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| 1 | Efficacy and safety of external application of Traditional Chinese Medicine for the treatment of acute gouty arthritis: a systematic review and Meta-analysis显示文摘OBJECTIVE:To evaluate the clinical efficacy and safety of external application of Traditional Chinese Medicine (EATCM) on acute gouty arthritis (AGA).METHODS:Six electronic data bases were retrieved from their inception to march 2017.15 randomized controlled clinical trials (RCTs) were included.The quality of the literatures was assessed according to Cochrane review criteria by using RevMan5.3 software;and related data was counted using Stata14.0 software.RESULTS:There was no significant difference in C-reactiveprotein (CRP) between experimental intervention group and control group [(WMD =1.093,95% C/(-2.514,4.701);P =0.553)].In terms of overall efficacy,the EATCM's treatment group was significantly superior to control group [(OR =3.692;95% CI (2.408,5.661);P <0.001)].The EATCM was better than western medicine treatments or other interventions in reducing the adverse reactions [(OR =0.135;95% CI (0.067,0.274);P < 0.001)].All these funnel plots showed unlikelihood of publishing bias.But due to excessive heterogeneity,the statistical results of serum uric acid and visual analogue scale and CRP between the two groups became uncertain.CONCLUSION:The results indicate that EATCM may have greater overall efficacy with fewer adverse drug reactions,although the evidence is weak owing to the low methodological quality and the small number of the included trials. | Huang Xinxing Zhu Zonghua Wu Guang-hui Min Peng Fei Peng Zhu Tao Wang Xuezong Xiao Lianbo | 2019 | Journal of Traditional Chinese Medicine2019，39，3： | 12 |
| 2 | Higher alcohol synthesis over Cu-Fe composite oxides with high selectivity to C_(2+)OH显示文摘Cu-Fe composite oxides were prepared by co-precipitation method and tested for higher alcohol synthesis from syngas. The selectivity to C2+OH and C6+OH in alcohol distribution was very high while the methane product fraction in hydrocarbon distribution was rather low, demonstrating a promising potential in higher alcohols synthesis from syngas. The distribution of alcohols and hydrocarbons approximately obeyed Anderson-Schulz-Flory distribution with similar chain growth probability, indicating alcohols and hydrocarbons derived from the same intermediates. The effects of Cu/Fe molar ratio, reaction temperature and gas hourly space velocity (GHSV) on catalytic performance were studied in detail. The sample with a Cu/Fe molar ratio of 10/1 exhibited the best catalytic performance. Higher reaction temperature accelerated water-gas-shift reaction and led to lower total alcohols selectivity. GHSV showed great effect on catalytic performance and higher GHSV increased the total alcohol selectivity, indicating there existed visible dehydration reaction of alcohol into hydrocarbon. | Zhenghong Bao Kang Xiao Xingzhen Qi Xinxing Wang Liangshu Zhong Kegong Fang Minggui Lin Yuhan Sun | 2013 | Journal of Energy Chemistry2013，22，1： | 10 |
| 3 | A Preliminary Review of Metallogenic Regularity of Molybdenum Deposits in China显示文摘Molybdenum is one of the dominant minerals in China because of its rich reserves.In recent years,outstanding breakthroughs have been made in molybdenum prospecting in China,and the distribution of molybdenum deposits in China is found to have a 'planar pattern'.In general,the molybdenum deposits are concentrated in eastern China,including the largest molybdenum reserves of Henan Province.In terms of the scale of molybdenum deposits,the identified resources of the superlarge deposits are the most important,which account for about 53% of the whole country,and those of the large deposits account for about 30%,those of the medium-sized deposits account for about 14%,those of the small-sized deposits,mine spots and mineralization account for about 3%.The molybdenum deposits are mainly classified as porphyry type,skarn type,hydrothermal(vein) type and sedimentary(metamorphic) type in genesis,and the identified resources of these types account for 85.75%,8.83%,2.79%and 2.63% of the total resources respectively.Based on the statistics of precise chronology data of molybdenites Re-Os,Mo-mineralization can be divided into 6 periods in Chinese geological history,which