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| 1 | Modeling on Heat and Mass Transfer in Stored Wheat during Forced Cooling Ventilation显示文摘A mathematical model based on the theory of heat and mass transfer in porous media was developed to simulate the evolution of grain temperature and moisture content in a wheat storage bin during ventilation with cooling air at the constant temperature and humidity.Unlike the previous works on this aspect,the present work was not focused on cooling the stored grain by ventilation with ambient air,but with the refrigerated air.Validation was performed by comparing between predicted and measured grain temperature and grain moisture content for two cases.Predicted data were in reasonable good agreement with measured ones.The model and the parameter values used in the model are applicable for predicting temperature and moisture of stored grains under ventilation conditions. | Yuancheng WANG,Haifeng DUAN,Hao ZHANG and Zhaohong FANG College of Thermal Energy Engineering,Shandong Jianzhu University,Jinan 250101,China | 2010 | Journal of Thermal Science2010，19，2： | 27 |
| 2 | Spatial Evolution and Locational Determinants of High-tech Industries in Beijing显示文摘Using datasets on high-tech industries in Beijing as empirical studies, this paper attempts to interpret spatial shift of high-tech manufacturing firms and to examine the main determinants that have had the greatest effect on this spatial evolution. We aimed at merging these two aspects by using firm level databases in 1996 and 2010. To explain spatial change of the high-tech firms in Beijing, the Kernel density estimation method was used for hotspot analysis and detection by comparing their locations in 1996 and 2010, through which spatial features and their temporal changes could be approximately plotted. Furthermore, to provide quantitative results, Ripley′s K-function was used as an instrument to reveal spatial shift and the dispersion distance of high-tech manufacturing firms in Beijing. By employing a negative binominal regression model, we evaluated the main determinants that have significantly affected the spatial evolution of high-tech manufacturing firms and compared differential influence of these locational factors on overall high-tech firms and each sub-sectors. The empirical analysis shows that high-tech industries in Beijing, in general, have evident agglomeration characteristics, and that the hotspot has shifted from the central city to suburban areas. In combination with the Ripley index, this study concludes that high-tech firms are now more scattered in metropolitan areas of Beijing as compared with 1996. The results of regression model indicate that the firms′ locational decisions are significantly influenced by the spatial planning and regulation policies of the municipal government. In addition, market processes involving transportation accessibility and agglomeration economy have been found to be important in explaining the dynamics of locational variation of high-tech manufacturing firms in Beijing. Research into how markets and the government interact to determine the location of high-tech manufacturing production will be helpful for policymakers to enact effective policies toward a more efficient urban spatial structure. | ZHANG Xiaoping HUANG Pingting SUN Lei WANG Zhaohong | 2013 | Chinese Geographical Science2013，23，2： | 19 |
| 3 | Dabrafenib,an inhibitor of RIP3 kinase-dependent necroptosis,reduces ischemic brain injury显示文摘Ischemic brain injury triggers neuronal cell death by apoptosis via caspase activation and by necroptosis through activation of the receptor-interacting protein kinases(RIPK) associated with the tumor necrosis factor-alpha(TNF-α)/death receptor. Recent evidence shows RIPK inhibitors are neuroprotective and alleviate ischemic brain injury in a number of animal models, however, most have not yet undergone clinical trials and safety in humans remains in question. Dabrafenib, originally identified as a B-raf inhibitor that is currently