|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Efficacy and safety of a novel anti-HER2 therapeutic antibody RC48 in patients with HER2-overexpressing,locally advanced or metastatic gastric or gastroesophageal junction cancer:a single-arm phase II study显示文摘Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 immunohistochemistry(IHC)2+and fluorescence in-situ hybridization-negative patients.Here,we report the efficacy and safety of a novel anti-HER2 antibody RC48 for patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer.Methods:Patients with HER2-overexpressing(IHC 2+or 3+),locally advanced or metastatic gastric or gastroesophageal junction cancer who were under at least second-line therapy were eligible and received RC482.5 mg/kg alone every 2 weeks.The primary endpoint was the objective response rate(ORR)assessed by an independent review committee.Secondary endpoints included progressionfree survival(PFS),overall survival(OS),duration of response,time to progression,disease control rate,and safety.Results:Of 179 patients screened,125 were eligible and received RC48 treatment.The ORR was 24.8%(95%confidence interval[CI]:17.5%-33.3%).The median PFS and OS were 4.1 months(95%CI:3.7-4.9 months)and 7.9 months(95%CI:6.7-9.9 months),respectively.The most frequently reported adverse events were decreased white blood cell count(53.6%),asthenia(53.6%),hair loss(53.6%),decreased neutrophil count(52.0%),anemia(49.6%),and increased aspartate aminotransferase level(43.2%).Serious adverse events(SAEs)occurred in 45(36.0%)patients,and RC48-related SAEs were mainly decreased neutrophil count(3.2%).Seven patients had adverse events that led to death were not RC48-related.Conclusions:RC48 showed promising activity with manageable safety,suggesting potential application in patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer who have previously received at least two lines of chemotherapy. | Zhi Peng Tianshu Liu Jia Wei Airong Wang Yifu He Liuzhong Yang Xizhi Zhang Nanfeng Fan Suxia Luo Zhen Li Kangsheng Gu Jianwei Lu Jianming Xu Qingxia Fan Ruihua Xu Liangming Zhang Enxiao Li Yuping Sun Guohua Yu Chunmei Bai Yong Liu Jiangzheng Zeng Jieer Ying Xinjun Liang Nong Xu Chao Gao Yongqian Shu Dong Ma Guanghai Dai Shengmian Li Ting Deng Yuehong Cui Jianmin Fang Yi Ba Lin Shen | 2021 | Cancer Communications2021，41，11： | 29 |
| 2 | A Pilot Study of the Therapeutic Efficacy and Mechanism of Artesunate in the MRL/lpr Murine Model of Systemic Lupus Erythematosus显示文摘Recent evidence indicates that artesunate has immunomodulatory properties that might be useful for treating autoimmune disease.In this study,we conducted a pilot study and explored the effect and mechanism of artesunate on the treatment of systemic lupus erythematosus using an MRL/lpr murine model.MRL/lpr mice were divided into control,cyclophosphamide(CTX)and artesunate treatment groups.Blood was collected to measure serum levels of creatinine,antinuclear antibody(ANA)and anti-double-stranded DNA(anti-dsDNA)antibody.Twenty-four-hour urine was collected to measure levels of proteinuria.The concentration of monocyte chemotactic protein-1(MCP-1)in serum and urine was measured.The expression of MCP-1 in kidney was detected by Western blot and immunohistochemistry assay,respectively.The expression of B cell activating factor(BAFF)in spleen was determined by real time-PCR and immunoblotting.We found that artesunate significantly increased the survival rate,body weight and blood leukocyte counts,and reduced the serum levels of ANA and anti-dsDNA antibody titer,24 h urinary protein,and serum creatinine.Our results indicated that artesunate could decrease MCP-1,major pro-inflammation cytokine,in serum,urine and kidney.We also found that the level of BAFF,the major B cell activation factor,was decreased in artesunate treated MRL/lpr mice.Its efficacy was comparable with that of CTX in this study.Taken together,we have demonstrated that artesunate can inhibit the progression of disease and reverse the pathologic lesion of lupus nephritis. | Ouyang Jin Huayong Zhang Zhifeng Gu Shengnan Zhao Ting Xu Kangxing Zhou Bo Jiang Jie Wang Xiaofeng Zeng Lingyun Sun | 2009 | Cellular & Molecular Immunology2009，6，6： | 20 |
