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| 1 | Assessment of neovascularization within carotid plaques in patients with ischemic stroke显示文摘AIM:To assess neovascularization within human ca-rotid atherosclerotic soft plaques in patients with isch-emic stroke.METHODS:Eighty-one patients with ischemic stroke and 95 patients without stroke who had soft athero-sclerotic plaques in the internal carotid artery were studied.The thickest soft plaque in each patient was examined using contrast-enhanced ultrasound.Time-intensity curves were collected from 5 s to 3 min after contrast injection.The neovascularization within the plaques in the internal carotid artery was evaluated using the ACQ software built into the scanner by 2 of the experienced investigators who were blinded to the clinical history of the patients.RESULTS:Ischemic stroke was present in 7 of 33 patients(21%) with grade Ⅰ plaque,in 14 of 51 pa-tients(28%) with grade Ⅱ plaque,in 26 of 43 patients(61%) with grade Ⅲ plaque,and in 34 of 49 patients(69%) with grade Ⅳ plaque(P < 0.001 comparing grade Ⅳ plaque with grade I plaque and with grade Ⅱ plaque and P = 0.001 comparing grade Ⅲ plaque with grade Ⅰ plaque and with grade Ⅱ plaque).Analysis of the time intensity curves revealed that patients with ischemic stroke had a significantly higher intensity of enhancement(IE) than those without ischemic stroke(P < 0.01).The wash-in time(WT) of plaque was signifi-cantly shorter in stroke patients(P < 0.05).The sensi-tivity and specificity for IE in the plaque were 82% and 80%,respectively,and for WT were 68% and 74%,respectively.There was no significant difference in the peak intensity or time to peak between the 2 groups.CONCLUSION:This study shows that the higher the grade of plaque enhancement,the higher the risk of ischemic stroke.The data suggest that the presence of neovascularization is a marker for unstable plaque. | Wilbert S Aronow Chandra K Nair David Cosgrove | 2010 | World Journal of Cardiology2010，2，4： | 29 |
| 2 | NETosis,complement,and coagulation:a triangular relationship显示文摘NETosis is a regulated form of neutrophil cell death that contributes to the host defense against pathogens and was linked to various diseases soon after its first description in 2004.During NETosis,neutrophils release neutrophil extracellular traps(NETs),which can capture and kill bacteria and other pathogens to prevent them from spreading.Although substantial progress has been made in our understanding of NETosis,the precise mechanism underlying NETosis is still a matter of debate.Research continues to elucidate the molecular pathways involved in NETosis.In recent years,interactions with the complement and coagulation systems have become increasingly apparent.Activated complement proteins can stimulate NET formation,and NETs,in turn,can serve as a platform for complement activation.In addition,NETs can act as a scaffold for thrombus formation during coagulation.While crosstalk between the coagulation and complement systems has been previously described,NETosis appears to be a third important player in this consortium to protect the host against pathogens.This review summarizes our current knowledge on the mutual interactions between NETosis,the complement system and the coagulation system,with an emerging description of their complex triangular relationship. | Cynthia M.de Bont Wilbert C.Boelens Ger J.M.Pruijn | 2019 | Cellular & Molecular Immunology2019，16，1： | 22 |
| 3 | Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno-or squamous cell carcinoma显示文摘AIM:To determine whether-1195 A→G and/or-765 G→C polymorphisms in Cyclooxygenase-2(COX-2 ) may have a risk modifying effect on the development of esophageal carcinoma in a Dutch Caucasian population.METHODS:Two study groups were recruited, 252 patients with esophageal carcinoma and 240 healthy controls, matched for race, age, gender and recruiting area.DNA was isolated from whole blood and used for genotyping.PCR products were digested with restriction enzymes and products were analyzed by agarose gel electrophoresis.Odds ratios(OR) and 95% confldence intervals(CI) were estimated.RESULTS:The distribution of the-1195 A→G polymorphism was signif icantly different in esophageal cancer patients compared to