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| 1 | Observational study of daytime ionospheric irregularities associated with typhoon显示文摘Spread-F is a manifestation of ionospheric irregularities and generally takes place at nighttime. However, it can also be observed seldom at daytime. It is recognized that acoustic gravity waves (AGWs) play an important role in triggering plasma instability which results in spread-F in the ionosphere. The typhoon is a main source of the AGWs. In this paper, two cases of ionospheric daytime spread-F in the period of typhoon were analyzed. One case was on July 29, 1988 and the other was on August 01, 1989. The results showed the following: 1) There were some wave-like disturbances appearing in the HF Doppler records firstly, consequently the Doppler echo traces became scattered, which indicated that the ionospheric spread-F was triggered; 2) the blurred echo traces in the both two cases appeared in the morning (08:30-11:30 Beijing time) and lasted for more than two hours; 3) with the blurred echoes gradually weakening, the traveling ionospheric disturbances (TIDs) still existed and became clearer; 4) the frequency shifts in the two cases were both positive, implying the effective reflecting surface of the radio wave in the ionosphere moved downwards. These results provide good observational evidence for daytime spread-F during the typhoon period in Asian region. | XIAO SalGuan SHI JianKui ZHANG DongHe HAO YongQiang HUANG WeiQuan | 2012 | Science China(Technological Sciences)2012，55，5： | 6 |
| 2 | Comparative expression analysis of three genes from the Arabidopsis vacuolar Na^+/H^+ antiporter (AtNHX) family in relation to abiotic stresses显示文摘Na^+/H^+ antiporters (NHX) are ubiquitous transmembrane proteins that play a key role in salt tolerance of plants. In this study, the sequence of 3 Arabidopsis NHX gene (AtNHX2―4) were compared with other AtNHX members. Putative cis-elements analysis identified elements that have been associated with stress responses. The activities of the promoters AtNHX2―4 were studied in transgenic plants carrying corresponding promoter-β-glucuronidase (GUS) fusions. The AtNHX2 promoter-GUS analysis indicated that AtNHX2 was expressed in constitutive pattern with high GUS activity in roots and leaves. AtNHX2 promoter activity was not up-regulated by NaCl or abscisic acid (ABA), in contrast to the AtNHX1 promoter which was previously studied. The AtNHX3 and AtNHX4 promoters showed tissue-specific activities. Strong GUS activity was detected in roots and vascular bundles of the stele in plants carry-ing an AtNHX4 promoter-GUS fusion, and GUS activity increased under salt stress suggesting a func-tion related to salt tolerance. Transgenic plants carrying the AtNHX3 promoter-GUS fusion showed strong GUS activity in petals, stamens and tops of siliques, suggesting a possible role of AtNHX3 in flower and seed development. Results of histochemical analysis suggested that AtNHX2―4 are involved in divergent functions and are differentially regulated under abiotic stress. The structure of AtNHX4 was predicted to include 12 transmembrane regions and a NHX domain. Overexpression of AtNHX4 in Arabidopsis transgenic lines confers greater salt tolerance than in wild type plants. These results suggest that AtNHX4 may encode a putative vacuolar NHX that plays an important role in salt tolerance. | WANG WeiQuan LI Yin ZHANG YiYue YANG CuiPing ZHENG NuoYan XIE Qi | 2007 | Chinese Science Bulletin2007，52，13： | 5 |
| 3 | Marsdenia tenacissima injection induces the apoptosis of prostate cancer by regulating the AKT/GSK3β/STAT3 signaling axis显示文摘Marsdenia tenacissima injection,a standard Marsdenia tenacissima extract(MTE),has been approved as an adjuvant therapeutic agent for various cancers.Our previous study showed that MTE inhibited the proliferation and metastasis of prostate cancer(PCa)cells.However,the underlying mechanisms and active ingredients of MTE against PCa were not completely understood.This study revealed that MTE induced significant decreases in cell viability and clonal growth in PCa cells.In addition,MTE induced the apoptosis of DU145 cells by reducing the mitochondrial membrane potential and increasing the expression of Cleaved Caspase 3/7,Cyt