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| 1 | Photoperiod- and thermo-sensitive genic male sterility in rice are caused by a point mutation in a novel noncoding RNA that produces a small RNA显示文摘光周期敏感、 thermo 敏感的遗传因子的男绝育(PGMS 和 TGMS ) 是为在庄稼的混合繁殖的核心部件。基于使用的较普通活字大一倍的系统, PGMS 和 TGMS 衬里的混合大米是成功地在农业广泛地发展了并且适用。然而,位于 PGMS 和 TGMS 的控制下面的分子的机制仍然保持阴暗。在这研究,我们印射并且克隆一个主要地点, p/tms12-1 (染色体 12 上的感光性或 thermo 敏感的遗传因子的男绝育地点) 它在装饰用的梨树米饭线 Nongken 58S (NK58S ) 授与 PGMS 和在 indica 米饭的 TGMS 衬里 Peiai 64S (PA64S,源于 NK58S ) 。包含野类型的等位基因 P/TMS12-1 的 A 2.4-kb DNA 碎片能在基因互补恢复 NK58S 和 PA64S 植物的花粉富饶。P/TMS12-1 编码唯一的 noncoding RNA,它生产 21 核苷酸我们说出 osa-smR5864w 的小 RNA。在 p/tms12-1 的 C-to-G 的替换,相对 P/TMS12-1 的唯一的多型性,在变异的小 RNA 是在场的,也就是 osa-smR5864m。而且,在转基因的 NK58S 和 PA64S 植物的 P/TMS12-1 的一个 375-bp 序列的 overexpression 也生产了 osa-smR5864w 并且恢复了花粉富饶。小 RNA 在年轻圆锥花序优先地被表示,但是它的表示没被不同的天长度或温度显著地影响。我们的结果表明在 p/tms12-1 的点变化,可能为 osa-smR5864m 导致 loss-of-function,分别地在装饰用的梨树和 indica 线为 PGMS 和 TGMS 组成一个普通原因。我们的调查结果因此建议那小 RNA 基因是的这 noncoding 男开发的一个重要管理者由在基因网络和环境条件之间的串音控制了。 | Hai Zhou Qinjian Liu Jing Li Dagang Jiang Lingyan Zhou Ping Wu Sen Lu Feng Li Liya Zhu Zhenlan Liu Letian Chen Yao-Guang Liu Chuxiong Zhuang | 2012 | Cell Research2012，22，4： | 99 |
| 2 | Tropoelastin improves adhesion and migration of intra-articular injected infrapatellar fat pad MSCs and reduces osteoarthritis progression显示文摘Intra-articular injection of mesenchymal stem cells(MSCs)is a promising strategy for osteoarthritis(OA)treatment.However,more and more studies reveal that the injected MSCs have poor adhesion,migration,and survival in the joint cavity.A recent study shows that tropoelastin(TE)regulates adhesion,proliferation and phenotypic maintenance of MSCs as a soluble additive,indicating that TE could promote MSCs-homing in regenerative medicine.In this study,we used TE as injection medium,and compared it with classic media in MSCs intra-articular injection such as normal saline(NS),hyaluronic acid(HA),and platelet-rich plasma(PRP).We found that TE could effectively improve adhesion,migration,chondrogenic differentiation of infrapatellar fat pad MSCs(IPFP-MSCs)and enhance matrix synthesis of osteoarthritic chondrocytes(OACs)in indirect-coculture system.Moreover,TE could significantly enhance IPFP-MSCs adhesion via activation of integrin β1,ERK1/2 and vinculin(VCL)in vitro.In addition,intra-articular injection of TE-IPFP MSCs suspension resulted in a short-term increase in survival rate of IPFP-MSCs and better histology scores of rat joint tissues.Inhibition of integrin β1 or ERK1/2 attenuated the protective effect of TE-IPFP MSCs suspension in vivo.In conclusion,TE promotes performance of IPFP-MSCs and protects knee cartilage from damage in OA through enhancement of cell adhesion and activation of integrin β1/ERK/VCL pathway.Our findings may provide new insights in MSCs intra-articular injection for OA treatment. | Junjun Yang Xin Wang Yahan Fan Xiongbo Song Jiangyi Wu Zhenlan Fu Tao Li Yang Huang ZheXiong Tang Shuo Meng Na Liu Jiajia Chen Pingju Liu Liu Yang Xiaoyuan Gong Cheng Chen | 2022 | Bioactive Materials2022，7，4： | 4 |
| 3 | The influence of hydrogen sulfide on corrosion of iron under different conditions显示文摘 | Houyi Ma Xiaoliang Cheng Guiqiu Li Shenhao Chen Zhenlan Quan Shiyong Zhao Lin Niu | 2000 | Corrosion Science2000，，10： | 4 |
| 4 | A Data-Driven Clustering Recommendation Method for Single-Cell RNA-Sequencing Data显示文摘Recently,the emergence of single-cell RNA-sequencing(scRNA-seq)technology makes it possible to solve biological problems at the single-cell resolution.One of the critical steps in cellular heterogeneity analysis is the cell type identification.Diverse scRNA-seq clustering methods have been proposed to partition cells into clusters.Among all the methods,hierarchical clustering and spectral clustering are the most popular approaches in the downstream clustering analysis with different preprocessing strategies such as similarity learning,dropout imputation,and dimensionality reduction.In this study,we