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| 1 | Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases显示文摘在各种各样的纸巾的 microRNAs (miRNAs ) 的 Dysregulated 表示与许多疾病被联系了,包括癌症。这里,我们证明 miRNAs 在象老鼠,老鼠,牛的胎儿,小牛,和马那样的人和另外的动物的浆液和血浆是在场的。在浆液的 miRNAs 的层次在一样的种类的个人之中稳定、可再现、一致。采用 Solexa,我们定序健康中国题目的所有浆液 miRNAs 并且分别地在男、女的题目发现超过 100 和 91 浆液 miRNAs。我们也为肺癌症, colorectal 癌症,和糖尿病识别了浆液 miRNAs 的特定的表示模式,提供证据那浆液 miRNAs 为各种各样的疾病包含指纹。癌症特定的浆液 miRNAs 由 Solexa 获得了的二个非小的房间肺进一步在 75 个健康施主和 152 个癌症病人的独立审判被验证,用量的反向的抄写聚合酶链反应试金。通过这些分析,我们断定浆液 miRNAs 能为各种各样的癌症和另外的疾病的察觉用作潜在的 biomarkers。 | Xi Chen Yi Ba Lijia Ma Xing Cai Yuan Yin Kehui Wang Jig ang Guo Yujing Zhang Jiangning Chen Xing Guo Qibin Li Xiaoying Li Wenjing Wang Yan Zhang Jin Wang Xueyuan Jiang Yang Xiang Chen Xu Pingping Zheng Juanbin Zhang Ruiqiang Li Hongjie Zhang Xiaobin Shang Ting Gong Guang Ning Jun Wang Ke Zen Junfeng Zhang Chen-Yu Zhang | 2008 | Cell Research2008，18，10： | 975 |
| 2 | Antigenic variation of the human influenza A(H3N2) virus during the 2014–2015 winter season显示文摘The human influenza A(H3N2) virus dominated the 2014–2015 winter season in many countries and caused massive morbidity and mortality because of its antigenic variation. So far, very little is known about the antigenic patterns of the recent H3N2 virus. By systematically mapping the antigenic relationships of H3N2 strains isolat ed since 2010, we discov ered that two groups with obvious antigenic divergence, named SW13(A/Switzerland/9715293/2013-like strains) and HK14(A/Hong Kong/5738/2014-like strains), co-circulated during the 2014–2015 winter season. HK14 group co-circulated with SW13 in Europe and the United States during this season, while there were few strains of HK14 in China's Mainland, where SW13 has dominated since 2012. Furthermore, we found that substitutions near the receptor-binding site on hemagglutinin played an important role in the antigenic variation of both the groups. These findings provide a comprehensive understanding of the recent antigenic evolution of H3N2 virus and will aid in the selection of vaccine strains. | HUA Sha LI XiYan LIU Mi CHENG YanHui PENG YouSong HUANG WeiJuan TAN MinJu WEI HeJiang GUO JunFeng WANG DaYan WU AiPing SHU YueLong JIANG TaiJiao | 2015 | Science China(Life Sciences)2015，58，9： | 17 |
| 3 | miR-181b functions as an oncomiR in colorectal cancer by targeting PDCDZ显示文摘 | Yanqing Liu Uzair-ur-Rehman Yu Guo Hongwei Liang Rongjie Cheng Fei Yang Yeting Hong Chihao Zhao Minghui Liu Mengchao Yu Xinyan Zhou Kai Yin Jiangning Chen Junfeng Zhang Chen-Yu Zhang Feng Zhi Xi Chen | 2016 | Protein & Cell2016，7，10： | 14 |
| 4 | Structural feature and its significance of the northernmost segment of the Tertiary Biluoxueshan-Chongshan shear zone,east of the Eastern Himalayan Syntaxis显示文摘Here we describe ductile,ductile-brittle and brittle deformation styles in the northern segment of the Tertiary Biluoxue-shan-Chongshan shear zone lying to the east of the Eastern Himalayan Syntaxis.In the northernmost part of the zone in the vicinity of the Eastern Himalayan Syntaxis,it consists of mylonitic gneiss,granite,and schist.Based on field relations andmineral assemblages,the rocks are classified into gneiss belt in the west limb,including banded gneiss,augen mylonite and migmatite gneiss,and schist belt in the east limb.Except for the massive granite pluton,the other three tectonites are affected by polystage deformation (D1-D4).Fold deformation of the first stage D1 is isoclinal to tight pattern with nearly N-S fold axes and steeply axial planar cleavage S1,which resulted in the local crustal thickening under a contractive setting.D2 overprinted D1 and is characterized by tight folds with steep axes and N-S fold axial planar,which are also characterized by large-scale ductile strike-slip shear foliation S2,parallel to the