used to treat melanoma, was later revealed to be a potent RIPK3 inhibitor at micromolar concentrations. Here, we investigated whether Dabrafenib would show a similar neuroprotective effect in mice subjected to ischemic brain injury by photothrombosis. Dabrafenib administered intraperitoneally at 10 mg/kg one hour after photothrombosis-induced focal ischemic injury significantly reduced infarct lesion size in C57BL6 mice the following day, accompanied by a markedly attenuated upregulation of TNF-α. However, subsequent lower doses(5 mg/kg/day) failed to sustain this neuroprotective effect after 4 days. Dabrafenib bl ocked lipopolysaccharides-induced activation of TNF-α in bone marrow-derived macrophages, suggesting that Dabrafenib may attenuate TNF-α-induced necroptotic pathway after ischemic brain injury. Since Dabrafenib is already in clinical use for the treatment of melanoma, it might be repurposed for stroke therapy. | Shelly A.Cruz Zhaohong Qin Alexandre E R.Stewart Hsiao-Huei Chen | 2018 | Neural Regeneration Research2018，13，2： | 17 |
| 4 | Consensus on the application of negative pressure wound therapy of diabetic foot wounds显示文摘Because China is becoming an aging society,the incidence of diabetes and diabetic foot have been increasing.Diabetic foot has become one of the main health-related killers due to its high disability and mortality rates.Negative pressure wound therapy(NPWT)is one of the most effective techniques for the treatment of diabetic foot wounds and great progress,both in terms of research and its clinical application,has been made in the last 20 years of its development.However,due to the complex pathogenesis and management of diabetic foot,irregular application of NPWT often leads to complications,such as infection,bleeding and necrosis,that seriously affect its treatment outcomes.In 2020,under the leadership of Burns,Trauma and Tissue Repair Committee of the Cross-Straits Medicine Exchange Association,the writing group for‘Consensus on the application of negative pressure wound therapy of diabetic foot wounds’was established with the participation of scholars from the specialized areas of burns,endocrinology,vascular surgery,orthopedics and wound repair.Drawing on evidence-based practice suggested by the latest clinical research,this consensus proposes the best clinical practice guidelines for the application and prognostic evaluation of NPWT for diabetic foot.The consensus aims to support the formation of standardized treatment schemes that clinicians can refer to when treating cases of diabetic foot. | Shizhao Ji Xiaobin Liu Jie Huang Junmin Bao Zhaohong Chen Chunmao Han Daifeng Hao Jingsong Hong Dahai Hu Yufeng Jiang Shang Ju Hongye Li Zongyu Li Guangping Liang Yan Liu Gaoxing Luo Guozhong Lv Xingwu Ran Zhongmin Shi Juyu Tang Aiping Wang Guangyi Wang Jiangning Wang Xin Wang Bing Wen Jun Wu Hailin Xu Maojin Xu Xiaofei Ye Liangxi Yuan Yi Zhang Shichu Xiao Zhaofan Xia | 2021 | Burns & Trauma2021，9，1： | 17 |
| 5 | Exosomes derived from human amniotic epithelial cells accelerate diabetic wound healing via PI3K-AKT-mTOR-mediated promotion in angiogenesis and fibroblast function显示文摘Background:Diabetic wounds are one of the most common and serious complications of diabetes mellitus,characterized by the dysfunction of wound-healing-related cells in quantity and quality.Our previous studies revealed that human amniotic epithelial cells(hAECs)could promote diabetic wound healing by paracrine action.Interestingly,numerous studies demonstrated that exosomes derived from stem cells are the critical paracrine vehicles for stem cell therapy.However,whether exosomes derived from hAECs(hAECs-Exos)mediate the effects of hAECs on diabetic wound healing remains unclear.This study aimed to investigate the biological effects of hAECs-Exos on diabetic wound healing and preliminarily elucidate the underlying mechanism.Methods:hAECs-Exos were isolated by ultracentrifugation and identified by transmission electron microscopy,dynamic light scattering and flow