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| 1 | Effects of continuously regenerating diesel particulate filters on regulated emissions and number-size distribution of particles emitted from a diesel engine显示文摘The effects of continuously regenerating diesel particulate filter (CRDPF) systems on regulated gaseous emissions, and number-size distribution and mass of particles emanated from a diesel engine have been investigated in this study. Two CRDPF units (CRDPF-1 and CRDPF-2) with different specifications were separately retrofitted to the engine running with European steady-state cycle (ESC). An electrical low pressure impactor (ELPI) was used for particle number-size distribution measurement and mass estimation. The conversion/reduction rate (R CR ) of hydrocarbons (HC) and carbon monoxide (CO) across CRDPF-1 was 83% and 96.3%, respectively. Similarly, the R CR of HC and CO and across CRDPF-2 was 91.8% and 99.1%, respectively. The number concentration of particles and their concentration peaks; nuclei mode, accumulation mode and total particles; and particle mass were highly reduced with the CRDPF units. The nuclei mode particles at downstream of CRDPF-1 and CRDPF-2 decreased by 99.9% to 100% and 97.8% to 99.8% respectively; and the particle mass reduced by 73% to 92.2% and 35.3% to 72.4%, respectively, depending on the engine conditions. In addition, nuclei mode particles increased with the increasing of engine speed due to the heterogeneous nucleation initiated by the higher exhaust temperature, while accumulation mode particles were higher at higher loads due to the decrease in the air-to-fuel ratio (A/F) at higher loads. | Zhihua Liu Asad Naeem Shah Yunshan Ge Yan Ding, Jianwei Tan Lei Jiang Linxiao Yu Wei Zhao Chu Wang Tao Zeng | 2011 | Journal of Environmental Sciences2011，23，5： | 15 |
| 2 | Impacts of continuously regenerating trap and particle oxidation catalyst on the NO_2 and particulate matter emissions emitted from diesel engine显示文摘Two continuously regenerating diesel particulate filter(CRDPF) with different configurations and one particles oxidation catalyst(POC) were employed to perform experiments in a controlled laboratory setting to evaluate their effects on NO 2,smoke and particle number emissions.The results showed that the application of the after-treatments increased the emission ratios of NO 2 /NOx significantly.The results of smoke emissions and particle number(PN) emissions indicated that both CRDPFs had sufficient capacity to remove more than 90% of total particulate matter(PM) and more than 97% of solid particles.However,the POC was able to remove the organic components of total PM,and only partially to remove the carbonaceous particles with size less than 30 nm.The negligible effects of POC on larger particles were observed due to its honeycomb structure leads to an inadequate residence time to oxidize the solid particles or trap them.The particles removal efficiencies of CRDPFs had high degree of correlations with the emission ratio of NO 2 /NOx.The PN emission results from two CRDPFs indicated that more NO 2 generating in diesel oxidation catalyst section could obtain the higher removal efficiency of solid particles.However this also increased the risk of NO 2 exposure in atmosphere. | Zhihua Liu Yunshan Ge Jianwei Tan Chao He Asad Naeem Shah Yan Ding LinxiaoYu Wei Zhao | 2012 | Journal of Environmental Sciences2012，24，4： | 11 |
| 3 | Methylation of RAR-β2, RASSF1A, and CDKN2A Genes Induced by Nickel Subsulfide and Nickel-carcinogenesis in Rats显示文摘Objective To investigate the expression variation of RAR‐β2, RASSF1A, and CDKN2A gene in the process of nickel‐induced carcinogenesis. Methods Nickel subsulfide (Ni 3 S 2 ) at dose of 10 mg was given to Wistar rats by intramuscular injection. The mRNA expression of the three genes in induced tumors and their lung metastasis were examined by Real‐time PCR. The methylation status of the 5' region of these genes were detected by Quantitative Real‐time methylation specific PCR. Results The mRNA expressions of the three genes both in muscle and lung tumor were decreased distinctly in comparison with normal tissue. But hypermethylation was found only in muscle tumor. Conclusion These findings suggest that loss of function or decrease of RAR‐β2, RASSF1A, and CDKN2A, as well as the hypermethylation of 5' region of these genes, are related with nickel exposure. | ZHANG Jun ZHANG Jing LI MengJie Wu YouJun FAN YingYing ZHOU Yang TAN LiLi SHAO ZhiHua SHI HongJun | 2011 | Biomedical and Environmental Sciences2011，24，2： | 4 |
