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| 1 | Oncogenic AURKA-enhanced N6-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells显示文摘RNase III DROSHA is upregulated in multiple cancers and contributes to tumor progression by hitherto unclear mechanisms.Here,we demonstrate that DROSHA interacts withβ-Catenin to transactivate STC1 in an RNA cleavage-independent manner,contributing to breast cancer stem-like cell(BCSC)properties.DROSHA mRNA stability is enhanced by N6-methyladenosine(m^(6)A)modification which is activated by AURKA in BCSCs.AURKA stabilizes METTL14 by inhibiting its ubiquitylation and degradation to promote DROSHA mRNA methylation.Moreover,binding of AURKA to DROSHA transcript further strengthens the binding of the m^(6)A reader IGF2BP2 to stabilize m^(6)A-modified DROSHA.In addition,wild-type DROSHA,but not an m^(6)A methylation-deficient mutant,enhances BCSC stemness maintenance,while inhibition of DROSHA m^(6)A modification attenuates BCSC traits.Our study unveils the AURKA-induced oncogenic m^(6)A modification as a key regulator of DROSHA in breast cancer and identifies a novel DROSHA transcriptional function in promoting the BCSC phenotype. | Fei Peng Jie Xu Bai Cui Qilan Liang Sai Zeng Bin He Hong Zou Manman Li Huan Zhao Yuting Meng Jin Chen Bing Liu Shasha Lv Peng Chu Fan An Zifeng Wang Junxiu Huang Yajing Zhan Yuwei Liao Jinxin Lu Lingzhi Xu Jin Zhang Zhaolin Su Zhiguang Li Fangjun Wang Eric W-FLam Quentin Liu | 2021 | Cell Research2021，31，3： | 9 |
| 2 | Quantitative evaluation of DNA damage caused by atmospheric and room-temperature plasma (ARTP) and other mutagenesis methods using a rapid umu-microplate test protocol for microbial mutation breeding显示文摘Mutagenesis is an important technique for microbial mutation breeding.As the source of mutations,DNA damage extent is a key indicator for the effectiveness of mutagenesis.Therefore,a rapid and easy DNA damage quantification method is required for the comparison of mutagenesis effects and development of mutagenesis tools.Here,we used the umu-microplate test system to quantitatively compare the DNA damage strength caused by atmospheric and room-temperature plasma(ARTP)and other traditional mutagenesis methods including:ultraviolet radiation(UV),diethyl sulfate(DES)and 4-nitroquinoline-1-oxide(4-NQO).The test strain of Salmonella typhimurium TA1535/pSK1002 was used to monitor the time-course profile of b-galactosidase activity induced by DNA damage caused by different mutagenesis methods using a microplate reader.The umu-microplate test results showed that ARTP caused higher extent of DNA damage than UV and chemical mutagens,which agrees well with the result obtained by SOS-FACS-based quantification method as reported previously.This umu-microplate test is accessible for broad researchers who are lack of the expensive FACS instruments and allows the quick quantitative evaluation of DNA damage among living cells for different mutagenesis methods in the study of the microbial mutation breeding. | Yuting Huang Liyang Wang Xue Zhang Nan Su Heping Li Yoshimitsu Oda Xinhui Xing | 2021 | Chinese Journal of Chemical Engineering2021，34，11： | 4 |
| 3 | Accelerated evolution of an Lhx2 enhancer shapes mammalian social hierarchies显示文摘Social hierarchies emerged during evolution,and social rank influences behavior and health of individuals.However,the evolutionary mechanisms of social hierarchy are still unknown in amniotes.Here we developed a new method and performed a genome-wide screening for identifying regions with accelerated evolution in the ancestral lineage of placental mammals,where mammalian social hierarchies might have initially evolved.Then functional analyses were conducted for the most accelerated region designated as placental-accelerated sequence 1(PAS1,P=3.15 × 10^-18).Multiple pieces of evidence show that PAS1 is an enhancer of the transcription factor gene Lhx2 involved in brain development.PAS1s isolated from various amniotes showed different c/s-regulatory activity in vitro,and affected the expression of Lhx2 differently in the nervous system of mouse embryos.PAS1 knock-out mice lack social stratification.PAS1 knock-in mouse models demonstrate that PAS1s determine the social dominance and subordinate of adult