cytometry.A series of in vitro functional analyses were performed to assess the regulatory effects of hAECs-Exos on human fibroblasts(HFBs)and human umbilical vein endothelial cells(HUVECs)in a high-glycemic microenvironment.Highthroughput sequencing and bioinformatics analyses were conducted to speculate the related mechanisms of actions of hAECs-Exos on HFBs and HUVECs.Subsequently,the role of the candidate signaling pathway of hAECs-Exos in regulating the function of HUVECs and HFBs,as well as in diabetic wound healing,was assessed.Results:hAECs-Exos presented a cup-or sphere-shaped morphology with a mean diameter of 105.89±10.36 nm,were positive for CD63 and TSG101 and could be internalized by HFBs and HUVECs.After that,hAECs-Exos not only significantly promoted the proliferation and migration of HFBs,but also facilitated the angiogenic activity of HUVECs in vitro.High-throughput sequencing revealed enriched miRNAs of hAECs-Exos involved in wound healing.Kyoto Encyclopedia of Genes and Genomes and Gene Ontology analyses have shown that the target genes of the top 15 miRNAs were highly enriched in the PI3K-AKT pathway.Further functional studies demonstrated that the PI3K-AKT-mTOR pathway was necessary for the induced biological effects of hAECs-Exos on HFBs and HUVECs,as well as on wound healing,in diabetic mice.Conclusions:Our findings demonstrated that hAECs-Exos represent a promising,novel strategy for diabetic wound healing by promoting angiogenesis and fibroblast function via activation of the PI3K-AKT-mTOR pathway. | Pei Wei Chenjian Zhong Xiaolan Yang Futing Shu Shichu Xiao Teng Gong Pengfei Luo Li Li Zhaohong Chen Yongjun Zheng Zhaofan Xia | 2020 | Burns & Trauma2020，8，1： | 12 |
| 6 | Singular analysis of bifurcation systems with two parameters显示文摘有二个参数的动态系统的分叉性质在这份报纸被调查。设置的转变的定义被建议,并且开发的途径被用来与非线性的反馈控制器调查非线性的强迫的未击中的系统的动态特征。整个参量的飞机被转变集合划分成几个坚持的区域,然后在不同坚持的区域的分叉图被获得。关键词二个参数 - 分叉 - 单个分析工程被中国(10632040 ) 的国家自然科学基础支持。 | Zhaohong Qin Yushu Chen | 2010 | Acta Mechanica Sinica2010，26，3： | 8 |
| 7 | A review of key strategies in realizing power system resilience显示文摘The world is witnessing increasing frequency of extreme events. The power system is the backbone critical infrastructure of our economy and is under treat of such events. The resilient power system is intended to cope with low probability, high risk extreme events including extreme natural disasters and man-made attacks. Realizing resilience in the power system has been an unprecedented mission. Equipped with today’s smart grid technologies, power system can be rendered more resilient by the strategies taken before, during and after a disruptive event erupts. Based on a thorough review of existing works, we present the most-investigated problems and solving measures according to their application stage. In the preparation stage, innovative planning frameworks considering disaster scenarios are discussed; after the event, the system can alter the topology and integrate resource allocation to alleviate load shedding. The characteristics of different disasters are investigated to facilitate enhancing resilience. The review provides a summary of resilience strategies in the power system and can shed light to future research and application. | Yanling Lin Zhaohong Bie Aici Qiu | 2018 | Global Energy Interconnection2018，1，1： | 7 |
| 8 | Matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 expression in early focal cerebral infarction following urokinase thrombolysis in rats显示文摘Activity of matrix metalloproteinase-9 increases following cerebral ischemia/reperfusion,and is associated with cerebral microvascular permeability,blood-brain barrier destruction,inflammatory cell infiltration and brain edema.Matrix metalloproteinase-9 also likely participates in thrombolysis.A rat model of middle cerebral artery infarction was established by injecting autologous blood clots into the internal carotid artery.At 3 hours following model induction,urokinase was injected into the caudal vein.Decreased neurological severity score,reduced infarct volume,and increased expression of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 were observed in the cerebral cortex 24 hours after urokinase thrombolysis.These results suggest that urokinase can suppress damage in the acute-early stage of cerebral infarction. | Yuqiang Song Hongli Zou Guofeng Wang Hongxia Yang Zhaohong Xie Jianzhong Bi | 2012 | Neural Regeneration Research2012，7，17： | 6 |
