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| 1 | Association of miRNA-122-binding site polymorphism at the interleukin-1 a gene and its interaction with hepatitis B virus mutations with hepatocellular carcinoma risk显示文摘 | Yan Du Xue Han Rui Pu Jiaxin Xie Yuwei Zhang Guangwen Cao | 2014 | Frontiers of Medicine2014，8，2： | 9 |
| 2 | Single-cell RNA sequencing reveals B cell-T cell interactions in vascular adventitia of hyperhomocysteinemia-accelerated atherosclerosis显示文摘Dear Editor Cardiovascular disease(CVD)is the leading cause of death around the world(Truelsen,et al.,2015).Atherosclerosis,the dominant underlying cause of CVD,is a chronic inflam-matory disease characterized by lipid accumulation and immune cell infiltration in plaques and vessels(Weber,et al.,1950).The immune microenvironment is critical for the development of atherosclerosis.Homocysteine(Hcy)is an intermediate product of methionine metabolism,and its ele-vation in plasma(>15μmol/L),known as hyperhomocys-teinemia(HHcy),is an independent risk factor for atherosclerosis.HHcy is more common in Asia because of genetic factors and dietary habits(Huo,et al.,2015).folic acid supplement is one of the most important way to treat HHcy in clinic.Although HHcy potentiates atherosclerosis mainly through endothelial injury and inflammatory activa-tion(Luo,et al.,2016),a comprehensive understanding of the immune microenvironment and potential mechanisms in HHcy-accelerated atherosclerotic aortas(HHcy-AA)is still lacking. | Xiaolong Ma Jiacheng Deng Lulu Han Yuwei Song Yutong Miao Xing Du Guohui Dang Dongmin Yang Bitao Zhong Changtao Jiang Wei Kong Qingbo Xu Juan Feng Xian Wang | 2022 | Protein & Cell2022，13，7： | 2 |
| 3 | B cell-derived anti-beta 2 glycoprotein I antibody mediates hyperhomocysteinemia-aggravated hypertensive glomerular lesions by triggering ferroptosis显示文摘Hyperhomocysteinemia(HHcy)is a risk factor for chronic kidney diseases(CKDs)that affects about 85%CKD patients.HHcy stimulates B cells to secrete pathological antibodies,although it is unknown whether this pathway mediates kidney injury.In HHcytreated 2-kidney,1-clip(2K1C)hypertensive murine model,HHcy-activated B cells secreted anti-beta 2 glycoprotein I(β2GPI)antibodies that deposited in glomerular endothelial cells(GECs),exacerbating glomerulosclerosis and reducing renal function.Mechanistically,HHcy 2K1C mice increased phosphatidylethanolamine(PE)(18:0/20:4,18:0/22:6,16:0/20:4)in kidney tissue,as determined by lipidomics.GECs oxidative lipidomics validated the increase of oxidized phospholipids upon Hcy-activated B cells culture medium(Hcy-B CM)treatment,including PE(18:0/20:4+3[O],PE(18:0a/22:4+1[O],PE(18:0/22:4+2[O]and PE(18:0/22:4+3[O]).PE synthases ethanolamine kinase 2(etnk2)and ethanolamine-phosphate cytidylyltransferase 2(pcyt2)were increased in the kidney GECs of HHcy 2K1C mice and facilitated polyunsaturated PE synthesis to act as lipid peroxidation substrates.In HHcy 2K1C mice and Hcy-B CM-treated GECs,the oxidative environment induced by iron accumulation and the insufficient clearance of lipid peroxides caused by transferrin receptor(TFR)elevation and down-regulation of SLC7A11/glutathione peroxidase 4(GPX4)contributed to GECs ferroptosis of the kidneys.In vivo,pharmacological depletion of B cells or inhibition of ferroptosis mitigated the HHcy-aggravated hypertensive renal injury.Consequently,our findings uncovered a novel mechanism by which B cell-derived pathogenic anti-β2GPI IgG generated by HHcy exacerbated hypertensive kidney damage by inducing GECs ferroptosis.Targeting B cells or ferroptosis may be viable therapeutic strategies for ameliorating lipid peroxidative renal injury in HHcy patients with hypertensive nephropathy. | Xing Du Xiaolong Ma Ying Tan Fangyu Shao Chun Li Yang Zhao Yutong Miao Lulu Han Guohui Dang Yuwei Song Dongmin Yang Zhenling Deng Yue Wang Changtao Jiang Wei Kong Juan Feng Xian Wang | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 2 |
