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| 1 | K-Ar dating of late Mesozoic volcanism and geochemistry of volcanic gravels in the North Huaiyang Belt, Dabie orogen: Constraints on the stratigraphic framework and exhumation of the northern Dabie orthogneiss complex显示文摘Two eruption episodes are identified through systematic field investigations and K-Ar dating of the late Mesozoic volcanic rocks in the North Huaiyang belt (NHB), Dabie orogenic belt, of which the earlier volcanic suite termed Maotanchang Fm. (Fm.) occurring at Jinzhai, Xianhualing and Maotanchang, etc., was erupted from 149 Ma to 138 Ma. The other named Xiaotian Fm. mainly distributed at Xiaotian, Shucheng, etc., was formed between 132 Ma and 116 Ma. During the eruption gap of the two volcanic suites deposited a volcano-sedimentary conglomerate layer, which are composed of the multi-compositional gravels, including the North Dabie orthogneiss complex (NDOC), volcanic gravels, etc. These volcanic gravels in the conglomerate layer show identical geochemical and isotopic compositions (87Sr/86Sr(t) =0.7084-0.7092,εNd(t) =-21.8--24.4) to the Maotanchang Fm. volcanic rocks (87Sr/86Sr = 0.7086-0.7102,εNd = -19.2-24.4), but significantly distinct from those of Xiaotian Fm. (87Sr/86Sr = 0.7076-0.7084, εNd= | Yuejun Wang Weiming Fan Feng Guo | 2002 | Chinese Science Bulletin2002，47，20： | 28 |
| 2 | Single-cell analysis reveals bronchoalveolar epithelial dysfunction in COVID-19 patients显示文摘Dear Editor,In 2019,a zoonotic coronavirus named severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)was identified as the causative agent of Coronavirus Disease 2019(COVID-19).As of 8 June 2020,the World Health Organization(WHO)has reported 6,912,751 globally confirmed cases with 400,469 deaths.Although generally causes mild disease,SARS-CoV-2 infection can result in serious outcomes,including acute lung injury(ALI)and acute respiratory distress syndrome(ARDS),the leading cause of mortality in patients with comorbidities.Recent autopsy studies of COVID-19 patients revealed mononuclear infiltration and excessive production of mucus in the infected lung,especially in the damaged small airways and alveoli(Bian and Team,2020;Liu et al.,2020). | Jiangping He Shuijiang Cai Huijian Feng Baomei Cai Lihui Lin Yuanbang Mai Yinqiang Fan Airu Zhu Huang Huang Junjie Shi Dingxin Li' Yuanjie Wei Yueping Li Yingying Zhao’ Yuejun Pan He Liu Xiaoneng Mo Xi He Shangtao Cao FengYu Hu Jincun Zhao Jie Wang Nanshan Zhong Xinwen Chen Xilong Deng Jiekai Chen | 2020 | Protein & Cell2020，11，9： | 7 |
| 3 | An individualized immune signature of pretreatment biopsies predicts pathological complete response to neoadjuvant chemoradiotherapy and outcomes in patients with esophageal squamous cell carcinoma显示文摘No clinically available biomarkers can predict pathological complete response(pCR)for esophageal squamous cell carcinomas(ESCCs)with neoadjuvant chemoradiotherapy(nCRT).Considering that antitumor immunity status is an important determinant for nCRT,we performed an integrative analysis of immune-related gene profiles from pretreatment biopsies and constructed the first individualized immune signature for pCR and outcome prediction of ESCCs through a multicenter analysis.During the discovery phase,14 differentially expressed immune-related genes(DEIGs)with greater than a twofold change between pCRs and less than pCRs( | Chaoqi Zhang Guochao Zhang Nan Sun Zhen Zhang Liyan Xue Zhihui Zhang Haijun Yang Yuejun Luo Xiaoli Zheng Yonglei Zhang Yufen Yuan Ruixue Lei Zhaoyang Yang Bo Zheng Le Wang Yun Che Feng Wang Sihui Wang Shugeng Gao Qi Xue Yi Zhang Jie He | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 7 |
| 4 | Dexamethasone-loaded ROS-responsive poly(thioketal)nanoparticles suppress inflammation and oxidative stress of acute lung injury显示文摘Acute lung injury(ALI)is associated with excessive inflammatory response,leading to acute respiratory distress syndrome(ARDS)without timely treatment.A fewer effective drugs are available currently to treat the ALI/ARDS.Herein,a therapeutic nanoplatform with reactive oxygen species(ROS)-responsiveness was developed for the regulation of inflammation.Dexamethasone acetate(Dex)was encapsulated into poly(thioketal)polymers to form polymeric nanoparticles(NPs)(PTKNPs@Dex).The NPs were composed of poly(1,4-phenyleneacetonedimethylene thioketal)(PPADT)and polythioketal