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| 1 | 炎性肌纤维母细胞肿瘤的分子特性:高频ALK和ROS1基因融合及罕见新型RET基因重排亚型显示文摘约50%的普通型炎性肌纤维母细胞肿瘤( IMTs)伴ALK基因重排和过表达。近年来,已证明其它激酶的基因融合,如ROS1和PDGFRB,与IMT的发病机制有关。然而这些新出现的基因型是否与IMT的临床病理特征有关仍然未知。本文作者对不同临床表现的IMT大样本进行详细的分子遗传学研究,并分析基因型-表型之间的潜在相关性。 | Antonescu C R Suurmeijer A J Zhang L 魏建国 邰艳红 | 2015 | 临床与实验病理学杂志2015，31，7： | 19 |
| 2 | 超重和肥胖的全球趋势及其与心血管疾病发生率之间的关系显示文摘虽然超重和肥胖的全球发病率逐日上升,但在不同地区、国家和性别中的发病趋势仍存在差异。据世界卫生组织报道,全球多个地区由体质量指数(body mass index,BMI)≥25kg/m2定义的超重/肥胖发生率几乎接近一半人口,有的甚至超过了一半,如美洲(61.1%),欧洲(54.8%)和东地中海地区(46.0%),然而,在非洲(26.9%),东南亚(13.7%)和西太平洋地区(25.4%),超重/肥胖发生率较低。 | 刘莉 叶鹏 Yatsuya H Li Y Hilawe EH Ota A Wang C Chiang C Zhang Y Uemura M Osako A Ozaki Y Aoyama A Circ J | 2014 | 中华高血压杂志2014，22，12： | 8 |
| 3 | Corrosion behavior of Mg-Y alloy in NaCl aqueous solution | Xin Zhang a,b,c,Kui Zhang a,Xia Deng a,Hongwei Li b,c,Yongjun Li a,Minglong Ma a,Ning Li b,c,Yanlong Wang b,c a State Key Laboratory for Fabrication and Processing of Nonferrous Metals,Beijing General Research Institute for Nonferrous Metals,Beijing 100088,China b Beijing Engineering Research Center for Advanced Manufacturing and Evaluation of Special Vehicle Parts,Beijing 100072,China c Center of Technology,Beijing North Vehicle Group Corporation,Beijing 100072,China | 2012 | Progress in Natural Science:Materials International2012，22，2： | 7 |
| 4 | Effective Hybrid Teaching-learning-based Optimization Algorithm for Balancing Two-sided Assembly Lines with Multiple Constraints显示文摘Due to the NP-hardness of the two-sided assembly line balancing(TALB) problem, multiple constraints existing in real applications are less studied, especially when one task is involved with several constraints. In this paper, an effective hybrid algorithm is proposed to address the TALB problem with multiple constraints(TALB-MC). Considering the discrete attribute of TALB-MC and the continuous attribute of the standard teaching-learning-based optimization(TLBO) algorithm, the random-keys method is hired in task permutation representation, for the purpose of bridging the gap between them. Subsequently, a special mechanism for handling multiple constraints is developed. In the mechanism, the directions constraint of each task is ensured by the direction check and adjustment. The zoning constraints and the synchronism constraints are satisfied by teasing out the hidden correlations among constraints. The positional constraint is allowed to be violated to some extent in decoding and punished in cost function. Finally, with the TLBO seeking for the global optimum, the variable neighborhood search(VNS) is further hybridized to extend the local search space. The experimental results show that the proposed hybrid algorithm outperforms the late acceptance hill-climbing algorithm(LAHC) for TALB-MC in most cases, especially for large-size problems with multiple constraints, and demonstrates well balance between the exploration and the exploitation. This research proposes an effective and efficient algorithm for solving TALB-MC problem by hybridizing the TLBO and VNS. | TANG Qiuhua LI Zixiang ZHANG Liping FLOUDAS C A CAO Xiaojun | 2015 | Chinese Journal of Mechanical Engineering2015，28，5： | 7 |