| 4 | HLA-DP Polymorphisms Affect the Outcomes of Chronic Hepatitis B Virus Infections, Possibly through Interacting with Viral Mutations显示文摘 | Qi Zhang Jianhua Yin Yuwei Zhang Yang Deng Xiaowei Ji Yan Du Rui Pu Yifang Han Jun Zhao Xue Han Hongwei Zhang Guangwen Cao | 2013 | Journal of Virology2013，，22： | 1 |
| 5 | Decolorization of acid orange 7 solution by gas–liquid gliding arc discharge plasma 显示文摘 | Du Changming Shi Taihong Sun Yuwei | 2008 | Journal of Hazardous Materials2008，154，13： | 1 |
| 6 | Decolofization of acid orange 7 solution by gas-liquid gliding arc discharge plasma 显示文摘 | DU Changming SHI Taihong SUN Yuwei | 2008 | Journal of Hazardous Materials2008，154，： | 1 |
| 7 | Decolorization of acid orange 7 solution by gas-liquid gliding arc discharge plasma 显示文摘 | Du Changming Shi Taihong Sun Yuwei | 2007 | Journal of Hazardous Materials2007，，13： | 1 |
| 8 | The decoupling relationship between China’s economic growth and carbon emissions from the perspective of industrial structure显示文摘This study analyses the decoupling relationship between energy-related CO_(2) emissions and economic growth in China from 2000-2017 from the perspective of industrial structure using the LMDI method and Tapio decoupling model.The decoupling driving force was decomposed into emission,energy intensity,industrial structure,economic activity,and population factors.Studies have shown that the restructuring of China’s industries has not led to a significant increase in CO_(2) emissions.Specifically,from 2000 to 2017,China’s economic development and carbon emissions are generally in a weak decoupling state.Strong decoupling occurred from 2000 to 2001 and from 2013 to 2016.The industrial structure change has a substantial impact on the primary sector(agriculture),followed by the tertiary sector(services),while the impact on the secondary sector(industry)is negligible.The GDP contribution of the primary industry is small,but it is an indispensable guarantee for a country.With the development of agricultural mechanization and technology,human and animal power in this industry has been decreasing year by year,and large-scale planting has improved energy efficiency.The level of technology should be continuously strengthened to promote the decoupling of carbon emissions.The contribution of the secondary industry to GDP is around 40%,but the secondary industry accounts for more than 80%of CO_(2) emissions,mainly caused by the use of fossil energy.In 2017,fossil energy still accounted for about 86.2%of China’s energy consumption,so fossil energy remains the most critical energy source for China’s economic development.Coal,in turn,accounts for the largest share of fossil energy consumption.Therefore,emphasis should be placed on increasing technological innovation and conversion from fossil to non-fossil energy sources.The Chinese government considers the service industry a new engine for sustainable social and economic development.The contribution of the tertiary sector to GDP has increased from 2000 to 2017,followed by resource and environmental problems.Although the current share of CO_(2) emissions directly caused by the tertiary sector is not high,as the tertiary sector continues to grow,plans to reduce the decoupling of carbon emissions from the tertiary sector should be made in advance. | Yuwei Du Yunxi Liu Md.Afzal Hossain Songsheng Chen | 2022 | Chinese Journal of Population,Resources and Environment2022，20，1： | 1 |
