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| 1 | Allele-defined genome reveals biallelic differentiation during cassava evolution显示文摘Dear Editor,Generation of heterozygous genomes by hybridization between or within species can help maintain plant diversity and serve as a potential source of new species(Baek et al.,2018).Moreover,genomic heterozygosity is associated with genomic coadaptation,developmental stability,and heterosis.Accurate definition of alleles in haplotypes is necessary to precisely characterize allelic variation controlling agriculturally important traits(Shi et al.,2019).Currently,most released genomes have mosaic assembly of haplotypes due to random selection or collapse of alleles during genome assembly(Shi et al.,2019),which masked allelic variation and functional differentiation of divergent alleles in heterozygous species. | Wei Hu Changmian Ji Haitao shi Zhe Liang Zehong Ding Jianqiu Ye Wenjun Ou Gang Zhou Weiwei Tie Yan Yan Jinghao Yang Xiaoying Yang Yunxie Wei Zhiqiang Jin Jianghui Xie Ming Peng Wenquan Wang Anping Guo Biyu Xu Jianchun Guo Songbi Chen Liming Ma Mingcheng Wang Yang Zhou Xiaolong Li Ruoxi Li Siyi Guo Xinhui Xiao Zhongqing Wan Feifei An Jie Zhang Qingyun Leng Yin Li Ray Ming Kaimian Li | 2021 | Molecular Plant2021，14，6： | 8 |
| 2 | Homozygous loss-of-function mutations in FSIP2 cause male infertility with asthenoteratospermia显示文摘Male infertility, as a major issue of human reproduction health, prevents successful natural conception. Asthenoteratospermia mainly presents one or multiple anomalies in head, neck and tail of spermatozoa, and impairs sperm function and motility (Coutton et al., 2015). Recurrent abnormalities of the fibrous sheath lead to multiple morphological abnormaliries of the sperm flagella (MMAF), which is a quite frequent type of asthenoteratospermia in male infertility (Chemes et al., 1987;Ben Khelifa et al, 2014). | Wangjie Liu Huan Wu Li Wang Xiaoyu Yang Chunyu Liu Xiaojin He Weiyu Li Jiajia Wang Yujie Chen Hongyan Wang Yang Gao Shuyan Tang Shenmin Yang Li Jin Feng Zhang Yunxi Cao | 2019 | Journal of Genetics and Genomics2019，46，1： | 7 |
| 3 | Neutrophil-derived heparin binding protein triggers vascular leakage and synergizes with myeloperoxidase at the early stage of severe burns(With video)显示文摘Background:Burn shock caused by vascular leakage is one of the main causes of high mortality in severe burn injury.However,the pathophysiological mechanism of vascular leakage is still unclear.The purpose of this study was to explore the molecular mechanism of vascular leakage in the early stage of severe burn and provide a new target for the treatment of severe burns.Methods:Neutrophils were isolated from human peripheral blood by magnetic beads sorting.ELISA was used to detect neutrophil-derived granule proteins and glycocalyx injury products in plasma.The vascular leakage and neutrophil movement were assessed by in vivo laser confocal imaging in mice,and high-quality video were provided.Adhesion-related molecules were investigated by qRT-PCR.The damage to glycocalyx of mice vascular endothelial cellswas observed by transmission electron microscope and scanning electron microscope.Proteomic analysis,flow cytometry and immunofluorescence were used to further study the relationship between human peripheral blood neutrophil-derived hypochlorite(HOCl)and CD44 of human vascular endothelial cells.Results:In this study,we found that rapidly increasing activated neutrophils secrete heparin binding protein(HBP)andmyeloperoxidase(MPO)after severe burn injury.Increased HBP triggers vascular leakage with synergy of MPO,results in systemic edema and burn shock.Furthermore,we found that the MPO catalytic product HOCl but not MPO triggers CD44 extracellular domain shedding from vascular endothelial cells to damage the glycocalyx.Damage to the glycocalyx results in firm adhesion of neutrophils and increases vascular leakage.However,MPO inhibitors partially protect the glycocalyx of vascular endothelial cells.The combination of HBP and MPO inhibitors markedly reduces vascular leakage and systemic edema in the early stage of severe burns.Conclusions:Taken together,these data reveal that neutrophil-derived HBP and MPO play an important synergies role in triggering vascular leakage at the early stage of severe burns.Targeted intervention in these two biomolecules may introduce new strategies for helping to reduce large amount of fluid loss and subsequent burn shock. | Lu Liu Yiming Shao Yixuan Zhang Yunxi Yang Jiamin Huang Linbin Li Ran Sun Yuying Zhou Yicheng Su Bingwei Sun | 2021 | Burns & Trauma2021，9，1： | 3 |