| 9 | Characterization and biological evaluation of a novel silver nanoparticle-loaded collagen-chitosan dressing显示文摘Effective coverage and protection is a priority in wound treatment.Collagen and chitosan have been widely used for wound dressings due to their excellent biological activity and biocompatibility.Silver nanoparticles(AgNPs)have a powerful antibacterial effect.In this study,a macromolecular and small-molecular collagen mixed solution,a macromolecular and small-molecular chitosan mixed solution were prepared,and a silver nanoparticle-loaded collagen-chitosan dressing(AgNPCCD)has been proposed.First,the effects of a collagen-chitosan mixed solution on the proliferation of human umbilical vein endothelial cells and the secretion of cytokines were evaluated.Then,the characteristics and antibacterial effects of the AgNP-CCD were tested,and the effects on wound healing and the influence of wound cytokine expression were investigated via a deep second-degree burn wound model.The results showed that at the proper proportion and concentration,the collagen-chitosan mixed solution effectively promoted cell proliferation and regulated the levels of growth factors(vascular endothelial growth factor[VEGF],epidermal growth factor[EGF],plateletderived growth factor[PDGF],transforming growth factor[TGF-b1],basic fibroblastic growth factor[bFGF])and inflammatory factors(TNF-α,IL-1β,IL-6,IL-8).Moreover,AgNP solutions at lower concentrations exerted limited inhibitory effects on cell proliferation and had no effect on cytokine secretion.The AgNP-CCD demonstrated satisfactory morphological and physical properties as well as efficient antibacterial activities.An in vivo evaluation indicated that AgNP-CCD could accelerate the healing process of deep second-degree burn wounds and played an important role in the regulation of growth and inflammatory factors,including VEGF,EGFL-7,TGF-β1,bFGF,TNF-α and IL-1β.This AgNP-CCD exerted excellent biological effects on wound healing promotion and cytokine expression regulation. | Rongfu Li Zhaorong Xu Qiong Jiang Yunquan Zheng Zhaohong Chen Xiaodong Chen | 2020 | Regenerative Biomaterials2020，7，4： | 4 |
| 10 | Distributed Energy Management of Integrated Electricity-thermal Systems for High-speed Railway Traction Grids and Stations显示文摘This paper proposes an integrated electricity-ther-mal energy management system(EMS)for high-speed railways.First,an operational model is built for the integrated electricity-thermal system,including a train operation EMS(TO-EMS)model and station operation EMS(SO-EMS)model.In the TO-EMS model,traction grids(TGs)are formulated with a solvable second-order cone programming problem.In the SO-EMS model,station indoor thermal systems are taken into account,and the building heat exchange process and solar radiation influence upon station indoor temperature are also included.Then the TO-EMS and the SO-EMS are coordinated with an alternating direction method of the multipliers-based(ADMM-based)algo-rithm,protecting the privacy and interests both for the train dispatch center and stations.To demonstrate the effectiveness of the proposed railway EMS,a modified realistic high-speed railway segment with six stations in North China with summer and winter scenarios is studied. | Lizhou Jiang Zhaohong Bie Tao Long Haipeng Xie Yao Xiao | 2021 | CSEE Journal of Power and Energy Systems2021，7，3： | 4 |
