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| 1 | Variation of head and facial morphological characteristics with increased age of Han in Southern China显示文摘We investigated 13940 (6735 male, 7250 female) adult head and facial physical attributes from 19 different Han ethnic groups in 10 southern-China provinces, and calculated 12 head and facial indexes. Indexes were used to analyze the variation of head and facial morphological characteristics with increased age. Results showed that as age increases: (1) Head breadth, minimum frontal breadth, face breadth, interocular breadth, external biocular breadth, lip height, lip thickness, head circumference, auricular height, length-breadth head index, length-height head index, and lip-index values decline significantly in a linear fashion. (2) Nose breadth, mouth breadth, morphological facial height, upper-lip height, physiognomic ear length, physiognomic ear breadth, visor skin-fold, and vertical head-facial index values significantly increase in a linear fashion. | LI YongLan ZHENG LianBin YU KeLi LU ShunHua ZHANG XingHua LI YuLing WANG Yang XUE Hong DENG Wei | 2013 | Chinese Science Bulletin2013，58，4： | 20 |
| 2 | Viral effector protein manipulates host hormone signaling to attract insect vectors显示文摘 | Dewei Wu Tiancong Qi Wan-Xiang Li Haixia Tian Hua Gao Jiaojiao Wang Jin Ge Ruifeng Yao Chunmei Ren Xian-Bing Wang Yule Liu Le Kang Shou-Wei Ding Daoxin Xie | 2017 | Cell Research2017，27，3： | 20 |
| 3 | Role of plant autophagy in stress response显示文摘Autophagy is a conserved pathway for the bulk degradation of cytoplasmic components in all eukaryotes.This process plays a critical role in the adaptation of plants to drastic changing environmental stresses such as starvation,oxidative stress,drought,salt,and pathogen invasion.This paper summarizes the current knowledge about the mechanism and roles of plant autophagy in various plant stress responses. | Shaojie Han Bingjie Yu Yan Wang Yule Liu | 2011 | Protein & Cell2011，2，10： | 15 |
| 4 | Traditional Chinese medicine in COVID-19显示文摘COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2(SARSCo V-2)has spread across the globe,posing an enormous threat to public health and safety.Traditional Chinese medicine(TCM),in combination with Western medicine(WM),has made important and lasting contributions in the battle against COVID-19.In this review,updated clinical effects and potential mechanisms of TCM,presented in newly recognized three distinct phases of the disease,are summarized and discussed.By integrating the available clinical and preclinical evidence,the efficacies and underlying mechanisms of TCM on COVID-19,including the highly recommended three Chinese patent medicines and three Chinese medicine formulas,are described in a panorama.We hope that this comprehensive review not only provides a reference for health care professionals and the public to recognize the significant contributions of TCM for COVID-19,but also serves as an evidence-based in-depth summary and analysis to facilitate understanding the true scientific value of TCM. | Ming Lyu Guanwei Fan Guangxu Xiao Taiyi Wang Dong Xu Jie Gao Shaoqin Ge Qingling Li Yuling Ma Han Zhang Jigang Wang Yuanlu Cui Junhua Zhang Yan Zhu Boli Zhang | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 14 |
| 5 | Modeling gross primary production of a temperate grassland ecosystem in Inner Mongolia, China, using MODIS imagery and climate data显示文摘Carbon fluxes in temperate grassland ecosystems are characterized by large inter-annual variations due to fluctuations in precipitation and land water availability. Since an eddy flux tower has been in operation in the Xilin Gol grassland, which belongs to typical temperate grassland in North China, in this study, observed eddy covariance flux data were used to critically evaluate the biophysical per- formance of different remote sensing vegetation indices in relation to carbon fluxes. Furthermore, vegetation photosynthesis model (VPM) was introduced to estimate gross primary production (GPP) of the