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| 1 | Dynamic and reversibility of heterochromatic gene silencing in human dis-ease显示文摘In eukaryotic organisms cellular fate and tissue specific gene expression are regulated by the activity of proteins known as transcription factors that by interacting with specific DNA sequences direct the activation or repression of target genes. The post genomic era has shown that transcription factors are not the unique key regulators of gene expression. Epigenetic mechanisms such as DNA methylation, post-translational modifications of histone proteins, remodeling of nucleosomes and expression of small regulatory RNAs also contribute to regulation of gene expression, determination of cell and tissue specificity and assurance of inheritance of gene expression levels. The relevant contri- bution of epigenetic mechanisms to a proper cellular function is highlighted by the effects of their deregulation that cooperate with genetic alterations to the development of various diseases and to the establishment and progression of tumors. | Giuseppe ZARDO Francesco FAZI Lorena TRAVAGLINI Clara NERVI | 2005 | Cell Research2005，15，9： | 5 |
| 2 | Optimizing Nitrogen Use Efficiency for No-Till Corn Production by Improving Root Growth and Capturing NO_(3)-N in Subsoil显示文摘Subsoil acidity restricts root growth and reduces crop yields in many parts of the world. More than half of the fertilizer nitrogen(N) applied in crop production is currently lost to the environment. This study aimed to investigate the effect of gypsum application on the efficiency of N fertilizer in no-till corn(Zea mays L.) production in southern Brazil. A field experiment examined the effects of surface-applied gypsum(0, 5, 10, and 15 Mg ha^(-1)) and top-dressed ammonium nitrate(NH_4NO_3)(60, 120, and 180 kg N ha^(-1)) on corn root length, N uptake, and grain yield. A greenhouse experiment was conducted using undisturbed soil columns collected from the field experiment site to evaluate NO_3-N leaching, N uptake, and root length with surface-applied gypsum(0 and 10 Mg ha^(-1)) and top-dressed NH_4NO_3(0 and 180 kg N ha^(-1)). Amelioration of subsoil acidity due to gypsum application increased corn root growth,N uptake, grain yield, and N use efficiency. Applying gypsum to the soil surface increased corn grain yield by 19%–38% and partial factor productivity of N(PFPN) by 27%–38%, depending on the N application rate. Results of the undisturbed soil column greenhouse experiment showed that improvement of N use efficiency by gypsum application was due to the higher N uptake from NO_3-N in the subsoil as a result of increased corn root length. Our results suggest that ameliorating subsoil acidity with gypsum in a no-till corn system could increase N use efficiency, improve grain yield, and reduce environmental risks due to NO_3-N leaching. | Eduardo F. CAIRES Renato ZARDO FILHO Gabriel BARTH Helio A. W. JORIS | 2016 | Pedosphere2016，26，4： | 2 |
| 3 | Performance of the cytologic examination for the diagnosis of endocervical adenocarcinoma in situ:cytologic-histologic correlation in 60 cases显示文摘 | Zardo LM Thuler LC Zeferino LC | 2009 | Acta Cytol2009，53，5： | 1 |
| 4 | Differential expression of class I HDACs: Roles of cell density andcell cycle显示文摘 | F. Dangond M. Henriksson G. Zardo P. Caiafa T. Ekstrom S. Gray | 2001 | International Journal of Oncology2001，，4： | 1 |
| 5 | Epigenetic silencing of the myelopoiesis regulator microRNA - 223 by the AML1/ETO oncoprotein 显示文摘 | Fazi F Racanicchi S Zardo G | 2007 | Cancer Cell2007，12，5： | 1 |
| 6 | External quality assess-ment:An effective tool for clinical governance in laboratory medi-cine显示文摘 | Sciacovelli L Secchiero S Zardo L | | Clin Chem Lab Med0，20，： | 1 |
| 7 | Epigenetic silencing of the myelopoiesis regulator microRNA-223 by the AML1/ETO oncoprotein显示文摘 | Fazi F Racanicchi S Zardo G | 2007 | Cancer Cell2007，12，5： | 1 |
| 8 | Immunohistochemicalevidence of vanilloid receptor 1 in normal human urinary bladder 显示文摘 | Lazzeri M Vannucchi MG Zardo C | 2004 | Eur Urol2004，46，6： | 1 |
| 9 | Epigenetic silencing of the myelopoiesis regulator miRNA-223 by the AML1/ETO oncoprotein显示文摘 | FAZI F RACANICCHI S ZARDO G | 2007 | Cancer Cell2007，12，5： | 1 |
| 10 | Integrated genomic and epigenomic analyses pinpoint biallelic gene inactivation in tumors显示文摘 | Zardo G Tiirikainen M I Hong C | 2002 | Nat Genet2002，32，3： | 1 |
| 11 | Epigenetic Silencing of the Myelopoiesis Regulator microRNA-223 by the AML1/ETO Oncoprotein显示文摘 | Francesco Fazi Serena Racanicchi Giuseppe Zardo Linda M. Starnes Marco Mancini Lorena Travaglini Daniela Diverio Emanuele Ammatuna Giuseppe Cimino Francesco Lo-Coco Francesco Grignani Clara Nervi | 2007 | Cancer Cell2007，，： | 1 |
| 12 | Smooth muscle- specific SM22 protein is expressed in the adventitial cells of balloon-injured rabbit carotid artery 显示文摘 | Faggin E Puato M Zardo L | 1999 | Arterioscler Thromb Vasc Biol1999，19，6： | 1 |
| 13 | Smooth muscle-specific SM22 protein is expressed in the adventitial cells of balloon- injured rabbit carotid artery显示文摘 | Faggin E Puato M Zardo L | 1999 | Arterioscler Thromb Vasc Biol1999，19，6： | 1 |
| 14 | Epigenetic treatment of myelodysplastic syndromes and acute myeloid leukemias显示文摘 | LEONE G D'ALO F ZARDO G | 2008 | Curr Med Chem2008，15，： | 1 |
| 15 | Integrated genomic and epigenomic analyses pinpoint biallelic gene inactivation in tumors显示文摘 | Zardo G Tiirikainen MI Hong C | 2002 | Nat Genet2002，32，3： | 1 |
| 16 | Smooth muscle-specific SM22 protein is expressed in the adventitial cells of balloon-injured rabbit carotid artery 显示文摘 | Faggin E Puato M Zardo L | 1999 | Arterioscler Thromb Vasc Biol1999，19，6： | 1 |
| 17 | Epigenetic silencing of the myelopoiesis regulator microRNA-223 by the AML1/ETO oncoprotein显示文摘 | Fazi F Racanicchi S Zardo G | 2007 | Cancer Cell2007，12，5： | 1 |
| 18 | Chest wall resection and reconstruction for locally advanced primary breast cancer显示文摘 | Hille U Soergel P Zardo P | 2013 | Arch Gynecol Obstet2013，287，6： | 1 |
| 19 | Smooth muscle-spe- cific SM22 protein is expressed in the adventitial cells of balloon-injured rabbit carotid artery 显示文摘 | Faqqin E Puato M Zardo L | 1999 | Arterioscler Thromb Vasc Biol1999，19，6： | 1 |
| 20 | Epigenetic silencing of the myelopoiesis regulator microRNA - 223 by the AML1/ETO oncoprotein 显示文摘 | FAZI F RACANICCHI S ZARDO G | 2007 | Cancer Cell2007，12，5： | 1 |
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