| 11 | Singular analysis of two-dimensional bifurcation system显示文摘Bifurcation properties of two-dimensional bifurcation system are studied in this paper.Universal unfolding and transition sets of the bifurcation equations are obtained.The whole parametric plane is divided into several different persistent regions according to the type of motion,and the different qualitative bifurcation diagrams in different persistent regions are given.The bifurcation properties of the two-dimensional bifurcation system are compared with its reduced one-dimensional system.It is found that the system which is reduced to one dimension has lost many bifurcation properties. | CHEN YuShu& QIN ZhaoHong School of Astronautics,Harbin Institute of Technology,Harbin 150001,China | 2010 | Science China(Technological Sciences)2010，53，3： | 3 |
| 12 | Dynamic analysis of a rotating tapered cantilever Timoshenko beam based on the power series method显示文摘The mathematical modeling of a rotating tapered Timoshenko beam with preset and pre-twist angles is constructed. The partial differential equations governing the six degrees, i.e., three displacements in the axial, flapwise, and edgewise directions and three cross-sectional angles of torsion, flapwise bending, and edgewise bending, are obtained by the Euler angle descriptions. The power series method is then used to investigate the natural frequencies and the corresponding complex mode functions. It is found that all the natural frequencies are increased by the centrifugal stiffening except the twist frequency, which is slightly decreased. The tapering ratio increases the first transverse,torsional, and axial frequencies, while decreases the second transverse frequency. Because of the pre-twist, all the directions are gyroscopically coupled with the phase differences among the six degrees. | Xiaodong YANG Shaowen WANG Wei ZHANG Zhaohong QIN Tianzhi YANG | 2017 | Applied Mathematics and Mechanics(English Edition)2017，38，10： | 3 |
| 13 | Some Special Types of Solitary Wave Solutions for (3+1)-Dimensional Jimbo-MiwaEquation显示文摘Using the extended homogeneous balance method, we find some special types of single solitary wave solution and new types of the multisoliton solutions of the (3+1)-dimensional Jimbo-Miwa equation. | BAICheng-Lin ZHAOHong | 2004 | Communications in Theoretical Physics2004，41，6： | 3 |
| 14 | Increased lateral root formation by CRISPR/Cas9-mediated editing of arginase genes in cotton显示文摘Dear Editor,Proper development of plant roots is critical for primary physiological functions,including water and nutrient absorption and uptake,physical support,and carbohydrate storage(Zhang et al.,2010).Crop root systems act as the key organ for sensing and response to abiotic and biotic stresses.Previous studies of crop root system development suggest that increased lateral root formation(LRF)could | Yanling Wang Zhigang Meng Chengzhen Liang Zhaohong Meng Yuan Wang Guoqing Sun Tao Zhu Yongping Cai Sandui Guo Rui Zhang Yi Lin | 2017 | Science China(Life Sciences)2017，60，5： | 3 |
| 15 | Optimal sizing method for stand-alone hybrid solar–wind system with LPSP technology by using genetic algorithm显示文摘 | Hongxing Yang Wei Zhou Lin Lu Zhaohong Fang | 2007 | Solar Energy2007，，4： | 3 |
| 16 | Coordinated Dispatch of Integrated Electricity-Natural Gas System and the Freight Railway Network显示文摘With the significant development of liquefied natural gas(LNG)rail transport,the railway system is increasingly more closely connected with the integrated electricity-natural gas system(IEGS).To coordinate the economic operations of the two systems,this paper innovatively proposes a coordinated dispatch model of IEGS with LNG infrastructures and a freight railway network with LNG transport.First,an operational scheduling model of the railway network,considering energy consumption,is put forward for both LNG transmission and ordinary freight transport.Then,the coordinated dispatch problem of IEGS and the railway network is formulated into a mixed-integer linear programming model via the big M method and a modified incremental linearization approach.Finally,a bi-level optimization algorithm based on generalized benders decomposition(GBD)is presented to solve the coordinated dispatch problem due to the restrictions on exchanging private information.Case studies demonstrate the effectiveness of the proposed model and algorithm as well as the potential benefit for wind power accommodation. | Tao Long Zhaohong Bie Lizhou Jiang Haipeng Xie | 2020 | CSEE Journal of Power and Energy Systems2020，6，4： | 3 |
