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| 1 | Modeling xeroderma pigmentosum associated neurological pathologies with patients-derived iPSCs显示文摘干皮病 pigmentosum (XP ) 是联系 XP 的基因的变化引起的一组基因混乱,导致 DNA 修理的缺陷。XP 病人经常展出神经病学的退化,而是内在的机制是未知的,部分地由于合适的疾病模型的缺乏。这里,我们产生了包括 XPA, XPB, XPC, XPG,和 XPV 在五不同 XP 基因怀有变化的病人特定的导致的 pluripotent 干细胞(iPSCs ) 。这些 iPSCs 进一步被区分到神经房间,并且他们到 DNA 损坏应力的危险性被调查。在神经干细胞(NSC ) 或神经原的 XPA 的变化导致了严重 DNA 损坏修理缺点,并且有变异的 XPA 的这些神经房间对 DNA 导致损坏的 apoptosis 过分敏感。因此, XP 变异的神经房间代表珍贵工具在 XP 病人澄清神经病学的畸形的分子的机制。 | Lina Fu Xiuling Xu Ruotong Ren Jun Wu Weiqi Zhang Jiping Yang Xiaoqing Ren Si Wang Yang Zhao Liang Sun Yang Yu Zhaoxia Wang Ze Yang Yun Yuan Jie Qiao Juan Carlos Izpisua Belmonte Jing Qu Guang-Hui Liu | 2016 | Protein & Cell2016，7，3： | 11 |
| 2 | CRISPR/Cas9-mediated targeted gene correction in amyotrophic lateral sclerosis patient iPSCs显示文摘 | Lixia Wang Fei Yi Lina Fu Jiping Yang Si Wang Zhaoxia Wang Keiichiro Suzuki Liang Sun Xiuling Xu Yang Yu Jie Qiao Juan Carlos Izpisua Belmonte Ze Yang Yun Yuan Jing Qu Guang-Hui Liu | 2017 | Protein & Cell2017，8，5： | 10 |
| 3 | Natural continuous influent nitrifier immigration effects on nitrification and the microbial community of activated sludge systems显示文摘Two sequencing batch reactors(SBRs) were operated for 100 days under aerobic conditions,with one being fed with unsterilized municipal wastewater(USBR), and the other fed with sterilized municipal wastewater(SSBR). Respirometric assays and fluorescence in situ hybridization(FISH) results show that active nitrifiers were present in the unsterilized influent municipal wastewater. The maximum ammonia utilization rate(AUR) and nitrite utilization rate(NUR) of the unsterilized influent were 0.32 ± 0.12 mg NH4+-N/(L·hr) and0.71 ± 0.18 mg NO2--N/(L·hr). Based on the maximum utilization rates, the estimated seeding intensity for the ammonia oxidizing bacteria(AOB) and nitrite oxidizing bacteria(NOB) of the USBR was 0.08 g AOB/(g AOB·day) and 0.20 g NOB/(g NOB·day) respectively. The fraction of nitrifiers/total bacteria in the influent was 5.35% ± 2.1%, the dominant AOB was Nitrosomonas spp., Nitrosococcus mobilis hybridizated with Nsm156, and the dominant NOB was Nitrospira hybridizated with Ntspa662. The influent nitrifiers potentially seeded the activated sludge of the bioreactor and hence demonstrated a mitigation of the acclimatization times and instability during start-up and early operation. The AUR and NUR in the USBR was 15% and 13% higher than the SSBR respectively during the stable stage, FISH results showed that nitrifiers population especially the Nitrospira in the USBR was higher than that in the SSBR. These results indicate that the natural continuous immigration of nitrifiers from municipal influent streams may have some repercussions on the modeling and design of bioreactors. | Lifang Yu Ren Li Robert Delatolla Ru Zhang Xiuling Yang Dangcong Peng | 2018 | Journal of Environmental Sciences2018，30，12： | 7 |
| 4 | A widely adaptable approach to generate integration-free iPSCs from non-invasively acquired human somatic cells显示文摘 | Zhichao Ding Lina Sui Ruotong Ren Yanjun Liu Xiuling Xu Lina Fu Ruijun Bai Tingting Yuan Ying Hao Weiqi Zhang Huize Pan Wensu Liu Han Yu Concepcion Rodriguez Esteban Xiaobing Yu Ze Yang Jian Li Xiaomin Wang Juan Carlos Izpisua Belmonte Guang-Hui Liu Fei Yi Jing Qu | 2015 | Protein & Cell2015，6，5： | 5 |
| 5 | Overexpression of cytoglobin gene inhibits hypoxic injury to SH-SY5Y neuroblastoma cells显示文摘A plasmid for cytoglobin expression, pAcGFP1-C1-cytoglobin, was transfected into SH-SY5Y cells. Cobalt chloride was used to establish a model of hypoxia. Western blotting indicated that cytoglobin was overexpressed and there was low expression of hypoxia-inducible factor-1α in SH-SY5Y cells after transfection. Following cobalt chloride-induced hypoxia, cytoglobin and hypoxia-inducible fac-tor-1α expression gradually increased in SH-SY5Y cells. Flow cytometry showed that with increas-ing duration of hypoxia, the proportion of normal cells significantly diminished in the transfected and non-transfected groups. The proportion of cells in the early stages of apoptosis increased. However, the proportion of apoptotic cells was significantly lower in the transfected group compared with the non-transfected group. These results demonstrate that cytoglobin and hypoxia-inducible factor-1α are strongly up-regulated by hypoxia, and that there is a strong relationship between hy-poxia-inducible factor-1α and cytoglobin during hypoxic injury. | Xiuling Yu Dianwen Gao | 2013 | Neural Regeneration Research2013，8，23： | 3 |
