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106篇 您的检索式：作者名="Yuan CS"

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	题名	作者	年代	出处	被引量
1	Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4 activities显示文摘Aim:To clarify the mechanism of the therapeutic action of icariin on erectlile dysfunction(ED).Methods:PDE5 was isolated from the human platelet and PDE4 form the rat liver tissue using the FPLC system (Pharmacia,Milton Keynes,UK)and the Mono Q column.The inhibitory effects of icariin on PDE5 and PDE4 activities were investigated by the two-step radioisotope procedure with [^3H]-c GMP/[^3H]-cAMP.Papaverine served as the control drug.Results:Icariin and papaverine showed dose-dependent inhibitory effects on PDE5 and PDE4 activities.The IC50 of Icariin and papaverine on PDE5 were 0.432μ mol/L and 0.680μmol/L,respectively and those on PDE4,73.50μmol/L and 3.07μmol/L,respectively.The potencies of selectivity of icariin and papaverine on PDE5(PDE4/PDE5 of IC50)were 167.67 times and 4.54 times,respectively.Conclusion:Icariin is a cGMP-specific PDE5 inhibitor that may be developed into an oral effective agent for the treatment of ED.	ZC Xin EK Kim CS Lin WJ Liu L Tian YM Yuan J Fu	2003	Asian Journal of Andrology2003，5，1：	38
2	ginseng reduces warfarin's Brief communication: American effect in healthy patients: a randomized, controlled trial 显示文摘	Yuan CS Wei G Dey L	2004	Ann Intern Med2004，141，：	1
3	Potential role of ginseng in the treatment ofcolorectal cancer 显示文摘	Wang CZ Yuan CS	2008	Am J Chin Med2008，36，：	1
4	Chemical modificationand site-directed mutagenesis of cysteine residues in human pla-cental S-adenosylhomocysteine hydrolase显示文摘	Yuan CS Ault-Riche DB Borchardt RT	1996	J Biol Chem1996，271，28：	1
5	Ginseng Pharmacology: multiple constituents and multiple actions显示文摘	Attele AS Wu JN Yuan CS	1999	Biochcm Pharma1999，58，11：	1
6	Iridoids from Pedicu- laris kansuensis forma albiflora 显示文摘	Yuan CS Zhang Q Xie WD	2003	Pharmazie2003，58，6：	1
7	Methylnaltrexone prevents morphine-induced delay in oral-cecal transit time without affecting analgesia: a double-blind randomized placebo-controlled trial显示文摘	Yuan CS Foss JF O'Connor M	1996	Clin Pharmacol Ther1996，59，4：	1
8	cDNA microarray and expression in virus infected cells 显示文摘	Chen YD Yuan J	1999	Chin Sci Bull1999，44，5：	1
9	American ginseng: Potential structure-function relationship in cancer chemoprevention 显示文摘	Qi LW Wang CZ Yuan CS	2010	Biochemical Pharmacology2010，80，7：	1
10	Ginseng pharmacology multi- ple constituents and multiple actions显示文摘	Attele AS Wu JA Yuan CS	1999	Biochem Pharma- col1999，58，11：	1
11	Effects of enteric coated methylnaltrexone in preventing opioid-induced de- lay in oral-cecal transit time显示文摘	Yuan CS Foss JF O' Connor M	2000	Clin Pharmacol Ther2000，67，4：	1
12	Ginseng pharmacology: multiple constituents and multiple actions 显示文摘	ATTELE AS WU JA YUAN CS	1999	Biochem Pharmacol1999，58，：	1
13	Leptin, gut,and food intake 显示文摘	Attele AS Shi ZQ Yuan CS	2002	Biothem Pharmacol2002，63，9：	1
14	The gamma-aminobutyric acidergic effects of valerian and valerenic acid on rat brainstem neuronal activity显示文摘	Yuan CS Mehendale S Xiao Y	2004	Anesth Analg2004，98，2：	1
15	Herbal medicines as adjuvants for cancer therapeutics 显示文摘	Wang CZ Calway T Yuan CS	2012	Am J Chin Med2012，41，：	1
16	American ginseng : po- tential structure-funetionrelationsbip in cancer chemopre- vention显示文摘	Qi LW Wang CZ Yuan CS	2010	Biochemical Pharmacology2010，80，7：	1
17	Urinary biomarkers of tea polyphenols and risk of colorectal cancer in the Shanghai Cohort Study显示文摘	Yuan JM Gao YT Yang CS Yu MC	2007	Int J Cancer2007，120，：	1
18	Herbal medicines and perioper?ative care显示文摘	Ang-Lee MK MossJ Yuan CS	2001	JAMA2001，286，：	1
19	Ginseng pharmacology: multipleconstit- uents and multiple actions 显示文摘	Attele AS Wu JA Yuan CS	1999	Biochemical Pharmacology1999，58，11：	1
20	Traditional Chinese herbal therapy asa treatment option for H1N1 influenza 显示文摘	Wang CZ Li P Yuan CS	2012	Ann Intern Med2012，156，2：	1

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