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| 1 | Identification and primary genetic analysis of Arabidopsis stomatal mutants in response to multiple stresses显示文摘In response to variable environmental conditions, guard cells located in the leaf epidermis can integrate and cope with a multitude of complicated stimuli, thereby making stomata in an appro- priate state. However, many signaling components in guard cell signaling remain elusive. In our laboratory, a tool for non-invasive remote infrared thermal images was used to screen an ethyl methane sulfonate-mutagenized population for Arabidopsis stomatal response mutants under multiple stresses (ABA, H2O2, CO2, etc.). More than forty 'hot' or 'cold' mutants were isolated (above or below 0.5℃ in con- trast to normal plantlets). Identification and primary genetic analysis of these mutants show that they are monogenic recessive mutations and there exist distinct difference in stomata apertures compared to wild type. These mutants in response to various environmental stresses and hormones were comprehen- sively investigated, which enables us to further un- derstand the cross-talk in different signal transduction pathways. | SONG Yuwei KANG Yanli LIU Hao ZHAO Xiaoliang WANG Pengtao AN Guoyong ZHOU Yun MIAO Chen SONG Chunpeng | 2006 | Chinese Science Bulletin2006，51，21： | 11 |
| 2 | Suppression of MAPK11 or HIPK3 reduces mutant Huntingtin levels in Huntington's disease models显示文摘 | Meng Yu Yuhua Fu Yijian Liang Haikun Song Yao Yao Peng Wu Yuwei Yao Yuyin Pan Xue Wen Lixiang Ma Saiyin Hexige Yu Ding Shouqing Luo Boxun Lu | 2017 | Cell Research2017，27，12： | 5 |
| 3 | Microstructural evolution and tensile properties of low-carbon steel with martensitic microstructure during warm deforming and annealing显示文摘For preparing large-scale nano-grained and ultrafine-grained steel sheets by warm rolling and annealing,the effects of de- forming temperature on both the flow stress and the microstructure evolution of 09MnNiD steel with lath martensitic microstructure were studied by warm-compression test and transmission electron microscopy(TEM)observation.Thereafter,the steel with the lath martensitic structure was multi-pass warm-rolled and then annealed.TEM results indicate that nano-grained and ultrafine-grained steel sheets are formed by warm rolling at 400℃and annealing at 400-600℃.In comparison with the as-warm-rolled specimen,the tensile strength at room temperature changes a little when the rolled samples are annealed below 450℃,and the tensile strength is greatly lowered as the annealing temperature increases to above 550℃. | Yuwei Gao Tianfu Jing Guiying Qiao Jinku Yu Tiansheng Wang Qun Li Xinyu Song Shuqiang Wang Hong Gao | 2008 | Journal of University of Science and Technology Beijing2008，15，3： | 4 |
| 4 | SARS-CoV-2 ORF10 suppresses the antiviral innate immune response by degrading MAVS through mitophagy显示文摘The global coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has caused severe morbidity and mortality in humans.It is urgent to understand the function of viral genes.However,the function of open reading frame 10(ORF10),which is uniquely expressed by SARS-CoV-2,remains unclear.In this study,we showed that overexpression of ORF10 markedly suppressed the expression of type I interferon(IFN-I)genes and IFN-stimulated genes.Then,mitochondrial antiviral signaling protein(MAVS)was identified as the target via which ORF10 suppresses the IFN-I signaling pathway,and MAVS was found to be degraded through the ORF10-induced autophagy pathway.Furthermore,overexpression of ORF10 promoted the accumulation of LC3 in mitochondria and induced mitophagy.Mechanistically,ORF10 was translocated to mitochondria by interacting with the mitophagy receptor Nip3-like protein X(NIX)and induced mitophagy through its interaction with both NIX and LC3B.Moreover,knockdown of NIX expression blocked mitophagy activation,MAVS degradation,and IFN-I signaling pathway inhibition by ORF10.Consistent with our observations,in the context of SARS-CoV-2 infection,ORF10 inhibited MAVS expression and facilitated viral replication.In brief,our results reveal a novel mechanism by which SARS-CoV-2 inhibits the innate immune response;that is,ORF10 induces mitophagy-mediated MAVS degradation by binding to NIX. | Xingyu Li Peili Hou Wenqing Ma Xuefeng Wang Hongmei Wang Zhangping Yu Huasong Chang Tiecheng Wang Song Jin Xue Wang Wenqi Wang Yudong Zhao Yong Zhao Chunqing Xu Xiaomei Ma Yuwei Gao Hongbin He | 2022 | Cellular & Molecular Immunology2022，19，1： | 4 |
