|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A Pilot Study of the Therapeutic Efficacy and Mechanism of Artesunate in the MRL/lpr Murine Model of Systemic Lupus Erythematosus显示文摘Recent evidence indicates that artesunate has immunomodulatory properties that might be useful for treating autoimmune disease.In this study,we conducted a pilot study and explored the effect and mechanism of artesunate on the treatment of systemic lupus erythematosus using an MRL/lpr murine model.MRL/lpr mice were divided into control,cyclophosphamide(CTX)and artesunate treatment groups.Blood was collected to measure serum levels of creatinine,antinuclear antibody(ANA)and anti-double-stranded DNA(anti-dsDNA)antibody.Twenty-four-hour urine was collected to measure levels of proteinuria.The concentration of monocyte chemotactic protein-1(MCP-1)in serum and urine was measured.The expression of MCP-1 in kidney was detected by Western blot and immunohistochemistry assay,respectively.The expression of B cell activating factor(BAFF)in spleen was determined by real time-PCR and immunoblotting.We found that artesunate significantly increased the survival rate,body weight and blood leukocyte counts,and reduced the serum levels of ANA and anti-dsDNA antibody titer,24 h urinary protein,and serum creatinine.Our results indicated that artesunate could decrease MCP-1,major pro-inflammation cytokine,in serum,urine and kidney.We also found that the level of BAFF,the major B cell activation factor,was decreased in artesunate treated MRL/lpr mice.Its efficacy was comparable with that of CTX in this study.Taken together,we have demonstrated that artesunate can inhibit the progression of disease and reverse the pathologic lesion of lupus nephritis. | Ouyang Jin Huayong Zhang Zhifeng Gu Shengnan Zhao Ting Xu Kangxing Zhou Bo Jiang Jie Wang Xiaofeng Zeng Lingyun Sun | 2009 | Cellular & Molecular Immunology2009，6，6： | 20 |
| 2 | Human placenta-derived mesenchymal stem cells loaded on linear ordered collagen scaffold improves functional recovery after completely transected spinal cord injury in canine显示文摘Traumatic spinal cord injury(SCI) is a major challenge in the clinic. In this study, we sought to examine the synergistic effects of linear ordered collagen scaffold(LOCS) and human placenta-derived mesenchymal stem cells(hPMSCs) when transplanted into completely transected beagle dogs. After 36 weeks observation, we found that LOCS+hPMSCs implants promoted better hindlimb locomotor recovery than was observed in the non-treatment(control) group and LOCS group. Histological analysis showed that the regenerated tissue after treatment was well integrated with the host tissue, and dramatically reduced the volume of cystic and chondroitin sulfate proteoglycans(CSPGs) expression. Furthermore, the LOCS+hPMSCs group also showed more neuron-specific βIII-tubulin(Tuj-1)-and NeuN-positive neurons in the lesion area, as well as axonal regeneration, remyelination and synapse formation in the lesion site. Additionally, dogs in the LOCS+hPMSCs group experienced enhanced sprouting of both ascending(CGRP-positive) sensory fibers and descending(5-HT-and TH-positive) motor fibers at the lesion area. All these data together suggested that the combined treatment had beneficial effects on neuronal regeneration and functional improvement in a canine complete transection model. Therefore, LOCS+hPMSCs implantation holds a great promise for bridging the nerve defect and may be clinically useful in the near future. | Sufang Han Zhifeng Xiao Xing Li Huan Zhao Bin Wang Zhixue Qiu Zhi Li Xin Mei Bai Xu Caixia Fan Bing Chen Jin Han Yanzheng Gu Huilin Yang Qin Shi Jianwu Dai | 2018 | Science China(Life Sciences)2018，61，1： | 15 |
| 3 | CD4^(+)CD25^(+)but not CD4^(+)Foxp3^(+) T cells as a regulatory subset in primary biliary cirrhosis显示文摘Increasing evidence indicates a role for regulatory T cells(Tregs)in the immune response and in autoimmune diseases,but the role of Tregs and cytokines in autoimmune hepatic diseases remains largely unclear and controversial,especially in patients with primary biliary cirrhosis(PBC).This study was undertaken to investigate Tregs and different cytokines in the liver and peripheral blood of PBC patients.We found that these patients demonstrated a reduction of CD4^(+)CD25^(+) T cells but elevated CD4^(+)Foxp3^(+) T cells in peripheral blood mononuclear cells(PBMCs)and CD41 T cells.The percentage of CD4^(+)CD25^(+) T cells in PBMCs was negatively correlated with elevated plasma interferon(IFN)-c levels.A liver-specific analysis showed that the frequency of Foxp31 Tregs,transforming growth factor(TGF)-b1 and IFN-c were increased in PBC patients.Our findings suggest that an imbalance between CD4^(+)CD25^(+) Tregs and cytotoxic cytokines plays a crucial role in the pathogenesis of PBC while the role of Foxp3 needs further investigation. | Dandan Wang Huayong Zhang Jun Liang Zhifeng Gu Qiang Zhou Xiangshan Fan Yayi Hou Lingyun Sun | 2010 | Cellular & Molecular Immunology2010，7，6： | 9 |