| 3 | Management of granulomatous lobular mastitis: an international multidisciplinary consensus(2021 edition)显示文摘Granulomatous lobular mastitis(GLM) is a rare and chronic benign inflammatory disease of the breast. Difficulties exist in the management of GLM for many front-line surgeons and medical specialists who care for patients with inflammatory disorders of the breast. This consensus is summarized to establish evidence-based recommendations for the management of GLM. Literature was reviewed using PubMed from January 1, 1971 to July 31, 2020. Sixty-six international experienced multidisciplinary experts from 11 countries or regions were invited to review the evidence.Levels of evidence were determined using the American College of Physicians grading system, and recommendations were discussed until consensus. Experts discussed and concluded 30 recommendations on historical definitions,etiology and predisposing factors, diagnosis criteria, treatment, clinical stages, relapse and recurrence of GLM. GLM was recommended as a widely accepted definition. In addition, this consensus introduced a new clinical stages and management algorithm for GLM to provide individual treatment strategies. In conclusion, diagnosis of GLM depends on a combination of history, clinical manifestations, imaging examinations, laboratory examinations and pathology.The approach to treatment of GLM should be applied according to the different clinical stage of GLM. This evidencebased consensus would be valuable to assist front-line surgeons and medical specialists in the optimal management of GLM. | Qian-Qian Yuan Shu-Yuan Xiao Omar Farouk Yu-Tang Du Fereshte Sheybani Qing Ting Tan Sami Akbulut Kenan Cetin Afsaneh Alikhassi Rami Jalal Yaghan Irmak Durur-Subasi Fatih Altintoprak Tae Ik Eom Fatih Alper Mustafa Hasbahceci David Martínez-Ramos Pelin Seher Oztekin Ava Kwong Cedric W.Pluguez-Turul Kirstyn EBrownson Shirish Chandanwale Mehran Habib Liu-Yi Lan Rui Zhou Xian-Tao Zeng Jiao Bai Jun-Wen Bai Qiong-Rong Chen Xing Chen Xiao-Ming Zha Wen-Jie Dai Zhi-Jun Dai Qin-Yu Feng Qing-Jun Gao Run-Fang Gao Bao-San Han Jin-Xuan Hou Wei Hou Hai-Ying Liao Hong Luo Zheng-Ren Liu Jing-Hua Lu Bin Luo Xiao-Peng Ma Jun Qian Jian-Yong Qin Wei Wei Gang Wei Li-Ying Xu Hui-Chao Xue Hua-Wei Yang Wei-Ge Yang Chao-Jie Zhang Fan Zhang Guan-Xin Zhang Shao-Kun Zhang Shu-Qun Zhang Ye-Qiang Zhang Yue-Peng Zhang Sheng-Chu Zhang Dai-Wei Zhao Xiang-Min Zheng Le-Wei Zheng Gao-Ran Xu Wen-Bo Zhou Gao-Song Wu | 2022 | Military Medical Research2022，9，4： | 13 |
| 4 | Redistribution of Pb, Zn and Cu Fractions in Tailing Soils Treated with Different Extractants显示文摘The efficiency of EDTA, HNO3 and CaCl2 as extractants to remove Pb, Zn and Cu from tailing soils without varying soil pH was investigated with distributions of Pb, Zn and Cu being determined before and after extraction using the sequential extraction procedure of the optimized European Community Bureau of Reference (BCR). Results indicated that EDTA and HNO3 were both effective extracting agents.The extractability of extractants for Pb and Zn was in the order EDTA > HNO3 > CaCl2, while for Cu it was HNO3 > EDTA > CaCl2. After EDTA extraction, the proportion of Pb, Zn and Cu in the four fractions varied greatly, which was related to the strong extraction and complexation ability. Before and after extraction with HNO3 and CaCl2, the percentages of Pb, Zn and Cu in the reducible, oxidizable and residual fractions changed little compared to the acid-extractable fraction. The lability of metal in the soil and the kinds of extractants were the factors controlling the effects of metal extraction. | LIU Yun-Guo WANG Xian-Hai ZENG Guang-Ming LI Xin ZHOU Chun-Hua FAN Ting LI Yong-Li YUAN Xin-Zhong | 2006 | Pedosphere2006，16，3： | 12 |