grassland ecosystem for assessing its dependability. As defined by the input variables of VPM, Moderate Resolution Imaging Spectroradimeter (MODIS) and standard data product MOD09A1 were downloaded for calculating enhanced vegetation index (EVI) and land surface water index (LSWI). Measured air temperature (Ta) and photosynthetically active radiation (PAR) data were also included for model simulating. Field CO2 flux data, during the period from May, 2003 to September, 2005, were used to estimate the 'observed' GPP (GPPobs) for validation. The seasonal dynamics of GPP predicted from VPM (GPPVPM) was compared quite well (R2=0.903, N=111, p<0.0001) with the observed GPP. The ag- gregate GPPVPM for the study period was 641.5 g C·m?2, representing a ~6% over-estimation, compared with GPPobs. Additionally, GPP predicted from other two typical production efficiency model (PEM) represents either higher overestimation or lower underestimation to GPPobs. Results of this study demonstrate that VPM has potential for estimating site-level or regional grassland GPP, and might be an effective tool for scaling-up carbon fluxes. | WU WeiXing WANG ShaoQiang XIAO XiangMing YU GuiRui FU YuLing HAO YanBin | 2008 | Science China Earth Sciences2008，51，10： | 13 |
| 6 | Prolonged manganese exposure induces severe deficits in lifespan,development and reproduction possibly by altering oxidative stress response in Caenorhabditis elegans显示文摘We examined the possible multiple defects induced by acute and prolonged exposure to high levels of manganese(Mn) solution by monitoring the endpoints of lifespan,development,reproduction,and stress response.Our data suggest that acute exposure(6 h) to Mn did not cause severe defects of life span,development,and reproduction,similarly,no significant defect could be found in animals exposed to a low concentration of Mn(2.5 μmol/L) for 48 h.In contrast,prolonged exposure(48 h) to high Mn concentrations(75 and 200 μmol/L) resulted in significant defects of life span,development,and reproduction,as well as the increase of the percentage of population with hsp-16.2::gfp expression indicating the obvious induction of stress responses in exposed animals.Moreover,prolonged exposure(48 h) to high concentrations(75 and 200 μmol/L) of Mn decreased the expression levels of antioxidant genes of sod-1,sod-2,sod-3,and sod-4 compared to control.Therefore,prolonged exposure to high concentrations of Mn will induce the severe defects of life span,development,and reproduction in nematodes possibly by affecting the stress response and expression of antioxidant genes in Caenorhabditis elegans. | XIAO Jing | 2009 | Journal of Environmental Sciences2009，21，6： | 13 |
| 7 | Study on the velocity structure of the crust in Southwest Yunnan of the north-south seismic belt—Results from the Menghai-Gengma-Lushui deep seismic sounding profile显示文摘Southwest Yunnan, located in the southern segment of the north-south seismic belt, is one of the regions with strong tectonic movement and seismic activity in China. Study on the characteristics of tectonic setting and deep geophysical field in the region is an important issue in basic science. In 2013, we conducted a 600-km-long Menghai-Gengma-Lushui profile of deep seismic wide-angle reflection/refraction and high-resolution seismic refraction in Southwest Yunnan. In this paper, we use 6 groups of clear intracrustal P-wave phases picked from the seismic record sections of 11 shots to build a velocity structure model of basement and 2D crustal P-wave of the region by using finite difference inversion and ray travel time forward fitting technology. The results show that, from south to north, the crust gradually thickens along the profile and its basement shows a significant lateral heterogeneity. In the vicinity of the Nanting River fault, the basement structure shows the character of alternate depressions and uplifts, and the shallowest basement is about 1.0 km. In the vicinity of Tengchong and Lancang, the basement is about 5.0 km deep. The velocity of the middle and