| 6 | Estrogen upregulates DNA2 expression through the PI3K-AKT pathway in endometrial carcinoma显示文摘Endometrial cancer is the most common gynecological malignancy,affecting up to 3%of women at some point during their lifetime(Morice et al.,2016;Li and Wang,2021).Based on the pathogenesis and bio‑logical behavioral characteristics,endometrial cancer can be divided into estrogen-dependent(I)and non-estrogen-dependent(II)types(Ulrich,2011).Type I accounts for approximately 80%of cases,of which the majority are endometrioid carcinomas,and the remaining are mucinous adenocarcinomas(Setiawan et al.,2013). | Xinyan WANG Xiuling XU Ting ZHANG Yang JIN Sheng XU Lifeng CHEN Yucheng LAI Ling ZHANG Ruolang PAN Yan YU | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，3： | 2 |
| 7 | Ancient DNA sequences of rice from the low Yangtze reveal significant genotypic divergence显示文摘Rice (Oryza sativa) was first domesticated in the lower and middle Yangtze regions of China, and rice remains have been found in many Chinese archaeological sites. Until now, only phenotypic archeobotanical evidence, such as the spikelet bases of ancient grains, has been used to speculate on the domestication process and domestication rate of rice. In this study, we sequenced 4 genomic segments from rice remains in Tianluoshan, a site of the local Hemudu Neolithic culture in the low Yangtze and two other archaeological sites (~2400 and 1200 BC, respectively). We compared our sequences with those of the current domesticated and wild rice (O. rufipogon) populations. At least two genotypes were found in the remains from each site, suggesting a heterozygotic state of the rice seeds. One ancient genotype was not found in the current domesticated population and might have been lost. The rice remains belonged to the japonica group, and most if not all were japonica-type, suggesting that the remains might be at an early stage of indica-japonica divergence or an indica-japonica mixture. We also identified sequences with significant similarity to those from species of Sapindales, Zygophyllales, and Brassicales, which is consistent with the identification of other plant remains in the Tianluoshan site and the common rice field weeds such as mustards in southern China. | FAN LongJiang GUI YiJie ZHENG YunFei WANG Yu CAI DaGuang YOU XiuLing | 2011 | Chinese Science Bulletin2011，56，28： | 2 |
| 8 | An analysis of the original driving forces behind the promotion of compulsory cleaner production assessment in key enterprises of China 显示文摘 | ZHIGANG DAN XIULING YU JIE YIN | 2013 | Journal of Cleaner Production2013，，46： | 1 |
| 9 | Emergence of Fatal PRRSV Variants: Unparalleled Outbreaks of Atypical PRRS in China and Molecular Dissection of the Unique Hallmark 显示文摘 | Kegong Tian Xiuling Yu Tiezhu Zhao | 2007 | PloSone2007，6，： | 1 |
| 10 | Emergence of Fatal PRRSV Variants: Unparalleled Outbreaks of Atypical PRRS in China and Molecular Dissection of the Unique Hall- mark显示文摘 | Kegong Tian Xiuling Yu Tiezhu Zhao | 2007 | PLoS ONE2007，，6： | 1 |
| 11 | Emergence of fatal PRRSV variants: unparalleled outbreaks of atypical PRRS in China and molecular dissection of the unique hallmark 显示文摘 | Tian Kegong Yu Xiuling Zhao Tiezhu | 2007 | PLoS ONE2007，，6： | 1 |
| 12 | Emergence of Fatal PRRSV Variants: Unparalleled Outbreaks of Atypical PRRS in China and Molecular Dissection of the Unique Hallmark显示文摘 | KEGONG TIAN XIULING YU | 2007 | Plos One2007，，6： | 1 |