| 5 | Intrinsic apoptotic pathway and G2/M cell cycle arrest involved in tubeimoside I-induced EC109 cell death显示文摘Objective: Squamous esophageal carcinoma is highly prevalent in developing countries, especially in China. Tu Bei Mu (TBM), a traditional folk medicine, has been used to treat esophageal squamous cell carcinoma (ESCC) for a long term. tubeimoside I (TBMS1) is the main component of TBM, exhibiting great anticancer potential. In this study, we investigated the mechanism of TBMS1 cytotoxic effect on EC109 cells. Methods: Comparative nuclear proteomic approach was applied in the current study and we identified several altered protein spots. Further biochemical studies were carried out to detect the mitochondrial membrane potential, cell cycle and corresponding proteins' expression and location. Results: Subcellular proteomic study in the nucleus from EC109 cells revealed that altered proteins were associated with mitochondrial function and cell proliferation. Further biochemical studies showed that TBMS1-induced molecular events were related to mitochondria-induced intrinsic apoptosis and P21-cyclin B1/cdc2 complex-related G2/M cell cycle arrest. Conclusions: Considering the conventional application of TBM in esophageal cancer, TBMS1 therefore may have a great potential as a chemotherapeutic drug candidate for ESCC. | Yang Xu Guanghui Wang Quancheng Chen Ting Lin Zhiping Zeng Qiang Luo Jie Liu Cuiling Sun | 2013 | Chinese Journal of Cancer Research2013，25，3： | 12 |
| 6 | The effect of subcutaneous injection duration on patients receiving low-molecular-weight heparin:Evidence from a systematic review显示文摘To assess the effect of the injection duration of subcutaneous low-molecular-weight heparin(LMWH)on pain and bruising in patients.Randomized controlled trials and quasiexperimental studies were searched for in four electronic databases.The pooled effect size was expressed as relative risk(RR)andmeandifference(MD)with95%confidence intervals(CI)for dichotomous and continuous data.Cochrane Q and p value were used to assess heterogeneity and the I2 statistic was adopted to quantify the level.Finally,eight studies involving a total of 532 participants met our inclusion criteria.The slow(30 second)injection was associated with a reduction in pain intensity and duration,and lower bruising occurrence at 48-72 hours and 48 hours post injection.The bruising area was also smaller at 48 hours and 60 hours post injection.Nodifferenceswere identified betweenthe slowand fast(10 second)injectionin bruising area and bruising occurrence at 24 hours and 60 hours post injection.With present evidences,slow injection of LMWH is beneficial to the patient's well being,but further studies to identify the feasibility and standardization of the technique is recommended. | Li-juan Yi Ting Shuai Xu Tian Zi Zeng Li Ma Guo-min Song | 2016 | International Journal of Nursing Sciences2016，3，1： | 12 |
| 7 | Allergy-related Evidences in Relation to Serum IgE:Data from the China State Key Laboratory of Respiratory Disease,2008-2013显示文摘Objective To investigate the serum total IgE(tlgE) and specific IgE(slgE) to common allergens among allergic patients in Guangzhou,China.Methods 7 085 patients were examined for tlgE and slgE to 15 allergens,based on the protocols of reversed enzyme allergosorbent test and the sandwich enzyme-linked immunosorbent assay.Results 3 758(53.04%) patients tested positive for tlgE,and 4 640(65.49%) for slgE.Der pteronyssinus,Der farinae,eggs,and cow's milk were the most common allergens leading to higher positive rates of slgE responses.Several peaks of sensitization were:Der pteronyssinus,Der farinae,and Blomia tropicalis at age 10-12;cow's milk at age below 3;eggs at age 4-6.The mean level and positive rate of tlgE tended to increase in subjects sensitized to more allergens.Sensitization