| 4 | A 10-miRNA risk score-based prediction model for pathological complete response to neoadjuvant chemotherapy in hormone receptor-positive breast cancer显示文摘Patients with hormone receptor(HR)-positive tumors breast cancer usually experience a relatively low pathological complete response(p CR)to neoadjuvant chemotherapy(NAC).Here,we derived a 10-micro RNA risk score(10-mi RNA RS)-based model with better performance in the prediction of p CR and validated its relation with the disease-free survival(DFS)in 755 HRpositive breast cancer patients(273,265,and 217 in the training,internal,and external validation sets,respectively).This model,presented as a nomogram,included four parameters:the 10-mi RNA RS found in our previous study,progesterone receptor(PR),human epidermal growth factor receptor 2(HER2)status,and volume transfer constant(K).Favorable calibration and discrimination of 10-mi RNA RS-based model with areas under the curve(AUC)of 0.865,0.811,and 0.804 were shown in the training,internal,and external validation sets,respectively.Patients who have higher nomogram score(>92.2)with NAC treatment would have longer DFS(hazard ratio=0.57;95%CI:0.39–0.83;P=0.004).In summary,our data showed the 10-mi RNA RS-based model could precisely identify more patients who can attain p CR to NAC,which may help clinicians formulate the personalized initial treatment strategy and consequently achieves better clinical prognosis for patients with HRpositive breast cancer. | Chang Gong Ziliang Cheng Yaping Yang Jun Shen Yingying Zhu Li Ling Wanyi Lin Zhigang Yu Zhihua Li Weige Tan Chushan Zheng Wenbo Zheng Jiajie Zhong Xiang Zhang Yunjie Zeng Qiang Liu RStephanie Huang Andrzej LKomorowski Eddy SYang François Bertucci Francesco Ricci Armando Orlandi Gianluca Franceschini Kazuaki Takabe Suzanne Klimberg Naohiro Ishii Angela Toss Mona PTan Mathew A Cherian Erwei Song | 2022 | Science China(Life Sciences)2022，65，11： | 3 |
| 5 | Real-world operation conditions and on-road emissions of Beijing diesel buses measured by using portable emission measurement system and electric low-pressure impactor显示文摘 | Zhihua Liu Yunshan Ge Kent C. Johnson Asad Naeem Shah Jianwei Tan Chu Wang Linxiao Yu | 2010 | Science of the Total Environment2010，，8： | 1 |
| 6 | Identification of Functional Genetic Variants in Cyclooxygenase-2 and Their Association With Risk of Esophageal Cancer显示文摘 | Xuemei Zhang Xiaoping Miao Wen Tan Baitang Ning Zhihua Liu Yuan Hong Wenguang Song Yongli Guo Xinyu Zhang Yan Shen Boqin Qiang Fred F. Kadlubar Dongxin Lin | 2005 | Gastroenterology2005，，2： | 1 |
| 7 | Clo- ning and characterisation of the gene encoding HMG- CoA reductase from Taxus media and its functional identification in yeast显示文摘 | Liao Zhihua Tan Qiumin Chai Yourong | 2004 | Functional Plant Biology2004，31，1： | 1 |
| 8 | Face recognitionfrom a single image per person:a survey显示文摘 | Tan Xiaoyang Chen Songcan Zhou Zhihua | 2006 | PatternRecognition2006，39，9： | 1 |
| 9 | Nanopolyphenol rejuvenates microglial surveillance of multiple misfolded proteins through metabolic reprogramming显示文摘Microglial surveillance plays an essential role in clearing misfolded proteins such as amyloid-beta,tau,andα-synuclein aggregates in neurodegenerative diseases.However,due to the complex structure and ambiguous pathogenic species of the misfolded proteins,a universal approach to remove the misfolded proteins remains unavailable.Here,we found that a polyphenol,α-mangostin,reprogrammed metabolism in the disease-associated microglia through shifting glycolysis to oxidative phosphorylation,which holistically rejuvenated microglial surveillance capacity to enhance microglial phagocytosis and autophagy-mediated degradation of multiple misfolded proteins.Nanoformulation ofα-mangostin efficiently deliveredα-mangostin to microglia,relieved the reactive status and rejuvenated the misfolded-proteins clearance capacity of microglia,which thus impressively relieved the neuropathological changes in both Alzheimer’s disease and Parkinson’s disease model mice.These findings provide direct evidences for the concept of rejuvenating microglial surveillance of multiple misfolded proteins through metabolic reprogramming,and demonstrate nanoformulatedα-mangostin as a potential and universal therapy against neurodegenerative diseases. | Dayuan Wang Xiao Gu Xinyi Ma Jun Chen Qizhi Zhang Zhihua Yu Juan Li Meng Hu Xiaofang Tan Yuyun Tang Jianrong Xu Minjun Xu Qingxiang Song Huahua Song Gan Jiang Zaiming Tang Xiaoling Gao Hongzhuan Chen | 2023 | Acta Pharmaceutica Sinica B2023，13，2： | 1 |
