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| 1 | Tailoring color emissions from N-doped graphene quantum dots for bioimaging applications显示文摘Unlike inorganic quantum dots,fluorescent graphene quantum dots(GQDs)display excitation-dependent multiple color emission.In this study,we report N-doped GQDs(N-GQDs)with tailored single color emission by tuning p-conjugation degree,which is comparable to the inorganic quantum dot.Starting from citric acid and diethylenetriamine,as prepared N-GQDs display blue,green,and yellow light emission by changing the reaction solvent from water,dimethylformamide(DMF),and solvent free.The X-ray photoelectron spectroscopy,ultraviolet-visible spectra results clearly show the N-GQDs with blue emission(N-GQDs-B)have relatively short effective conjugation length and more carboxyl group because H_(2)O is a polar protic solvent,which tends to donate proton to the reagent to depress the H_(2)O elimination reaction.On the other hand,the polar aprotic solvent(DMF)cannot donate hydrogen,the elimination of H_(2)O is promoted and more nitrogen units enter GQD framework.With the increase of effective p-conjugation length and N content,the emission band of N-GQDS red-shifts to green and yellow.We also demonstrate that N-GQDs could be a potential great biomarker for fluorescent bioimaging. | Dan Qu Min Zheng Jing Li Zhigang Xie Zaicheng Sun | 2015 | Light(Science & Applications)2015，4，1： | 13 |
| 2 | Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2显示文摘Host cellular receptors play key roles in the determination of virus tropism and pathogenesis.However,little is known about SARS-CoV-2 host receptors with the exception of ACE2.Furthermore,ACE2 alone cannot explain the multi-organ tropism of SARS-CoV-2 nor the clinical differences between SARS-CoV-2 and SARS-CoV,suggesting the involvement of other receptor(s).Here,we performed genomic receptor profiling to screen 5054 human membrane proteins individually for interaction with the SARS-CoV-2 capsid spike(S)protein.Twelve proteins,including ACE2,ASGR1,and KREMEN1,were identified with diverse S-binding affinities and patterns.ASGR1 or KREMEN1 is sufficient for the entry of SARS-CoV-2 but not SARS-CoV in vitro and in vivo.SARS-CoV-2 utilizes distinct ACE2/ASGR1/KREMEN1(ASK)receptor combinations to enter different cell types,and the expression of ASK together displays a markedly stronger correlation with virus susceptibility than that of any individual receptor at both the cell and tissue levels.The cocktail of ASK-related neutralizing antibodies provides the most substantial blockage of SARS-CoV-2 infection in human lung organoids when compared to individual antibodies.Our study revealed an interacting host receptome of SARS-CoV-2,and identified ASGR1 and KREMEN1 as alternative functional receptors that play essential roles in ACE2-independent virus entry,providing insight into SARS-CoV-2 tropism and pathogenesis,as well as a community resource and potential therapeutic strategies for further COVID-19 investigations. | Yunqing Gu Jun Cao Xinyu Zhang Hai Gao Yuyan Wang Jia Wang Juan He Xiaoyi Jiang Jinlan Zhang Guanghui Shen Jie Yang Xichen Zheng Gaowei Hu Yuanfei Zhu Shujuan Du Yunkai Zhu Rong Zhang Jianqing Xu Fei Lan Di Qu Guoliang Xu Yun Zhao Dong Gao Youhua Xie Min Luo Zhigang Lu | 2022 | Cell Research2022，32，1： | 8 |
| 3 | Effect of electrode Pt-loading and cathode flow-field plate type on the degradation of PEMFC显示文摘The electrode Pt-loading has an effect on the number of active sites and the thickness of catalyst layer,which has huge influence on the mass transfer and water management during dynamic process in PEMFCs. In this study, membrane electrode assemblies with different Pt-loadings were prepared, and PEMFCs were assembled using those membrane electrode assemblies with traditional solid plate and water transport plate as cathode flow-field plates, respectively. The performance and electrochemical surface area of cells were characterized to evaluate the membrane electrode assemblies degradation after rapid currentvariation cycles. Scanning electron microscope and transmission electron microscope were used to investigate the decay of catalyst layers and Pt/C catalyst. With the increase of Pt-loading, the performance degradation of membrane electrode assemblies will be mitigated. But higher Pt-loading means thicker catalyst layer, which leads to a longer pathway of mass transfer, and it may result in carbon material corrosion in membrane electrode assemblies. The decay of Pt/C catalyst in cathode is mainly caused by the corrosion of carbon support, and the degradation of anode Pt/C catalyst is a consequence of migration and aggregation of Pt particles. And using water transport plate is beneficial to alleviating the age of cathode Pt/C catalyst. | Lijuan Qu Zhiqiang Wang Xiaoqian Guo Wei Song Feng Xie Liang He Zhigang Shao Baolian Yi | 2019 | Journal of Energy Chemistry2019，28，8： | 4 |