lower crust in the region generally increases with the increasing of depth. At the block boundary and beneath the fault tectonic belt, the velocity contours show apparent irregularity and the P-wave velocity changes sharply. In this region, the Moho gradually deepens from south to north with relatively large lateral undulations. The shallowest point of the Moho is located near Menghai at a depth of about 32.0 km. The deepest point of the Moho is located near Tengchong at a depth of about 40.5 km. Between Gengma and Yongde, the Moho shows significantly fast uplifting and depressing with an amplitude of about 4.0 km. Beneath the Nanting River fault, Longling-Ruili fault, Dayingjiang fault and Tengchong volcano, the basement velocity structure, 2D crustal P-wave velocity structure, distribution of average profile velocity and intracrustal interface spreading also show significant changes from the basement to the top of the Moho, indicating that the crustal velocity and medium physical properties beneath the fault tectonic belt are apparently different from the crustal materials on its both sides, which suggests that these faults should be in a certain scale and may extend to the lower crust or the top of the upper mantle. The earthquakes in the region mainly occurred at a depth of 10–20 km, and the seismic activity is related to the intracrustal medium velocity difference and fault belt distribution. The results can serve as the important data of the crust-mantle structure for the analysis of the deep tectonic setting, earthquake precise positioning, seismogenic structure modeling of the seismic activities in Southwest Yunnan, as well as the important reference for the evaluation of seismic hazard and the planning of earthquake disaster mitigation of this region. | WANG ShuaiJun LIU BaoJin ZHANG JianShi LIU BaoFeng DUAN YuLing SONG XiangHui DENG XiaoGuo MA CeJun ZANG YiRan | 2015 | Science China Earth Sciences2015，58，12： | 13 |
| 8 | Characterizing CO_2 fluxes for growing and non-growing seasons in a shrub ecosystem on the Qinghai-Tibet Plateau显示文摘To assess carbon budget for shrub ecosystems on the Qinghai-Tibet Plateau, CO2flux was measured with an open-path eddy covariance system for an alpine shrub ecosystem during growing and non-growing seasons. CO2 flux dynamics was distinct between the two seasons. During the growing season from May to September, the ecosystem exhibited net CO2uptake from 08:00 to 19:00 (Beijing Standard Time), but net CO2 emission from 19:00 to 08:00.Maximum CO2 uptake appeared around 12:00 with values of 0.71, 1.19, 1.46 and 0.67 g CO2m-2 h-1 for June, July, August and September, respectively. Diurnal fluctuation of CO2 flux showed higher correlation with photosynthetic photon flux density than temperature. The maximum net CO2 influx occurred in August with a value of 247 g CO2 m-2. The total CO2 uptake by the ecosystem was up to 583 g CO2 m-2 for the growing season. During the non-growing season from January to April and from October to December, CO2 flux showed small fluctuation with the largest net CO2 efflux of 0.30 g CO2 m-2 h-1 in April. The diurnal CO2 flux was close to zero during most time of the day, but showed a small net CO2 efflux from 11:00 to 18:00. Diurnal CO2 flux, is significantly correlated to diurnal temperature in the non-growing season. The maximum monthly net CO2 efflux appeared in April, with a value of 105 g CO2 m-2. The total net CO2 efflux for the whole non-growing season was 356 g CO2 m-2. | XU Shixiao, ZHAO Xinquan, FU Yuling, ZHAO Liang, LI Yingnian, CAO Guangmin, GU Song, WANG Qinxue & DU Mingyuan Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining 810001, China Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China Graduate School of the Chinese Academy of Sciences, Beijing 100136, China National Institute for Environmental Studies, Tsukuba 305-8569, Japan National Institute for Agro-Environmental Science, Tsukuba 305-8604, Japan | 2005 | Science China Earth Sciences2005，48，z1： | 12 |