controls.The-1195 GG genotype resulted in a higher risk of developing esophageal adenocarcinoma(OR = 3.85, 95% CI:1.45-10.3) compared with the-1195 AA genotype as a reference.The-765 G→C genotype distribution was not different between the two groups.The GG/ GG haplotype was present more often in esophageal adenocarcinoma patients than in controls(OR = 3.45, 95% CI:1.24-9.58;with AG/AG as a reference).The same trends were observed in patients with squamous cell carcinomas, however, the results did not reach statistical signif icance.CONCLUSION:Presence of the COX-2-1195 GG genotype and of the GG/GG haplotype may result in a higher risk of developing esophageal carcinoma. | Jón O Kristinsson Paul van Westerveld Rene HM te Morsche Hennie MJ Roelofs T Wobbes Ben JM Witteman Adriaan CITL Tan Martijn GH van Oijen Jan BMJ Jansen Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，28： | 11 |
| 4 | COX-2 polymorphisms-765G→C and-1195A→G and colorectal cancer risk显示文摘AIM:To determine the possible modulating effect of the COX-2 polymorphisms,-765G→C and-1195A→G, on the risk of colorectal cancer(CRC)in a Dutch population. METHODS:This case-control study includes 326 patients with CRC and 369 age-and gender-matched controls.Genotypes of the COX-2 polymorphisms -765G→C and-1195A→G were determined by polymerase chain reaction-based restriction fragment length polymorphism.COX-2 genotypes and haplotypes were analyzed and odds ratios with 95%confi- dence intervals were estimated by logistic regression. RESULTS:The-765GG genotype was associated with an increased risk of developing CRC(OR,1.45; 95%CI,1.03-2.04).No significant difference was observed in the genotype distribution of the-1195A→ G polymorphism between patients and controls.The GG/AC haplotype was present significantly less often in patients than in controls(OR 0.44;95%CI,0.22-0.85). When the AC,AG and GG haplotypes were investigated separately,the AC haplotype showed a tendency to be less frequent in patients than in controls(OR(AG/AC)0.78; 95%CI,0.57-1.06). CONCLUSION:The-765GG genotype is associatedwith an increased risk of developing CRC and the GG/ AC haplotype seems to protect against CRC.These findings suggest a modulating role for the COX-2 polymorphisms-765G→C and-1195A→G in the development of CRC in a Dutch population. | Juliёt H Hoff Rene HM te Morsche Hennie MJ Roelofs Elise MJ van der Logt Fokko M Nagengast Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，36： | 6 |
| 5 | Polymeric foams for flexible and highly sensitive low-pressure capacitive sensors显示文摘Flexible low-pressure sensors(<10 kPa)are required in areas as diverse as blood-pressure monitoring,human–computer interactions,robotics,and object detection.For applications,it is essential that these sensors combine flexibility,high sensitivity,robustness,and low production costs.Previous works involve surface micro-patterning,electronic amplification(OFET),and hydrogels.However,these solutions are limited as they involve complex processes,large bias voltages,large energy consumption,or are sensitive to evaporation.Here,we report a major advance to solve the challenge of scalable,efficient and robust e-skin.We present an unconventional capacitive sensor based on composite foam materials filled with conductive carbon black particles.Owing to the elastic buckling of the foam pores,the sensitivity exceeds 35 kPa^(−1) for pressure<0.2 kPa.These performances are one order of magnitude higher than the ones previously reported.These materials are low-cost,easy to prepare,and display high capacitance values,which are easy to measure using low-cost electronics.These materials pave the road for the implementation of e-skin in commercialized applications. | Mickaël Pruvost Wilbert J.Smit Cécile Monteux Philippe Poulin Annie Colin | 2019 | npj Flexible Electronics2019，3，1： | 5 |
| 6 | Illumina Sequencing Technology as a Method of Identifying T-DNA Insertion Loci in Activation- Tagged Arabidopsis thaliana Plants显示文摘 | Joanna K. Polko Mohamed-Ramzi Temanni Martijn van Zanten Wilbert van Workum Sven Iburg Ronald Pierik Laurentius A.C.J. Voesenek Anton J.M. Peeters | 2012 | Molecular Plant2012，5，4： | 3 |