to Der pteronyssinus(OR,1.6;P<0.05),Der farinae(OR,1.5;P<0.05),Blomia tropicalis(OR,1.4;P<0.05),Blattella germanica(OR,1.5;P<0.05),cow's milk(OR,1.3;P<0.05),and soy beans(OR,2.0;P<0.05) were independently correlated with allergy-related conditions in preliminary diagnosis.Conclusion The major allergens in Guangzhou include Der pteronyssinus,Der farinae,cow's milk,and eggs.Sensitization to these allergens appears to be predictors of allergy-related disorder. | SUN Bao Qing CHEN De Hui ZHENG Pei Yan HUANG Hui Min LUO Wen Ting ZENG Guang Qiao ZHANG Xiao Wen | 2014 | Biomedical and Environmental Sciences2014，27，7： | 11 |
| 8 | Forest canopy height mapping over China using GLAS and MODIS data显示文摘The Geoscience Laser Altimeter System(GLAS)accurately detects the vertical structural information of a target within its laser spot and is a promising system for the inversion of structural features and other biophysical parameters of forest ecosystems.Since the GLAS footprints are discontinuously distributed with a relativity low density,continuous vegetation height distributions cannot be mapped with a high accuracy using GLAS data alone.The MODIS BRDF product provides more forest structural information than other optical remote sensing data.This study aimed to map forest canopy heights over China from the GLAS and MODIS BRDF data.Firstly,the waveform characteristic parameters were extracted from the GLAS data by the method of wavelet analysis,and the terrain index was calculated using the ASTER GDEM data.Secondly,the model reducing the topographic influence was constructed from the waveform characteristic parameters and terrain index.Thirdly,the final canopy height estimation model was constructed from the neural network combining the canopy height estimated with the GLAS point and the MODIS BRDF data,and applied to get the continuous canopy height map over China.Finally,the map was validated by the measured data and the airborne Li DAR data,and the validation results indicated that forest canopy heights can be estimated with high accuracy from combined GLAS and MODIS data. | YANG Ting WANG Cheng LI GuiCai LUO SheZhou XI XiaoHuan GAO Shuai ZENG HongCheng | 2015 | Science China Earth Sciences2015，58，1： | 8 |
| 9 | E3 ligase UHRF2 stabilizes the acetyltransferase TIP60 and regulates H3K9ac and H3K14ac via RING finger domain显示文摘UHRF2 是调整房间周期, genomic 稳定性和 epigenetics 的 ubiquitin 蛋白质 ligase E3。我们进行了 co-immunoprecipitation 试金并且发现 TIP60 和 HDAC1 与 UHRF2 交往。我们以前证明 UHRF2 在正常和癌症房间调整了 H3K9ac 和 H3K14ac 差别。然而,精确信号 transduction 机制不是清楚的。在这研究,我们发现 TIP60 UHRF2 下游地行动了调整 H3K9ac 和 H3K14ac 表示。TIP60 被 UHRF2 ubiquitination 在正常房间稳定。然而, TIP60 在癌症房间被使动摇。TIP60 的弄空或抑制破坏在 UHRF2, H3K9ac 和 H3K14ac 之间的规章的关系。在摘要,调查结果建议 UHRF2 调停了癌症的 histones 和开始和前进的 translational 以后修正。 | Shengyuan Zeng YangyangWang Ting Zhang Lu Bai Yalan Wang Changzhu Duan | 2017 | Protein & Cell2017，8，3： | 8 |
| 10 | Psychophysiological Effects of Bamboo Plants on Adults显示文摘The present study was conducted to clarify the psychophysiological relaxation effects of viewing bamboo on university students. Forty healthy Chinese participants enrolled in this study to clarify the psychophysiological relaxation effects of viewing bamboo. The effects of visual stimulation using a pot both with and without a bamboo were recorded by measuring the student's blood pressure, EEG and STAI. We observed that viewing bamboo plants resulted in significantly lower systolic(female, P < 0.001; male, P < 0.001; P < 0.05) and diastolic(female,P < 0.001; male, P < 0.001; P < 0.05) blood pressures, but no changes in the pulse rate(female, P = 0.09; male, P = 0.07; P > 0.05) were observed. The results of the EEG analysis indicated brainwave variation(all P < 0.05) and lower anxiety scores(P < 0.01) after 3 min of viewing bamboo compared with the control. These findings indicate that visual stimulation with bamboo plants induced psychophysiological relaxation effects on adults. | Ahmad Hassan CHEN Qi Bing JIANG Tao LYU Bing Yang LI Nian LI Shu SHANGGUAN Zi Yue LI Yun Ting JUN Zhou Li LUO Qian CHEN Xin Yi WANG Yi Yan ZENG Cheng Cheng YANG Jun Muhammad Sohaib Tahir | 2017 | Biomedical and Environmental Sciences2017，30，11： | 8 |