carry out a comprehensive analysis by combining different strategies with these two categories of clustering methods on scRNA-seq datasets under different biological conditions.The analysis results show that the methods with spectral clustering tend to perform better on datasets with continuous shapes in two-dimension,while those with hierarchical clustering achieve better results on datasets with obvious boundaries between clusters in two-dimension.Motivated by this finding,a new strategy,called QRS,is developed to quantitatively evaluate the latent representative shape of a dataset to distinguish whether it has clear boundaries or not.Finally,a data-driven clustering recommendation method,called DDCR,is proposed to recommend hierarchical clustering or spectral clustering for scRNA-seq data.We perform DDCR on two typical single cell clustering methods,SC3 and RAFSIL,and the results show that DDCR recommends a more suitable downstream clustering method for different scRNA-seq datasets and obtains more robust and accurate results. | Yu Tian Ruiqing Zheng Zhenlan Liang Suning Li Fang-Xiang Wu Min Li | 2021 | Tsinghua Science and Technology2021，26，5： | 3 |
| 5 | STM and XPS study on the self-assembled films of Schiff base on copper surface显示文摘SAMs (self-assembled monolayers) of Schiff base were prepared on the copper surface, and characterized by the modern technique of surface analysis. The results demonstrated that the well-ordered and densely packed SAMs of N-2-hydroxyphenyl-(3-methoxy-salicylidenimine), designated as V-bso, were formed on the Cu(lll) surface. And two benzene rings in the V-bso molecule were not flat on the copper surface, but tilted at a certain angle. The development of this new system of self-assembly would be of significance to the application of the SAMs in the field of metal corrosion and protection. | QUAN Zhenlan CHEN Shenhao HUA Lan LEI Shengbin CUI Xuegui | 2002 | Chinese Science Bulletin2002，47，12： | 3 |
| 6 | The influence of hydrogen sulfide on corrosion of iron under different conditions显示文摘 | Houyi Ma Xiaoliang Cheng Guiqiu Li Shenhao Chen Zhenlan Quan Shiyong Zhao Lin Niu | 2000 | Corrosion Science2000，，10： | 2 |
| 7 | Methylesterification of cell-wall pectin controls the diurnal flower-opening times in rice显示文摘Flowers are the core reproductive organ of plants, and flowering is essential for cross-pollination. Diurnal flower-opening time is thus a key trait influencing reproductive isolation, hybrid breeding, and thermostability in plants. However, the molecular mechanisms controlling this trait remain unknown. Here, we report that rice Diurnal Flower Opening Time 1 (DFOT1) modulates pectin methylesterase (PME) activity to regulate pectin methylesterification levels of the lodicule cell walls, which affect lodicule swelling to control diurnal flower-opening time. DFOT1 is specifically expressed in the lodicules, and its expression gradually increases with the approach to flowering but decreases with flowering. Importantly, a knockout of DFOT1 showed earlier diurnal flower opening. We demonstrate that DFOT1 interacts directly with multiple PMEs to promote their activity. Knockout of PME40 also resulted in early diurnal flower opening, whereas overexpression of PME42 delayed diurnal flower opening. Lower PME activity was observed to be associated with higher levels of pectin methylesterification and the softening of cell walls in lodicules, which contribute to the absorption of water by lodicules and cause them to swell, thus promoting early diurnal flower opening. Higher PME activity had the opposite effect. Collectively, our work uncovers a molecular mechanism underlying the regulation of diurnal flower-opening time in rice, which would help reduce the costs of hybrid breeding and improve the heat tolerance of flowering plants by avoiding higher temperatures at anthesis. | Mumei Wang Xiaopei Zhu Guoqing Peng Minglong Liu Shuqing Zhang Minghao Chen Shitang Liao Xiaoying Wei Peng Xu Xiyu Tan Fangping Li Zhichuan Li Li Deng Ziliang Luo Liya Zhu Shuai Zhao Dagang Jiang Jing Li Zhenlan Liu Xianrong Xie Shaokui Wang Aimin Wu Chuxiong Zhuang Hai Zhou | 2022 | Molecular Plant2022，15，6： | 2 |