| 7 | Disparities of conjugating protective enzyme activities in the colon of patients with adenomas and carcinomas显示文摘AIM:To investigate the metabolic enzymatic capacity of the colon mucosa to detoxify noxious carcinogenic compounds.METHODS:We investigated the activity of 2 conjugating enzymes-the microsomal uridine glucuronosyltransferase(UGT)and the cytosomal glutathione S-transferase(GST)in the uninvolved mucosa of the colon transversum and sigmoideum in patients with adenomatous polyps and colorectal cancer.Biopsies were taken from the mucosa during colonoscopies which were done for clinical(diagnostic)reasons.After storage,the biopsy material was homogenized and after differential centrifugation the enzyme assays were performed with 4-nitrophenol(UGT)and 1-chloro 2,4-dinitrobenzene(GST)as substrates.RESULTS:About 48 patients were included of which28 had adenomas and 20 had colorectal carcinomas confirmed by histopathology.Enzyme activities were expressed as nmol/mg per minute protein for the GST and as pmol/mg per minute protein for the UGT.Analysis of variance(F-test)indicated that both enzymes were more widely distributed in adenoma than in cancer patients.The means±SD were smaller for cancer patients:GST for adenomas 268±152 vs 241±69 for carcinomas and UGT for adenomas 197±200 vs 150±86 for carcinomas.CONCLUSION:Compared to patients with adenomatous colon polyps those with colorectal carcinoma exhibited a lower capacity of detoxifying enzyme metabolism and their activities clustered over a smaller range. | Harald P Hoensch Hennie MJ Roelofs Lutz Edler Wilhelm Kirch Wilbert HM Peters | 2013 | World Journal of Gastroenterology2013，19，36： | 3 |
| 8 | Assessment of oxidative stress in chronic pancreatitis patients显示文摘AIM: To assess the levels of antioxidant capacity and oxidative damage in blood of chronic pancreatitis (CP) patients in comparison with those in healthy control sub- jects, by using several different analytical techniques. METHODS: Thirty-five CP patients and 35 healthy con- trol subjects were investigated prospectively with re- spect to plasma levels of thiols, ferric reducing ability of plasma (FRAP, i.e. antioxidant capacity), levels of protein carbonyls and thiobarbituric acid reactive substances (TBARS). Additionally, we evaluated the production of reactive oxygen species (ROS) in whole blood. RESULTS: The antioxidative thiols including cysteine, cysteinylglycine and glutathione were significantly lower in CP patients. In addition, the non-enzymatic antioxi- dant capacity was significantly lower in CP patients, which correlated with the amount of oxidative protein (protein carbonyls) and the extent of lipid damage (TBARS), both were significantly higher in CP patients. The ROS production in whole blood after stimulation with phorbol 12-myritate 13-acetaat, demonstrated a strong tendency to produce more ROS in CP patients. CONCLUSION: Oxidative stress may contribute to the pathogenesis of chronic pancreatitis by decreasing anti- oxidant capacity and increasing oxidative damage in CP patients may be a rationale for intervention with antioxi- dant therapy. | Mariette Verlaan Hennie MJ Roelofs Annie van Schaik Geert JA Wanten Jan BMJ Jansen Wilbert HM Peters Joost PH Drenth | 2006 | World Journal of Gastroenterology2006，12，35： | 3 |
| 9 | 学习动机及方法与学科成绩的相关性(英文)显示文摘目的探讨大学生上课出席次数、学习方法及动机与学科成绩之间的相关性。方法采用学习的动力对策量表对大学生进行评分,并计算上课出席次数与各课程成绩的相关系数,这些课程包括心理学方法学、普通生物学、英国文学、普通心理学、普通社会学。结果与结论大学生上课出席次数是预测课程成绩的最佳指标。根据教学方案调整学习方法也可提升课程成绩,但有效的学习方法仍无法弥补经常缺课带来的不良影响。 | 林贻光 Wilbert J.Mckeachie | 2014 | 教育生物学杂志2014，2，4： | 2 |
| 10 | Protein secretion mechanisms in Gram-negative bacteria显示文摘 | Margot Koster Wilbert Bitter Jan Tommassen | 2000 | International Journal of Medical Microbiology2000，，4： | 2 |
| 11 | Effects of Digoxin on Morbidity and Mortality in Diastolic Heart Failure: The Ancillary Digitalis Investigation Group Trial显示文摘 | Ali Ahmed Michael W. Rich Jerome L. Fleg Michael R. Zile James B. Young Dalane W. Kitzman Thomas E. Love Wilbert S. Aronow Kirkwood F. Adams Mihai Gheorghiade | 2006 | Circulation2006，，5： | 2 |