| 11 | Heat shock protein 90 promotes RNA helicase DDX5 accumulation and exacerbates hepatocellular carcinoma by inhibiting autophagy显示文摘Objective:Hepatocellular carcinoma(HCC),the main type of liver cancer,has a high morbidity and mortality,and a poor prognosis.RNA helicase DDX5,which acts as a transcriptional co-regulator,is overexpressed in most malignant tumors and promotes cancer cell growth.Heat shock protein 90(HSP90)is an important molecular chaperone in the conformational maturation and stabilization of numerous proteins involved in cell growth or survival.Methods:DDX5 m RNA and protein expression in surgically resected HCC tissues from 24 Asian patients were detected by quantitative real-time PCR and Western blot,respectively.The interaction of DDX5-HSP90 was determined by molecular docking,immunoprecipitation,and laser scanning confocal microscopy.The autophagy signal was detected by Western blot.The cell functions and signaling pathways of DDX5 were determined in 2 HCC cell lines.Two different murine HCC xenograft models were used to determine the function of DDX5 and the therapeutic effect of an HSP90 inhibitor.Results:HSP90 interacted directly with DDX5 and inhibited DDX5 protein degradation in the AMPK/ULK1-regulated autophagy pathway.The subsequent accumulation of DDX5 protein induced the malignant phenotype of HCC by activating theβ-catenin signaling pathway.The silencing of DDX5 or treatment with HSP90 inhibitor both blocked in vivo tumor growth in a murine HCC xenograft model.High levels of HSP90 and DDX5 protein were associated with poor prognoses.Conclusions:HSP90 interacted with DDX5 protein and subsequently protected DDX5 protein from AMPK/ULK1-regulated autophagic degradation.DDX5 and HSP90 are therefore potential therapeutic targets for HCC. | Ting Zhang Xinrui Yang Wanping Xu Jing Wang Dawei Wu Zhixian Hong Shengxian Yuan Zhen Zeng Xiaodong Jia Shanshan Lu Rifaat Safadi Sen Han Zhihong Yang Leonard M.Neckers Suthat Liangpunsakul Weiping Zhou Yinying Lu | 2021 | Cancer Biology & Medicine2021，18，3： | 7 |
| 12 | Relationship of serum vitamin D level on geriatric syndromes and physical performance impairment in elderly hypertensive patients显示文摘ObjectiveTo 与 hypertension.MethodsAccording 在长辈在浆液维生素 D 层次,物理表演缺陷,和衰老老人症候群之中调查关系到维生素 D 层次的集中,有高血压的 143 个老病人的一个总数被分类进维生素 D 缺乏的组(维生素 D ≤20 ng/mL, n = 94 ) 并且维生素 D 适当的组(维生素 D >20 ng/mL, n = 49 ) 。衰老老人症候群和物理性能被使用全面衰老老人评价(CGA ) 估计。在维生素 D 层次,衰老老人症候群和物理性能之中的关联是统计差别在在二个组之间的衰老老人症候群的各种各样的方面被发现的 analyzed.ResultsNo (P >0.05 ) 。当关联分析显示维生素 D 层次与 ADL 有一个积极协会时,得分(r = 0.235, P <0.01 ) 并且有莫尔斯秋天规模 20 的一个否定协会(r =-0.238, P <0.01 ) 。有缺乏的维生素 D 的病人在五次两个都铺平有的更长的时间坐承受测试(5tSTS ) ,(15.765 ±5.593 ) 并且四米的散步测试[7.440 (5.620, 9.200 )] ,在掌握力量测试的一只更弱的有力的握手(28.049 ±9.522 ) ,并且一个更低的 Tinetti 面向表演的活动性评价(Tinetti POMA )[26 (22, 27 )] 并且 Tinetti 面向表演的活动性评价(B-POMA ) 的平衡 subscale 得分[14 (12, 16 )] ,与适当维生素 D 相比水平[(13.275 ±3.692 ) ;5.810 (4.728, 7.325 )] ;( 31.989 ±10.217 ) ;[26.5 (25, 28 )] ;[15 (14, 16 ) ,分别地所有 P <0.05 ] 。而且,逻辑回归的结果显示维生素 D 显著地与 5tSTS 被联系(或 = 1.2, 95% CI = 1.050-1.331, P <0.01 ) , Tinetti POMA (或 = 3.7, 95% CI:1.284-10.830, P <0.05 ) 并且 B-POMA (或 = 0.8, 95% CI:0.643-0.973, P <0.05 ).ConclusionsIn 老高血压的病人,浆液维生素 D 缺乏的水平与物理性能被联系缺陷。然而,没有统计意义在维生素 D 和衰老老人症候群之间被发现。进一步的学习被要求为在维生素 D 和物理性能之间的协会调查可能的机制。 | Xing-Kun ZENG Shan-Shan SHEN Jiao-Jiao CHU Ting HE Lei CHENG Xu-Jiao CHEN | 2016 | Journal of Geriatric Cardiology2016，13，6： | 7 |