| 4 | Functional hydrogel coatings显示文摘Hydrogels—natural or synthetic polymer networks that swell in water—can be made mechanically,chemically and electrically compatible with living tissues.There has been intense research and development of hydrogels for medical applications since the invention of hydrogel contact lenses in 1960.More recently,functional hydrogel coatings with controlled thickness and tough adhesion have been achieved on various substrates.Hydrogel-coated substrates combine the advantages of hydrogels,such as lubricity,biocompatibility and anti-biofouling properties,with the advantages of substrates,such as stiffness,toughness and strength.In this review,we focus on three aspects of functional hydrogel coatings:(i)applications and functions enabled by hydrogel coatings,(ii)methods of coating various substrates with different functional hydrogels with tough adhesion,and(iii)tests to evaluate the adhesion between functional hydrogel coatings and substrates.Conclusions and outlook are given at the end of this review. | Junjie Liu Shaoxing Qu Zhigang Suo Wei Yang | 2021 | National Science Review2021，8，2： | 4 |
| 5 | A FINITE ELEMENT METHOD FOR DIELECTRIC ELASTOMER TRANSDUCERS显示文摘We present a finite element method for dielectric elastomer(DE) transducers based on the nonlinear field theory of DE.The method is implemented in the commercial finite element software ABAQUS,which provides a large library functions to describe finite elasticity.This method can be used to solve electromechanical coupling problems of DE transducers with complex configurations and under inhomogeneous deformation. | Shaoxing Qu Zhigang Suo | 2012 | Acta Mechanica Solida Sinica2012，25，5： | 3 |
| 6 | Integrating Oxaliplatin with Highly Luminescent Carbon Dots: An Unprecedented Theranostic Agent for Personalized Medicine显示文摘 | Min Zheng Shi Liu Jing Li Dan Qu Haifeng Zhao Xingang Guan Xiuli Hu Zhigang Xie Xiabin Jing Zaicheng Sun | 2014 | Mater2014，，21： | 2 |
| 7 | Atmospheric emissions estimation of Hg, As, and Se from coal-fired power plants in China, 2007显示文摘 | Hezhong Tian Yan Wang Zhigang Xue Yiping Qu Fahe Chai Jiming Hao | 2011 | Science of the Total Environment2011，，16： | 2 |
| 8 | Curcumin inhibits the invasion of lung cancer cells by modulating thePKCα/Nox-2/ROS/ATF-2/MMP-9 signaling pathway显示文摘 | Zhigang Fan Xiaoyi Duan Hui Cai Li Wang Min Li Jingkun Qu Wanjun Li Yongheng Wang Jiansheng Wang | 2015 | Oncology Reports2015，，2： | 2 |
| 9 | Current status and trends in forest genomics显示文摘Forests are not only the most predominant of the Earth's terrestrial ecosystems,but are also the core supply for essential products for human use.However,global climate change and ongoing population explosion severely threatens the health of the forest ecosystem and aggravtes the deforestation and forest degradation.Forest genomics has great potential of increasing forest productivity and adaptation to the changing climate.In the last two decades,the field of forest genomics has advanced quickly owing to the advent of multiple high-throughput sequencing technologies,single cell RNA-seq,clustered regularly interspaced short palindromic repeats(CRISPR)-mediated genome editing,and spatial transcriptomes,as well as bioinformatics analysis technologies,which have led to the generation of multidimensional,multilayered,and spatiotemporal gene expression data.These technologies,together with basic technologies routinely used in plant biotechnology,enable us to tackle many important or unique issues in forest biology,and provide a panoramic view and an integrative elucidation of molecular regulatory mechanisms underlying phenotypic changes and variations.In this review,we recapitulated the advancement and current status of 12 research branches of forest genomics,and then provided future research directions and focuses for each area.Evidently,a shift from simple biotechnology-based research to advanced and integrative genomics research,and a setup for investigation and interpretation of many spatiotemporal development and differentiation issues in forest genomics have just begun to emerge. | Dulal Borthakur Victor Busov Xuan Hieu Cao Qingzhang Du Oliver Gailing Fikret Isik Jae-Heung Ko Chenghao Li Quanzi Li Shihui Niu Guanzheng Qu Thi Ha Giang Vu Xiao-Ru Wang Zhigang Wei Lin Zhang Hairong Wei | 2022 | Forestry Research2022，2，1： | 2 |