| 5 | Water permeability in MXene membranes: Process matters显示文摘Recent studies have shown impressive transport behaviors of water and ions within lamellar MXene membranes,which endows great promise in developing advanced separation application based high performance MXene membranes.However,most of the researches focused on modification of MXene nanoflakes and optimizing interlayer distance,leaving the impact of membrane fabrication process marginal.In this work,we studied the water flux of membranes made by vacuum filtration using delaminated MXene nanoflakes as the building-blocks.Our results show that the water permeability is extremely sensitive to the process,especially at the drying process,loading and deposit rate of nanoflakes(the feeding concentration).We find that the voids from less ordered stack rather than in-plane defects and interlayer galleries contribute to the large water permeability.The voids can be effectively avoided via deposition of MXene nanoflakes at a slow rate.Manipulating the stack of MXene nanoflakes during vacuum filtration and drying are critical for development of MXene membranes with desired performance for water permeation. | Hang Zhou Yuwei Wang Fuqiang Wang Hao Deng Yongchen Song Changping Li Zheng Ling | 2020 | Chinese Chemical Letters2020，31，6： | 3 |
| 6 | Low-Complexity Channel Reconstruction Methods Based on SVD-ZF Precoding in Massive 3D-MIMO Systems显示文摘In this paper, we study the low-complexity channel reconstruction methods for downlink precoding in massive multiple-Input multiple-Output(MIMO) systems. When the user is allocated less streams than the number of its antennas, the base station(BS) or user usually utilizes the singular value decomposition(SVD) to get the effective channels, whose dimension is equal to the number of streams. This process is called channel reconstruction and done in BS for time division duplex(TDD) mode. However, with the increasing of antennas in BS, the computation burden of SVD is getting incredible. Here, we propose a series of novel low-complexity channel reconstruction methods for downlink precoding in 3D spatial channel model. We consider different correlations between elevation and azimuth antennas, and divide the large dimensional matrix SVD into two kinds of small-size matrix SVD. The simulation results show that the proposed methods only produce less than 10% float computation than the traditional SVD zero-forcing(SVD-ZF) precoding method, while keeping nearly the same performance of 1Gbps. | REN Yuwei SONG Yang SU Xin | 2015 | China Communications2015，12，S1： | 2 |
| 7 | Single-cell RNA sequencing reveals B cell-T cell interactions in vascular adventitia of hyperhomocysteinemia-accelerated atherosclerosis显示文摘Dear Editor Cardiovascular disease(CVD)is the leading cause of death around the world(Truelsen,et al.,2015).Atherosclerosis,the dominant underlying cause of CVD,is a chronic inflam-matory disease characterized by lipid accumulation and immune cell infiltration in plaques and vessels(Weber,et al.,1950).The immune microenvironment is critical for the development of atherosclerosis.Homocysteine(Hcy)is an intermediate product of methionine metabolism,and its ele-vation in plasma(>15μmol/L),known as hyperhomocys-teinemia(HHcy),is an independent risk factor for atherosclerosis.HHcy is more common in Asia because of genetic factors and dietary habits(Huo,et al.,2015).folic acid supplement is one of the most important way to treat HHcy in clinic.Although HHcy potentiates atherosclerosis mainly through endothelial injury and inflammatory activa-tion(Luo,et al.,2016),a comprehensive understanding of the immune microenvironment and potential mechanisms in HHcy-accelerated atherosclerotic aortas(HHcy-AA)is still lacking. | Xiaolong Ma Jiacheng Deng Lulu Han Yuwei Song Yutong Miao Xing Du Guohui Dang Dongmin Yang Bitao Zhong Changtao Jiang Wei Kong Qingbo Xu Juan Feng Xian Wang | 2022 | Protein & Cell2022，13，7： | 2 |