| 13 | Effects of wind waves of the Pacific westerly on the eastern Pacific wave transport显示文摘There exists a tongue-shaped swell-dominance pool known as Swell Pool(SP) in the Eastern Pacific region.The monthly-mean wave transports(WT) for each month of 2000 is computed using the wave products of ECMWF reanalysis data.By comparing the 2000 monthly-mean WT and monthly-mean wind field from QUICKSCAT,large differences are found between the wave transport direction and the wind direction over the Eastern Pacific.This may serve as an evidence for the existence of the SP in this region.The work done in this study indicates that the sources of swell in the Tropical Eastern Pacific(TEP) are in the westerly regions of the Southern and Northern Pacific. | DENG Zeng' an WU Kejian ZHAO Dongliang YU Ting | 2009 | Acta Oceanologica Sinica2009，28，1： | 6 |
| 14 | Mussel-inspired agarose hydrogel scaffolds for skin tissue engineering显示文摘Polysaccharide hydrogels are widely used in tissue engineering because of their superior biocompatibility and low immunogenicity.However,many of these hydrogels are unrealistic for practical applications as the cost of raw materials is high,and the fabrication steps are tedious.This study focuses on the facile fabrication and optimization of agarose-polydopamine hydrogel(APG)scaffolds for skin wound healing.The first study objective was to evaluate the effects of polydopamine(PDA)on the mechanical properties,water holding capacity and cell adhesiveness of APG.We observed that APG showed decreased rigidity and increased water content with the addition of PDA.Most importantly,decreased rigidity translated into significant increase in cell adhesiveness.Next,the slow biodegradability and high biocompatibility of APG with the highest PDA content(APG3)was confirmed.In addition,APG3 promoted full-thickness skin defect healing by accelerating collagen deposition and promoting angiogenesis.Altogether,we have developed a straightforward and efficient strategy to construct functional APG scaffold for skin tissue engineering,which has translation potentials in clinical practice. | Ting Su Mengying Zhang Qiankun Zeng Wenhao Pan Yijing Huang Yuna Qian Wei Dong Xiaoliang Qi Jianliang Shen | 2021 | Bioactive Materials2021，6，3： | 6 |
| 15 | Bi2WO6 doped with rare earth ions:Preparation,characterization and photocatalytic activity under simulated solar irradiation显示文摘Rare-earth modification Bi2WO6 composites(RE/Bi2WO6)were studied by experimental performance and theory computation based on the different 4 f orbits of selected rare earth elements(La,Ce,Gd,and Yb).The prepared RE/Bi2WO6 was characterized by XRD,SEM/TEM,XPS,UV-vis DRS,and N2 adsorption to learn their physical-chemical properties.Azo dye Rhodamine B(RhB)was photodegraded as a target pollutant to investigate the photocatalytic activity of prepared RE/Bi2WO6 composites.The results of experiment and computation show that four rare earth elements with different electron configurations retain the phase and morphology of Bi2 WO6 and enhance the removal efficiency of RhB under simulated solar irradiation.The optimum doping contents are 0.01%,0.05%,0.05%and 0.01%for La-,Ce-,Gd-,and Yb-doped Bi2WO6,respectively.However,light rare earth La and Ce doped composites indicate some difference in visible light adso rption capacity and mineralization on RhB co mpared with heavy rare earth Gd and Yb doped composites.Both La/Bi2WO6 and Ce/Bi2 WO6 possess larger pore size and higher mineralization ability than Gd/Bi2 WO6 and Yb/Bi2WO6 under the same experimental conditions while Gd/Bi2WO6 and Yb/Bi2WO6 show stronger red shift to the visible light due to the more 4 f electrons.The hole oxidation plays a major role in the photodegradation of RhB by all RE/Bi2WO6. | Chunying Wang Chuantao Gu Ting Zeng Qingqing Zhang Xianping Luo | 2021 | Journal of Rare Earths2021，39，1： | 6 |