urethane(PTKU),in which the thioketal bonds could be cleaved by the high level of ROS at the ALI site.The PTKNPs@Dex could accumulate in the pulmonary inflammatory sites and release the encapsulated payloads rapidly,leading to the decreased ROS level,less generation of pro-inflammatory cytokines,and reduced lung injury and mortality of mice.RNA sequencing(RNA-seq)analysis showed that the therapeutic efficacy of the NPs was associated with the modulation of many immune and inflammation-linked pathways.These findings provide a newly developed nanoplatform for the efficient treatment of ALI/ARDS. | Zihe Zhai Wei Ouyang Yuejun Yao Yuqi Zhang Haolan Zhang Feng Xu Changyou Gao | 2022 | Bioactive Materials2022，7，8： | 5 |
| 5 | Petrochemistry and Tectonic Setting of the Middle Triassic Arc-Like Volcanic Rocks in the Sayabouli Area,NW Laos显示文摘The volcanic rocks from the Sayabouli area in northwestern Laos have been poorly studied. These volcanic rocks are traditionally mapped as the Permian–Early Triassic sequences on the geological map. One basaltic-andesite from the Sayabouli area yields a zircon U-Pb age of 237.7±1.7 Ma, suggesting a Middle Triassic origin. All basalt and basaltic-andesite samples from the Sayabouli area show depletions in HFSEs(e.g., Nb, Ta, Ti) and have high LILE/HFSE ratios, and exhibit the geochemical affinity to the continental arc volcanic rocks and are geochemically similar to the continental arc volcanic rocks from the Phetchabun belt in northeastern Thailand, suggesting a Late Permian–Middle Triassic continental margin in the Sayabouli area of northwestern Laos and Phetchabun area of northeastern Thailand. Our data indicate that the Phetchabun arc volcanic belt through the western Loei sub-belt can be linked to the Sayabouli area in northwestern Laos. | Xin Qian Qinglai Feng Yuejun Wang Wenqiang Yang Chongpan Chonglakmani Denchok Monjai | 2016 | Journal of Earth Science2016，27，3： | 5 |
| 6 | Geochemical and Geochronological Constraints on the Origin of the Meta-basic Volcanic Rocks in the Tengtiaohe Zone, Southeast Yunnan显示文摘The meta-basic volcanic rocks in the Tengtiaohe Zone yield zircon U–Pb ages of 258.8±2.5 Ma and 259.2±1.8 Ma, respectively which agree with the ages of flood basalts of ELIP and are similar to the basaltic rocks and komatiites from the Song Da Zone in northern Vietnam. The results suggest that the age of meta-basic volcanic rocks is Late Permian, rather than the Early Permian or Early Carboniferous ages as previously inferred. Most meta-basic volcanic rocks are strongly enriched in LREEs relative to HREEs and display trace element patterns similar to the ELIP high-Ti basalts, and are enriched in LILEs with negative Sr anomalies. Their initial ^(87)Sr/^(86) Sr ratios range from 0.705974 to 0.706188 and εNd(t) from-0.82 to-2.11. Their magmas were derived from an enriched and deep mantle source without significant crustal contamination. These meta-basic volcanic rocks formed in ELIP. Therefore, the Tengtiaohe Zone is not an ophiolite zone and can link to the Song Da Zone in northern Vietnam. | QIAN Xin FENG Qinglai WANG Yuejun ZHANG Zhibin | 2016 | Acta Geologica Sinica(English Edition)2016，90，2： | 3 |
| 7 | Geochemistry of early Mesozoic potassium-rich diorites-granodiorites in Southeastern Hunan Province, South China: petrogenesis and tectonic implication显示文摘 | Wang Yuejun Fan Weiming Guo Feng | 2003 | Geochemical Journal2003，37，4： | 1 |
| 8 | Origin of early Cretaceous talc-alkaline lamprophyres from the Sulu orogen in eastern China: Implications for enrichment proc- esses beneath continental collisional belt 显示文摘 | Guo Feng Fan Weiming Wang Yuejun Zhang Ming | 2004 | Lithos2004，78，3： | 1 |
| 9 | Geochemical, 4^40Ar/^39Ar geochronological and Sr-Nd isotopic constraints on the origin of Paleoproterozoic mafic dikes from the southern Taihang Mountains and implications for the North China Craton显示文摘 | Wang Yuejun Fan Weiming Yanhua Zhang Guo Feng Zhang Hongfu Peng Touping | 2004 | Precambn Res2004，135，12： | 1 |
| 10 | Nature of the Mesozoic lithospheric mantle andtectonic decoupling beneath the Dabie Orogen, Central China:Evidence from 40Ar/39Ar geochronology, elemental andSr-Nd-Pb isotopic compositions of Early Cretaceous maficigneous rocks 显示文摘 | Wang Yuejun Fan Weiming Peng Touping Zhang Hongfu Guo Feng | 2005 | Chem Geol2005，220，16： | 1 |