| 4 | JAK-STAT signaling mediates the senescence of bone marrow-mesenchymal stem cells from systemic lupus erythematosus patients显示文摘以前的研究揭示了那根骨头从病人们早展出了的全身的豺狼座 erythematosus (SLE ) 的髓间充质的干细胞(BM-MSCs ) 老朽签名,它可以参予 SLE 的发展。然而,关于这现象的分子的机制充分没被阐明。在当前的学习,我们试图调查表明发信号的抄写(STAT ) 的变换器和使活跃之物的 Janus kinase (JAK ) 是否调停了从 SLE 病人的 BM-MSCs 的老朽。12 个女 SLE 病人和健康题目在学习被注册。所有 BM-MSCs 被密度坡度 centrifugation 孤立。西方的污点分析被用来测试表明分子的 JAK-STAT 的表示。我们由流动 cytometry 观察了房间,由染色的 F 肌动朊的细胞骨架结构的变化,和房间周期的分发的女郎的活动。从 SLE 病人的 BM-MSCs 显示出表明 transduction, phosphorylated JAK2 的高水平,和 STAT3 的 JAK-STAT 的老朽,和反常激活的突出的特征。在在正常 MSC 的 IFN- 的刺激以后,发信号的 JAK-STAT 被激活。房间体积和联系老朽的牛乳糖的数字(SA -- 女郎) 在 SLE BM-MSCs 积极被增加。细胞骨架的组织是将近混乱的。房间增长的率被减少。AG490, JAK2 的禁止者,并且在 BM-MSCs 的 STAT3 击倒,能显著地颠倒老朽。在摘要,我们的学习显示 JAK-STAT 发信号小径可以在 SLE BM-MSCs 的老朽起一个关键作用。 | Juan Ji Yeqing Wu Yan Meng Lijuan Zhang Guijuan Feng Yunfei Xia Wenrong Xue Shuyang Zhao Zhifeng Gu Xiaoyi Shao | 2017 | Acta Biochimica et Biophysica Sinica2017，49，3： | 8 |
| 5 | Joint Trajectory and Passive Beamforming Optimization in IRS-UAV Enhanced Anti-Jamming Communication Networks显示文摘This paper investigates the anti-jamming communication scenario where an intelligent reflecting surface(IRS)is mounted on the unmanned aerial vehicle(UAV)to resist the malicious jamming attacks.Different from existing works,we consider the dynamic deployment of IRS-UAV in the environment of the mobile user and unknown jammer.Therefore,a joint trajectory and passive beamforming optimization approach is proposed in the IRS-UAV enhanced networks.In detail,the optimization problem is firstly formulated into a Markov decision process(MDP).Then,a dueling double deep Q networks multi-step learning algorithm is proposed to tackle the complex and coupling decision-making problem.Finally,simulation results show that the proposed scheme can significantly improve the anti-jamming communication performance of the mobile user. | Zhifeng Hou Jin Chen Yuzhen Huang Yijie Luo Ximing Wang Jiangchun Gu Yifan Xu Kailing Yao | 2022 | China Communications2022，19，5： | 4 |
| 6 | N-Type Mg_(3)Sb_(2-x)Bi_(x) Alloys as Promising Thermoelectric Materials显示文摘N-type Mg_(3)Sb_(2-x)Bi_(x) alloys have been extensively studied in recent years due to their significantly enhanced thermoelectric figure of merit(zT),thus promoting them as potential candidates for waste heat recovery and cooling applications.In this review,the effects resulting from alloying Mg_(3)Bi_(2) with Mg_(3)Sb_(2),including narrowed bandgap,decreased effective mass,and increased carrier mobility,are summarized.Subsequently,defect-controlled electrical properties in n-type Mg_(3)Sb_(2-x)Bi_(x) are revealed.On one hand,manipulation of intrinsic and extrinsic defects can achieve optimal carrier concentration.On the other hand,Mg vacancies dominate carrier-scattering mechanisms(ionized impurity scattering and grain boundary scattering).Both aspects are discussed for Mg_(3)Sb_(2-x)Bi_(x) thermoelectric materials.Finally,we review the present status of,and future outlook for,these materials in power generation and cooling applications. | Hongjing Shang Zhongxin Liang Congcong Xu Jun Mao Hongwei Gu Fazhu Ding Zhifeng Ren | 2020 | Research2020，，1： | 4 |
| 7 | Hyaluronic acid-based dual-responsive nanomicelles mediated mutually synergistic photothermal and molecular targeting therapies显示文摘Precise clinical treatment of triple-negative breast cancer(TNBC)is an obstacle in clinic.Nanotechnology-assisted photothermal therapy(PTT)is a superior treatment modality for TNBC in terms of precision.However,thermoresistance arising from PTT and insufficient drug release from nanocarriers decrease the efficacy of PTT.AT13387 is a novel HSP90 inhibitor that can weaken thermoresistance and undergoing clinic II phase study,showing satisfactory antitumour activity through molecularly targeted therapy(MTT).Whereas,it has poor solubility.Hence hyaluronic acid and stearic acid were connected by hydrazone bonds and disulfide bonds,forming an amphipathic copolymer that could self-assembled into nanomicelles,followed by encapsulating Cypate and AT13387.These nanomicelles exhibited great features,including achieving mutually synergistic PTT/MTT for overcoming thermoresistance and promoting translocation of drugs,increasing the solubility of Cypate and AT13387,showing a pH/redox dual response that contributes to drug release,and having the ability of active targeting.Thus,the nanomicelles developed in this study may be a promising strategy for the precise treatment of TNBC. | Liangliang Cai Ronghua Ni Xiaofei Ma Rongrong Huang Zhiyuan Tang Jinqiu Xu Yong Han Yuehua Guo Zhifeng Gu | 2022 | Nano Research2022，15，7： | 1 |