| 16 | Comparison of Clinical Efficacy of Three Methods for Cervical Ripening followed by Surgical Evacuation in Early Missed Abortion显示文摘Objective To compare clinical efficacy of three cervical preparations for surgical evacuation in first trimester missed abortion.Methods Two hundred and ten women with early missed abortion were equally randomized into three groups.Three cervical preparations,Dilapan-dilator method(group A,n=70),mifepristone method(group B,n=70),and misoprostol method(group C,n=70),were used 24 h before curettage for terminating missed abortion,respectively.Clinical outcomes and complications for these three methods were compared.Results No differences were found in rates of successful treatment among the three groups(P>0.05).The incidence of fitting number 8 Hegar dilator was slightly high in group A,but it was not different compared with that in group B or group C(P>0.05).Bleeding in previous 24 h in group C was significantly greater than that in group A or group B(P<0.01).The cases of blood loss(>50 ml) during evacuation in group B were more than those in group A(P>0.05).Women in group B had less abdominal pain than those in group A or group C(P<0.01).Side effects in group C were more than those in group A on nausea(P<0.01),vomiting(P<0.05),and diarrhea(P<0.01).Group B had the highest acceptability among the three groups(P<0.05).Conclusion Three methods have the similar clinical efficacies in cervical ripening for surgical treatment of early missed abortion.Based on individual characteristics,different approach would be chosen to avoid some adverse events and improve the clinical application of Dilapan-dilator. | Yu-xia WANG Mi-jiao HUANG Ting HE Rong ZENG Wei-jie ZHU Mei TU | 2012 | Journal of Reproduction and Contraception2012，23，2： | 6 |
| 17 | Two Cases of Multi-antibiotic Resistant Cronobacter spp. Infections of Infants in China*显示文摘Infections by Cronobacter spp. are hazardous to infants since they can lead to neonatal meningitis, bacteremia, and necrotizing enterocolitis. Cronobacter spp. are frequently resistant to β-lactam derivatives, macrolides, and aminoglycosides. In addition, multi-resistant strains have also been detected. In China, the isolation rate of Cronobacter spp. from commercial powdered infant formula(PIF) or follow-up formula(FUF) is relatively high. Nevertheless, clinical cases of Cronobacter infection have been ignored to date. Here we describe two cases of Cronobacter infection detected at the Wuhan Women and Children Medical Care Center Hospital(Wuhan City, China). We provide the genomic analysis of the isolates and the antibiotic-resistance profiles of the two strains. The Cronobacter strains identified in this study were not susceptible to third-generation cephalosporins, aminoglycoside, and/or trimethoprim-sulfamethoxazole. Whole genome sequencing revealed various genes known to encode antibiotic resistance. Future studies are needed to determine whether the genes predicted in this study are functional. As with Enterobacter spp., the antibiotic resistance of Cronobacter is a serious issue that requires more attention. | CUI Jing Hua YU Bo XIANG Yun ZHANG Zhen ZHANG Ting ZENG Ying Chun CUI Zhi Gang HUO Xi Xiang | 2017 | Biomedical and Environmental Sciences2017，30，8： | 6 |
| 18 | Fifteen novel universal primer pairs for sequencing whole chloroplast genomes and a primer pair for nuclear ribosomal DNAs显示文摘叶绿体染色体信息帮助改进种系发生的决定并且当在最近的细胞器规模 barcodes 散发了植物组,能行动。以前,我们报导九通用教材对能由远程的聚合酶链反应并且用下一代的定序放大被子植物全部叶绿体染色体。尽管这些教材为在被子植物定序整个叶绿体染色体显示出高普遍性和效率,他们充分没解决包围定序被子植物叶绿体染色体的下列二个问题:(i) 约 30% 被子植物不能成功地被放大;并且(ii ) 仅仅新鲜的叶子能被使用。在这研究,我们为放大被子植物全部叶绿体染色体补充九份教材配对的原版设计了 15 通用教材对的另一个集合。而且,我们为原子 ribosomal DNA (nrDNAs ) 设计了教材对。验证教材的功能,我们与硅石测试了 44 种类有被显示出到的新鲜叶子的弄干胶化的叶子和 15 种类没与原版被放大九教材对。结果证明在有硅石的 44 种类中的 65.9% 个和 88.6% 弄干胶化的叶子,整个叶绿体染色体和 nrDNAs 能分别地被放大。另外,所有 15 件新鲜的叶样品能把整个叶绿体染色体成功地放大了。nrDNAs 包括 18S 和 26S 的部分序列,与 5.8S 和内部抄录分隔符 ITS1 和 ITS2 的完全的顺序一起。nrDNA 的吝啬的尺寸是 5800 bp。这研究证明 15 通用教材集合是为在被子植物放大整个叶绿体染色体的一个不可缺少的工具,并且这些是对九报导教材对的重要补充。 | Ting Zhang Chun-Xia Zeng Jun-Bo Yang Hong-Tao Li De-Zhu Li | 2016 | Journal of Systematics and Evolution2016，54，3： | 5 |