| 9 | EGFR signaling promotes nuclear translocation of plasma membrane protein TSPAN8 to enhance tumor progression via STAT3-mediated transcription显示文摘TSPAN family of protei ns are gen erally con sidered to assemble as multimeric complexes on the plasma membra ne.Our previous work uncovered that TSPAN8 can translocate into the nucleus as a membrane-free form,a process that requires TSPAN8 palmitoylation and association with cholesterol to promote its extraction from the plasma membrane and subsequent binding with 14-3-30 and importin-p.However,what upstream signal(S)regulate(s)the nuclear translocation of TSPAN8,the potential function of TSPAN8 in the n ucleus,and the un derlying molecular mechanisms all remai n unclear.Here,we dem on strate that,epidermal growth factor receptor(EGFR)signaling induces TSPAN8 nuclear translocation by activating the kinase AKTZ which in turn directly phosphorylates TSPAN8 at Ser129,an event essential for its binding with 14-3-30 and importin B1.In the nucleus,phosphorylated TSPAN8 interacts with STAT3 to enhance its chromatin occupancy and therefore regulates transcription of downstream cancer-promoting genes,such as MYC,BCL2,MMP9,etc.The EGFR-AKT-TSPAN8-STAT3 axis was found to be hyperactivated in multiple human cancers,and associated with aggressive phe no type and dismal prog nosis.We further developed a humanized mono clonal antibody hT8Ab4 that specifically recognizes the large extracellular loop of TSPAN8(TSPAN8-LEL),thus being able to block the extract!on of TSPAN8 from the plasma membrane and consequently its nuclear localization.Importantly,both in vitro and in vivo studies demonstrated an antitumor effect of hT8Ab4.Collectively,we discovered an unconventional function of TSPAN8 and dissected the underlying molecular mechanisms,which not only showcase a new layer of biological complexity of traditional membrane proteins,but also shed light on TSPAN8 as a novel therapeutic target for refractory cancers. | Xiaoqing Lu Liwei An Guangjian Fan Lijuan Zang Weiyi Huang Junjian Li Jun Liu Weiyu Ge Yuwei Huang Jingxuan Xu Shaoqian Du Tianhao Zhou Huijing Yin Li Yu Shi Jiao Hongxia Wang | 2022 | Cell Research2022，32，4： | 1 |
| 10 | Application of immersed boundary method in turbomachines显示文摘Simulating unsteady turbulent flow in turbomachines is still challenging due to the complexity of blade geometry and relative motion between rotor and stator.This study presents an Immersed Boundary Method(IBM)for high-Reynolds turbomachinery internal flows,and shows the advantage of the automatic grid generation techniques and flexible moving boundary treatments.The wall functions are used in the present method to alleviate the wall resolution restriction of turbulence simulation.The Two-Dimensional(2-D)IBM solver,which was previously developed and tested for a low-speed compressor,is further validated for a well-documented Low-Pressure Turbine(LPT)cascade.Both the blade loading and the total pressure losses in the wake are well captured by the present 2-D solver.The complex Three-Dimensional(3-D)effects in turbomachines motivate the further development of an extended 3-D IBM solver by using a curvilinear-coordinate system that facilitates the hub and casing boundary treatment.The good performance of the 3-D solver is demonstrated through comparison with CFX solver solutions for the rotor configuration of Advanced Noise Control Fan(ANCF).Further effects of the grid resolution on capturing the blade wake are discussed.The results indicate that the present 3-D solver is capable of reproducing the evolution of the blade wake with suitable computational grid. | Congcong CHEN Yuwei WANG Zhuo WANG Lin DU Xiaofeng SUN | 2023 | Chinese Journal of Aeronautics2023，36，5： | 1 |
| 11 | Relationship Between Learning and Memory Deficits and Arp2 Expression in the Hippocampus in Rats with Traumatic Brain Injury显示文摘 | Xuewei Xia Yuwei Dong Yiqing Du Yongdong Yang Wenbo Wang Yong Li | 2012 | World Neurosurgery2012，，6： | 1 |