| 11 | Nature of the Mesozoic lithospheric mantle and tectonic decoupling beneath the Dabie Oregen, Central China: Evidence from ^40Ar/^39Ar geochronology, elemental and Sr-Nd-Pb isotopic compositions of early Cretaceous mafic igneous recks显示文摘 | Wang Yuejun Fan Weiming Peng Touping Zhang Hongfu Guo Feng | 2005 | Chem Geol2005，220，34： | 1 |
| 12 | In situ & contro -lled preparation of platinum nanoparticles dopping into graphene sheets@cerium oxide nanocomposites sensitized screen printed electrode for nonenzymatic electrochemical sensing of hydrogen peroxide显示文摘 | Xin Yang Yuejun Ouyang Feng Wu et a/ | 2016 | Journal of Electroanalyti -cal Chemistry2016，，9： | 1 |
| 13 | Elemental and Sr–Nd isotopic systematics of the early Mesozoic volcanic sequence in southern Jiangxi Province, South China: petrogenesis and tectonic implications显示文摘 | Yuejun Wang Weiming Fan Touping Peng Feng Guo | 2005 | International Journal of Earth Sciences2005，，1： | 1 |
| 14 | Late Mesozoic volcanism in the northern Huaiyang tectono-magmatic belt,central China:Prtial melts from a lithospheric mantle with subducted continental crust relicts beneath the Dabie orogen?显示文摘 | Fan Weiming Guo Feng Wang Yuejun Zhang Ming | 2004 | Chemical Geology2004，209，： | 1 |
| 15 | Geochemistry of Mesozoic mafic rocks adjacent to the Chenzhou-Linwu fault, South China: Implications for the lithospheric boundary between the Yangtze and Cathaysia blocks显示文摘 | Wang Yuejun Fan Weiming Guo Feng Peng Touping Li Chaowen | 2003 | Int Geol Rev2003，45，3： | 1 |
| 16 | When did the Emeishan mantle plume activity start? geochronological and geochemical evidence from ultramafic-mafic dikes in southwestern China显示文摘 | Guo Feng Fan Weiming Wang Yuejun | 2004 | International Geology Review2004，46，3： | 1 |
| 17 | Evolution of lithofacies and paleogeography and hydrocarbon distribution worldwide(I)显示文摘By using a large amount of geological and geophysical data, the geological characteristics such as lithofacies and paleogeography of 4981 geological units at thirteen key geological periods or epoches since the Precambrian in the world have been figured out. The global lithofacies and paleogeography charts have been compiled by ArcGis mapping technology. Combined with the results of plate-paleogeography reconstruction, the lithofacies and paleogeography as well as the prototype basins of these global paleoplates have been restored with the Gplate software. Results show that there are 22 kinds of lithofacies combinations and 10 types of paleogeography units developed since Precambrian. These features of lithofacies and paleogeography as well as their evolution were mainly controlled by the divergent and convergent movements of those plates. Taking the results of the lithofacis and paleogeography at the present and paleoplate location during the seven key geological periods from the Precambrian to Paleozoic for example, during the Late Precambrian and Cambrian, the large-scale disintegration of the Rodinia supercontinent resulted in reduction of uplift denudation area and clastic terrestrial facies area, the expansion of coastal-shallow marine facies and shallow-water carbonate platform. In Devonian, uplift denudation area and clastic terrestrial facies area began to increase and littoral-shallow marine facies area and shallow-water carbonate platform shrank as a result of the formation of Larussia supercontinent. In the Permian, with the formation of the Pangea continent, the development of the global uplift denudation area and clastic terrestrial facies reached its peak, while the littoral and shallow marine facies were very limited in distribution. The lithofacies and paleogeography features and evolution patterns of different stages lay a solid foundation for analyzing the formation conditions of geological elements, such as source rocks, reservoirs and cap rocks for oil and gas accumulation, and revealing the distribution regularity of oil and gas around the world. | ZHANG Guangya TONG Xiaoguang XIN Renchen WEN Zhixin MA Feng HUANG Tongfei WANG Zhaoming YU Bingsong LI Yuejun CHEN Hanlin LIU Xiaobing LIU Zuodong | 2019 | Petroleum Exploration and Development2019，46，4： | 0 |