| 19 | Structural Engineering of Hierarchical Aerogels Comprised of Multi-dimensional Gradient Carbon Nanoarchitectures for Highly Efficient Microwave Absorption显示文摘Recently,multilevel structural carbon aerogels are deemed as attractive candidates for microwave absorbing materials.Nevertheless,excessive stack and agglomeration for low-dimension carbon nanomaterials inducing impedance mismatch are significant challenges.Herein,the delicate“3D helix-2D sheet-1D fiber-0D dot”hierarchical aerogels have been successfully synthesized,for the first time,by sequential processes of hydrothermal self-assembly and in-situ chemical vapor deposition method.Particularly,the graphene sheets are uniformly intercalated by 3D helical carbon nanocoils,which give a feasible solution to the mentioned problem and endows the as-obtained aerogel with abundant porous structures and better dielectric properties.Moreover,by adjusting the content of 0D core-shell structured particles and the parameters for growth of the 1D carbon nanofibers,tunable electromagnetic properties and excellent impedance matching are achieved,which plays a vital role in the microwave absorption performance.As expected,the optimized aerogels harvest excellent performance,including broad effective bandwidth and strong reflection loss at low filling ratio and thin thickness.This work gives valuable guidance and inspiration for the design of hierarchical materials comprised of dimensional gradient structures,which holds great application potential for electromagnetic wave attenuation. | Yongpeng Zhao Xueqing Zuo Yuan Guo Hui Huang Hao Zhang Ting Wang Ningxuan Wen Huan Chen Tianze Cong Javid Muhammad Xuan Yang Xinnan Wang Zeng Fan Lujun Pan | 2021 | Nano-Micro Letters2021，13，9： | 5 |
| 20 | Weekly taxane-anthracycline combination regimen versus tri-weekly anthracycline-based regimen for the treatment of locally advanced breast cancer:a randomized controlled trial显示文摘Background:Extensive studies have confirmed the efficacy of taxanes in combination with anthracycline-based chemotherapy on breast cancer.However,few studies have assessed the efficacy of weekly taxane-anthracycline regimens on locally advanced breast cancer.This study was to compare the efficacy and safety of a weekly taxaneanthracycline regimen with those of tri-weekly anthracycline-based regimen in patients with locally advanced breast cancer.Methods:Patients with locally advanced breast cancer were randomized to receive 4-6 cycles of neoadjuvant chemotherapy with tri-weekly 5-fluorouracil-epirubicin-cyclophosphamide(FEC) regimen or weekly paclitaxel-epirubicin(PE) regimen.The primary endpoint was the pathologic complete response(pCR) rate.Other endpoints included the clinical tumor response,breast-conserving surgery rate,and adverse events.Results:Between March 2010 and September 2013,293 patients were randomized to the FEC(n=151) and PE(n=142) arms.The overall clinical response rate was significantly higher in the PE arm than in the FEC arm(76.06%vs.59.95%,P=0.001).Consistently,the post-chemotherapy pathologic T and N stages were significantly lower in the PE arm than in the FEC arm(P<0.001).However,the pCR rate was similar in the two arms(10.61%vs.12.31%,P=0.665).Overall,36(27.27%) patients in the FEC arm and 6(35.28%) in the PE arm were qualified for breast-conserving surgery.Most adverse events were comparable in both arms,with more severe neutropenia in the PE arm than in the FEC arm(11.97%vs.5.96%,P=0.031).Conclusions:In patients with locally advanced breast cancer,weekly PE was not superior to FEC in terms of pCR.However,weekly PE has a higher response rate and superior down-staging effects.On this account,the PE regimen may be considered an alternative option for locally advanced breast cancer.Long-term follow-up data are needed to confirm the efficacy of this regimen on locally advanced breast cancer.Trial registration Chinese clinical trial registry,ChiCTR-TRC-10001043,September 21。 | Qiu-Wen Tan Ting Luo Hong Zheng Ting-Lun Tian Ping He Jie Chen He-Lin Zeng Qing Lv | 2017 | Chinese Journal of Cancer2017，36，6： | 5 |
您所在的机构暂未开通此部分的功能，请联系管理员