mice,and that social ranks could even be turned over by mutated PAS1.All homozygous mutant mice had normal huddled sleeping behavior,motor coordination and strength.Therefore,PAS1-Lhx2 modulates social hierarchies and is essential for establishing social stratification in amniotes,and positive Darwinian selection on PAS1 plays pivotal roles in the occurrence of mammalian social hierarchies. | Yuting Wang Guangyi Dai Zhili Gu Guopeng Liu Ke Tang Yi-Hsuan Pan Yujie Chen Xin Lin Nan Wu Haoshan Chen Su Feng Shou Qiu Hongduo Sun Qian Li Chuan Xu Yanan Mao Yong Edward Zhang Philipp Khaitovich Yan-Ling Wang Qunxiu Liu Jing-Dong Jackie Han Zhen Shao Gang Wei Chun Xu Naihe Jing Haipeng Li | 2020 | Cell Research2020，30，5： | 4 |
| 4 | Sandwiching Sulfur into the Dents Between N,O Co-Doped Graphene Layered Blocks with Strong Physicochemical Confinements for Stable and High-Rate Li-S Batteries显示文摘The development of lithium-sulfur batteries(LSBs)is restricted by their poor cycle stability and rate performance due to the low conductivity of sulfur and severe shuttle effect.Herein,an N,O co-doped graphene layered block(NOGB)with many dents on the graphene sheets is designed as effective sulfur host for high-performance LSB s.The sulfur platelets are physically confined into the dents and closely contacted with the graphene scaffold,ensuring structural stability and high conductivity.The highly doped N and O atoms can prevent the shuttle effect of sulfur species by strong chemical adsorption.Moreover,the micropores on the graphene sheets enable fast Li^+transport through the blocks.As a result,the obtained NOGB/S composite with 76 wt%sulfur content shows a high capacity of 1413 mAh g^-1 at 0.1 C,good rate performance of 433 mAh g^-1 at 10 C,and remarkable stability with 526 mAh g^-1 at after 1000 cycles at 1 C(average decay rate:0.038%per cycle).Our design provides a comprehensive route for simultaneously improving the conductivity,ion transport kinetics,and preventing the shuttle effect in LSBs. | Mengjiao Shi Su Zhang Yuting Jiang Zimu Jiang Longhai Zhang Jin Chang Tong Wei Zhuangjun Fan | 2020 | Nano-Micro Letters2020，12，11： | 3 |
| 5 | Decomposition Methods for Manufacturing System Scheduling:A Survey显示文摘Manufacturing is the application of labor, tools,machines, chemical and biological processing, to an original raw material by changing its physical and geometrical characteristics, in order to make finished products. Since the first industrial revolution, to accommodate the large-scale production,tremendous changes have happened to manufacturing through the innovations of technology, organization, management, transportation and communication. This work first reviews the highvolume low-mix process by focusing on the quantity production,transfer line and single model assembly line. Then, it reviews the high-volume high-mix process. For such a process type,mixed/multi model assembly line is usually adopted. Hence,two main decisions on them, i.e., balancing and, sequencing are reviewed. Thereafter, it discusses the low-volume high-mix process in detail. Then, technology gap and future work is discussed, and at last, conclusions are given. | Fajun Yang Kaizhou Gao Ian Ware Simon Yuting Zhu Rong Su | 2018 | IEEE/CAA Journal of Automatica Sinica2018，5，2： | 3 |
| 6 | Enhanced thermoelectric performance in Cl-doped BiSbSe_(3) with optimal carrier concentration and effective mass显示文摘Possessing inherently low thermal conductivity,BiSbSe_(3) is a promising thermoelectric material for medium temperature.Therefore,to substantially optimize the thermoelectric performance of BiSbSe_(3),researchers mainly focus on the strategies to improve its electrical transport properties.Among these strongly coupled thermoelectric parameters,carrier concentration and effective mass are two intrinsic variables to decisively affect the electrical transport properties.In this work,Cl as a donor dopant is effective to provide extra electrons in n-type BiSbSe_(3),and the carrier concentration and effective mass can be well optimized simultaneously with increasing Cl content owing to the multiple conduction bands in BiSbSe_(3).What’s more,maximum weighted mobility~53 cm^(2)V^(-1)s^(-1)is obtained in Cl-doped BiSbSe_(3),which contributes to a largely enhanced power factor~4.8μW cm^(-1)K^(-2)at room temperature and outperforms other halogen-doped BiSbSe_(3) samples.Finally,combining the significantly enhanced power factor and maintained low thermal conductivity,a maximum ZT~1.0 is achieved in Cl-doped BiSbSe_(3) at 800 K. | Sining Wang Lizhong Su Yuting Qiu Yu Xiao Li-Dong Zhao | 2021 | Journal of Materials Science & Technology2021，，11： | 2 |