are Precambrian(>800 Ma),Cambrian-Silurian(540-415 Ma,Caledonian),Devonian-Permian(400-290 Ma,Hecynian),Triassic(260-200 Ma,Indosinian),Jurassic-Cretaceous(195-70 Ma,Yanshanian) and Paleogene-Neogene(65-10 Ma,Himalayan).Mo mineralization during the Yanshanian period is the strongest one,in which about 76.69% of the Chinese total identified resources was formed.The second is the Himalayan period.According to spatial-temporal distribution characteristics of molybdenum deposits,the metallogenic regularity of molybdenum deposits was preliminarily summarized,and 41 level-Ⅲ molybdenum-forming belts,13 level-Ⅱ molybdenum-forming provinces and 4 level-Ⅰ molybdenum-forming domains were ascertained in the mainland of China.There are 39 metallogenic series of and 60 sub-series of molybdenum deposits with molybdenum as the dominant metal and corresponding representative molybdenum deposits proposed.Metallogenic lineages of molybdenum deposits were also established.Spatial-temporal evolution of different types of molybdenum deposits,and the relationship between Mo-mineralization and tectonic evolution have been discussed in this paper.On this basis,the authors think that element Mo is an effective tracer for recording the crustal evolution history of China.At present,there are some problems in the exploration of Mo deposits in China,such as uneven exploration degrees in eastern and western China,shallow exploration depth,low and uneven grade,complex associated components,difficulty of mineral development and utilization,increasing costs of prospecting,and so on.According to successful experience of superficial and deep prospecting and considering also the discussion above,some suggestions are proposed for the prospecting of molybdenum deposits in the future. | HUANG Fan LIU Xinxing WANG Denghong WANG Chenghui | 2015 | Acta Geologica Sinica(English Edition)2015，89，3： | 7 |
| 4 | Rod-shape inorganic biomimetic mutual-reinforcing MnO2-Au nanozymes for catalysis-enhanced hypoxic tumor therapy显示文摘Biomimetic nanozymes possessing natural enzyme-mimetic activities have been extensively applied in nanocatalytic tumor therapy.However,engineering hybrid biomimetic nanozymes to achieve superior nanozyme activity remained to be an intractable challenge in hypoxic tumors.Herein,a rod-like biomimetic hybrid inorganic MnO2-Au nanozymes are developed,where MnO2 and ultrasmall Au nanoparticles(NPs)are successively deposited on the mesoporous silica nanorod to cooperatively improve the O2 content and thermal sensitivity of hypoxic solid tumors guided by multi-modal imaging.Under the catalyzing of MnO2,the intratumoral H2O2 is decomposed to greatly accelerate O2 generation,which could boost the curative effect of radiation therapy(RT)and further enhance the Au-catalyzed glucose oxidation.Mutually,the Au NPs can steadily and efficiently catalyze the oxidation of glucose in harsh tumor microenvironment,thus sensitizing tumor cells to thermal ablation for mild photothermal therapy and further promoting the catalytic efficiency of MnO2 with the self-supplied H2O2/H+.As a result,this mutual-reinforcing cycle can endow the nanoplatform with accelerated O2 generation,thus alleviating hypoxic environment and further boosting RT effect.Furthermore,acute glucose consuming can induce downregulation expression of heat shock protein(HSP),achieving starvation-promoted mild photothermal therapy.This synthesized hybrid nanozymes proves to be a versatile theranostic agent for nanocatalytic cancer therapy. | Lifang Yang Chuchu Ren Min Xu Yilin Song Qianglan Lu Yule Wang Yan Zhu Xinxing Wang Nan Li | 2020 | Nano Research2020，13，8： | 5 |
| 5 | Sin1/mTORC2 regulate B cell growth and metabolism by activating mTORC1 and Myc显示文摘Proper control of B cell growth and metabolism is crucial for B-cell-mediated immunity,but the underlying molecular mechanisms remain incompletely understood.In this study,Sin1,a key component of mTOR complex 2(mTORC2),specifically regulates B cell growth and metabolism.Genetic ablation of Sin1 in B cells reduces the cell size at either the transitional stage or upon antigen stimulation and severely impairs metabolism.Sin1 deficiency also severely impairs B-cell proliferation,antibody responses,and anti-viral immunity.At the molecular level,Sin1 controls the expression and stability of the c-Myc protein and maintains the activity of mTORC1 through the Akt-dependent inactivation of GSK3 and TSC1/2,respectively.Therefore,our study reveals a novel and specific role for Sin1 in coordinating the activation of mTORC2 and mTORC1 to control B cell growth and metabolism. | Man Li Adam S.Lazorchak Xinxing Ouyang Huihui Zhang Hongzhi Liu Omotooke A.Arojo Lichong Yan Jingsi Jin Yuheng Han Guojun Qu Yuhong Fu Xiaocao Xu Xiaobo Liu Wenqian Zhang Zhengfeng Yang Chuan Ruan Qijun Wang Dou Liu Chuanxin Huang Lu Lu Shibo Jiang Fubin Li Bing Su | 2019 | Cellular & Molecular Immunology2019，16，9： | 4 |