| 4 | Neutrophil extracellular traps contribute to myofibroblast differentiation and scar hyperplasia through the Toll-like receptor 9/nuclear factor Kappa-B/interleukin-6 pathway显示文摘Background:Inflammation is an important factor in pathological scarring.The role of neutrophils,one of the most important inflammatory cells,in scar hyperplasia remains unclear.The purpose of this article is to study the correlation between neutrophil extracellular traps(NETs)and scar hyperplasia and identify a new target for inhibiting scar hyperplasia.Methods:Neutrophils were isolated from human peripheral blood by magnetic-bead sorting.NETs in plasma and scars were detected by enzyme-linked immunosorbent assays(ELISAs),immunofluorescence and flow cytometry.Immunohistochemistry was used to assess neutrophil(CD66B)infiltration in hypertrophic scars.To observe the entry of NETs into fibroblasts we used immunofluorescence and flow cytometry.Results:We found that peripheral blood neutrophils in patients with hypertrophic scars were more likely to form NETs(p<0.05).Hypertrophic scars showed greater infiltration with neutrophils and NETs(p<0.05).NETs activate fibroblasts in vitro to promote their differentiation and migration.Inhibition of NETs with cytochalasin in wounds reduced the hyperplasia of scars in mice.We induced neutrophils to generate NETs with different stimuli in vitro and detected the proteins carried by NETs.We did not find an increase in the expression of common scarring factors[interleukin(IL)-17 and transforming growth factor-β(TGF-β),p>0.05].However,inhibiting the production of NETs or degrading DNA reduced the differentiation of fibroblasts intomyofibroblasts.In vitro,NETs were found to be mediated by Toll-like receptor 9(TLR-9)in fibroblasts and further phosphorylated nuclear factor Kappa-B(NF-κB).We found that IL-6,which is downstream of NF-κB,was increased in fibroblasts.Additionally,IL-6 uses autocrine and paracrine signaling to promote differentiation and secretion.Conclusions:Our experiments found that NETs activate fibroblasts through the TLR-9/NF-κB/IL-6 pathway,thereby providing a new target for regulating hypertrophic scars. | Yiming Shao Zaiwen Guo Yunxi Yang Lu Liu Jiamin Huang Yi Chen Linbin Li Bingwei Sun | 2022 | Burns & Trauma2022，10，1： | 2 |
| 5 | Influence of Procedure Parameters on Rheological Property of Semi-Solid AZ91D Magnesium Alloy显示文摘Semi-solid AZ91D magnesium alloy was investigated in isothermal steady-state condition. The influence of stirring technological parameters such as stirring temperature and shear rate to apparent viscosity of semi-solid alloy slurry was discussed. Apparent viscosity increases with stirring temperature decreases at the same shear rate. At the same stirring temperature, apparent viscosity decreases rapidly at first with shear rate increases, and then apparent viscosity decreases slowly with shear rate increases, when shear rate reaches a certain value, apparent viscosity appears tiny increase. According to the experimental data, the relation between solid volume fraction and apparent viscosity of semi-solid AZ9l D alloy at shear rate 238 s- 1 is fitted by regression method, it supplies useful data to the numerical simulation of semi-solid AZ91D alloy die casting process. | Jiang Yunxi Xie Shuisheng Li Xinggang Li Lei | 2004 | Journal of Rare Earths2004，22，z2： | 2 |
| 6 | Delay-range-dependent exponential stability criteria and decay estimation for switchedHopfield neural networks of neural type显示文摘 | ZONG Guangdeng LIU Jia ZHANG Yunxi | 2010 | Nonlinear Analysis2010，4，3： | 1 |
| 7 | Geochemistry Characteristics of Granodiorite Porphyry in the Degongniuchang Copper Deposit, Muli, Sichuan Province, China显示文摘1 Introduction 1The Sanjiang region in SE Tibet Plateau and NW Yunnan is known to have formed by amalgamation of Gongwanaderived continental blocks and arc terranes as a result of oceanic subduction followed by | MA Pengcheng WANG Fudong XIE Yunxi PENG Dong LI Hujie XU Gang | 2017 | Acta Geologica Sinica(English Edition)2017，91，S1： | 1 |