| 18 | Development of a Kind of Immunomagnetic Bead Kit to Separate and Enrich Salbutamol显示文摘An immunomagnetic bead kit to separate and enrich salbutamol was prepared through the reaction between salbutamol and 4-aminobenzoic acid.The kit had a catch of 20 ng/ml to salbutamol in samples,and showed no cross reaction with competitive drugs with structure and function similar to salbutamol: clenbuterol,ractopamine,phenylethanolamine A, bromchlorbuterol, brombuterol, terbutaline, hydroxymethyl salbutamol,cimaterol,tulobuterol,mapenterol,cimbuterol,clenpenterol,zilpaterol,penbutolol,clenproperol,mabuterol and clorprenaline. | Yuping WAN Xiaosheng WU Fangfang JIA Jing LI Zhaoqin WANG Yuejun FENG Meihong DU Fangyang HE | 2018 | Agricultural Biotechnology2018，7，6： | 0 |
| 19 | The combination of novel immune checkpoints HHLA2 and ICOSLG:A new system to predict survival and immune features in esophageal squamous cell carcinoma显示文摘Studies on immune checkpoint inhibitors targeting B7-CD28 family pathways in esophageal squamous cell carcinoma(ESCC)have shown promising results.However,a comprehensive understanding of B7-CD28 family members in ESCC is still limited.This study aimed to construct a novel B7-CD28 family-based prognosis system to predict survival in patients with ESCC.We collected 179 cases from our previously published microarray data and 86 cases with qPCR data.Specifically,119 microarray data(GSE53624)were used as a training set,whereas the remaining 60 microarray data(GSE53622),all 179 microarray data(GSE53625)and an independent cohort with 86 qPCR data were used for validation.The underlying mechanism and immune landscape of the system were also explored using bioinformatics and immunofluorescence.We examined 13 well-defined B7-CD28 family members and identified 2 genes(ICSOLG and HHLA2)with the greatest prognostic value.A system based on the combination HHLA2 and ICOSLG(B7-CD28 signature)was constructed to distinguish patients as high-or low-risk of an unfavorable outcome,which was further confirmed as an independent prognostic factor.As expected,the signature was well validated in the entire cohort and in the independent cohort,as well as in different clinical subgroups.The signature was found to be closely related to immune-specific biological processes and pathways.Additionally,high-risk group samples demonstrated high infiltration of Tregs and fibroblasts and distinctive immune checkpoint panels.Collectively,we built the first,practical B7-CD28 signature for ESCC that could independently identify high-risk patients.Such information may help inform immunotherapy-based treatment decisions for patients with ESCC. | Chaoqi Zhang Feng Wang Nan Sun Zhen Zhang Guochao Zhang Zhihui Zhang Yuejun Luo Yun Che Hong Cheng Jiagen Li Jie He | 2022 | Genes & Diseases2022，9，2： | 0 |
| 20 | Coupling a titanium dioxide based heterostructure photoanode with electroless-deposited nickel-phosphorus alloy coating on magnesium alloy for enhanced corrosion protection显示文摘The utilization of photoelectrochemical cathodic protection(PECCP)enables an indirect corrosion pro-tection of metals with low self-corrosion potential by introducing a metallic nickel interlayer.However,the ability to enhance the PECCP efficiency remains challenging because of the inherent property of the semiconductor.Herein,this ability is demonstrated by coupling a covalent organic framework(TpBD)dec-orated TiO 2 photoanode(TiO 2/TpBD)with nickel coating on magnesium alloy for an effective corrosion protection.The composite photoanode showed direct PECCP for the nickel interlayer and indirect corro-sion protection of the magnesium alloy.The composite structure of the nanotube array and the covalent organic framework for the photoanode were confirmed by field emission scanning electron microscopy(FESEM),transmission electron microscopy(TEM),and X-ray photoelectron spectroscopy(XPS).The en-hanced photoelectrochemical conversion capability and PECCP performance of the nickel-coated Mg alloy were evidenced by the results from electrochemical and photoelectrochemical measurements including Mott-Schottky curves,photoinduced potential variations,and electrochemical impedance spectroscopy(EIS).Lastly,a corrosion protection mechanism is proposed,where the enhanced PECCP efficiency is at-tributed to the formation of a direct Z-scheme heterojunction,which is substantiated by the results from valence band(VB)XPS and electron spin resonance characterizations. | Yue Liu Feng Peng Guang-Ling Yang Zhi-Hui Xie Wenxin Dai Yuejun Ouyang Liang Wu Chuan-Jian Zhong | 2022 | Journal of Materials Science & Technology2022，，31： | 0 |
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