| 6 | Short-working-distance optical imaging system and method for surface detection of underwater structures显示文摘In the surface imaging of underwater structures, long working distance will reduce image quality due to the turbidity of water. To acquire high definition and large field of view(FOV) images for surface detection, a short-working-distance underwater imaging system is proposed based on camera array. A multi-view calibration and rectification method is developed. A look-up table(LUT) method and a multi-resolution spline(MRS) method are applied to stitch array images real-time and seamlessly.Experiments both in the air and in the water are conducted. Strength and weakness of the LUT and MRS methods are discussed.Based on the results, the effectiveness in surface detection of underwater structures is verified. | LIU Cong WANG ChengFei XU YingJun LI Xu LUO ChunHao DAI MeiLing SHAO XinXing HE XiaoYuan | 2018 | Science China(Technological Sciences)2018，61，5： | 4 |
| 7 | Review of the Metallogenic Regularity of Magnesite Deposits in China显示文摘China has abundant reserves of magnesite, making it the world's leading source of this strategic mineral.Sparry magnesite is the main type of magnesite deposit, and is easy to exploit.It occurs mainly as the sedimentary-metamorphic type.Production is centred on eastern Liaoning Province, where a world-class large to super large magnesite ore processing and production facility has been developed.Hydrothermal metasomatic deposits, associated with ultramafic complexes and eluvial deposits produced by weathering, are two other important types found in China.The Western section of the Bangonghu-Nujiang metallogenic belt is an important target region for prospecting lake-sedimentary magnesite deposits.Based on a systematic analysis of material from 62 magnesite production areas, this study investigated the metallogeny of magnesite and delineated 13 magnesite metallogenic belts.Maps were produced showing metallogenic regularities in magnesite deposits, the metallogenic system of the magnesite deposits, and the distribution of the metallogenic belts of Chinese magnesite deposits.It provides a theoretical basis for forecasting the location of potential magnesite resources in China.Finally, it explores some key scientific issues, including the formation processes of ultra magnesite ore-concentrated areas, and their sources of magnesium. | ZHAO Zheng CUI Xiaolin WANG Denghong CHEN Yuchuan BAI Ge LI Jiankang LIU Xinxing | 2015 | Acta Geologica Sinica(English Edition)2015，89，5： | 3 |
| 8 | Controllable fabrication of Au micro/nanostructures on self-doped polyaniline nanofibers via electrochemical deposition and its application for DNA immobilization显示文摘Four electrochemical methods, cyclic voltammetric deposition, potentiostatic electrodeposition, multi-potential step electrodeposition and three-step electrodeposition, were used to fabricate Au micro/nanostructures on self-doped polyaniline nanofibers-coated glassy carbon electrodes (Au/nanoSPAN/GCEs). The Au micro/nanostructures deposited on the nanoSPAN-modified electrodes were shown by scanning electron microscopy to exhibit different morphologies, such as Au nanoparticle clusters, monodisperse nanoparticles and homogeneously dispersed flower-like microparticles, depending on the deposition method. This phenomenon demonstrates that control over the morphology of Au metal can be easily achieved by adjusting the electrodeposition method. The electrochemical behaviors of the Au/nanoSPAN/GCEs also varied with above four methods, which were characterized by cyclic voltammetry and electrochemical impedance spectroscopy. In comparison with Au nanoparticle clusters and monodisperse Au nanoparticles, homogeneously dispersed flower-like