| 8 | Th1 and Th2 cytokine profiles induced by hepatitis C virus F protein in peripheral blood mononuclear cells from chronic hepatitis C patients显示文摘 | Ming Yue Xiaozhao Deng Xiangjun Zhai Ke Xu Jing Kong Jinhai Zhang Zhenxian Zhou Xiaojie Yu Xiaodong Xu Yunxi Liu Danyan Zhu Yun Zhang | 2013 | Immunology Letters2013，，2： | 1 |
| 9 | Mechanism and method of DPF regeneration by oxygen radical gen?erated by NTP technology 显示文摘 | Shi Yunxi Cai Yixi Li Xiaohua | 2014 | International J oumal of Automotive Technology2014，15，6： | 1 |
| 10 | Potential prebiotic effects of nonabsorptive components of Keemun and Dianhong black tea:an in vitro study显示文摘Black tea is a healthy and popular tea beverage.However,its main bioactive compounds(theaflavins and thearubigins)are not easily absorbed.The aim of this study was to investigate the modulation of intestinal microbiota by the nonabsorptive components of Keemun black tea(KBT)and Dianhong black tea(DBT),and fructooligosaccharide(FOS)was selected for use in the control group.KBT,DBT,and FOS significantly increased total short-chain acid production.Specifically,FOS treatment predominantly increased the production of acetic acids and black tea treatments increased the production of acetic,propionic,and butyric acids at similar rates.Moreover,FOS exerted a strong bifidogenic effect after 24 h of fermentation;KBT and DBT increased the abundance of the beneficial genus Bacteroides and Roseburia.In summary,the nonabsorptive components of KBT and DBT could serve as novel prebiotics,the underlying mechanisms of which are quite different from those of FOS. | Wenjing Liao Wenjiao Li Suyu Liu Dong Tang Yunxi Chen Yijun Wang Zhongwen Xie Jinbao Huang | 2022 | Food Science and Human Wellness2022，11，3： | 1 |
| 11 | Quantitative determination of diterpenoid alkaloid Fuziline by hydrophilic interaction liquid chromatography (HILIC)–electrospray ionization mass spectrometry and its application to pharmacokinetic study in rats显示文摘 | Jianguo Sun Fengyi Zhang Ying Peng Jinghan Liu Yunxi Zhong Guangji Wang | 2013 | Journal of Chromatography B2013，，： | 1 |
| 12 | Clinical applica- tion of RT-nested PCR integrated with RFLP in Hantavirus detection and genotyping: a prospective study in Shandong Province, PR China 显示文摘 | Liu Yunxi Zhao Zhongtang Cao Wuchun | 2013 | Cell Biochem Biophys2013，67，3： | 1 |
| 13 | Epidemiological study of autumn-winter type scrub typhus in a new endemic focus of Fei county,Shandong province,China显示文摘 | Liu yunxi Yang zhanqing Wu qinyong | 2000 | Systematic & Applied Acarology2000，5，： | 1 |
| 14 | New exact solutions for an (n+ 1)-dimensional generalized Boussinesq eciuati~n显示文摘 | GUO Yunxi LAI Shaoyong | 2010 | Nonlinear Analysis: Theory Methods and Applications2010，72，6： | 1 |
| 15 | Finite-time convergent guidance law with impact angle constraint based on sliding-mode control显示文摘 | Yunxi Zhang Mingwei Sun Zengqiang Chen | 2012 | Nonlinear Dynamics2012，，： | 1 |
| 16 | Hospital biosecurity capacitation:Analysis and recommendations for the prevention and control of COVID-19显示文摘The outbreak of the coronavirus disease 2019(COVID-19)in December 2019 highlighted several concerns regarding hospital biosafety capacitation in the People’s Republic of China,although the epidemic is now under control.This study examined the primary problems related to hospital biosecurity,including the absence of a hospital emergency system,inadequate management and control of nosocomial infection,limited hospital laboratory capacity,and poor hospital admission capacity.Accordingly,this study puts forward the following countermeasures and suggestions for hospitals to deal with future biosecurity events,such as a major epidemic:first,biosecurity management systems and emergency response mechanisms in hospitals need to be set up;second,the investment and guarantee mechanisms for hospital biosecurity construction should be improved;third,the capacity building of biosecurity incident management requires special attention in general hospitals;and finally,comprehensive plans need to be developed for the integrated construction of medical treatment and prevention facilities through diseasecontrol systems. | Hui Ma Jiangong Zhu Jianfei Liu Xin Zhang Yunxi Liu Quansheng Yang | 2020 | Journal of Biosafety and Biosecurity2020，2，1： | 1 |