| 10 | Recent advances in nonlinear optics for bio‐imaging applications显示文摘Nonlinear optics,which is a subject for studying the interaction between intense light and materials,has great impact on various research fields.Since many structures in biological tissues exhibit strong nonlinear optical effects,nonlinear optics has been widely applied in biomedical studies.Especially in the aspect of bio-imaging,nonlinear optical techniques can provide rapid,label-free and chemically specific imaging of biological samples,which enable the investigation of biological processes and analysis of samples beyond other microscopy techniques.In this review,we focus on the introduction of nonlinear optical processes and their applications in bio-imaging as well as the recent advances in this filed.Our perspective of this field is also presented. | Silu Zhang Liwei Liu Sheng Ren Zilin Li Yihua Zhao Zhigang Yang Rui Hu Junle Qu | 2020 | Opto-Electronic Advances2020，3，10： | 2 |
| 11 | Fractal Design Boosts Extrusion-Based 3D Printing of Bone-Mimicking Radial-Gradient Scaffolds显示文摘Although extrusion-based three-dimensional(EB-3D)printing technique has been widely used in the complex fabrication of bone tissue-engineered scaffolds,a natural bone-like radial-gradient scaffold by this processing method is of huge challenge and still unmet.Inspired by a typical fractal structure of Koch snowflake,for the first time,a fractal-like porous scaffold with a controllable hierarchical gradient in the radial direction is presented via fractal design and then implemented by EB-3D printing.This radial-gradient structure successfully mimics the radially gradual decrease in porosity of natural bone from cancellous bone to cortical bone.First,we create a design-to-fabrication workflow with embedding the graded data on basis of fractal design into digital processing to instruct the extrusion process of fractal-like scaffolds.Further,by a combination of suitable extruded inks,a series of bone-mimicking scaffolds with a 3-iteration fractal-like structure are fabricated to demonstrate their superiority,including radial porosity,mechanical property,and permeability.This study showcases a robust strategy to overcome the limitations of conventional EB-3D printers for the design and fabrication of functionally graded scaffolds,showing great potential in bone tissue engineering. | Huawei Qu Zhenyu Han Zhigang Chen Lan Tang Chongjian Gao Kaizheng Liu Haobo Pan Hongya Fu Changshun Ruan | 2021 | Research2021，，1： | 2 |
| 12 | Detection of the abnormal events along the oil and gas pipeline and multi- scale chaotic character analysis of the detected signals 显示文摘 | Qu Zhigang Zhou Yan Zeng Zhoumo | 2008 | Measurement Science & Technology2008，19，02： | 1 |
| 13 | Coexistence of situs inversus totalis and hepatocellular carcinoma:A series of nine cases and a literature review显示文摘Hepatocellular carcinoma(HCC)is the most commonly diagnosed carcinoma and one of the leading causes of cancer-related deaths worldwide.Situs inversus totalis(SIT)is a congenital condition where in the internal organs of the abdomen and thorax lie in mirror images of their normal position.Thus far,there are very few reports on cases of SIT coexisting with HCC.Our case series is probably the largest series in world literature.The cohort of this retrospective study included a total of nine patients diagnosed with SIT-HCC and treated in our hospital between January 2013 and May 2018.Clinical characteristics,prognostic factors,and outcomes were summarized.Treatment strategies included surgery,transarterial chemoembolization,and microwave ablation.The diagnosis and treatment of patients with SIT are challenging because of organ reversion.The current treatment strategies for different stages of liver cancer are safe and feasible for patients with SIT-HCC. | Xiaowei Li Zhigang Fu Jiaming Zhong Kunkun Cao Xiaoxia Chen Ning Ding Li Liu Jian Zhai Zengqiang Qu | 2022 | Journal of Interventional Medicine2022，5，1： | 1 |
| 14 | Landscape and Dynamics of the Transcriptional Regulatory Network During Natural Killer Cell Differentiation显示文摘Natural killer(NK)cells are essential in controlling cancer and infection.However,little is known about the dynamics of the transcriptional regulatory machinery during NK cell differentiation.In this study,we applied the assay of transposase accessible chromatin with sequencing(ATAC-seq)technique in a home-developed in vitro NK cell differentiation system.Analysis of ATAC-seq data illustrated two distinct transcription factor(TF)clusters that dynamically regulate NK cell differentiation.Moreover,two TFs from the second cluster,FOS-like 2(FOSL2)and early growth response 2(EGR2),were identified as novel essential TFs that control NK cell maturation and function.Knocking down either of these two TFs significantly impacted NK cell differentiation.Finally,we constructed a genome-wide transcriptional regulatory network that provides a better understanding of the regulatory dynamics during NK cell differentiation. | Kun Li Yang Wu Young Li Qiaoni Yu Zhigang Tian Haiming Wei Kun Qu | 2020 | Genomics, Proteomics & Bioinformatics2020，18，5： | 1 |