Au microparticles had the largest surface area and obviously enhanced electrochemical response towards the redox reactions of [Fe(CN)6]3–/4– on the modified electrode. DNA immobilization on the Au/nanoSPAN/GCEs was investigated by differential pulse voltammetry using [Fe(CN)6]3–/4– as an indicator. The efficiency of DNA immobilization was inherently related to their different Au micro/nanostructure morphologies. The Au/nano-SPAN/GCE fabricated by three-step electrodeposition showed the largest capacity for immobilization of single stranded DNA, which makes it a promising DNA biosensor. | WANG XinXing YANG Tao JIAO Kui | 2010 | Chinese Science Bulletin2010，55，36： | 3 |
| 9 | MAP3K2 augments Th1 cell differentiation via IL-18 to promote T cell-mediated colitis显示文摘T cell-mediated immunity in the intestine is stringently controlled to ensure proper immunity against pathogenic microbes and to prevent autoimmunity,a known cause of inflammatory bowel disease.However,precisely how T cells regulate intestine immunity remains to be fully understood.In this study,we found that mitogen-activated protein kinase kinase kinase 2(MAP3K2)is required for the CD4^(+)T cell-mediated inflammation in the intestine.Using a T cell transfer colitis model,we found that MAP3K2-deficient naïve CD4^(+)T cells had a dramatically reduced ability to induce colitis compared to wild type T cells.In addition,significantly fewer IFN-γ-but more IL-17A-producing CD4^(+)T cells in the intestines of mice receiving MAP3K2-deficient T cells than in those from mice receiving wild type T cells was observed.Interestingly,under well-defined in vitro differentiation conditions,MAP3K2-deficient naïve T cells were not impaired in their ability to differentiate into Th1,Th17 and Treg.Furthermore,the MAP3K2-regulated colitis severity was mediated by Th1 but not Th17 cells in the intestine.At the molecular level,we showed that MAP3K2-mediated Th1 cell differentiation in the intestine was regulated by IL-18 and required specific JNK activation.Together,our study reveals a novel regulatory role of MAP3K2 in intestinal T cell immunity via the IL-18-MAP3K2-JNK axis and may provide a novel target for intervention in T cell-mediated colitis. | Ningbo Wu Dongping Chen Hongxiang Sun Jianmei Tan Yao Zhang Tianyu Zhang Yuheng Han Hongzhi Liu Xinxing Ouyang Xiao-Dong Yang Xiaoyin Niu Jie Zhong Zhengting Wang Bing Su | 2021 | Science China(Life Sciences)2021，64，3： | 3 |
| 10 | Enhanced stretch formability and mechanical properties of a magnesium alloy processed by cold forging and subsequent annealing显示文摘 | Xinxing Wu Xuyue Yang Jijun Ma Qinghuan Huo Jun Wang Huan Sun | 2013 | Materials and Design2013，，： | 2 |
| 11 | High level architecture evolved modular federation object model显示文摘To improve the agility,dynamics,composability,reusability,and development efficiency restricted by monolithic federation object model(FOM),a modular FOM is proposed by high level architecture(HLA)evolved product development group.This paper reviews the state-of-the-art of HLA evolved modular FOM.In particular, related concepts,the overall impact on HLA standards,extension principles,and merging processes are discussed. Also permitted and restricted combinations,and merging rules are provided,and the influence on HLA interface specification is given.The comparison between modular FOM and base object model(BOM)is performed to illustrate the importance of their combination.The applications of modular FOM are summarized.Finally,the significance to facilitate compoable simulation both in academia and practice is presented and future directions are pointed out. | Wang Wenguang Xu Yongping Chen Xinx Chen Xin Li Qun Wang Weiping | 2009 | Journal of Systems Engineering and Electronics2009，20，3： | 2 |