| 7 | Model updating for real time dynamic substructures based on UKF algorithm显示文摘Combining the advantages of numerical simulation with experimental testing,real-time dynamic substructure(RTDS)testing provides a new experimental method for the investigation of engineered structures.However,not all unmodeled parts can be physically tested,as testing is often limited by the capacity of the test facility.Model updating is a good option to improve the modeling accuracy for numerical substructures in RTDS.In this study,a model updating method is introduced,which has great performance in describing this nonlinearity.In order to determine the optimal parameters in this model,an Unscented Kalman Filter(UKF)-based algorithm was applied to extract the knowledge contained in the sensors data.All the parameters that need to be identified are listed as the extended state variables,and the identification was achieved via the step-by-step state prediction and state update process.Effectiveness of the proposed method was verified through a group of experimental data,and results showed good agreement.Furthermore,the proposed method was compared with the Extended Kalman Filter(EKF)-based method,and better accuracy was easily found.The proposed parameter identification method has great applicability for structural objects with nonlinear behaviors and could be extended to research in other engineering fields. | Su Tingli Tang Zhenyun Peng Lingyun Bai Yuting Jin Xuebo Kong Jianlei | 2020 | Earthquake Engineering and Engineering Vibration2020，19，2： | 2 |
| 8 | Immobilization of heparin on decellularized kidney scaffold to construct microenvironment for antithrombosis and inducing reendothelialization显示文摘In recent years, rapid development of tissue engineering technology provides possibilities for the construction of artificial tissues or organs. In construction of engineered kidneys, researchers used native decellularized extracellular matrix(ECM) as the scaffolds to recellularization. However, thrombosis has been a great issue that hinders the progress of transplantation in vivo. In this study, heparin was immobilized to the collagen part of decellularized scaffold with collagen-binding peptide(CBP). Through the anticoagulant and endothelial cell reperfusion experiments, it can be demonstrated that the heparinized scaffolds absorbed less platelets and red blood cells which can effectively reduce the formation of thrombosis. Moreover, it is conducive to longterm adhesion of endothelial cells which is important for the formation of subsequent vascularization. Taken together, our results reveal that the whole kidney can be modified by CBP-heparin composite to reduce the thrombosis and provide the better conditions for neovascularization. | Miao Wang Lili Bao Xinyu Qiu Xiaoshan Yang Siying Liu Yuting Su Lulu Wang Bo Liu Qing He Shiyu Liu Yan Jin | 2018 | Science China(Life Sciences)2018，61，10： | 1 |
| 9 | Video steganalysis based on aliasing detection 显示文摘 | Zhang Chenqian Su Yuting | 2008 | Electronics Letters2008，44，13： | 1 |
| 10 | Different levels of thyroid hormones between impaired fasting glucose and impaired glucose tolerance: free T3 affects the prevalence of impaired fasting glucose and impaired glucose tolerance in opposite ways显示文摘 | Su Jing Ding Xiaoying Xu Ying Liu Rui Gu Mingyu Chen Yuting Yin Yanhua Wang Yufan Sun Haiyan Peng Yongde | 2014 | Clin Endocrinol2014，，6： | 1 |