| 10 | Face Recognition from a Single Image Per Person:A Survey显示文摘 | Tan Xiaoyan Chen Songcan Zhou Zhihua | 2006 | Pattern Recognition2006，39，9： | 1 |
| 11 | The state-space model of the HIV epidenfic with variable infection in the homosexual populations显示文摘 | Wai-Yuan Tan Zhihua Xiang | 1999 | Journal of Statistical Planning and Inference1999，78，12： | 1 |
| 12 | Identification of Functional Genetic Variants in Cyclooxygenase-2 and Their Association With Risk of Esophageal Cancer显示文摘 | Xuemei Zhang Xiaoping Miao Wen Tan Baitang Ning Zhihua Liu Yuan Hong Wenguang Song Yongli Guo Xinyu Zhang Yan Shen Boqin Qiang Fred F. Kadlubar Dongxin Lin | 2005 | Gastroenterology2005，，2： | 1 |
| 13 | Face recog- nition from a single image per person : A survey 显示文摘 | Tan Xiaoyang Chen Songcan Zhou Zhihua | 2012 | Pattern recognition2012，39，9： | 1 |
| 14 | Identification of Functional Genetic Variants in Cyclooxygenase-2 and Their Association With Risk of Esophageal Cancer显示文摘 | Xuemei Zhang Xiaoping Miao Wen Tan Baitang Ning Zhihua Liu Yuan Hong Wenguang Song Yongli Guo Xinyu Zhang Yan Shen Boqin Qiang Fred F. Kadlubar Dongxin Lin | 2005 | Gastroenterology2005，，2： | 1 |
| 15 | Face recog- nition from a single image per person: a survey显示文摘 | Tan Xiaoyang Chen Songcan Zhou Zhihua | 2006 | Pattern recognition2006，39，9： | 1 |
| 16 | A state space model for the HIV epidemic in homosexual populations and some applications显示文摘 | Wai-Yuan Tan Zhihua Xiang | 1998 | Mathematical Biosciences1998，152，1： | 1 |
| 17 | Face recognition from a single image per person: A survey 显示文摘 | Tan Xiaoyang Chen Songcan Zhou Zhihua | 2006 | Pattern Recognition2006，39，9： | 1 |
| 18 | Characterization of polycyclic aromatic hydrocarbon emissions from diesel engine retrofitted with selective catalytic reduction and continuously regenerating trap显示文摘Two after treatment units,selective catalytic reduction(SCR) and continuously regenerating trap(CRT),were independently retrofitted to a diesel engine,with the objective to investigate their impact on the conversion/reduction(CR) of polycyclic aromatic hydrocarbons(PAHs).The experiments were conducted under the European steady state cycle(ESC) first without any retrofits to get baseline emissions,and then with SCR and CRT respectively,on the same engine.The particulate matter(PM)-phase PAHs were trapped in fiberglass filters,whereas gas-phase PAHs were collected in cartridges,and then analyzed using a gas chromatograph-mass spectrometer(GC-MS).Both PM-phase and gas-phase PAHs were greatly reduced with CRT showing respective CR of 90.7% and above 80%,whereas only gas-phase PAHs were abated in the case of SCR,with CR of above 75%.Lower molecular weight(LMW) PAHs were in abundance,while naphthalene exhibited a maximum relative contribution(RC) to LMW-PAHs for all three cases.Further,the CR of naphthalene and anthracene were increased with increasing catalyst temperature of SCR,most likely due to their conversion to solid particles.Moreover,the Benzo[a]Pyrene equivalent(BaP eq) of PAHs was greatly reduced with CRT,owing to substantial reduction of total PAHs. | Asad Naeem Shah Yunshan Ge Jianwei Tan Zhihua Liu Chao He Tao Zeng | 2012 | Journal of Environmental Sciences2012，24，8： | 1 |
| 19 | The social environmental factors on chil- dren's intellectual influence on 显示文摘 | Zhang Liemin Xu Haiqing Tan Zhihua | 1999 | China eugenic genetic magazine1999，05，： | 1 |
| 20 | Recog- nizing partially occluded, expression variant faces from sin- gle training image per person with SOM and soft k-NN en- semble显示文摘 | Tan Xiaoyang Chen Songcan Zhou Zhihua | 2005 | IEEE Transactions on Neural Networks2005，16，4： | 1 |
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