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| 1 | Postmarketing safety evaluation: depside salt injection made from Danshen(Radix Salviae Miltiorrhizae)显示文摘OBJECTIVE: To systematically examine the postmarketing safety of depside salt injection made from Danshen(Radix Salviae Miltiorrhizae),identifythe potential risk factors, and ensure its clinical safety.METHODS: We examined a comprehensive series of studies on the production process, quality standards, pharmacology, population pharmacokinetics, and safety evaluation of depside salt injection made from Danshen(Radix Salviae Miltiorrhizae). Data from Ⅰ-Ⅳ clinical drug trials, hospital information systems(HIS), and spontaneous reporting systems(SRS) were also analyzed.RESULTS: The effective components of salvianolic acid salt content reached almost 100%, and the magnesium lithospermate B content reached morethan 80%. The median lethal dose(LD50) calculated by the Bliss method was 1.49 g/kg, with 95%confidence intervals of 1.29-1.72 g/kg. Long-term tests on Beagle dogs indicated that doses of less than 80 mg/kg were safe and doses of 320 mg/kg were toxic. Adverse drug reactions(ADRs) included digestive disorders; drug-induced erythrocyte deformation in lung, liver, spleen, kidney, bone marrow, intestinal mucosa, lymph nodes, and other tissues; megakaryocytes in lung, liver, and spleen resulting from mild hemolysis; and mild hyperplasia in bone marrow hematopoietic tissue. Other studies indicated no irritative effect of the injection on local tissues and blood vessels, and no allergic reactions, erythrocyte coagulation, or hemolysis. SRS data showed that the most common ADRs were headache, head distention, dizziness, facial flushing, skin itching, thrombocytopenia, and the reversibility of elevated Aspartate transaminase. HIS data indicated no damage to renal function from using depside salt injection made from Danshen(Radix Salviae Miltiorrhizae) at a dosage higher than the recommended dose.CONCLUSION: This study analyzes the clinical characteristics of ADRs from depside salt injection made from Danshen(Radix Salviae Miltiorrhizae),and discusses the factors influencing such reactions. It provides scientific reference and recommendations for clinically safe medication of the Danshen injection. | Yanpeng Chang Wen Zhang Yanming Xie Xiangyang Xu Rendi Sun Zheng Wang Ruihua Yan | 2014 | Journal of Traditional Chinese Medicine2014，34，6： | 8 |
| 2 | Stepwise-Nanocavity-Assisted Transmissive Color Filter Array Microprints显示文摘Visible-light color flters using patterned nanostructures have attracted much interest due to their various advantages such as compactness,enhanced stability,and environmental friendliness compared with traditional pigment or dye-based optical flters.While most existing studies are based on planar nanostructures with lateral variation in size,shape,and arrangement,the vertical dimension of structures is a long-ignored degree of freedom for the structural colors.Herein,we demonstrate a synthetic platform for transmissive color flter array by coordinated manipulations between height-varying nanocavities and their lateral flling fractions.Te thickness variation of those nanocavities has been fully deployed as an alternative degree of freedom,yielding vivid colors with wide gamut and excellent saturation.Experimental results show that the color-rendering capability of the pixelated nanocavities can be still retained as pixels are miniaturized to 500 nm.Crosstalk between closely spaced pixels of a Bayer color flter arrangement was calculated,showing minimal crosstalk for 1μm2 square subpixels.Our work provides an approach to designing and fabricating ultracompact color flter arrays for various potential applications including stained-glass microprints,microspectrometers,and high-resolution image sensing systems. | Yasi Wang Mengjie Zheng Qifeng Ruan Yanming Zhou Yiqin Chen Peng Dai Zhengmei Yang Zihao Lin Yuxiang Long Ying Li Na Liu Cheng-Wei Qiu Joel K.W.Yang Huigao Duan | 2018 | Research2018，，1： | 8 |