| 17 | Weather index insurance for wind energy显示文摘As China vigorously promotes the development of new energy,photovoltaic power curtailment and wind power curtailment have been effectively resolved.At the same time,the yield from new energy power generation is becoming an important factor that affects the scale of investment in new energy.This paper focuses on the weather risks faced by wind power producers.By studying current research on weather index insurance in China and abroad,the functions and design methods for weather index insurance have been clarified.In addition,the feasibility of wind-power generation index insurance is discussed.The calculation methods for wind power generation index and the weather index insurance pricing methods for wind power enterprises are proposed.A weather index insurance model for wind power generation was established.The rationality and feasibility of the weather index insurance model proposed in this paper were verified using data from an existing power plant.The simulation results show that wind power enterprises can effectively avoid economic losses caused by weather risks through weather index insurance. | Xiao Han Guoxing Zhang Yixiang Xie Jiaxuan Yin Haiming Zhou Yunxi Yang Junhui Li Wenlei Bai | 2019 | Global Energy Interconnection2019，2，6： | 1 |
| 18 | Serological reports of human infections of H7 and H9 avian influenza viruses in northern China 显示文摘 | Jia Na de Vlas SJ Liu Yunxi | 2009 | J Clin Virol2009，44，3： | 1 |
| 19 | The decoupling relationship between China’s economic growth and carbon emissions from the perspective of industrial structure显示文摘This study analyses the decoupling relationship between energy-related CO_(2) emissions and economic growth in China from 2000-2017 from the perspective of industrial structure using the LMDI method and Tapio decoupling model.The decoupling driving force was decomposed into emission,energy intensity,industrial structure,economic activity,and population factors.Studies have shown that the restructuring of China’s industries has not led to a significant increase in CO_(2) emissions.Specifically,from 2000 to 2017,China’s economic development and carbon emissions are generally in a weak decoupling state.Strong decoupling occurred from 2000 to 2001 and from 2013 to 2016.The industrial structure change has a substantial impact on the primary sector(agriculture),followed by the tertiary sector(services),while the impact on the secondary sector(industry)is negligible.The GDP contribution of the primary industry is small,but it is an indispensable guarantee for a country.With the development of agricultural mechanization and technology,human and animal power in this industry has been decreasing year by year,and large-scale planting has improved energy efficiency.The level of technology should be continuously strengthened to promote the decoupling of carbon emissions.The contribution of the secondary industry to GDP is around 40%,but the secondary industry accounts for more than 80%of CO_(2) emissions,mainly caused by the use of fossil energy.In 2017,fossil energy still accounted for about 86.2%of China’s energy consumption,so fossil energy remains the most critical energy source for China’s economic development.Coal,in turn,accounts for the largest share of fossil energy consumption.Therefore,emphasis should be placed on increasing technological innovation and conversion from fossil to non-fossil energy sources.The Chinese government considers the service industry a new engine for sustainable social and economic development.The contribution of the tertiary sector to GDP has increased from 2000 to 2017,followed by resource and environmental problems.Although the current share of CO_(2) emissions directly caused by the tertiary sector is not high,as the tertiary sector continues to grow,plans to reduce the decoupling of carbon emissions from the tertiary sector should be made in advance. | Yuwei Du Yunxi Liu Md.Afzal Hossain Songsheng Chen | 2022 | Chinese Journal of Population,Resources and Environment2022，20，1： | 1 |
| 20 | Silane coupling agents used for natural fiber/polymer composites显示文摘 | Yan Yunxie Callum A S Hill Ze Fangxiao | 2010 | Composites: Part A2010，4，1： | 1 |
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