| 17 | The migration and transformation of dissolved organic matter during the freezing processes of water显示文摘This study investigated the partitioning behavior of dissolved organic matter(DOM) in liquid and ice phases, as well as the changes in the optical properties and chlorine reactivity of DOM during the freezing processes of water. DOM was rejected from the ice phase and accumulated in the remaining liquid phase during water freezing. Moreover, the decrease in freezing temperature, as well as the increase in dissolved organic carbon(DOC)concentration of feed water, caused an increase in DOM captured in the ice phase. The ultraviolet-absorbing compounds, trihalomethane precursors, as well as fulvic acid- and humic acid-like fluorescent materials, were more liable to be to be rejected from the ice phase and were more easily retained in the unfrozen liquid phase during water freezing, as compared with organics(on average) that comprise DOC. In addition, it was also found a higher accumulation of these organics in the unfrozen liquid phase during water freezing at higher temperature. The freeze/thaw processes altered the quantity, optical properties, and chlorine reactivity of DOM. The decrease in ultraviolet light at 254 nm as well as the production of aromatic protein- and soluble microbial byproduct-like fluorescent materials in DOM due to freeze/thaw were consistently observed. On the other hand, the changes in DOC, trihalomethane formation potential, and fulvic acid- and humic acid-like fluorescence caused by freeze/thaw varied significantly between samples. | Shuang Xue Yang Wen Xiujuan Hui Lina Zhang Zhaohong Zhang Jie Wang Ying Zhang | 2015 | Journal of Environmental Sciences2015，27，1： | 3 |
| 18 | Hundred-Joule-level,nanosecond-pulse Nd:glass laser system with high spatiotemporal beam quality显示文摘A 100-J-level Nd:glass laser system in nanosecond-scale pulse width has been constructed to perform as a standard source of high-fluence-laser science experiments. The laser system, operating with typical pulse durations of 3–5 ns and beam diameter 60 mm, employs a sequence of successive rod amplifiers to achieve 100-J-level energy at 1053 nm at3 ns. The frequency conversion can provide energy of 50-J level at 351 nm. In addition to the high stability of the energy output, the most valuable of the laser system is the high spatiotemporal beam quality of the output, which contains the uniform square pulse waveform, the uniform flat-top spatial fluence distribution and the uniform flat-top wavefront. | Sensen Li Yulei Wang Zhiwei Lu Lei Ding Yi Chen Pengyuan Du Dexin Ba Zhenxing Zheng Xin Wang Hang Yuan Chengyu Zhu Weiming He Dianyang Lin Yongkang Dong Dengwang Zhou Zhenxu Bai Zhaohong Liu Can Cui | 2016 | High Power Laser Science and Engineering2016，4，1： | 3 |
| 19 | Zbed3 participates in the subcortical maternal complex and regulates the distribution of organelles显示文摘我们以前识别了 subcortical 在老鼠为早 embryogenesis 和女富饶是必要的母亲的建筑群(SCMC ) 。然而, SCMC 由影响女富饶的分子的机制大部分仍然是 uncharacterized。这里,我们报导那新奇母亲的蛋白质,包含 3 的锌手指床类型(Zbed3 ) ,参予 SCMC。母亲的 Zbed3 的弄空导致女性的减少的肥沃,因为在变异的胚胎的一个比例的损害并且推迟的发展。母亲的 Zbed3 的损失在影响卵母细胞和接合子导致不对称的 zygotic 分割和细胞器的反常分布,类似于与破坏核心 SCMC 基因在女性观察的显型。进一步的调查表明这些显型与微导管的破坏动力学或细胞质的格子(CPL ) 的形成被联系。Zbed3 的稳定性和本地化取决于,但是没被要求为, SCMC 的形成。因此,我们的数据作为调停的下游的蛋白质之一建议 Zbed3 SCMC 功能并且在女富饶提供进一步的卓见进 SCMC 和 CPL 的角色。 | Zheng Gao Xiaoxin Zhang Xingjiang Yu Dandan Qin Yi Xiao Yang Yu Yunlong Xiang Xiaoqing Nie Xukun Lu Wenbo Liu Zhaohong Yi Lei Li | 2018 | Journal of Molecular Cell Biology2018，10，1： | 2 |
| 20 | Forty years later: Updating the Fossilization Hypothesis显示文摘 | ZhaoHong Han | 2013 | Language Teaching2013，，2： | 2 |
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