| 5 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 6 | Through-needle all-optical ultrasound imaging in vivo: a preclinical swine study显示文摘High-frequency ultrasound imaging can provide exquisite visualizations of tissue to guide minimally invasive procedures.Here,we demonstrate that an all-optical ultrasound transducer,through which light guided by optical fibers is used to generate and receive ultrasound,is suitable for real-time invasive medical imaging in vivo.Broad-bandwidth ultrasound generation was achieved through the photoacoustic excitation of a multiwalled carbon nanotube-polydimethylsiloxane composite coating on the distal end of a 300-μm multi-mode optical fiber by a pulsed laser.The interrogation of a high-finesse Fabry–Pérot cavity on a single-mode optical fiber by a wavelength-tunable continuous-wave laser was applied for ultrasound reception.This transducer was integrated within a custom inner transseptal needle(diameter 1.08 mm;length 78 cm)that included a metallic septum to acoustically isolate the two optical fibers.The use of this needle within the beating heart of a pig provided unprecedented realtime views(50 Hz scan rate)of cardiac tissue(depth:2.5 cm;axial resolution:64μm)and revealed the critical anatomical structures required to safely perform a transseptal crossing:the right and left atrial walls,the right atrial appendage,and the limbus fossae ovalis.This new paradigm will allow ultrasound imaging to be integrated into a broad range of minimally invasive devices in different clinical contexts. | Malcolm C Finlay Charles A Mosse Richard J Colchester Sacha Noimark Edward Z Zhang Sebastien Ourselin Paul C Beard Richard J Schilling Ivan P Parkin Ioannis Papakonstantinou Adrien E Desjardins | 2017 | Light(Science & Applications)2017，6，1： | 6 |
| 7 | 血清netrin-1增加与缺血性脑卒中预后改善相关显示文摘先前的实验研究表明,血清netrin-1与缺血性脑卒中进展相关。进一步了解缺血性脑卒中患者中netrin-1的变化可能为缺血性脑卒中的预后评估提供新的思路。该研究旨在探讨血清netrin-1与缺血性脑卒中预后的关系。研究人员测定3346例中国急性缺血性脑卒中抗高血压试验(China antihypertensive trial in acute ischemic stroke,CATIS)中缺血性脑卒中患者基线血清netrin-1水平,所有患者均在脑卒中发病后3个月进行随访。主要观察指标是脑卒中发病后3个月内死亡和严重残疾(改良Rankin 量表评分≥3)。 | 刘莉 叶鹏 Guo D Zhu Z Zhong C Peng H Wang A Xu T Peng Y Xu T Chen CS Li Q Ju Z Geng D Chen J Zhang Y He J | 2019 | 中华高血压杂志2019，27，5： | 6 |
| 8 | Campylobacter concisus and inflammatory bowel disease显示文摘Investigation of the possible role of Campylobacter concisus(C. concisus) in inflammatory bowel disease(IBD) is an emerging research area. Despite the association found between C. concisus and IBD, it has been difficult to explain how C. concisus, a bacterium that is commonly present in the human oral cavity, may contribute to the development of enteric diseases. The evidence presented in this review shows that some C. concisus strains in the oral cavity acquired zonula occludens toxin(zot) gene from a virus(prophage) and that C. concisus Zot shares conserved motifs with both Vibrio cholerae Zot receptor binding domain and human zonulin receptor binding domain. Both Vibrio cholerae Zot and human zonulin are known to increase intestinal permeability by affecting the tight junctions. Increased intestinal permeability is a feature of IBD. Based on these data, we propose that a primary barrier function defect caused by C. concisus Zot is a mechanism by which zot-positive C. concisus strains may trigger the onset and relapse of IBD. | Li Zhang Hoyul Lee Michael C Grimm Stephen M Riordan Andrew S Day Daniel A Lemberg | 2014 | World Journal of Gastroenterology2014，20，5： | 4 |
| 9 | 超重和正常体质量患者的心力衰竭新发率的荟萃分析显示文摘肥胖和新发心力衰竭之间的关系已经反复确立,关于超重与心力衰竭发展风险知之甚少。该系统回顾和荟萃分析旨在探讨超重、肥胖与新发心力衰竭发生率的关系。在该研究中,研究者从数据库创建开始到2017年6月,系统检索了MEDLINE,Medline InProcess and Other Non-Indexed Citations,EMBASE,Scopus和Cochrane对照试验中心登记册。 | Krittanawong C Tunhasiriwet A Wang Z Zhang H Prokop LJ Chirapongsathorn S Sun T Kitai T Tang WHW 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，4： | 4 |