| 8 | Experimental repetitive quantum channel simulation显示文摘Universal control of quantum systems is a major goal to be achieved for quantum information processing,which demands thorough understanding of fundamental quantum mechanics and promises applications of quantum technologies. So far, most studies concentrate on ideally isolated quantum systems governed by unitary evolutions, while practical quantum systems are open and described by quantum channels due to their inevitable coupling to environment. Here, we experimentally simulate arbitrary quantum channels for an open quantum system, i.e. a single photonic qubit in a superconducting quantum circuit.The arbitrary channel simulation is achieved with minimum resource of only one ancilla qubit and measurement-based adaptive control. By repetitively implementing the quantum channel simulation,we realize an arbitrary Liouvillian for a continuous evolution of an open quantum system for the first time. Our experiment provides not only a testbed for understanding quantum noise and decoherence,but also a powerful tool for full control of practical open quantum systems. | Ling Hu Xianghao Mu Weizhou Cai Yuwei Ma Yuan Xu Haiyan Wang Yipu Song Chang-Ling Zou Luyan Sun | 2018 | Science Bulletin2018，63，23： | 2 |
| 9 | B cell-derived anti-beta 2 glycoprotein I antibody mediates hyperhomocysteinemia-aggravated hypertensive glomerular lesions by triggering ferroptosis显示文摘Hyperhomocysteinemia(HHcy)is a risk factor for chronic kidney diseases(CKDs)that affects about 85%CKD patients.HHcy stimulates B cells to secrete pathological antibodies,although it is unknown whether this pathway mediates kidney injury.In HHcytreated 2-kidney,1-clip(2K1C)hypertensive murine model,HHcy-activated B cells secreted anti-beta 2 glycoprotein I(β2GPI)antibodies that deposited in glomerular endothelial cells(GECs),exacerbating glomerulosclerosis and reducing renal function.Mechanistically,HHcy 2K1C mice increased phosphatidylethanolamine(PE)(18:0/20:4,18:0/22:6,16:0/20:4)in kidney tissue,as determined by lipidomics.GECs oxidative lipidomics validated the increase of oxidized phospholipids upon Hcy-activated B cells culture medium(Hcy-B CM)treatment,including PE(18:0/20:4+3[O],PE(18:0a/22:4+1[O],PE(18:0/22:4+2[O]and PE(18:0/22:4+3[O]).PE synthases ethanolamine kinase 2(etnk2)and ethanolamine-phosphate cytidylyltransferase 2(pcyt2)were increased in the kidney GECs of HHcy 2K1C mice and facilitated polyunsaturated PE synthesis to act as lipid peroxidation substrates.In HHcy 2K1C mice and Hcy-B CM-treated GECs,the oxidative environment induced by iron accumulation and the insufficient clearance of lipid peroxides caused by transferrin receptor(TFR)elevation and down-regulation of SLC7A11/glutathione peroxidase 4(GPX4)contributed to GECs ferroptosis of the kidneys.In vivo,pharmacological depletion of B cells or inhibition of ferroptosis mitigated the HHcy-aggravated hypertensive renal injury.Consequently,our findings uncovered a novel mechanism by which B cell-derived pathogenic anti-β2GPI IgG generated by HHcy exacerbated hypertensive kidney damage by inducing GECs ferroptosis.Targeting B cells or ferroptosis may be viable therapeutic strategies for ameliorating lipid peroxidative renal injury in HHcy patients with hypertensive nephropathy. | Xing Du Xiaolong Ma Ying Tan Fangyu Shao Chun Li Yang Zhao Yutong Miao Lulu Han Guohui Dang Yuwei Song Dongmin Yang Zhenling Deng Yue Wang Changtao Jiang Wei Kong Juan Feng Xian Wang | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 2 |
| 10 | Clinical characteristics and risk factors for mortality in cancer patients with COVID-19显示文摘Patients with cancer are at increased risk of severe infections.From a cohort including 3060 patients with confirmed COVID-19,109(3.4%)cancer patients were included in this study.Among them,23(21.1%)patients died in the hospital.Cancer patients,especially those with hematological malignancies(41.6%),urinary carcinoma(35.7%),malignancies of the digestive system(33.3%),gynecological malignancies(20%),and lung cancer(14.3%),had a much higher mortality than patients without cancer.A total of 19(17.4%)cancer patients were infected in the hospital.The clinical characteristics