| 12 | The Research Progress and Development Trend of Carbon Accounting:An Analysis Based on CiteSpace显示文摘In this study,we analyzed the carbon accounting literature from 2015 to 2020 included in the Web of Science database to determine the current research status,hotspots,and trends of carbon accounting.CiteSpace visual analysis software and bibliometric method were used to analyze major countries,journals,research institutions,authors,keywords,and annual publication volume related to carbon accounting research.The results show that in recent years,the number of published papers has been increasing in recent years,and several major research institutions have been formed,such as the Chinese Academy of Sciences,the University of Leeds,and the Beijing Institute of Technology.Geoffrey P.Hammond,Paul W.Griffin,Connor C.Turvey,Jiahui Hong,et al.are the main contributors to carbon accounting publications.However,there is still a lack of cooperation between scholars and institutions.Currently,research on carbon accounting focuses on climate change,carbon emissions,and carbon footprints.This research will provide carbon accounting researchers and practitioners with the latest information on the current research status,hotspots,and trends in the field of carbon accounting research. | Yuwei Du Songsheng Chen Luyao Tang | 2021 | China-USA Business Review2021，20，4： | 0 |
| 13 | Whole lifecycle observation of single‐spore germinated Streptomyces using a nanogap‐stabilized microfluidic chip显示文摘Streptomyces is a model bacterium to study multicellular differentiation and the major reservoir for antibiotics discovery.However,the cellular‐level lifecycle of Streptomyces has not been well studied due to its complexity and lack of research tools that can mimic their natural conditions.In this study,we developed a simple microfluidic chip for the cultivation and observation of the entire lifecycle of Streptomyces development from the single‐cell perspective.The chip consists of channels for loading samples and supplying nutrients,microwell arrays for the seeding and growth of single spores,and air chambers beside the microwells that facilitate the development of aerial hyphae and spores.A unique feature of this chip is that each microwell is surrounded by a 1.5µm nanogap connected to an air chamber,which provides a stabilized water–air interface.We used this chip to observe the lifecycle development of Streptomyces coelicolor and Streptomyces griseus germinated from single spores,which revealed differentiation of aerial hyphae with progeny spores at micron‐scale water–air interfaces and air chambers.Finally,we demonstrated the applicability of this chip in phenotypic assays by showing that the microbial hormone A‐Factor is involved in the regulatory pathways of aerial hyphae and spore formation.The microfluidic chip could become a robust tool for studying multicellular differentiation,single‐spore heterogeneity,and secondary metabolism of single‐spore germinated Streptomyces. | Dongwei Chen Mengyue Nie Wei Tang Yuwei Zhang Jian Wang Ying Lan Yihua Chen Wenbin Du | 2022 | mLife2022，1，3： | 0 |
| 14 | A novel protein complex that regulates active DNA demethylation in Arabidopsis显示文摘Active DNA demethylation is critical for altering DNA methylation patterns and regulating gene expression.The 5-methylcytosine DNA glycosylase/lyase ROS1 initiates a base-excision repair pathway for active DNA demethylation and is required for the prevention of DNA hypermethylation at 1000 s of genomic regions in Arabidopsis.How ROS1 is regulated and targeted to specific genomic regions is not well understood.Here,we report the discovery of an Arabidopsis protein complex that contains ROS1,regulates ROS1 gene expression,and likely targets the ROS1 protein to specific genomic regions.ROS1 physically interacts with a WD40 domain protein(RWD40),which in turn interacts with a methyl-DNA binding protein(RMB1)as well as with a zinc finger and homeobox domain protein(RHD1).RMB1 binds to DNA that is methylated in any sequence context,and this binding is necessary for its function in vivo.Loss-of-function mutations in RWD40,RMB1,or RHD1 cause DNA hypermethylation at several tested genomic regions independently of the known ROS1 regulator IDM1.Because the hypermethylated genomic regions include the DNA methylation