| 10 | ZrO_2 strengthened NiAl/Cr(Mo,Hf) composite fabricated by powder metallurgy | L.Y. Sheng a,b, J.T. Guo c, T.F. Xi a,b, B.C. Zhang c, H.Q. Ye c a PKU-HKUST ShenZhen-Hong Kong Institution, Shenzhen 518057, China b College of Engineering, Peking University, Beijing 100871, China c Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China | 2012 | Progress in Natural Science:Materials International2012，22，3： | 3 |
| 11 | Global land cover mapping from MODIS: algorithms and early results显示文摘 | M.A Friedl D.K McIver J.C.F Hodges X.Y Zhang D Muchoney A.H Strahler C.E Woodcock S Gopal A Schneider A Cooper A Baccini F Gao C Schaaf | 2002 | Remote Sensing of Environment2002，，1： | 2 |
| 12 | The strain amplitude-controlled cyclic fatigue behavior of Al_2O_3 fiber reinforced Al-Si alloy composite at elevated temperatures | Guohua Zhang a,c,Bingchao Li b,Jianxin Zhang b,Wei Cai a a School of Materials Science and Engineering,Harbin Institute of Technology,Harbin 150001,China b School of Materials Science and Engineering,Shandong University,Jinan 250061,China c Shandong Binzhou Bohai Piston Co.,Ltd,Binzhou 256602,China | 2012 | Progress in Natural Science:Materials International2012，22，2： | 2 |
| 13 | Unique cyclic deformation behavior of a heavily alloyed Al-Si piston alloy at different temperatures | Guohua Zhang a,c,Bingchao Li b,Jianxin Zhang b,Zengjian Feng c,Zuoshan Wei c,Wei Cai a a School of Materials Science and Engineering,Harbin Institute of Technology,92 West Dazhi Street,P.O.Box 405,Harbin 150001,China b School of Materials Science and Engineering,Shandong University,17923 Jingshi Road,Jinan 250061,China c Shandong Binzhou Bohai Piston Co.,Ltd,569 Bohai Ershiyi Road,Binzhou 256602,China | 2012 | Progress in Natural Science:Materials International2012，22，5： | 2 |
| 14 | Dependency of Colorectal Cancer on a TGF-β-Driven Program in Stromal Cells for Metastasis Initiation显示文摘 | Alexandre Calon Elisa Espinet Sergio Palomo-Ponce Daniele V.F. Tauriello Mar Iglesias María Virtudes Céspedes Marta Sevillano Cristina Nadal Peter Jung Xiang H.-F. Zhang Daniel Byrom Antoni Riera David Rossell Ramón Mangues Joan Massagué Elena Sancho Edua | 2012 | Cancer Cell2012，，5： | 2 |
| 15 | A gene for hereditary pancreatitis maps to chromosome 7q35显示文摘 | DC Whitcomb RA Preston CE Aston MJ Sossenheimer PS Barua Y Zhang A Wong- Chong GJ White PG Wood LK Gates C Ulrich SP Martin JC Post GD Ehrlich | 1996 | Gastroenterology1996，，6： | 2 |
| 16 | A propective study of maternal serum C- reactive protein concentrations and risk of preeclampsia 显示文摘 | Qiu C Luthy D A Zhang C | 2004 | Hypertension2004，44，5： | 1 |
| 17 | Reconciliation of experimental results on H2O speciation in rhyolitic glass using in-situ and quenching techniques显示文摘 | A C WITHERS Y ZHANG H BEHRENS | 1999 | Ear & Planet Sci Lett1999，173，： | 1 |
| 18 | Rotating machinery prognostics : State of the art, challenges and opportunities显示文摘 | Heng A Zhang S Tan A C C | 2009 | Mechanical Systems and Signal Processing2009，23，3： | 1 |
| 19 | JADE: adaptive differential evolution with optional external archive 显示文摘 | Zhang J Q Sanderson A C | 2009 | IEEE Transactions on Evolutionary Computation2009，13，5： | 1 |
| 20 | Tumor necrosis factor-alpha stimulates lipolysis in differentiated human adipocytes through activation of extracel lular signal related kinase and elevation of intracellular Camp 显示文摘 | Zhang H H Halbleib M Ahmad F Manganiello V C Greenberg A S | 2002 | Diabetes2002，51，： | 1 |
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