| 3 | Cloning of Ln Gene Through Combined Approach of Map-based Cloning and Association Study in Soybean显示文摘Increasing yield is one of the most important goals in crop breeding.Soybean(Glycine max L.Merr.),one of the most economically important leguminous seed crops,provides the majority of plant proteins,and more than a quarter of the world's food and animal feed(Graham and Vance,2003). The yield of soybean is finally determined by the number of seeds per unit area,which affected by many characters,such as height,branching number,photosynthesis,seed size,seed number.The number of seeds per pod is taken for one of the critical components that related to yield(You et al.,1995),and it has long been considered in soybean production(Takahashi, | Chao Fang Weiyu Li Guiquan Li Zheng Wang Zhengkui Zhou Yanming Ma Yanting Shen Congcong Li Yunshuai Wu Baoge Zhu Weicai Yang Zhixi Tian | 2013 | Journal of Genetics and Genomics2013，40，2： | 7 |
| 4 | Antibody-drug conjugates:Recent advances in linker chemistry显示文摘Antibody-drug conjugates(ADCs)are gradually revolutionizing clinical cancer therapy.The antibody-drug conjugate linker molecule determines both the efficacy and the adverse effects,and so has a major influence on the fate of ADCs.An ideal linker should be stable in the circulatory system and release the cytotoxic payload specifically in the tumor.However,existing linkers often release payloads nonspecifically and inevitably lead to off-target toxicity.This defect is becoming an increasingly important factor that restricts the development of ADCs.The pursuit of ADCs with optimal therapeutic windows has resulted in remarkable progress in the discovery and development of novel linkers.The present review summarizes the advance of the chemical trigger,linker-antibody attachment and linker-payload attachment over the last 5 years,and describes the ADMET properties of ADCs.This work also helps clarify future developmental directions for the linkers. | Zheng Su Dian Xiao Fei Xie Lianqi Liu Yanming Wang Shiyong Fan Xinbo Zhou Song Li | 2021 | Acta Pharmaceutica Sinica B2021，11，12： | 5 |
| 5 | Targeting PFKL with penfluridol inhibits glycolysis and suppresses esophageal cancer tumorigenesis in an AMPK/FOXO3a/BIM-dependent manner显示文摘As one of the hallmarks of cancer,metabolic reprogramming leads to cancer progression,and targeting glycolytic enzymes could be useful strategies for cancer therapy.By screening a small molecule library consisting of 1320 FDA-approved drugs,we found that penfluridol,an antipsychotic drug used to treat schizophrenia,could inhibit glycolysis and induce apoptosis in esophageal squamous cell carcinoma(ESCC).Gene profiling and Ingenuity Pathway Analysis suggested the important role of AMPK in action mechanism of penfluridol.By using drug affinity responsive target stability(DARTS)technology and proteomics,we identified phosphofructokinase,liver type(PFKL),a key enzyme in glycolysis,as a direct target of penfluridol.Penfluridol could not exhibit its anticancer property in PFKL-deficient cancer cells,illustrating that PFKL is essential for the bioactivity of penfluridol.High PFKL expression is correlated with advanced stages and poor survival of ESCC patients,and silencing of PFKL significantly suppressed tumor growth.Mechanistically,direct binding of penfluridol and PFKL inhibits glucose consumption,lactate and ATP production,leads to nuclear translocation of FOXO3a and subsequent transcriptional activation of BIM in an AMPK-dependent manner.Taken together,PFKL is a potential prognostic biomarker and therapeutic target in ESCC,and penfluridol may be a new therapeutic option for management of this lethal disease. | Cancan Zheng Xiaomei Yu Yiyao Liang Yidong Zhu Yan He Long Liao Dingkang Wang Yanming Yang Xingfeng Yin Ang Li Qingyu He Bin Li | 2022 | Acta Pharmaceutica Sinica B2022，12，3： | 4 |