| 11 | Fast-chargingand dendrite-free lithiummetal anodeeenabledby partial lithiation ofgraphene aerogel显示文摘The development of deeply cyclable lithium metal batteries with fast-charging capability offers a promising solution to relieve the“range anxiety”in driving electric vehicles.Conventional lithium metal anodes suffered from low operating current densities and shallow charge/discharge depths,owing to the intrinsic dendrite growth governed by Sand’s law.Herein,we come up with a novel design of heavy-duty lithium metal anode fabricated by partially infusing the three-dimensional(3D)porous graphene aerogel with molten Li.Both electroanalytical measurements and simulations show that the unique electrode architecture brings notable advantages in mediating smooth Li plating/stripping,including reduced local current density,inhibited dendrite growth,buffered volume fluctuation,as well as more efficient Li utilization.Consequently,a remarkable cycling performance in symmetric cells for over 400 cycles(800 h)with an ultrahigh cycling capacity of 15 mAh·cm^(−2) at 15 mA·cm^(−2) is achieved,which,to our best knowledge,has been never seen in literature.LiFePO4 full cells demonstrate a superb rate capability up to 10 C and a prolonged cycling of 1,600 cycles at 2 C with the per-cycle capacity decay of only 0.023%.This study paves the way for the ultimate deployment of lithium metal batteries in real-world applications that require fast charging and deep cycling. | Yong Ma Yuting Gu Ying He Le Wei Yuebin Lian Weiyi Pan Xinjian Li Yanhui Su Yang Peng Zhao Deng Zhongfan Liu | 2022 | Nano Research2022，15，11： | 1 |
| 12 | Multi-modal Correlated Network for emotion recognition in speech显示文摘With the growing demand of automatic emotion recognition system,emotion recognition is becoming more and more crucial for human-computer interaction(HCI)research.Recently,there is a continuous improvement in the performance of automatic emotion recognition due to the development of both hardware and deep learning methods.However,because of the abstract concept and multiple expressions of emotion,automatic emotion recognition is still a challenging task.In this paper,we propose a novel Multi-modal Correlated Network for emotion recognition aiming at exploiting the information from both audio and visual channels to achieve more robust and accurate detection.In the proposed method,the audio signals and visual signals are first preprocessed for the feature extraction.After preprocessing,we obtain the Mel-spectrograms,which can be treated as images,and the representative frames from visual segments.Then the Mel-spectrograms are fed to the convolutional neural network(CNN)to get the audio features and the representative frames are fed to the CNN and LSTM to get features.Specially,we employ the triplet loss to increase the differentiation of inter-class.Meanwhile,we propose a novel correlated loss to reduce the differentiation of intra-class.Finally,we apply the feature fusion method to fuse the audio and visual feature for emotion recognition classification.The experimental result on AEFW dataset demonstrates the correlation information of multiple modals is crucial for automatic emotion recognition and the proposed method can achieve the state-of-the-art performance on the classification task. | Minjie Ren Weizhi Nie Anan Liu Yuting Su | 2019 | Visual Informatics2019，3，3： | 1 |
| 13 | Effect of ultramicropores and inner space of carbon materials on the capacitive sodium storage performance显示文摘1.Introduction Carbon materials have been widely investigated as the anode materials for Na+storage due to their moderate capacity,good stability,and low cost.The Na+storage mechanisms of carbon are generally classified into diffusion-controlled interlayer insertion/desertion and capacitive-controlled surface adsorption/desorption[1]. | Zimu Jiang Su Zhang Jing Feng Yuting Jiang Shichuan Liang Qiqi Li Mengjiao Shi Meng Cao Mingyi Zhang Tong Wei Zhuangjun Fan | 2022 | Journal of Energy Chemistry2022，31，10： | 0 |
| 14 | A deep network prediction model for heavy metal cadmium in the rice supply chain显示文摘Cadmium and its compounds are currently known as Class I carcinogens,and excessive intake can cause severe health damage to humans.Rice has a strong absorption effect on cadmium,and rice products with excessive cadmium content have caused several significant public health contamination incidents.It is essential to predict the development trend of cadmium hazards in the rice supply chain so that countermeasures can be formulated to reduce the hazards.This paper proposes a deep prediction model for cadmium hazards in the rice supply chain based on the regularization method.Firstly,a long and short-term memory