| 9 | Spatial correlation analysis of sea-bottom backscattering显示文摘The principle of the spatial correlation characteristics of sea-bottom backscattering was expounded.The Kirchhoff model is introduced to simulate sea-bottom backscattering and the spatial correlation is calculated.Some sediment characteristic parameters,such as the ratio of sediment mass density to water mass density,the ratio of sediment sound speed to water sound speed,the attenuation coefficient of sound waves,the strength and exponent of seabottom interface roughness spectrum,are considered while simulating and their influences on spatial correlation are analyzed.By establishing the expressions of the sediment characteristic parameters with the logarithmic sediment grain size,the variation tendency of the spatial correlation versus the logarithmic sediment grain size is obtained.The width of the major lobe of the spatial correlation function narrows as the logarithmic sediment grain size increases.The comparisons between simulated data and in-situ data collected in October 2007 have proven that their spatial correlation function waveforms agree well under the same sediment characteristics. | KUAI Duojie WANG Changhong FENG Lei WANG Yuling QIU Wei YI Huiqin CHEN Long | 2012 | Chinese Journal of Acoustics2012，31，3： | 9 |
| 10 | Targeted delivery of chlorogenic acid by mannosylated liposomes to effectively promote the polarization of TAMs for the treatment of glioblastoma显示文摘Tumor-associated macrophages(TAMs)generally display an immunosuppressive M2 phenotype and promote tumor progression and metastasis,suggesting their potential value as a target in cancer immunotherapy.Chlorogenic acid(CHA)has been identified as a potent immunomodulator that promotes the polarization of TAMs from an M2 to an M1 phenotype.However,rapid clearance in vivo and low tumor accumulation have compromised the immunotherapeutic efficacy of CHA in clinical trials.In this study,mannosylated liposomes are developed for targeted delivery of CHA to TAMs.The immunoregulatory effects of CHA,along with the overall antitumor efficacy of CHA-encapsulated mannosylated liposomes,are investigated through in vitro and in vivo experiments.The prepared CHA-encapsulated mannosylated liposomes exhibit an ideal particle size,favorable stability,and preferential accumulation in tumors via the mannose receptor-mediated TAMs-targeting effects.Further,CHA-encapsulated mannosylated liposomes inhibit G422 glioma tumor growth by efficiently promoting the polarization of the pro-tumorigenic M2 phenotype to the anti-tumorigenic M1 phenotype.Overall,these findings indicate that CHA-encapsulated mannosylated liposomes have great potential to enhance the immunotherapeutic efficacy of CHA by inducing a shift from the M2 to the M1 phenotype. | Jun Ye Yanfang Yang Jing Jin Ming Ji Yue Gao Yu Feng Hongliang Wang Xiaoguang Chen Yuling Liu | 2020 | Bioactive Materials2020，5，3： | 9 |
| 11 | Multi-scale image segmentation of coal piles on a belt based on the Hessian matrix显示文摘Segmenting images of coal piles on a belt is an unsolved problem in coal-based machine vision research,though it is an essential step for estimating size distribution and classifying coal.In this investigation,a new algorithm for segmenting images of coal piles on a belt is proposed.A multi-scale linear filter,constructed of a Hessian matrix and Gaussian function,forms the core of this algorithm and obtains an edge intensity image to form good seed regions for a watershed segmentation.Manual segmentation is used to define ground truth segmentation images to quantify the errors of the proposed method.Tests indicate that 12.76%of the visible regions are under- or over-segmented,and that this algorithm is feasible and effective in practical applications. | Zelin Zhang JianguoYang Xiaolan Su Lihua Ding Yuling Wang | 2013 | Particuology2013，11，5： | 9 |
