, and single-crystal X-ray diffraction. | CHEN ShuJian Glenn P.A.YAP XUE ZiLing | 2009 | Science China Chemistry2009，52，10： | 2 |
| 20 | Flesh quality of hybrid grouper(Epinephelus fuscoguttatus♀×Epinephelus lanceolatus♂)fed with hydrolyzed porcine mucosasupplemented low fishmeal diet显示文摘Iso-nitrogenous and iso-lipidic diets containing 0%,3%,6%,9%,and 12%hydrolyzed porcine mucosa(namely,HPM0,HPM3,HPM6,HPM9,and HPM12)were prepared to evaluate their effects on the growth performance,muscle nutrition composition,texture property,and gene expression related to muscle growth of hybrid groupers(Epinephelus fuscoguttatus\Epinephelus lanceolatus_).Groupers were fed to apparent satiation at 08:00 and 16:00 every day for a total of 56 days.It was found that the weight gain percentage in the HPM0,HPM3,and HPM6 groups did not differ(P>0.05).The cooking loss and drip loss of the dorsal muscle in the HPM3 group were lower than those in the HPM6 and HPM9 groups(P<0.05).The hardness and chewiness of the dorsal muscle in the HPM3 group were higher than those in the HPM0,HPM9,and HPM12 groups(P<0.05).The gumminess in the HPM3 group was higher than that in the HPM9 and HPM12 groups(P<0.05).The total essential amino acid content of the dorsal muscle in the HPM12 group was higher than that in the HPM0 group(P<0.05).The contents of total n-3 polyunsaturated fatty acid and total n-3 highly unsaturated fatty acid,as well as the ratio of n-3/n-6 polyunsaturated fatty acid in the dorsal muscle was higher in the HPM0 group than in all other groups(P<0.05).The relative expressions of gene myogenic factor 5,myocyte enhancer factor 2c,myocyte enhancer factor 2a,myosin heavy chain,transforming growth factor-beta 1(TGF-b1),and follistatin(FST)were the highest in the dorsal muscle of the HPM3 group.The results indicated that the growth performance of hybrid grouper fed a diet with 6%HPM and 27%fish meal was as good as that of the HPM0 group.When fish ingested a diet containing 3%HPM,the expression of genes TGF-β1 and FST involved in muscle growth were upregulated,and then the muscle quality related to hardness and chewiness were improved.An appropriate amount of HPM could be better used in grouper feed. | Xuanyi Yang Xinyan Zhi Ziling Song Guanghui Wang Xumin Zhao Shuyan Chi Beiping Tan | 2022 | Animal Nutrition2022，，1： | 2 |
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