| 8 | Review on key technologies and typical applications of multi-station integrated energy systems显示文摘To realize the low-carbon development of power systems,digital transformation,and power marketization reform,the substation,data center,energy storage,photovoltaic,and charging stations are important components for the construction of new infrastructure.The integration infrastructure represented by multi-station integrated energy systems(MSIESs)represents the development trend,and its connotation and denotation are not immutable.This study firstly analyzed the components of MSIESs and their sub-stations and overall characteristics,and proposed an overall architecture for MSIESs.Thereafter,this system was characterized in detail from three aspects:planning and design,operation control,and market operation.The planning and construction of MSIESs was analyzed from the aspects of planning and design process,typical fusion subsystems,supply and demand prediction,and capacity determination;the operational control of MSIESs was analyzed from the aspects of model construction,coordination control,and safety assessment.Moreover,the market operation of MSIESs was examined from the aspects of the business model and spot market.Furthermore,the technical development trend of MSIESs has been explored in this study. | Zhenlan Dou Chunyan Zhang Wei Wang Dan Wang Qiqi Zhang Yanxing Cai Ruitian Fan | 2022 | Global Energy Interconnection2022，5，3： | 2 |
| 9 | Protection of copper corrosion by modification of self-assembled films of Schiff bases with alkanethiol显示文摘 | Zhenlan Quan Shenhao Chen Shulan Li | 2001 | Corrosion Science2001，43，： | 1 |
| 10 | Extensive Alterations in DNA Methylation and Transcription in Rice Caused by Introgression from Zizania Latifolia显示文摘 | Zhenlan Liu Yongming Wang Ye Shen Wanli Guo Shui Hao Bao Liu | 2004 | Plant Molecular Biology2004，，4： | 1 |
| 11 | Extensive Alterations in DNA Methylation and Transcription in Rice Caused by Introgression from Zizania Latifolia显示文摘 | Zhenlan Liu Yongming Wang Ye Shen Wanli Guo Shui Hao Bao Liu | 2004 | Plant Molecular Biology2004，，4： | 1 |
| 12 | Extensive alterations in DNA methylation and transcription in rice caused by introgression from Zizania latifolia显示文摘 | Liu Zhenlan Wang Yongming Shen Ye | 2004 | Plant Molecular Biology2004，54，4： | 1 |
| 13 | Corrosionwear monitoring of TiN coated AISI 316 stainless steel by electrochemical noise measurements 显示文摘 | Quan Zhenlan Wu Peiqiang Tang Lin | 2006 | Applied Surface Science2006，253，3： | 1 |
| 14 | Corrosionwear monitoring of TiN coated ASP23 steel by electrochemical noise measurements 显示文摘 | Quan Zhenlan Wu Peiqiang Tang Lin | 2006 | Colloids and Surfaces A : Physicochemical Engineering Aspects2006，280，123： | 1 |
| 15 | Immobilization of Phospholipase A1 and its Application in Soybean Oil Degumming显示文摘 | Dianyu Yu Lianzhou Jiang Zhenlan Li John Shi Jun Xue Yukio Kakuda | 2012 | Journal of the American Oil Chemists’ Society2012，，4： | 1 |
| 16 | Adsorption behavior of Schiff base and corrosion protection of resulting films to copper substrate显示文摘 | Zhenlan Quan Shenhao Chen Ying Lib and Xuegui Cui | 2002 | Corrosion Science2002，44，4： | 1 |
| 17 | 显示文摘 | Quan Zhenlan Chen Shenhao Li Shulan | 2001 | Corrosion Science2001，43，： | 1 |
| 18 | 显示文摘 | Quart Zhenlan Chen Shenhao Li Ying | 2002 | Corrosion Science2002，44，： | 1 |
| 19 | Bioaccumulation of heavy metals in the earthworm Eisenia fetida in relation to bioavailable metal concentrations in pig manure显示文摘 | Li Lingxiangyu Xu Zhenlan Wu Jianyang | 2010 | Bioresource Technol2010，101，10： | 1 |
| 20 | Protection of copper corrosion by modification of self-assembled films of schiff bases with alkanethiol显示文摘 | Quan Zhenlan Chen Shenhao Shulan Li | 2001 | Corrosion Scienee2001，43，6： | 1 |
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