of deceased cancer patients were compared with those of recovered cancer patients.Multivariate Cox regression analysis indicated that a Nutritional Risk Screening(NRS2002)score≥3(adjusted hazard ratio(HR)11.00;95%confidence interval(CI)4.60–26.32;P<0.001),high-risk type(adjusted HR 18.81;95%CI 4.21–83.93;P<0.001),tumor stage IV(adjusted HR 4.26;95%CI 2.34–7.75;P<0.001),and recent adjuvant therapy(<1 month)(adjusted HR 3.16;95%CI 1.75–5.70;P<0.01)were independent risk factors for in-hospital death after adjusting for age,comorbidities,D-dimer,and lymphocyte count.In conclusion,cancer patients showed a higher risk of COVID-19 infection with a poorer prognosis than patients without cancer.Cancer patients with high-risk tumor,NRS2002 score≥3,advanced tumor stage,and recent adjuvant therapy(<1 month)may have high risk of mortality. | Junnan Liang Guannan Jin Tongtong Liu Jingyuan Wen Ganxun Li Lin Chen Wei Wang Yuwei Wang Wei Liao Jia Song Zeyang Ding Xiao-ping Chen Bixiang Zhang | 2021 | Frontiers of Medicine2021，15，2： | 2 |
| 11 | Synergistic in-situ growth of silver nanoparticles with nanozyme activity for dual-mode biosensing and cancer theranostics显示文摘A multifunctional nanocomposite of AgNPs@GQDs is prepared by synergistic in-situ growth of silver nanoparticles(AgNPs)on the complex of tannic acid(TA)and graphene quantum dots(GQDs)for the construction of dual-mode biosensing platform and cancer theranostics.The nanocomposite exhibits a hydrogen peroxide(H_(2)O_(2))-responsive degradation,in which Ag^(0)is oxidized to Ag^(+)along with the release of oxidized TA and GQDs.The degradation induces the decreased absorbance and enhanced fluorescence(FL)intensity due to the suppression of Forster resonance ene rgy transfer(FRET)in AgNPs@GQDs,which is employed for colorimetric/fluorescence dual-mode sensing of H_(2)O_(2).The intrinsic peroxidase-like activity of GQDs nanozyme can effectively catalyze the oxidation reaction,enhancing the detection sensitivity significantly.Based on the generation of H_(2)O_(2)from the oxidation of glucose with the catalysis of glucose oxidase(GOx),this nanoprobe is versatilely used for the determination of glucose in human serum.Further,through combining the H_(2)O_(2)-responsive degradation of AgNPs@GQDs with high H_(2)O_(2)level in cancer cells,the nanocomposites exhibit good performance in cancer cell recognition and therapy,in which the synergistic anticancer effect of Ag^(+)and oxidized TA contribute to effective cell death,and the liberated GQDs are used to monitor the therapeutic effect by cell imaging. | Xin Hai Yuwei Li Kaixin Yu Shuzhen Yue Yuanfang Li Weiling Song Sai Bi Xueji Zhang | 2021 | Chinese Chemical Letters2021，32，3： | 1 |
| 12 | Electrical conductivity and electromagnetic interference shielding characteristics of multiwalled carbon nanotube filled polyacrylate composite films显示文摘 | Yong Li Changxin Chen Song Zhang Yuwei Ni Jie Huang | 2008 | Applied Surface Science2008，，18： | 1 |
| 13 | Recent progress on single-molecule nanocatalysis based on single-molecule fluorescence microscopy显示文摘Understanding the heterogeneous catalytic properties of nanoparticles is of great significance for the development of high efficient nanocatalysts, but the intrinsic heterogeneities of nanocatalysts were always covered in traditional ensemble studies. This issue can be overcome if one can follow the catalysis of individual nanoparticles in real time. This paper mainly summarizes recent developments in singlemolecule nanocatalysis at single particle level in Changchun Institute of Applied Chemistry, Chinese Academy of Sciences. These developments include the revealing of catalytic kinetics of different types(plane & edge) of surface atoms on individual Pd nanocubes, the observing of in situ deactivation of individual carbon-supported Pt nanoparticles during the electrocatalytic hydrogen-oxidation reaction, and the measurement of catalytic activation energies on single nanocatalysts for both product formation process and dissociation process, etc. These studies further indicate the advantages or unique abilities of single-molecule methods in the studies of nanocatalysis or even chemical reactions. | Yuwei Zhang Tao Chen Ping Song Weilin Xu | 2017 | Science Bulletin2017，62，4： | 1 |