nearly N-S trending axial planes of D1 and D2.The structural pattern of D2 represents a transpression along the zone.D3 occurred during the late stage of the transpression or post-transpression,produc-ing the NW-SE and NE-SW trending strike-slip faults of the third stage D3.Following the D3 deformation,the zone was ex-humed to shallow crustal level where the various tectonites underwent a brittle transtensional deformation D4,combined with one N-S trending strike-slip component and one normal faulting component.Structures and previous geochronologies presented in the paper suggest that the study area is correlated with those in the adjacent tectonic zones,Ailaoshan-Red River shear zone and Gaoligong shear zone in the western Yunnan.It underwent intensive polyphase deformation,namely,crustal thickening,transpression,and transtension,responding to syn-collision and post-collision of India-Eurasia from 65 Ma to current period east of the Eastern Himalayan Syntaxis. | ZHANG Bo ZHANG JinJiang ZHONG DaLai WANG XiaoXian QU JunFeng GUO Lei | 2011 | Science China Earth Sciences2011，54，7： | 11 |
| 5 | Fuel optimal low thrust rendezvous with outer planets via gravity assist显示文摘Low thrust propulsion and gravity assist (GA) are among the most promising techniques for deep space explorations.In this paper the two techniques are combined and treated comprehensively,both on modeling and numerical techniques.Fuel optimal orbit rendezvous via multiple GA is first formulated as optimal guidance with multiple interior constraints and then the optimal necessary conditions,various transversality conditions and stationary conditions are derived by Pontryagin's Maximum Principle (PMP).Finally the initial orbit rendezvous problem is transformed into a multiple point boundary value problem (MPBVP).Homotopic technique combined with random searching globally and Particle Swarm Optimization (PSO),is adopted to handle the numerical difficulty in solving the above MPBVP by single shooting method.Two scenarios in the end show the merits of the present approach. | GUO TieDing JIANG FangHua BAOYIN HeXi LI JunFeng | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，4： | 8 |
| 6 | Fossil Association from the Lower Cambrian Yanjiahe Formation in the Yangtze Gorges Area,Hubei,South China显示文摘摘要:除了以前报导的小壳的石块(SSF ) ,一个宏观的石块集合,包括的丰富的水藻,锥形的管状的石块形式,和可能的印象一放大了后生动物,在西方的湖北省的 Yangtze 峡区域来自更低的寒武纪的 Yanjiahe 形成,华南。可见石块在 thinlaminated siltstone 被保存或泥泞 siltstone 在 815 公里厚的碳酸盐存款之间设置了,浅水里的抑制本地消沉的可能代表的沉积背景在早寒武纪的 Meishucunian 阶段期间焦化站台。宏观的石块协会关于生活的进化提供重要石块证据从对寒武纪的爆炸间隔晚前寒武纪。 | GUO Junfeng LI Yong HAN Jian ZHANG Xingliang ZHANG Zhifei OU Qiang LIU Jianni SHU Degan Shigenori MARUYAMA Tsuyoshi KOMIYA | 2008 | Acta Geologica Sinica(English Edition)2008，82，6： | 8 |
| 7 | Aerobic Oxidation of Benzyl Alcohol Catalyzed by Cu-Mn Mixed Oxides and 2,2,6,6-Tetramethyl-piperidyl-1-oxyl显示文摘异构的 Cu-Mn 混合了氧化物能调停由在中立状况下面的分子的氧的本甲基酒精的催化速度的选择氧化,并且是 recyclable。在超过 1 的 Cu 和 Mn 的摩尔比率的情况中,在 Cu-Mn 内的高度分散的 CuO 混合了氧化物为在催化氧化的好表演负责。给词调音:Cu-Mn 氧化物;2,2,6,6-tetramethyl-piperidyl-l-oxyl;氧气的氧化; | Yanchun Guo Junfeng Zhao Jinxia Xu Wei Wang Fengshou Tian Guanyu Yang Maoping Song | 2007 | Journal of Natural Gas Chemistry2007，16，2： | 6 |
| 8 | Clinical effects of Xingnao Kaiqiao acupuncture on neurological impairment following cerebral infarction显示文摘BACKGROUND: Although the curative effects of acupuncture have been confirmed by various treatments of cerebral infarction, few studies have investigated when acupuncture can attain the best clinical effect. OBJECTIVE: Four different time points were selected for acupuncture treatment of cerebral infarction to evaluate the appropriate time course for Xingnao Kaiqiao therapy in terms of improved neurological function. DESIGN: Controlled observation. SETTING: Department of Traditional Chinese Medicine