| 6 | Deposition of sandstorms in a vegetation-covered sand dune in Ejin Oasis and its characteristics显示文摘“Ejin Section” found in a typical vegetation-covered sand dune in Ejin Oasis was investigated. In this study, 263 samples were taken from the section for grain-size analysis, 25 for chemical analysis, 11 for 14C dating and 6 for scanning electron microscope (SEM). The results of the study indicate that 3 types of the sediments in the section can be identified, YS, LS and ST. YS, homogeneous yellow-brown dune sands, is equal to those of inland deserts, LS, loess-like sandy soils, is the same as the sandy loess in the middle Yellow River and modern falling dusts, and ST, sandy sediments interbeded with the deadwood and defoliation of Tamarix spp, represents the depositional process of the section interrupted by abrupt changes in climate. The Ejin Section has recorded the repeated dust-storms or sandstorms since 2500 yr BP and the peak periods of the dust-storms or sandstorms revealed by the section are consistent with the records of “dust rains” in historical literatures, indicating that the change of climate is a key factor to increase sandstorms or dust-storms, whereas, “artificial” factor may only be an accelerating one for desertification. | WENXiaohao LI Baosheng WANG Wei LI Sen OU Xianjiao ZHENG Yanming | 2006 | Journal of Geographical Sciences2006，16，4： | 3 |
| 7 | Raman spectroscopy regulation in van der Waals crystals显示文摘Raman spectroscopy is a versatile tool widely used for comprehensive probing of crystal information. However,generally when applied in narrow-band-gap van der Waals crystals, it is liable to form a 'bug,' especially in transition-metal-dichalcogenides(TMDs). That is, several resonant Raman-scattering(RS) modes will inevitably appear in the Raman spectra with strong intensity, interfering with the desired signal of optical-phonon modes.Here, we propose cross-sectional polarized Raman scattering capable of regulating the intensity of RS modes in accordance with quasi-sinusoidal rules. Typically, for MoS_2 and WS_2, when the polarization vector of excited light is along the c axis of the crystal, all RS modes are nearly completely 'expunged' from the Raman spectra. The mechanism is that the absorption of most TMDs with a space group of R_(3m)for the light polarized along the c axis is infinitesimal, thus forming a small coupling intensity of electronic states excited optically and acoustic-phonon modes at point M, which in turn restrain the appearance of RS modes. The regulating strategy proposed can be applied to other van der Waals crystals so as to obtain a high signal-to-noise ratio Raman spectrum. | WEI ZHENG YANMING ZHU FADI LI FENG HUANG | 2018 | Photonics Research2018，，11： | 3 |
| 8 | Glucose metabolism controls humanγδ-cell-mediated tumor immunosurveillance in diabetes显示文摘Patients with type 2 diabetes mellitus(T2DM)have an increased risk of cancer.The effect of glucose metabolism onγδT cells and their impact on tumor surveillance remain unknown.Here,we showed that high glucose induced Warburg effect type of bioenergetic profle in Vy9vδ2 T cells,leading to excessive lactate accumulation,which further inhibited lytic granule secretion by impairing the traffcking of cytolytic machinery to the Vy9vδ2 T-cell-tumor synapse by suppressing AMPK activation and resulted in the loss of antitumor activity in vitro,in vivo and in patients.Strikingly,activating the AMPK pathway through glucose control or metformin treatment reversed the metabolic abnormalities and restored the antitumor activity of Vy9vδ2 T cells.These results suggest that the impaired antitumor activity of Vy9vδ2 T cells induced by dysregulated glucose metabolism may contribute to the increased cancer risk in T2DM patients and that metabolic reprogramming by targeting the AMPK pathway with metformin may improve tumor immunosurveillance. | Xiaofeng Mu Zheng Xiang Yan Xu Jing He Jianwen Lu Yuyuan Chen Xiwei Wang Chloe Ran Tu Yanme Wenyue Zhang Zhinan Yin Wing-hang Leung Yu-Lung Lau Yinping Liu Wenwei Tu | 2022 | Cellular & Molecular Immunology2022，19，8： | 2 |