| 14 | Big Data Based Mobile Terminal Performance Evaluation 显示文摘 | SONG CHUNTAO JIA YUWEI | 2015 | ICSINC2015，2015，12： | 1 |
| 15 | Generation of the genetic mutant population for the screening and characterization of the mutants in response to drought in maize显示文摘The autonomous Mutator(Mu)transposon in maize(Zea mays L.)lines 115F,330I,and 715D were crossed with inbred lines B73,Mo17,97108,and H9-21,M1were self-pollinated to establish the Mu insertion-mutagenized M2seeds pool and The M2plants encompassed a large amount of biological variation relevant to improving agronomy traits by observed in the field.Next we statistically analyzed these candidate mutants.Under drought stress,we screened seedlings at 3-leaf stage by using the infrared thermography,and successfully got 108 droughtinsensitive and 121 drought-sensitive candidate mutants from more than 38,000 lines,which temperature were significant different with others.These candidate mutants were primarily analyzed by infrared thermography,chlorophyll fluorescence,leaf water losing,photosynthetic characteristics,content of soluble sugars,soluble protein,and proline assay.The selected mutants were cloned by MuTAIL–PCR methods.Here we provide the better genetic materials for research on maize breeding for drought tolerance. | Zhiyong Gao Hao Liu Hongliang Wang Ning Li Daojie Wang Yuwei Song Yuchen Miao Chunpeng Song | 2014 | Chinese Science Bulletin2014，59，8： | 1 |
| 16 | Adsorption and desorption mechanisms on graphene oxide nanosheets: Kinetics and tuning显示文摘A knowledge of the adsorption and desorption behavior of sorbates on surface adsorptive site(SAS)is the key to optimizing the chemical reactivity of catalysts.However,direct identification of the chemical reactivity of SASs is still a challenge due to the limitations of characterization techniques.Here,we present a new pathway to determine the kinetics of adsorption/desorption on SASs of graphene oxide(GO)based on total internal reflectance fluorescence microscopy.The switching on and off of the fluorescent signal of SAS lit by carbon dots(CDs)was used to trace the adsorption process and desorption process.We find that sodium pyrophosphate(PPi)could increase the adsorption equilibrium of CDs thermodynamically and promote the substrate-assisted desorption pathway kinetically.At the single turnover level,it was disclosed that the species that can promote desorption may also be an adsorption promoter.Such discovery provides significant guidance for improving the chemical reactivity of the heterogeneous catalyst. | Xiaodan Qu Qiong Hu Zhongqian Song Zhonghui Sun Baohua Zhang Jialing Zhong Xuyou Cao Yuanjin Liu Bolin Zhao Zhenbang Liu Yujie Shen Yu Bao Zhenxin Wang Yuwei Zhang Li Niu | 2021 | The Innovation2021，2，3： | 0 |
| 17 | Spatial effect and resonance energy transfer for the construction of carbon dots composites with long-lived multicolor afterglow for advanced anticounterfeiting显示文摘Carbon dots(CDs)with room-temperature phosphorescence(RTP)have attracted dramatically growing interest in optical functional materials.However,the photoluminescence mechanism of CDs is still a vital and challenging topic.In this work,we prepared CD-based RTP materials via melting boric acid with various lengths of alkyl amine compounds as precursors.The spatial effect on the structure and the RTP properties of CDs were systematically investigated.With the increase in carbon chain length,the interplanar spacing of the carbon core expands and crosslink-enhanced emission weakens,resulting in a decrease in the phosphorescence intensity and lifetimes.Meanwhile,based on triplet-to-singlet resonance energy transfer,we employed intense and long-lived phosphorescence CDs as the donor and short-lived fluorescent dyes as the acceptor to achieve long-lived multicolor afterglow.By the triplet-to-singlet resonance energy transfer,the afterglow color can change from green to orange.The afterglow lifetimes are more than 0.9 s.Thanks to the outstanding afterglow properties,the composites were used for timeresolved and multiple-color advanced anticounterfeiting.This work will promote the design of multicolor and long-lived afterglow materials and expand their applications. | Qian Cheng Zhiyuan Chen Lai Hu Yuwei Song Senqiang Zhu Rui Liu Hongjun Zhu | 2023 | Chinese Chemical Letters2023，34，8： | 0 |