c,and Bax.In vivo,DU145 xenografted NOD-SCID mice treated with MTE showed significantly decreased tumor size.TUNEL staining and Western blot confirmed the pro-apoptotic effects of MTE.Network pharmacology analysis collected 196 ingredients of MTE linked to 655 potential targets,and 709 PCa-associated targets were retrieved,from which 149 overlapped targets were screened out.Pathway enrichment analysis showed that the HIF-1,PI3K-AKT,and ErbB signaling pathways were closely related to tumor apoptosis.Western blot results confirmed that MTE increased the expression of p-AKT^(Ser473) and p-GSK3β^(Ser9),and decreased the expression of p-STAT3^(Tyr705) in vitro and in vivo.A total of 13 compounds in MTE were identified by HPLC-CAD-QTOF-MS/MS and UPLCQTOF-MS/MS.Molecular docking analysis indicated that six compounds may interact with AKT,GSK3β,and STAT3.In conclusion,MTE induces the endogenous mitochondrial apoptosis of PCa by regulating the AKT/GSK3β/STAT3 signaling axis,resulting in inhibition of PCa growth in vitro and in vivo. | LI Xiaolan HE Songhua LIANG Wei ZHANG Weiquan CHEN Xin LI Qiaofeng YANG Xin LIU Yanying ZHU Dan LI Li LIU Buming SU Zhiheng CHEN Jie GUO Hongwei | 2023 | Chinese Journal of Natural Medicines2023，21，2： | 2 |
| 4 | Low Voltage hybrid bulk/SOI CMOS active pixel image sensor显示文摘 | Chen Xu Zhang Weiquan Mansun Chan | 2001 | IEEE Electron Devices2001，22，5： | 2 |
| 5 | Apelin inhibits motor neuron apoptosis in the anterior horn following acute spinal cord and sciatic nerve injuries显示文摘Rat models of acute spinal cord injury and sciatic nerve injury were established.Apelin expression in spinal cord tissue was determined.In normal rat spinal cords,apelin expression was visible;however,2 hours post spinal cord injury,apelin expression peaked.Apelin expression increased 1 day post ligation of the sciatic nerve compared with normal rat spinal cords,and peaked at 3 days.Apelin expression was greater in the posterior horn compared with the anterior horn at each time point when compared with the normal group.The onset of neuronal apoptosis was significantly delayed following injection of apelin protein at the stump of the sciatic nerve,and the number of apoptotic cells after injury was reduced when compared with normal spinal cords.Our results indicate that apelin is expressed in the normal spinal cord and central nervous system after peripheral nerve injury.Apelin protein can reduce motor neuron apoptosis in the spinal cord anterior horn and delay the onset of apoptosis. | Zhiyue Li Weiguo Wang Qun Zhao Weiquan Ning Bin Yang Suling Zhang Siyin Feng | 2011 | Neural Regeneration Research2011，6，20： | 2 |
| 6 | Prep- aration of ehitosan/PLA blend micro/nanofibers by electrospinning显示文摘 | Jia Xu Jinhui Zhang Weiquan Gao | 2009 | Materials Letters2009，83，65： | 1 |
| 7 | Azeotropic distillation-assisted preparation of macro-mesostructurecl γ-Al2 O3 nanofibres of crumpled sheet-like morphology 显示文摘 | Cai Weiquan Li Huiquan Zhang Yi | 2006 | Mater Chem Phys2006，，96： | 1 |
| 8 | Accurate formulas of transmission ratio and tuning characteristics of birefringent filters 显示文摘 | Weiquan Zhang | 2000 | Optik2000，111，2： | 1 |
| 9 | Preparationof chitosan/PLA blend micro/ nanofibers by electro-spinning 显示文摘 | XU Jia ZHANG Jinhui GAO Weiquan | 2009 | Materials Letters2009，，63： | 1 |
| 10 | A large insert Thellungiella halophila BIBAC library for genomics and identification of stress tolerance genes显示文摘 | Weiquan Wang Yaorong Wu Yin Li Jiaying Xie Zhonghui Zhang Zhiyong Deng Yiyue Zhang Cuiping Yang Jianbin Lai Huawei Zhang Hongyan Bao Sanyuan Tang Chengwei Yang Peng Gao Guixian Xia Huishan Guo Qi Xie | 2010 | Plant Molecular Biology (-)2010，，1： | 1 |
| 11 | Immunohistochemical and in situ hybridization studies of gonadotropin releasing hormone (GnRH) and its receptor in rat digestive tract显示文摘 | Huang WeiQuan Yao Bing Sun Lan Pu RuoLei Wang Lei Zhang RongQing | 2001 | Life Sciences2001，，15： | 1 |
| 12 | Characteristics of spongiform leukoencephalopathy induced by heroin:MRI detection显示文摘 | Weiquan Zheng Xuelin Zhang | 2001 | Chin Med J2001，114，1： | 1 |
| 13 | Low voltage hybrid bulk/SOI CMOS active pixel image sensor 显示文摘 | Zhang Xuchen Chan Weiquan Sun Man | 2001 | IEEE Electron Device2001，22，5： | 1 |