| 12 | Cardiac papillary fibroelastoma:The need for a timely diagnosis显示文摘Cardiac papillary fibroelastomas(CPFs) are the second most common primary cardiac tumors and the most common cardiac valvular tumors. Although they are histologically benign and usually asymptomatic, CPFs can lead to serious and life-threatening complications like myocardial infarction, stroke, pulmonary embolus, cardiac arrest etc. CPFs represent a rare entity in clinical medicine and literature regarding their management is limited. We report two cases which illustrate such complications arising from undiagnosed CPFs on the aortic valve. We further stress on the importance of identifying CPFs early so that they can be managed appropriately based on recommendations from the available literature. | Srikanth Yandrapalli Bella Mehta Pratik Mondal Tanush Gupta Pallavi Khattar John Fallon Randy Goldberg Sachin Sule Wilbert S Aronow | 2017 | World Journal of Clinical Cases2017，5，1： | 2 |
| 13 | Editorial on hemoglobin A1c, blood pressure, and lowdensity lipoprotein cholesterol goals in diabetics显示文摘The American Diabetes Association (ADA) 2013 guidelines state that a reasonable hemoglobin A1c goal for many nonpregnant adults with diabetes is less than 7.0% a hemoglobin A1c level of less than 6.5% may be considered in adults with short duration of diabetes, long life expectancy, and no significant cardiovascular disease if this can be achieved without significant hypoglycemia or other adverse effects of treatment. A hemoglobin A1c level less than 8.0% may be appropriate for patients with a history of severe hypoglycemia, limited life expectancy, advanced macrovascular and microvascular complications, extensive comorbidities, and long-standing diabetes in whom the hemoglobin A1c goal is difficult to attain despite multiple glucoselowering drugs including insulin. The ADA 2013 guidelines recommend that the systolic blood pressure in most diabetics with hypertension should be reduced to less than 140 mmHg. These guidelines also recommend use of an angiotensin-converting enzyme inhibitor or angiotensin receptor blocker in the treatment of hypertension in diabetics unless they are pregnant. Diabetics at high risk for cardiovascular events should have theirserum low-density lipoprotein (LDL) cholesterol lowered to less than 70 mg/dL with statins. Lower-risk diabetics should have their serum LDL cholesterol reduced to less than 100 mg/dL. Combination therapy of a statin with either a fibrate or niacin has not been shown to provide additional cardiovascular benefit above statin therapy alone and is not recommended. Hypertriglyceridemia should be treated with dietary and lifestyle changes. Severe hypertriglyceridemia should be treated with drug therapy to reduce the risk of acute pancreatitis. | Wilbert S Aronow | 2013 | World Journal of Cardiology2013，5，5： | 2 |
| 14 | Effects of Digoxin on Morbidity and Mortality in Diastolic Heart Failure: The Ancillary Digitalis Investigation Group Trial显示文摘 | Ali Ahmed Michael W. Rich Jerome L. Fleg Michael R. Zile James B. Young Dalane W. Kitzman Thomas E. Love Wilbert S. Aronow Kirkwood F. Adams Mihai Gheorghiade | 2006 | Circulation2006，，5： | 2 |
| 15 | 马拉维Nyika高原三种溪流鱼类的生境类型(英文)显示文摘本研究调查了生活在非洲马拉维北部Nyika高原三种溪流鱼类的栖息地。分3个时期选择3条河流的24个地点进行取样,每个样点长100 m左右;分急流和回水湾两种生境类型作为独立的栖息地单元取样,据此观察研究对象和物理环境间的关系;用喜好指数和逻辑回归分析每种鱼重要栖息地是否稳定。瞻星平鳍鲇(Amphilius uranoscopus)通常喜欢生活在水深小于50 cm、流速0·4 -1 m/s的缓流河段,这里水色较深,河底多卵石。黄鱼(Labeobarbus johnstonii)常被发现在水深大于50 cm的河段,河水流速中等或较急。引入种虹鳟(Oncorhynchus mykiss)的活动范围常局限在水温低于20℃的河段,这些河段水深中等,流速较快,沿河多植物。虹鳟栖息地与土著种相似,可能与同域分布的土著种,特别是与广泛分布的瞻星平鳍鲇存在生存竞争。 | Wilbert T. KADYE Ngonidzashe A. G. MOYO Christopher H. D.MAGADZA Shakkie KATIVU | 2008 | 动物学报2008，54，1： | 2 |
| 16 | Risk factors for antisperm antibodies in infertile men显示文摘 | Heidenreich A Bonfig R Wilbert D | 1994 | Am J Reprod Immunol1994，31，： | 1 |
| 17 | Positioning accuracy of cone-beam computed tomography in combination with a HexaPOD robot treat- ment table显示文摘 | Meyer J Wilbert J Baier K | 2007 | Int J Radiat Oncol Biol Phys2007，67，： | 1 |
| 18 | Lipid-lowering therapy in high-risk persons显示文摘 | Wilbert S. Aronow | 2006 | Comprehensive Therapy2006，，2： | 1 |
| 19 | Systems toxicology: ap plications of toxicogenomics, transeriptomics, proteomics and metabolornics in toxicology显示文摘 | Heijne Wilbert HM Kienhuis | 2005 | Expert Rev Proteomies''2005，2，5： | 1 |
| 20 | Complications with portable ESWL a multicenter study显示文摘 | Wilbert DM Heinz A Jocham D | 1997 | Urologe A1997，36，3： | 1 |
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