network is used to build the depth prediction model by using the regularization method,and the noise penalty term is added to reduce the model fitting to the noise and prevent the over-fitting caused by the noise.Finally,the optimization of the model hyperparameters was carried out using a Bayesian optimization approach to develop the prediction performance.Then,early warning system for prediction of cadmium hazards in the rice supply chain is built based on the deep prediction model proposed in this paper with SOA architecture,including data resource,business logic,and application service layers.The proposed model performs well on an actual data set of cadmium hazards in the rice supply chain and fits the data well. | Xuebo Jin Jiashuai Zhang Xiaoyi Wang Xin Zhang Tianyang Guo Ce Shi Tingli Su Jianlei Kong Yuting Bai | 2021 | Journal of Future Foods2021，1，2： | 0 |
| 15 | Glutamate drives local Ca^(2+)release'in cardiac pacemaker cells显示文摘The sinoatrial node(SAN)is the origin of the electrical signals for rhythmic heartbeats in mammals.The spontaneous fring of SAN pacemaker cells(SANPCS)triggers cardiac contraction.'Local Ca^(2+)release'(LCR),a unique cellular activity,acts as the'engine'of the spontaneous fring of SANPCs.However,the mechanism of LCR initiation remains unclear.Here,we report that endogenous glutamate drives LCRs in SANPCs.Using a glutamate sensor,we unraveled a tight correlation between glutamate accumulation and LCR occurrence,indicating a potential relationship between glutamate and LCRs.Intracellular application of glutamate significantly enhanced the LCRs in both intact and permeabilized SANPCs.Mechanitically,we revealed that mitochondrial excitatory amino acid transporter 1(EAAT 1)-dependent mitochondrial glutamate import promoted ROS generation,which in turn led to the oxidation of Ca^(2+)-handling proteins,ultimately resulting in enhanced LCRs.Importantly,EAAT1 depletion reduced both the spontaneous fring rates of isolated SANPCs and the heart rate in vitro and in vivo,suggesting the central role of EAAT1 as a glutamate transporter in the regulation of cardiac autonomic rhythm.In conclusion,our results indicate that glutamate serves as an LCR igniter in SANPCs,adding a potentially important element to the coupled clock theory that explains the origin of spontaneous firing.These findings shed new light on the future prevention and treatment of cardiac pacemaker cell-related arrhythmias. | Duanyang Xie Ke Xiong Xuling Su Guanghua Wang Qicheng Zou Luxin Wang Caihong Zhang Yuting Cao Beihua Shao Yixin Zhang Peidong Zhang Dandan Liang Yi Liu Yi-Han Chen | 2022 | Cell Research2022，32，9： | 0 |
| 16 | Reversible conductivity recovery of highly sensitive flexible devices by water vapor显示文摘With decreasing size of integrated circuits in wearable electronic devices,the circuit is more susceptible to aging or fracture problem,subsequently decreasing the transmission efficiency of electricity.Micro-healing represents a good approach to solve this problem.Herein,we report a water vapor method to repair microfiber-based electrodes by precise positioning and rapid healing at their original fracture sites.To realize this micro-level conducting healing,we utilize a bimaterial composed of polymeric microfibers as healing agents and electrically conductive species on its surface.This composite electrode shows a high-performance conductivity,great transparency,and ultra-flexibility.The transmittance of our electrode could reach up to 88 and 90%with a sheet resistance of 1 and 2.8Ωsq^(−1),respectively,which might be the best performance among Au-based materials as we know.Moreover,after tensile failure,water vapor is introduced to mediate heat transfer for the healing process,and within seconds the network electrode could be healed along with recovering of its resistance.The recovering process could be attributed to the combination of adhesion force and capillary force at this bimaterial interface.Finally,this functional network is fabricated as a wearable pressure/strain sensing device.It shows excellent stretchability and mechanical durability upon 1000 cycles. | Yuting Wang Yingchun Su Zegao Wang Zhongyang Zhang Xiaojun Han Mingdong Dong Lifeng Cui Menglin Chen | 2018 | npj Flexible Electronics2018，2，1： | 0 |