| 12 | A New Species of Phoenicopsis Subgenus Windwardia(Florin) Samylina(Czekanowskiales) from the Middle Jurassic of Inner Mongolia, China显示文摘A new species of Phoenicopsis subgenus Windwardia(Florin) Samylina, Phoenicopsis neimengguensis sp.nov., is recognized from the Middle Jurassic Zhaogou Formation in the Shiguai Basin, a Jurassic coal-bearing sedimentary basin in Inner Mongolia, China. Linear leaves are in bundles of six to eight and are attached on a short shoot. The leaf is amphistomatic with one or two irregular rows of longitudinally oriented stomata in each intercostal zone on the upper epidermis and three or four(occasionally six) rows of stomata in each intercostal zone on the lower epidermis. Each stomata is surrounded by four to six subsidiary cells with unevenly developed papillae. The anticlinal walls of epidermal cells are straight. Cuticular thickenings or papillae are present on the outer surface of the periclinal walls. This is the first time that Phoenicopsis subgenus Windwardia(Florin) Samylina is recognized from the Middle Jurassic of Inner Mongolia, China. The occurrence of the new species is noteworthy because it extends the geological and geographic distribution of Phoenicopsis subg. Windwardia in China and Eurasia. The discovery is significant as it increases our knowledge of Phoenicopsis subg. Windwardia by providing new data on morphological and epidermal features. | SUN Chunlin NA Yuling David L.DILCHER WANG Hongshan LI Tao LI Yunfeng | 2015 | Acta Geologica Sinica(English Edition)2015，89，1： | 7 |
| 13 | Effect of organic amine alkali and inorganic alkali on benzotriazole removal during post Cu-CMP cleaning显示文摘Benzotriazole(BTA), an anticorrosion agent of slurry, is the main organic pollutant remaining after CMP of multilayer copper wiring, and also the main removal object of post CMP cleaning. The adsorption of BTA onto the copper could form a dense Cu-BTA film, which makes the copper surface strongly passivated. According to this characteristic, quantitative analysis of BTA residue after cleaning is carried out by contact angle measurement and electrochemical measurement in this paper. A scanning electron microscope(SEM) with EDX was used to observe and analyze the BTA shape and elements. The efficiencies of organic alkali and inorganic alkali on the removal of BTA were studied. The corresponding reaction mechanism was also analyzed. The results show that the adsorption structure of Cu(I)-BTA cannot be destroyed in an alkaline environment with a pH less than 10; the effect of BTA removal by inorganic alkali is worse than that of the organic amine alkali with the coordination structure under the same pH environment; the FA/O Ⅱ chelating agent with the fraction of 200 ppm can effectively remove BTA residue on the surface of copper wafer. | Liu Yang Baimei Tan Yuling Liu Baohong Gao Yilin Liu Chunyu Han Qi Wang Siyu Tian | 2018 | Journal of Semiconductors2018，39，12： | 6 |
| 14 | Differential gene expression analysis of ‘Chili’ (Pyrus bretschneideri) fruit pericarp with two types of bagging treatments显示文摘Preharvest bagging is a simple,grower-friendly and safe physical protection technique commonly applied to many fruits,and the application of different fruit bags can have various effects.To explore the molecular mechanisms underlying the fruit quality effects of different bagging treatments,digital gene expression(DGE)profiling of bagged and unbagged‘Chili’(Pyrus bretschneideri Rehd.)pear pericarp during development was performed.Relative to unbagged fruit,a total of 3022 and 769 differentially expressed genes(DEGs)were detected in the polyethylene(PE)-bagged and non-woven fabric-bagged fruit,respectively.DEGs annotated as photosynthesis-antenna proteins and photosynthesis metabolism pathway were upregulated in non-woven fabric-bagged fruit but downregulated in the PE-bagged fruit.Non-woven fabric bagging inhibited lignin synthesis in‘Chili’pear pericarp by downregulating DEGs involved in phenylpropanoid biosynthesis;consequently,the fruit lenticels in non-woven fabric-bagged fruit were smaller than those in the other treatments.The results indicate that the non-woven fabric bagging method has a positive effect on the appearance of‘Chili’pear fruit but neither of the two bagging treatments is conducive to the accumulation of soluble sugar. | Yuling Wang Xinfu Zhang Ran Wang Yingxin Bai Chenglian Liu Yongbing Yuan Yingjie Yang Shaolan Yang | 2017 | Horticulture Research2017，4，1： | 6 |