| 9 | Grain-size Characteristics and Climate Variability in TMS5e Sequence of Tumen Section in Southern Tengger Desert,Northwestern China显示文摘The TMS5e sequence from the Tumen section,at the southern edge of Tengger Desert in the northwestern China,is synchronous with Marine Isotope Stage 5e(MIS5e).It consists of 16 layers of aeolian dune sands,11 layers of lacustrine loess-like facies,and 5 layers of lacustrine facies.The results of grain-size analysis shows that the palaeo-mobile dune sands,palaeo-fixed to semi-fixed dune sands and loess-like sandy loams are mainly composed of sands,ranging from 70% to 96%;their silt contents ranged from 4% to 20%,and their clay contents ranged from 1% to 5%;the climate under which the aeolian dune sands were deposited is similar to that under which modern mobile dune sands form,which is caused by the dominance of the cold,dry East Asian winter monsoon.In contrast,the lacustrine loess-like facies and lacustrine facies had a lower sand contents than those of the three aeolian dune sands,but have higher silt and clay contents,most of their sand content ranged from 30% to 60%,their silt contents ranged from 35% to 55%,and their clay contents ranged from 6% to 20%.The lacustrine loess-like facies and lacustrine facies formed under the influence of the warm,humid East Asian summer monsoon based on their similarity with modern sediments.The grain-size indicator Mz(mean grain diameter) and the SC/D value in the TMS5e sequence indicate climatic insta-bility at the southern edge of the Tengger Desert during MIS5e,with at least 14 fluctuations between a warm,humid climate and a cold,dry climate,divided into five stages:TMS5e5(139 kyr to 129.3 kyr B.P.),TMS5e4(129.3 kyr to 124 kyr B.P.),TMS5e3(124 kyr to 119.5 kyr B.P.),TMS5e2(119.5 kyr to 116.5 kyr B.P.),and TMS5e1(116.5 kyr to 113.7 kyr B.P.).These correspond roughly to MIS5e5,MIS5e4,MIS5e3,MIS5e2,and MIS5e1,respectively,in the GRIP ice core data. | WEN Xiaohao LI Baosheng WANG Fengnian ZHENG Yanming NIU Dongfeng SI Yuejin OU Xianjiao | 2012 | Chinese Geographical Science2012，22，1： | 2 |
| 10 | Heteroatom substitution-induced asymmetric A–D–A type non-fullerene acceptor for efficient organic solar cells显示文摘Research on asymmetric A–D–A structured non-fullerene acceptors has lagged far behind the development of symmetric counterpart.In this contribution,by simply replacing one sulfur atom in indacenodithiophene unit with a selenium atom,an asymmetric building block Se PT and a corresponding asymmetric non-fullerene acceptor Se PT-IN have been developed.Asymmetric Se PT-IN achieved a high efficiency of 10.20% in organic solar cells when blended with PBT1-C,much higher than that of symmetric TPT-IN counterpart(8.91%).Our results demonstrated an effective heteroatom substitution strategy to develop asymmetric A–D–A structured non-fullerene acceptors. | Chao Lia Jiali Song Yunhao Cai Guangchao Han Wenyu Zheng Yuanping Yi Hwa Sook Ryu Han Young Woo Yanming Sun | 2020 | Journal of Energy Chemistry2020，29，1： | 2 |
| 11 | CRISPRs provide broad and robust protection to oral microbial flora of gingival health against bacteriophage challenge显示文摘 | Huiyue Zhou (1) (2) Hui Zhao (3) Jiayong Zheng (3) Yuan Gao (1) (2) Yanming Zhang (1) Fangqing Zhao (1) Jinfeng Wang (1) | 2015 | Protein & Cell2015，6，7： | 2 |