| 12 | Analysis of GNSS radio occultation data from satellite ZH-01显示文摘The electromagnetic satellite Zhangheng 01(ZH-01) was successfully launched on February 2, 2018. The GNSS Radio Occultation(GRO) receiver on board the satellite is able to observe the occultation events of GPS and BeiDou navigation satellites. We analyzed the data acquired during the in-orbit testing period. We concludes that the GRO ionosphere inversion results are reasonable,the trend is correct, the satellite can observe about 600 ionosphere occultation events each day. The global coverage of more than 30000 consecutive GRO events in more than two months were analyzed and compared with COSMIC observations: both the GRO and COSMIC occultation can realize global coverage: the Nm F2 and Hm F2 global distributions are similar and change obviously with latitude. We used three digisondes at different latitudes to analyze and compare the spatio-temporally consistent GRO data: the RMSE of GRO Nm F2 relative to digisonde is better than 9.41%, the correlation coefficient is better than 0.8682: the relative RMSE of Hm F2 is better than 7.80% and the correlation coefficient is better than 0.7066. | Yan Cheng Jian Lin XuHui Shen Xiang Wan XinXing Li WenJun Wang | 2018 | Earth and Planetary Physics2018，2，6： | 2 |
| 13 | A systematic review of the Physiological and Operative Severity Score for the enUmeration of Mortality and morbidity and its Portsmouth modification as predictors of post-operative morbidity and mortality in patients undergoing pancreatic surgery显示文摘 | Haolu Wang Tao Chen Hui Wang Yanyan Song Xinxing Li Jian Wang | 2013 | The American Journal of Surgery2013，，： | 2 |
| 14 | Effect of Dietary Vitamin E on the Sperm Quality of Turbot(Scophthalmus maximus)显示文摘A 3-month feeding experiment was conducted in an in-door seawater system to investigate the effect of dietary vitamin E(Ve) on the sperm quality of turbot(Scophthalmus maximus). D-α-tocopherol acetate was supplemented to the basal(control) diet(65.14 mg kg–1 Ve) to obtain low and high levels of dietary Ve(244.60 mg kg–1, LVe; 721.60 mg kg–1, HVe). Compared with the control, sperm concentration was significantly increased in Ve-supplemented groups(LVe and HVe); while relative sperm volume and testis-somatic index were significantly increased in group HVe only. Sperm motility duration was significantly longer in group HVe than in the control, but no significant difference was observed in percent motility among groups. Sperm size, the uniformity of mitochondrial size, and the integrity of mitochondria cristae and plasma membrane were improved by dietary Ve, especially in HVe. The content of Ve in testis and liver as well as polyunsaturated fatty acids in sperm increased with dietary Ve. These results suggested that dietary Ve, especially at the high level(721.60 mg kg–1), significantly improved sperm concentration and motility duration and maintained normal sperm morphology of turbot. | XU Houguo HUANG Lina LIANG Mengqing ZHENG Keke WANG Xinxing | 2015 | Journal of Ocean University of China2015，14，4： | 2 |
| 15 | HPV16E7-HSP70 Hybrid DNA Vaccine Induces E7-Specific Cytotoxic T Cells and Antitumor Immunity显示文摘Using human papillomavirus type 16 (HPV16) E7 as an antigen and Heat Shock Protein 70 as adjuvant, we constructed a DNA vaccine by linking HSP70 gene to E7~ C91G gene. Mice, after being immunized with E7~ C91G -HSP70, E7~ C91G /HSP70, E7~ C91G , and wild E7 DNA vaccines respectively, produced E7 specific CD8^+ T-cell precursor frequencies of 280.33±2.52, 144.34±4.04, 164.34±5.13 and 82.33±3.51 respectively within every 1×10~5 mouse splenocytes. This proves that E7~ C91G -HSP70 fusion vaccine can significantly enhance the E7 specific cellular immunity within the mice body(p<0.01). After being immunized with E7~ C91G -HSP70 fusion vaccine, tumor-bearing mice of the group being treated have significantly longer latency and survival periods, comparing with other three categories of E7 vaccines. Experiment shows that this vaccine has a significant effect on enhancing E7 positive tumor-treatment within mice body. After being immunized with E7~ C91G -HSP70 vaccine, there were no pathological changes found in livers, kidneys and spleens of the mice, which proves that the vaccine is quite safe. After all, E7~ C91G -HSP70 fusion vaccine has a much stronger tumor- treatment effect than that of wild type E7 DNA vaccine. | ZHU Liqin LI Hui XIONG Jinhu WANG Tongxiang OU Xuan WEI Yun WU Xinxing | 2006 | Wuhan University Journal of Natural Sciences2006，11，3： | 2 |
| 16 | Generation of human hepatocytes from extended pluripotent stem cells显示文摘Dear Editor,Human pluripotent stem cells have great potential for application in regenerative medicine,as they permit the generation of different lineages of functional cell types via directed differentiation.1 However,application of conventional human pluripotent stem cells is limited due to several factors,including heterogeneity in pluripotency,differentiation bias,relatively slow proliferation,and poor single-cell survival.2 Toovercome these problems. | Qiming Wang Da Sun Zhen Liang Junyi Wang Xinxing Zhong Yulin Lyu Junning Cao Zhongqing Lin Yuanyuan Du Zhenchuan Miao Shichun Lu Cheng Li Jun Xu Yan Shi Hongkui Deng | 2020 | Cell Research2020，30，9： | 1 |