monitoring sequence in the ROS1 promoter,plants mutated in RWD40,RMB1,or RHD1 show increased ROS1 expression.Importantly,ROS1 binding to the ROS1 promoter requires RWD40,RMB1,and RHD1,suggesting that this complex dictates ROS1 targeting to this locus.Our results demonstrate that ROS1 forms a protein complex with RWD40,RMB1,and RHD1,and that this novel complex regulates active DNA demethylation at several endogenous loci in Arabidopsis. | Pan Liu Wen-Feng Nie Xiansong Xiong Yuhua Wang Yuwei Jiang Pei Huang Xueqiang Lin Guochen Qin Huan Huang Qingfeng Niu Jiamu Du Zhaobo Lang Rosa Lozano-Duran Jian-Kang Zhu | 2021 | Journal of Integrative Plant Biology2021，63，4： | 0 |
| 15 | Low Carbon Beijing:Research on the Influencing Factors of Carbon Emission Trading Price显示文摘The international community has taken extensive actions to achieve carbon neutrality and sustainable development with the intensification of global warming and climate change.China has also carried out a long-term layout,setting the goal of achieving a carbon peak by 2030 and carbon neutrality by 2060.In 2021,with the official launch of a unified national carbon emissions trading market,China’s nationwide carbon emissions trading kicked off.Carbon emission trading is an important policy tool for China’s carbon peak and carbon-neutral action and an essential part of the country’s promotion of a comprehensive green transformation of the economy and society.This study uses a VAR(Vector Autoregressive)model to analyze the influencing factors of the Beijing carbon emissions trading price from January 2014 to December 2019.The study found that coal prices have the most significant impact on Beijing’s carbon emissions trading prices.Oil prices,industrial development indexes,and AQI(Air Quality Index)impacted Beijing’s carbon emissions trading prices.In contrast,natural gas prices and economic indexes have the most negligible impact.These findings will help decision-makers determine a reasonable price for carbon emissions trading and contribute to the market’s healthy development. | Yuwei Du Songsheng Chen | 2021 | Journal of Environmental Science and Engineering(A)2021，10，4： | 0 |
| 16 | Photo-induced Ag modulating carbon dots:Greatly improved fluorescent properties and derived sensing application显示文摘Carbon dots(CDs)have been attracted much attention and widely studied due to their excellent fluorescence(FL)properties,better biocompatibility and outstanding photo/chemical stability.However,the disadvantage of lower quantum yield(QY)still limits its wide application.Herein,we reported a novel and convenient strategy to prepare photo-induced Ag/CDs(p-Ag/CDs)by irradiating the mixed Ag+and hydrophobic CDs(h-CDs)acetone solution with ultraviolet(UV)light.The obtained p-Ag/CDs exhibit a greatly enhanced FL emission together with a blue shift(460 nm)than h-CDs(520 nm).The QY of p-Ag/CDs is measured to be 51.1%,which is 10.4 times higher than that of h-CDs(4.9%),indicating that photo-induced Ag modulation can effectively improve the optical properties of CDs.The mechanisms for the FL enhancement and blue shift of h-CDs are studied in detail.The results prove that the greatly enhanced FL emission is from the generated Ag nanoparticles(AgNPs)by UV light irradiation based on metal-enhanced fluorescence(MEF),and the increased oxygen-contained groups in this process lead to the blue shift in CDs fluorescence.Interestingly,the p-Ag/CDs exhibit higher sensitivity and selectivity for sulfide ions(S2-)detection than that of h-CDs,which have a lower response to S2-.This work not only offers a novel strategy to improve the FL properties of materials but also endows them with new functions and broadens their application fields. | Yuwei Wang Ye Li Guixiang Yang Xiaofeng Yang Chenglu Yan Huaqiao Peng Huiyong Wang Juan Du Baozhan Zheng Yong Guo | 2024 | Chinese Chemical Letters2024，35，1： | 0 |
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