| 12 | A New High-resolution Late Glacial-Holocene Climatic Record from Eastern Nanling Mountains in South China显示文摘A 350-cm-long sediment core sequence from Dahu Swamp situated in the eastern Nanling Mountains was selected for high-resolution paleoclimatic reconstruction since the Late Glacial period. The multi-proxy records of this paper reveal several evidently dry and cold events that may coincide with the Oldest Dryas, the Older Dryas, the Younger Dryas in the late deglacial period. Two relatively wetter and warmer phases occurred in ca. 15,000-14,400 cal yr B.P. and 13,500-12,800 cal yr B.P. respectively may correspond to the Blling and Allerd warming events. The Younger Dryas event (ca. 12,800-11,500 cal yr B.P.) revealed by multi-proxies was characterized by relatively colder and drier climate. A warmer and wetter climate, occurred in ca. 10,000-6000 cal yr B.P., was consistent with the Holocene Optimum, which coincided with the maximum Northern Hemisphere insolation. The '8.2kyr cool event' and even the '8.8kyr cool event' were indicated as well from our sediment core. A dry mid-Holocene period (ca. 6000- 3000 cal yr B.P.) indicated by multi-proxies does not follow the traditional concept of the wet mid-Holocene conditions observed in other regions in China. | XUE Jibin ZHONG Wei ZHENG Yanming MA Qiaohong CAI Ying OUYANG Jun | 2009 | Chinese Geographical Science2009，19，3： | 2 |
| 13 | Efficient interpolations to GPS orbits for precise wide area applications显示文摘 | Yanming Feng Yi Zheng | 2005 | GPS Solutions2005，，4： | 1 |
| 14 | Climate variability in the Salawusu River valley ofthe Ordos Plateau(Inner Mongolia,China)during Marine Isotope Stage 3显示文摘 | Wen Xiaohao Li Baosheng Zheng Yanming | 2009 | Journal of Quaternary Science2009，24，1： | 1 |
| 15 | Variations of monsoonal precipitation over the last 16,000 years in the eastern Nanling Mountains, South China显示文摘 | Wei Zhong Jibin Xue Yanming Zheng Qiaohong Ma Ying Cai Jun Ouyang Liubin Xu Shangzhe Zhou Xuefeng Yu | 2010 | Journal of Paleolimnology2010，，1： | 1 |
| 16 | Liquid crys- talline behaviour of chitooligosaeeharides显示文摘 | Dong Yanming Wang Huiwu Zheng Weiya | 2004 | Carbohydrate Pol- ymers2004，57，3： | 1 |
| 17 | Magnetism and work function of Ni-Cu alloys as metal gates显示文摘The magnetism and work function of pure Ni(001) and Ni-Cu slab alloys were investigated using first-principles methods based on density functional theory. The calculated results reveal that both magnetic moments and work functions of the alloys depend strongly on the surface orientation, but hardly on the distribution of doped Cu atoms for a given surface orientation. It is found that the doped Cu atoms have evident influence on the magnetic moment of Ni-Cu slabs, and the average magnetic moment of Ni atoms for Ni-Cu alloys decreases with increasing concentration of Cu atoms. Moreover, it is observed that the work function of Ni(001) is insensitive to the supercell thickness and the inner concentration of Cu atoms. In the meantime, the spin polarization is found to have an obvious role on the work function of the Ni-Cu alloys, which may give a new way to modulate the work function of the metal gate. | Cheng, Yanming Zheng, Yongping Huang, Xu Zhong, Kehua Chen, Zhigao Huang, Zhigao | 2012 | Rare Metals2012，31，2： | 1 |
| 18 | Liquid crystalline behavior of chitooligosaccharides显示文摘 | Dong Yanming Wang Huiwu Zheng Weiya | 2004 | Carbohydr Polym2004，57，3： | 1 |
| 19 | Sensitive determination of norepinephrine, synephrine, and isoproterenol by capillary electrophoresis with indirect electrochemiluminescence detection 显示文摘 | LIU Yanming CAO Juntao ZHENG Yanli | 2008 | J Sep Sci2008，31，13： | 1 |
| 20 | Liquid crystalline behaviour of chitooligosaccharides 显示文摘 | Dong Yanming Wang Huiwu Zheng Weiya et ul | 2004 | Carbohydrate Polymers2004，57，3： | 1 |
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