| 15 | Characteristics of Pegmatite-Related Fluids and Significance to Ore-Forming Processes in the Zhaxikang Pb-Zn-Sb Polymetallic Deposit,Tibet,China显示文摘The Zhaxikang Pb-Zn-Sb polymetallic deposit is one of the most important deposits in the newly recognized southern Tibet antimony-gold metallogenic belt.Compared to the porphyry deposits in the Gangdese belt,much less researches have addressed these deposits,and the genesis of the Zhaxikang deposit is still controversial.Based on field investigation,petrographic,microthermometric,Laser Raman Microprobe(LRM) and SEM/EDS analyses of fluid,melt-fluid,melt and solid inclusions in quartz and beryl from pegmatite,this paper documents the characteristics and the evolution of primary magmatic fluid which was genetically related to greisenization,pegmatitization,and silification in the area.The results show that the primary magmatic fluids were derived from unmixing between melt and fluid and underwent a phase separation process soon after the exsolution.The primary magmatic fluids are of low salinity,high temperature,and can be approximated by the H_2O-NaCl-CO_2 system.The presence of Mn-Fe carbonate in melt-fluid inclusions and a Zn-bearing mineral(gahnite) trapped in beryl and in inclusions from pegmatite indicates high Mn,Fe,and Zn concentrations in the parent magma and magmatic fluids,and implies a genetic link between pegmatite and Pb-Zn-Sb mineralization.High B and F concentrations in the parent magma largely lower the solidus of the magma and lead to late fluid exsolution,thus the primary magmatic fluids related to pegmatite have much lower temperature than those in most porphyry systems.Boiling of the primary magmatic fluids leads to high-salinity and high-temperature fluids which have high capacity to transport Pb,Zn and Sb.The decrease in temperature and mixing with fluids from other sources may have caused the precipitation of Pb-Zn-Sn(Au) minerals in the distal fault systems surrounding the causative intrusion. | XIE Yuling WANG Bogong LI Yingxu LI Guangming DONG Suiliang GUO Xiang WANG Lei | 2015 | Acta Geologica Sinica(English Edition)2015，89，3： | 6 |
| 16 | Synthesis and characterization of yttrium hydroxide and oxide microtubes显示文摘有六角形的阶段 Y 的六角形的微试管(哦)3 被一个灵巧的 solvothermal 方法成功地经由一条水晶转变线路当表面活化剂或模板不在时为 12 h 在 160 ° C 综合。扫描电子显微镜学(SEM ) 结果证明准备六角形的微试管与 50 100 nm, ∼1 μ m 的一条外部直径,并且长度在十测微计上面去的墙厚度。立方的阶段 Y 2 O 3 微试管在 Y 的热处理以后被获得(哦)3 在为 4 h 的 700 ° C 的微试管。Eu 3+-doped Y 2 有在 610 nm 的强壮的红排放的微试管也是的 O 3 准备了,他们的光致发光(PL ) 性质被学习。为微试管的形成的可能的机制简短被讨论。 | WANG Shijin ZHONG Shengliang WEN Zubiao WANG Yuling WANG Shangping CHEN Jianjun XU Rong LUO Longfei | 2009 | Rare Metals2009，28，5： | 5 |
| 17 | Single-cell transcriptome analysis reveals widespread monoallelic gene expression in individual rice mesophyll cells显示文摘Monoallelic gene expression refers to the phenomenon that all transcripts of a gene in a cell are expressed from only one of the two alleles in a diploid organism. Although monoallelic gene expression has been occasionally reported with bulk transcriptome analysis in plants, how prevalent it is in individual plant cells remains unknown. Here, we developed a single-cell RNA-seq protocol in rice and investigated allelic expression patterns in mesophyll cells of indica(93-11) and japonica(Nipponbare) inbred lines, as well as their F1 reciprocal hybrids. We observed pervasive monoallelic gene expression in individual mesophyll cells, which could be largely explained by stochastic and independent transcription of two alleles. By contrast, two mechanisms that were proposed previously based on bulk transcriptome analyses, parent-oforigin effects and allelic repression, were not well supported by our data. Furthermore, monoallelically expressed genes exhibited a number of characteristics, such as lower expression levels, narrower H3K4me3/H3K9ac/H3K27me3 peaks, and larger expression divergences between 93-11 and Nipponbare. Taken together, the development of a single-cell RNA-seq protocol in this study offers us an excellent opportunity to investigate the origins and prevalence of monoallelic gene expression in plant cells. | Yingying Han Xiao Chu Haopeng Yu Ying-Ke Ma Xiu-Jie Wang Wenfeng Qian Yuling Jiao | 2017 | Science Bulletin2017，62，19： | 5 |