| 17 | Deployment Strategy for Multiple Controllers Based on the Aviation On-Board Software-Defined Data Link Network显示文摘In light of the escalating demand and intricacy of services in contemporary terrestrial,maritime,and aerial combat operations,there is a compelling need for enhanced service quality and efficiency in airborne cluster communication networks.Software-Defined Networking(SDN)proffers a viable solution for the multifaceted task of cooperative communication transmission and management across different operational domains within complex combat contexts,due to its intrinsic ability to flexibly allocate and centrally administer network resources.This study pivots around the optimization of SDN controller deployment within airborne data link clusters.A collaborative multi-controller architecture predicated on airborne data link clusters is thus proposed.Within this architectural framework,the controller deployment issue is reframed as a two-fold problem:subdomain partition-ing and central interaction node selection.We advocate a subdomain segmentation approach grounded in node value ranking(NDVR)and a central interaction node selection methodology predicated on an enhanced Artificial Fish Swarm Algorithm(AFSA).The advanced NDVR-AFSA(Node value ranking-Improved artificial fish swarm algorithm)algorithm makes use of a chaos algorithm for population initialization,boosting population diversity and circumventing premature algorithm convergence.By the integration of adaptive strategies and incorporation of the genetic algorithm’s crossover and mutation operations,the algorithm’s search range adaptability is enhanced,thereby increasing the possibility of obtaining globally optimal solutions,while concurrently augmenting cluster reliability.The simulation results verify the advantages of the NDVR-IAFSA algorithm,achieve a better load balancing effect,improve the reliability of aviation data link cluster,and significantly reduce the average propagation delay and disconnection rate,respectively,by 12.8%and 11.7%.This shows that the optimization scheme has important significance in practical application,and can meet the high requirements of modern sea,land,and air operations to aviation airborne communication networks. | Yuting Zhu Yanfang Fu Yang Ce Pan Deng Jianpeng Zhu Huankun Su | 2023 | Computers, Materials & Continua2023，77，12： | 0 |
| 18 | Regulation of serotonin production by specific microbes from piglet gut显示文摘Background Serotonin is an important signaling molecule that regulates secretory and sensory functions in the gut.Gut microbiota has been demonstrated to affect serotonin synthesis in rodent models.However,how gut microbes regulate intestinal serotonin production in piglets remains vague.To investigate the relationship between microbiota and serotonin specifically in the colon,microbial composition and serotonin concentration were analyzed in ileum-cannulated piglets subjected to antibiotic infusion from the ileum when comparing with saline infusion.Microbes that correlated positively with serotonin production were isolated from piglet colon and were further used to investi-gate the regulation mechanisms on serotonin production in IPEC-J2 and a putative enterochromaffin cell line RIN-14B cells.Results Antibiotic infusion increased quantities of Lactobacillus amylovorus(LA)that positively correlated with increased serotonin concentrations in the colon,while no effects observed for Limosilactobacillus reuteri(LR).To understand how microbes regulate serotonin,representative strains of LA,LR,and Streptococcus alactolyticus(SA,enriched in feces from prior observation)were selected for cell culture studies.Compared to the control group,LA,LR and SA supernatants significantly up-regulated tryptophan hydroxylase 1(TPH1)expression and promoted serotonin production in IPEC-J2 cells,while in RIN-14B cells only LA exerted similar action.To investigate potential mechanisms mediated by microbe-derived molecules,microbial metabolites including lactate,acetate,glutamine,andγ-aminobutyric acid were selected for cell treatment based on computational and metabolite profiling in bacte-rial supernatant.Among these metabolites,acetate upregulated the expression of free fatty acid receptor 3 and TPH1 