| 13 | Emergence of Fatal PRRSV Variants: Unparalleled Outbreaks of Atypical PRRS in China and Molecular Dissection of the Unique Hallmark 显示文摘 | Kegong Tian Xiuling Yu Tiezhu Zhao | 2007 | PLoS ONE2007，2，6： | 1 |
| 14 | Emergence of Fatal PRRSV Variants:Unparalleled Outbreaks of Atypical PRRS in China and Molecular Dissection of the Unique Hallmark显示文摘 | Kegong Tian Xiuling Yu Tiezhu Zhao | 2007 | Plos One2007，，6： | 1 |
| 15 | Emergence of Fatal PRRSV Variants: Unparalleled Outbreaks of Atypical PRRS in China and Molecular Dissection of the Unique Hallmark显示文摘 | Kegong Tian Xiuling Yu Tiezhu Zhao et d | 2007 | PLoS 0NE2007，2，6： | 1 |
| 16 | Development and validation of a machine learning-based nomogram for prediction of intrahepatic cholangiocarcinoma in patients with intrahepatic lithiasis显示文摘Background:Accurate diagnosis of intrahepatic cholangiocarcinoma(ICC)caused by intrahepatic lithiasis(IHL)is crucial for timely and effective surgical intervention.The aim of the present study was to develop a nomogram to identify ICC associated with IHL(IHL-ICC).Methods:The study included 2,269 patients with IHL,who received pathological diagnosis after hepatectomy or diagnostic biopsy.Machine learning algorithms including Lasso regression and random forest were used to identify important features out of the available features.Univariate and multivariate logistic regression analyses were used to reconfirm the features and develop the nomogram.The nomogram was externally validated in two independent cohorts.Results:The seven potential predictors were revealed for IHL-ICC,including age,abdominal pain,vomiting,comprehensive radiological diagnosis,alkaline phosphatase(ALK),carcinoembryonic antigen(CEA),and cancer antigen(CA)19-9.The optimal cutoff value was 2.05μg/L for serum CEA and 133.65 U/mL for serum CA 19-9.The accuracy of the nomogram in predicting ICC was 82.6%.The area under the curve(AUC)of nomogram in training cohort was 0.867.The AUC for the validation set was 0.881 from The Second Affiliated Hospital of Wenzhou Medical University,and 0.938 from The First Affiliated Hospital of Fujian Medical University.Conclusions:The nomogram holds promise as a novel and accurate tool to predict IHL-ICC,which can identify lesions in IHL in time for hepatectomy or avoid unnecessary surgical resection. | Xian Shen Huanhu Zhao Xing Jin Junyu Chen Zhengping Yu Kuvaneshan Ramen Xiangwu Zheng Xiuling Wu Yunfeng Shan Jianling Bai Qiyu Zhang Qiqiang Zeng | 2021 | Hepatobiliary Surgery and Nutrition2021，10，6： | 1 |
| 17 | Emergence of Fatal PRRSV Variants:Unparalleled outbreaks of Atypical PRRS in China and Molecular Dissection of the Unique Hallmark显示文摘 | Kegong Tian Xiuling Yu Tiezhu Zhao | 2007 | PLoS ONE2007，2，6： | 1 |
| 18 | Ancient water wells reveal a prolonged drought in the lower Yellow River area about 2800 years ago显示文摘Proxy records from the North Atlantic realm reveal that large and rapid cooling known as the Bond events continued into the Holocene [1],repeatedly punctuating what is conventionally thought to have been a relatively stable climate.Given that the Holocene is the most recent interglacial period that has spurred the development of modern societies,scrutinizing climate variabil- ity during this period is important not only for predicting the trend of future climate changes,but also for better understanding the driving forces behind the rise and fall of ancient civilizations. | Shiyong Yu Xuexiang Chen Xiuling Liu Zhen Fang Junfeng Guo Senyang Zhan Hui Fang Fahu Chen | 2018 | Science Bulletin2018，63，20： | 1 |
| 19 | Emergence of fatal PRRSV variants: unparalleled outbreaks of atypical PRRS in China and molecular dissection of the unique hallma 显示文摘 | Kegong Tian Xiuling Yu Tiezhu Zhao Youjun Feng | 2007 | PLOS ONE2007，，6： | 1 |
| 20 | Emergence of novel Euro- pean genotype porcine reproductive and respiratory syndrome virus in mainland China 显示文摘 | Nanhua Chen Zhen Cao Xiuling Yu | 2011 | Journal of General Virology2011，，92： | 1 |
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