| 18 | EBV-Induced Human CD8^+ NKT Cells Synergise CD4^+ NKT Cells Suppressing EBV-Associated Tumours upon Induction of Thl-Bias显示文摘 | Wei Xiao Li Li Rui Zhou Ruijing Xiao Yujuan Wang Xiang Ji Mengjun Wu Lan Wang Wei Huang Xiaoling Zheng Xinti Tan Lang Chen Tao Xiong Jie Xiong Youxin Jin Jinquan Tan Yuling He | 2009 | Cellular & Molecular Immunology2009，6，5： | 5 |
| 19 | Rod-shape inorganic biomimetic mutual-reinforcing MnO2-Au nanozymes for catalysis-enhanced hypoxic tumor therapy显示文摘Biomimetic nanozymes possessing natural enzyme-mimetic activities have been extensively applied in nanocatalytic tumor therapy.However,engineering hybrid biomimetic nanozymes to achieve superior nanozyme activity remained to be an intractable challenge in hypoxic tumors.Herein,a rod-like biomimetic hybrid inorganic MnO2-Au nanozymes are developed,where MnO2 and ultrasmall Au nanoparticles(NPs)are successively deposited on the mesoporous silica nanorod to cooperatively improve the O2 content and thermal sensitivity of hypoxic solid tumors guided by multi-modal imaging.Under the catalyzing of MnO2,the intratumoral H2O2 is decomposed to greatly accelerate O2 generation,which could boost the curative effect of radiation therapy(RT)and further enhance the Au-catalyzed glucose oxidation.Mutually,the Au NPs can steadily and efficiently catalyze the oxidation of glucose in harsh tumor microenvironment,thus sensitizing tumor cells to thermal ablation for mild photothermal therapy and further promoting the catalytic efficiency of MnO2 with the self-supplied H2O2/H+.As a result,this mutual-reinforcing cycle can endow the nanoplatform with accelerated O2 generation,thus alleviating hypoxic environment and further boosting RT effect.Furthermore,acute glucose consuming can induce downregulation expression of heat shock protein(HSP),achieving starvation-promoted mild photothermal therapy.This synthesized hybrid nanozymes proves to be a versatile theranostic agent for nanocatalytic cancer therapy. | Lifang Yang Chuchu Ren Min Xu Yilin Song Qianglan Lu Yule Wang Yan Zhu Xinxing Wang Nan Li | 2020 | Nano Research2020，13，8： | 5 |
| 20 | Shear-responsive boundary-lubricated hydrogels attenuate osteoarthritis显示文摘Lipid-based boundary layers formed on liposome-containing hydrogels can facilitate lubrication.However,these boundary layers can be damaged by shear,resulting in decreased lubrication.Here,a shear-responsive boundary-lubricated drug-loaded hydrogel is created by incorporating celecoxib(CLX)-loaded liposomes within dynamic covalent bond-based hyaluronic acid(HA)hydrogels(CLX@Lipo@HA-gel).The dynamic cross-linked network enables the hydrogel to get restructured in response to shear,and the HA matrix allows the accumulation of internal liposome microreservoirs on the sliding surfaces,which results in the formation of boundary layers to provide stable lubrication.Moreover,hydration shells formed surrounding the hydrogel can retard the degradation process,thus helping in sustaining lubrication.Furthermore,in vitro and in vivo experiments found that CLX@Lipo@HA-gels can maintain anabolic-catabolic balance,alleviate cartilage wear,and attenuate osteoarthritis progression by delivering CLX and shear-responsive boundary lubrication.Overall,CLX@Lipo@HA-gels can serve as shear-responsive boundary lubricants and drug-delivery vehicles to alleviate friction-related diseases like osteoarthritis. | Yiting Lei Xingkuan Wang Junyi Liao Jieliang Shen Yuling Li Zhengwei Cai Ning Hu Xiaoji Luo Wenguo Cui Wei Huang | 2022 | Bioactive Materials2022，7，10： | 4 |
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