| 14 | Reliability analysis for vertical integration of protection,measurement,merge unit,and intelligent terminal device显示文摘The reliability analysis of vertically integrated protection devices is crucial for designing International Electrotechnical Commission(IEC)61850-based substations.This paper presents the hardware architecture of a four-inone vertically integrated device and the information transmission path of each function based on the functional information transmission chain of protection devices,measurement and control devices,merging units,and intelligent terminals.Additionally,a reliability analysis model of the protection device and its protection system is constructed using the fault tree analysis method while considering the characteristics of each module of the vertically integrated device.The stability probability of the protection system in each state is analyzed by combining the state-transfer equations of line and busbar protection with a Markov chain.Finally,the failure rate and availability of the protection device and its protection system are calculated under different ambient temperatures using a 110 kV intelligent substation as an example.The sensitivity of each device module is analyzed. | Ying Li Weiquan Wang Liang Zhang Zhujian Liang Zhenli Xu Yuansheng Liang | 2023 | Global Energy Interconnection2023，6，6： | 1 |
| 15 | FOXP3 Is an X-Linked Breast Cancer Suppressor Gene and an Important Repressor of the HER-2/ErbB2 Oncogene显示文摘 | Tao Zuo Lizhong Wang Carl Morrison Xing Chang Huiming Zhang Weiquan Li Yan Liu Yin Wang Xingluo Liu Michael W.Y. Chan Jin-Qing Liu Richard Love Chang-gong Liu Virginia Godfrey Rulong Shen Tim H.-M. Huang Tianyu Yang Bae Keun Park Cun-Yu Wang Pan Zheng Yan | 2007 | Cell2007，，7： | 1 |
| 16 | FOXP3 Is an X-Linked Breast Cancer Suppressor Gene and an Important Repressor of the HER-2/ErbB2 Oncogene显示文摘 | Tao Zuo Lizhong Wang Carl Morrison Xing Chang Huiming Zhang Weiquan Li Yan Liu Yin Wang Xingluo Liu Michael W.Y. Chan Jin-Qing Liu Richard Love Chang-gong Liu Virginia Godfrey Rulong Shen Tim H.-M. Huang Tianyu Yang Bae Keun Park Cun-Yu Wang Pan Zheng Yan | 2007 | Cell2007，，7： | 1 |
| 17 | Build-in Reliability Analysis for Circuit Design in the Nanometer Technology Era 显示文摘 | Liu Zhihong Zhang Weiquan Mu Fuchen | 2004 | IEEE International Conference on Integrated Circuit Design and Technology2004，，： | 1 |
| 18 | Preparation of chitosan/PLA blend miero/nanofibers by electrospinning 显示文摘 | Xu Jia Zhang Jinhui Gao Weiquan | 2009 | Mater Lett2009，63，8： | 1 |
| 19 | Preparation of chitosan/PLA blend micro/nanofibers by electrospinning显示文摘 | XU Jia ZHANG Jinhui GAO Weiquan | 2009 | Materials Letters2009，63，8： | 1 |
| 20 | Omnidirectional Antenna Diversity System for High-Speed Onboard Communication显示文摘In this article,an omnidirectional dual-polarized antenna with synergetic electromagnetic and aerodynamic properties is propounded for high-speed diversity systems.The propounded antenna comprises a probe-fed cavity for horizontally polarized radiation and a microstrip-fed slot for vertical polarization.Double-layer metasurfaces are properly designed as artificial magnetic conductor boundaries with direct metal-mountable onboard installation and compact sizes.An attached wedge-shaped block is utilized for windage reduction in hydrodynamics.The propounded antenna is fabricated for design verification,and the experimental results agree well with the simulated ones.For vertical polarization,the operating bandwidth is in the range of 2.37–2.55 GHz,and the realized gain variation in the azimuthal radiation pattern is 3.67 decibels(dB).While an impedance bandwidth in the range of 2.45–2.47 GHz and a gain variation of 3.71 dB are also achieved for horizontal polarization.A port isolation more than 33 dB is obtained in a compact volume of 0.247λ_(0)×0.345λ_(0)×0.074λ_(0),whereλ_(0)represents the wavelength in vacuum at the center frequency,wherein the wedge-shaped block is included.The propounded diversity antenna has electromagnetic and aerodynamic merits,and exhibits an excellent potential for high-speed onboard communication. | Yongjian Zhang Yue Li Weiquan Zhang Zhijun Zhang Zhenghe Feng | 2022 | Engineering2022，8，4： | 0 |
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