| 8 | Wnt/β-catenin signaling mediates the senescence of bone marrow-mesen- chymal stem cells from systemic lupus erythematosus pa- tients through the p53/p21 pathway 显示文摘 | Gu Zhifeng Tan Wei Feng Guijuan | 2014 | Mol Cell Bio-ehem2014，387，12： | 1 |
| 9 | Iodoform-mediated free radical emulsion polymerization of chloroprene显示文摘 | Gu Juming Fu Zhifeng Shi Yan | 2012 | Jour- nal of Applied Polymer Science2012，128，4： | 1 |
| 10 | Study on digital image watermark algorithm based on chaos mapping and DWT显示文摘 | Gu Zhifeng Li Guangfeng Yang Zongxiao | | 0，，： | 1 |
| 11 | Service Data Correlation Modeling and Its Application in Data-driven Service Composition 显示文摘 | Gu Zhifeng Xu Bin Li Juanzi | 2010 | IEEE Transaction on Services Computing2010，3，4： | 1 |
| 12 | Photoacoustic image-guided corpus cavernosum intratunical injection of adipose stem cell-derived exosomes loaded polydopamine thermosensitive hydrogel for erectile dysfunction treatment显示文摘Stem cell-derived exosomes(SC-EXO)was an emerging therapeutic agent in regenerative medicine.Intratunical injection of SC-EXO is considered as a prospective approach for erectile dysfunction(ED)treatment.However,high vascularization of cavernous body makes effective retention a major challenge for SC-EXO intratunical injection.In this study,a Polydopamine nanoparticles(PDNPs)incorporated poly(ethylene glycol)-poly(ε-caprolactone-co-lactide)(PDNPs-PELA)thermosensitive hydrogels were fabricated by a facile in situ polymerization for intratunical administration of adipose stem cell-derived exosomes(EXO).The hydrogels exhibited sol-gel transition at body temperature.Moreover,the in-situ polymerization of PDNPs using poly(ethylene glycol)-poly(ε-caprolactone-co-lactide)(PELA)block copolymer as a template was found to be more stable dispersion in the gel system.After being encapsulated into the hydrogel,EXO shows sustained release behavior within two weeks.In vivo animal experiments revealed that exosomes released from hydrogel lead to the healing of endothelial cells and neurons,increase of the cavity’s pressure,thereby restoring the erectile function.In particular,since the PDNPs in thermosensitive gels have excellent photoacoustic performance,the hydrogel can be accurately delivered into the tunica albuginea by the guidance of real-time photoacoustic imaging.These results suggest that the as-prepared PDNPs-PELA has a promising future as an injectable exosome carrier for ED treatment. | Li Liang Yi Shen Zhifeng Dong Xin Gu | 2022 | Bioactive Materials2022，7，3： | 0 |
| 13 | Polydopamine functionalized mesoporous silica as ROS-sensitive drug delivery vehicles for periodontitis treatment by modulating macrophage polarization显示文摘Periodontitis is recognized as the major cause of tooth loss in adults, posing an adverse impact on systemic health. In periodontitis, excessive production of reactive oxygen species (ROS) at the inflamed site culminates in periodontal destruction. In this study, a novel ROS-responsive drug delivery system based on polydopamine (PDA) functionalized mesoporous silica nanoparticles was developed for delivering minocycline hydrochloride (MH) to treat periodontitis. The outer PDA layer and the inner MH of the nanoparticles acted as ROS scavengers and anti-inflammatory agents, respectively. Under the synergistic action of PDA and MH, macrophages were polarized from the pro-inflammatory M1 to the anti-inflammatory M2 phenotype. The in vitro experiments provided convincing evidence that PDA could scavenge ROS effectively, and the expression of pro-inflammatory cytokines was attenuated and the secretion of anti-inflammatory cytokines was enhanced through M1 to M2 polarization of macrophages with the cooperation of MH. In addition, the results obtained from the periodontitis rat models demonstrated that the synergetic effect of PDA and MH prevented alveolar bone loss without causing any adverse effect. Taken together, the results from the present investigation provide a new strategy to remodel the inflammatory microenvironment by inducing the polarization of macrophages from M1 toward M2 state for the treatment of periodontitis. | Bingbing Bai Chaoyu Gu Xiaohui Lu Xingyu Ge Junling Yang Chenfei Wang Yongchun Gu Aidong Deng Yuehua Guo Xingmei Feng Zhifeng Gu | 2021 | Nano Research2021，14，12： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员