Rehabilitation and Physiotherapy of the Affiliated Hospital of Medical College of Chinese Armed Police Forces. PARTICIPANTS: A total of 120 inpatients with cerebral infarction of different stages, including 75 males and 45 females, aged 41-75 years, were selected from November 2005 to December 2006 at the Department of Traditional Chinese Medicine Rehabilitation and Physiotherapy in Affiliated Hospital of Medical College of Chinese Armed Police Forces. Diagnostic criteria: in accordance with 'main points of diagnosis on different cerebrovascular disease' secondly revised in the Second Cerebrovascular Disease Academic Meeting of Chinese Medicine Association in 1986. All accepted subjects provided confirmed consent, and the experiment received ethical permission from the hospital’s ethics committee. METHODS: ① Experiment grouping: All inpatients were divided into four groups with non-stochastic concurrent control method according to the disease course: Group I (onset within 7 hours), group Ⅱ (onset from 7 hours to 3 days), group Ⅲ (onset within 4-7 days), and group Ⅳ (onset within 21-180 days). On the basis of symptomatic treatment with western medicine, each group received Xingnao Kaiqiao therapy after onset within 7 hours, 7 hours to 3 days, 4 to 7days, and 21 to 180 days. ② The principal acupoints were Neiguan, Renzhong, and Sanyinjiao. ③ The auxiliary acupoints were Jiquan, Chize, and Weizhong. ④Acupuncture manipulations: initially, Neiguan (PC6, bilateral) was needled at 0.5-1.0 cun vertically with a reducing technique achieved by rotating-swirling and lifting-inserting for 1 minute. Subsequently, Renzhong (GV26) was needled at 0.3-0.5 cun obliquely towards the nasal septum, with a heavy bird-pecking method until eyeballs were moist or shed tears. Sanyinjiao (SP6, affected limb) was needled at 1.0-1.5 cun obliquely along the medial border of the tibia with a 45° angle between the needle and skin. The technique of reinforcing was achieved by a lifting-inserting method until the affected lower limb twitched three times. The auxiliary acupoint, Jiquan, was selected when the patient extended the affected upper limb abduction. Jiquan was along the downward channel, 1 cun from the quondam Jiquan (HT1) acupoint; the armpit hair was avoided. Jiquan (affected limb) was needled vertically at 1.0-1.5 cun. The technique of reduction was achieved by lifting-inserting until the affected upper limb twitched three times. Chize (LU5) was selected when the patient flexed the elbow at 120°. Chize was vertically needled at 1 cun with a lifting-inserting reducing technique until the affected forearm and fingers twitched three times. Weizhong (BL40) was selected when the patient’s leg was raised straight in a supine position. Weizhong was vertically needled at 0.5-1.0 cun with a lifting-inserting reducing technique until the affected lower limb twitched three times. ⑤ Acupuncture manipulations were achieved by the doctor who is an associate chief physician and doctor of acupuncture and moxibustion and has aptitude for the post’s specification. ⑥One course of treatment lasted for 10 days and each group was treated for two courses of treatment. ⑦Experiment evaluation: To apply neurological impairment scores for evaluating clinical curative effects before and after treatment with Xingnao Kaiqiao therapy on day 7, 14, and 21(range of 0-45; decreasing score indicates functional improvement).To evaluate clinical curative effect by clinical effective power:Basic recovery: equal to ormore than 81%; significant improvement: 56% to 81% (including 56%); Improvement: between 36% to 56% (including 36%); Slight Improvement: 11% to 36% (including 11%); No change: less than 11%; Aggravation (including death): negative value. Total effective rate was computed at the same time. MAIN OUTCOME