while downregulated indoleamine 2,3-dioxygenase 1.Similar effects were also recapitulated when treating the cells with AR420626,an agonist targeting free fatty acid receptor 3.Conclusions Overall,these results suggest that Lactobacillus amylovorus showed a positive correlation with sero-tonin production in the pig gut and exhibited a remarkable ability to regulate serotonin production in cell cultures.These findings provide evidence that microbial metabolites mediate the dialogue between microbes and host,which reveals a potential approach using microbial manipulation to regulate intestinal serotonin biosynthesis. | Ziyu Liu Yidan Ling Yu Peng Shuibing Han Yuting Ren Yujia Jing Wenlu Fan Yong Su Chunlong Mu Weiyun Zhu | 2023 | Journal of Animal Science and Biotechnology2023，14，6： | 0 |
| 19 | MSCs-derived apoptotic extracellular vesicles promote muscle regeneration by inducing Pannexin 1 channel-dependent creatine release by myoblasts显示文摘Severe muscle injury is hard to heal and always results in a poor prognosis.Recent studies found that extracellular vesicle-based therapy has promising prospects for regeneration medicine,however,whether extracellular vesicles have therapeutic effects on severe muscle injury is still unknown.Herein,we extracted apoptotic extracellular vesicles derived from mesenchymal stem cells(MSCs-Apo EVs)to treat cardiotoxin induced tibialis anterior(TA)injury and found that MSCs-Apo EVs promoted muscles regeneration and increased the proportion of multinucleated cells.Besides that,we also found that apoptosis was synchronized during myoblasts fusion and MSCs-Apo EVs promoted the apoptosis ratio as well as the fusion index of myoblasts.Furthermore,we revealed that MSCs-Apo EVs increased the relative level of creatine during myoblasts fusion,which was released via activated Pannexin 1 channel.Moreover,we also found that activated Pannexin 1 channel was highly expressed on the membrane of myoblasts-derived Apo EVs(Myo-Apo EVs)instead of apoptotic myoblasts,and creatine was the pivotal metabolite involved in myoblasts fusion.Collectively,our findings firstly revealed that MSCs-Apo EVs can promote muscle regeneration and elucidated that the new function of Apo EVs as passing inter-cell messages through releasing metabolites from activated Pannexin 1 channel,which will provide new evidence for extracellular vesicles-based therapy as well as improving the understanding of new functions of extracellular vesicles. | Qingyuan Ye Xinyu Qiu Jinjin Wang Boya Xu Yuting Su Chenxi Zheng Linyuan Gui Lu Yu Huijuan Kuang Huan Liu Xiaoning He Zhiwei Ma Qintao Wang Yan Jin | 2023 | International Journal of Oral Science2023，15，1： | 0 |
| 20 | A multiple copyright identification watermarking algorithm based on code division multiple access显示文摘A multiple watermarking algorithm is presented according to the multiple accessing technique of thecode division multiple access (CDMA) system.Multiple watermarks are embedded into digital images inthe wavelet transform domain.Each of the watermarks is embedded and extracted independently withoutimpacts to each other.Multiple watermarks are convolution encoded and block interleaved,and the or-thogonal Gold sequences are used to spread spectrum of the copyright messages.CDMA encoded water-mark messages are embedded into the wavelet sub-bands excluding the wavelet HH1 sub-bands.The em-bedment amplitude is decided by Watson's perceptual model of wavelet transform domain,and the em-bedment position in the selected wavelet sub-bands is decided randomly by a pseudo-random noise (PN)sequence.As a blind watermarking algorithm,watermarks are extracted without original image.The wa-termarking capacity of proposed algorithm is also discussed.When two watermarks are embedded in animage at the same time,the capacity is larger than the capacity when a single watermark is embedded,and is smaller than the sum of the capacity of two separately embedded watermarks.Experimental resultsshow that the proposed algorithm improves the detection bits error rate (BER) observably,and the multi-pie watermarks have a preferable robustness and invisibility. | 张帆 li Jie Su Yuting Zhang Chuntian | 2008 | High Technology Letters2008，14，4： | 0 |
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