| 17 | Distributed cache replacement method for geospatial data using spatiotemporal localitybased sequence显示文摘Specific features of tile access patterns can be applied in a cache replacement strategy to a limited distributed high-speed cache for the cloud-based networked geographic information services(NGISs),aiming to adapt to changes in the access distribution of hotspots.By taking advantage of the spatiotemporal locality,the sequential features in tile access patterns,and the cache reading performance in the burst mode,this article proposes a tile sequence replacement method,which involves structuring a Least Recently Used(LRU)stack into three portions for the different functions in cache replacement and deriving an expression for the temporal locality and popularity of the relevant tile to facilitate the replacement process.Based on the spatial characteristics of both the tiles and the cache burst mode with regard to reading data,the proposed method generates multiple tile sequences to reflect spatiotemporal locality in tile access patterns.Then,we measure the caching value by a technique based on a weighted-based method.This technique draws on the recent access popularity and low caching costs of tile sequences,with the aim of balancing the temporal and spatial localities in tile access.It ranks tile sequences in a replacement queue to adapt to the changes in accessed hotspots while reducing the replacement frequency.Experimental results show that the proposed method effectively improves the hit rate and utilization rate for a limited distributed cache while achieving satisfactory response performance and high throughput for users in an NGIS.Therefore,it can be adapted to handle numerous data access requests in NGISs in a cloud-based environment. | Rui LI Jiapei FAN Xinxing WANG Zhen ZHOU Huayi WU | 2015 | Geo-Spatial Information Science2015，18，4： | 1 |
| 18 | Multilayer nanocapsules of polysaccharide chitosan and alginate through layer-by-layer assembly directly on PS nanoparticles for release显示文摘 | Shiqu Ye Chaoyang Wang Xinxing Liu Zhen Tong | 2005 | Journal of Biomaterials Science Polymer Edition2005，，7： | 1 |
| 19 | Estimation of the accumulation rates and health risks of heavy metals in residential soils of three metropolitan cities in China显示文摘Heavy metal concentrations in urban soils are likely to increase over time because of contin-uous urbanization and heavy metal emissions.To estimate the accumulation rates of heavy metals in urban soils,we collected soil samples from residential areas with different build-ing ages in the metropolitan cities of Shanghai,Shenzhen,and Beijing,China.Heavy metal concentrations in the soils varied among the cities and were primarily affected by soil parent material and the intensity of anthropogenic sources.Regression analyses revealed that the accumulation rates of Cd and Cu in the soils ranged from 0.0034 to 0.0039 mg/(kg·year)and 0.343 to 0.391 mg/(kg·year),respectively,and were similar across the three cities,while ac-cumulation rates of Zn and Pb in Shanghai were higher than those in Shenzhen and Beijing.The higher accumulation rates of Zn and Pb in Shanghai can be explained by differences in city history and industrial structures among the cities.Residential soils with high health risks posed by the heavy metals were mostly collected from old towns of Shanghai because of high Pb content in the areas.Although recent urbanization resulted in elevated concen-trations of Cd,Cu,Zn,and Pb in the residential soils,the effect on the total health risks of residents exposed to the soils was negligible. | Chi Peng Kai Zhang Meie Wang Xinxing Wan Weiping Chen | 2022 | Journal of Environmental Sciences2022，34，5： | 1 |
| 20 | Synthesis and dual response of ionic nanocomposite hydrogels with ultrahigh tensibility and transparence显示文摘 | Xiaobo Hu Lijun Xiong Tao Wang Zemin Lin Xinxing Liu Zhen Tong | 2009 | Polymer2009，，8： | 1 |
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