| 15 | The Impact of Changes of Property Rights on Farmland Use:An Empirical Study of China during Transition显示文摘In China, farmland property rights characterized by the household-responsibility system (HRS) have been improved since the reform and opening-up. The rights of use, transfer and gain become more stable, authorized and complete. This paper firstly analyzes the impact on farmland productivity, which comes from the improvement of farmland property rights. Then, an economet- ric model is built to test the above analysis. It concludes that changes of property rights will affect farmland performance in China. In the end, some policy implications are explored for fur- ther reforms. | Chen Zhigang Qu Futian Wang Qing | 2007 | Chinese Journal of Population,Resources and Environment2007，5，1： | 1 |
| 16 | Initial results of precise orbit and clock determination for COMPASS navigation satellite system显示文摘 | Qile Zhao Jing Guo Min Li Lizhong Qu Zhigang Hu Chuang Shi Jingnan Liu | 2013 | Journal of Geodesy2013，，5： | 1 |
| 17 | A SVM-based pipeline leakage detection and pre-warning system显示文摘 | Zhigang Qu Hao Feng Zhoumo Zeng Jingchang Zhuge Shijiu Jin | 2009 | Measurement2009，，4： | 1 |
| 18 | A SVM-based pipeline leakage detection and pre-warning system显示文摘 | QU Zhigang FENG Hao ZENG Zhoumo | 2010 | Measure- ment2010，43，： | 1 |
| 19 | Melphalan-loaded methoxy poly(ethylene glycol)-poly(D,L-lactide)copolymer nanomicelles in the treatment of multiple myeloma显示文摘Multiple myeloma(MM)is the second most common hematological tumor characterized by the proliferation of monoclonal plasma cells.Melphalan(MEL)is commonly used in the treatment of MM and is especially essential for patients undergoing autologous stem cell transplantation(ASCT).Although many drugs for MM have been developed in recent years,chemotherapy followed by ASCT remains the optimal option.Melphalan,the backbone of the conditioning regimen,brings severe toxicities at a high dose.Nanodrug delivery systems enable drugs to be highly effective and have low toxicity.In this study,methoxy poly(ethylene glycol)-poly(D,L-lactide)copolymer(MPEG-PDLLA)was chosen to encapsulate melphalan,and the characteristics,effectiveness,and safety of MEL/MPEG-PDLLA in vitro and in vivo were investigated.MEL/MPEG-PDLLA showed slow release and was easily engulfed by MM cells despite a result of the antitumor assay comparable to that of free melphalan in vitro.The in vivo results showed that MEL/MPEG-PDLLA could significantly alleviate tumor burden and prolong survival time without increasing the toxicity to vital organs.In addition,MEL/MPEG-PDLLA could significantly reduce the damage to the intestinal mucosa caused by melphalan.In conclusion,MEL/MPEG-PDLLA shows improved antitumor activity and has the potential to alleviate pains of MM patients undergoing ASCT. | Yingying Chen Qiang Zeng Bingyang Chu Zhigang Liu Xue Wei Mengran Chen Peipei Yang Minghai Tang Ting Niu Yongqian Jia Ying Qu Zhiyong Qian | 2023 | Chinese Chemical Letters2023，34，9： | 0 |
| 20 | Visualization of nasal powder distribution using biomimetic human nasal cavity model显示文摘Nasal drug delivery efficiency is highly dependent on the position in which the drug is deposited in the nasal cavity.However,no reliable method is currently available to assess its impact on delivery performance.In this study,a biomimetic nasal model based on three-dimensional(3D)reconstruction and three-dimensional printing(3DP)technology was developed for visualizing the deposition of drug powders in the nasal cavity.The results showed significant differences in cavity area and volume and powder distribution in the anterior part of the biomimetic nasal model of Chinese males and females.The nasal cavity model was modified with dimethicone and validated to be suitable for the deposition test.The experimental device produced the most satisfactory results with five spray times.Furthermore,particle sizes and spray angles were found to significantly affect the experimental device’s performance and alter drug distribution,respectively.Additionally,mometasone furoate(MF)nasal spray(NS)distribution patterns were investigated in a goat nasal cavity model and three male goat noses,confirming the in vitro and in vivo correlation.In conclusion,the developed human nasal structure biomimetic device has the potential to be a valuable tool for assessing nasal drug delivery system deposition and distribution. | Jiawen Su Yan Liu Hongyu Sun Abid Naeem Huipeng Xu Yue Qu Caifen Wang Zeru Li Jianhua Lu Lulu Wang Xiaofeng Wang Jie Wu Lixin Sun Jiwen Zhang Zhigang Wang Rui Yang Li Wu | 2024 | Acta Pharmaceutica Sinica B2024，14，1： | 0 |
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