| 18 | Catalyst-free reductions of nitriles to amino-boranes using sodium amidoborane and lithiumborohydride显示文摘An efficient and facile method to reduce nitriles to amine-boranes was developed.Aromatic and aliphatic nitriles were readily reduced in the presence of both sodium amidoborane(NaAB)and LiBH4 at room temperature in THF without catalysts,affording products in up to 99%yield.The products can be easily hydrolyzed to afford primary amines or utilized as reducing reagents for one-pot reductive amination.The key finding of the reaction study is the synergy effect between NaAB and LiBH4;otherwise the reaction yield would drop substantially from 92%to 22%or 12%when NaAB and LiBH4 are used separately. | Jiamin Peng Yuwei Song Yingying Wang Zhenxing Liu Xuenian Chen | 2022 | Organic Chemistry Frontiers2022，9，6： | 0 |
| 19 | xtraction of internal phase motions in femtosecond soliton molecules using an orbital-angular-momentum-resolved method显示文摘Internal motions in femtosecond soliton molecules provide insight into universal collective dynamics in various nonlinear systems.Here we introduce an orbital-angular-momentum(OAM)-resolved method that maps the relative phase motion within a femtosecond soliton molecule into the rotational movement of the interferometric beam profile of two optical vortices.By this means,long-term relative phase evolutions of doublet and triplet soliton molecules generated in an all-polarization-maintaining mode-locked Er-fiber laser are revealed.This simple and practical OAM-resolved method represents a promising way to directly visualize the complex phase dynamics in a diversity of multisoliton structures. | YUWEI ZHAO JNTAO FAN YOUJIAN SONG UWE MORGNER MINGLIE HU | 2020 | Photonics Research2020，8，10： | 0 |
| 20 | Transcriptomic but not genomic variability confers phenotype of breast cancer stem cells显示文摘Background:Breast cancer stem cells(BCSCs)are considered responsible for cancer relapse and drug resistance.Understanding the identity of BCSCs may open new avenues in breast cancer therapy.Although several discoveries have been made on BCSC characterization,the factors critical to the origination of BCSCs are largely unclear.This study aimed to determine whether genomic mutations contribute to the acquisition of cancer stem-like phenotype and to investigate the genetic and transcriptional features of BCSCs.Methods:We detected potential BCSC phenotype-associated mutation hotspot regions by using whole-genome sequencing on parental cancer cells and derived serial-generation spheres in increasing order of BCSC frequency,and then performed target deep DNA sequencing at bulk-cell and single-cell levels.To identify the transcriptional program associated with BCSCs,bulk-cell and single-cell RNA sequencing was performed.Results:By using whole-genome sequencing of bulk cells,potential BCSC phenotype-associated mutation hotspot regions were detected.Validation by target deep DNA sequencing,at both bulk-cell and single-cell levels,revealed no genetic changes specifically associated with BCSC phenotype.Moreover,single-cell RNA sequencing showed profound transcriptomic variability in cancer cells at the single-cell level that predicted BCSC features.Notably,this transcriptomic variability was enriched during the transcription of 74 genes,revealed as BCSC markers.Breast cancer patients with a high risk of relapse exhibited higher expression levels of these BCSC markers than those with a low risk of relapse,thereby highlighting the clinical significance of predicting breast cancer prognosis with these BCSC markers.Conclusions:Transcriptomic variability,not genetic mutations,distinguishes BCSCs from non-BCSCs.The identified 74 BCSC markers have the potential of becoming novel targets for breast cancer therapy. | Mengying Tong Ziqian Deng Mengying Yang Chang Xu Xiaolong Zhang Qingzheng Zhang Yuwei Liao Xiaodi Deng Dekang Lv Xuehong Zhang Yu Zhang Peiying Li Luyao Song Bicheng Wang Aisha Al-Dherasi Zhiguang Li Quentin Liu | 2018 | Cancer Communications2018，38，1： | 0 |
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