MEASURES: The total effective rate and amelioration of neurological impairment of the patients after treatment. RESULTS: All 120 patients with cerebral infarction were included in the final analysis, without deletion. ① Comparison of the total effective rate: the total effective rate of group Ⅰ, group Ⅱ, group Ⅲ, and group Ⅳ was 97%, 93%, 93%, and 67%, respectively. There were significant differences of interclass synthetic curative effects (χ2 = 36.351 7, P < 0.01). ② Amelioration of neurological impairment: A decreased neurological impairment score was observed in group I on day 7, 14, and 21 after Xingnao Kaiqiao therapy. The differences between group IV and the remaining three groups were significant (P < 0.05). CONCLUSION: Xingnao Kaiqiao therapy is helpful for amelioration of neurological impairment in patients during the acute stage cerebral infarction. | Jie Xiong Lina Ning Jinling Bian Jun Li Junfeng Xu Zhilong Zhang Jiakui Guo YadongLi Xuemin Shi | 2008 | Neural Regeneration Research2008，3，3： | 5 |
| 9 | New Macroscopic Problematic Fossil from the Early Cambrian Yanjiahe Biota,Yichang,Hubei,China显示文摘Yanjiahella 情报。nov,从在 Yichang 的早寒武纪的 Yanjiahe 生物区系的特殊石块 taxon,湖北省,旁边被描绘:1 ) 一个全面身体计划梗和一个花萼创作了(也在某种类武装) ;2 ) 梗与仔细 spaced,横向的皱纹和一条中间的、纵的山脉;并且 3 ) 与三维的放射的有条纹或刻痕之状态保存的一个花萼,以及在一些标本的可能的 madreporite。能被分到这个类的三种,它是 Y。ancarpa sp。nov, Y。monocarpa sp。nov,和 Y。biscarpa sp。nov。Yanjiahella 以形态学和一些生物结构比得上某些棘皮动物类的动物 taxa,它可能从早早的寒武纪的 Yangtze 站台显示祖先的棘皮动物类的动物系的早进化和多样化。在 Yanjiahe 生物区系的通常认为的棘皮动物类的动物的发现关于 deuterostome 门棘皮类的起源和进化提供重要线索。 | GUO Junfeng LI Yong HAN Huiping OU Qiang ZHOU Jianren ZHENG Yajuan | 2012 | Acta Geologica Sinica(English Edition)2012，86，4： | 5 |
| 10 | Interpretation models and charts of production profiles in horizontal wells显示文摘Stratified flow is common for the gravity segregation and flow regimes are very complex because of borehole inclination,therefore,all the conventional production logging tools cannot be effectively applied in horizontal wells,thus significantly increasing the difficulties in log interpretation. In this paper,firstly,the overseas progress in updated integration tools for horizontal wells and production profile interpretation methods has been discussed in brief. Secondly,by means of theory study and experimental simulations,we have obtained the production profile interpretation model and experimental interpretation charts,which have been calibrated by the improved downhole technology and optimization methods. Finally,we have interpreted X-well with the production profile interpretation software designed by us,and it proves that the methods are useful for the production profile interpretation in horizontal wells. | GUO HaiMin,LIU JunFeng,DAI JiaCai,WANG Kai & SONG HongWei Key Laboratory of Exploration Technologies for Oil and Gas Resources,Ministry of Education of China and School of Geophysics & Oil Resources of Yangtze University,Jingzhou 434023,China | 2009 | Science China Earth Sciences2009，52，S1： | 5 |
| 11 | Paliurus(Paliureae,Rhamnaceae) from the Miocene of East China and its Macrofossil-based Phylogenetic and Phytogeographical History显示文摘The extant genus Paliurus Miller is divided into P.ramosissimus and P.spina-christi groups and is diagnostically characterized by distinctive orbicular-winged fruits with a trilocular(or often bilocular) ovary and basally triveined leaves with a subentire to serrate margin.Here,structurally preserved winged fruits and associated compressed leaves of Paliurus(Paliureae,Rhamnaceae) are reported from the Middle-Upper Miocene Shengxian Formation of Tiantai,Zhejiang,eastern China.The fruits can be identified as Paliurus microcarpa Xiang-Chuan Li sp.nov.,the diagnostic characters of external morphology and anatomy of which differ from those of both extant and fossil generic members;the leaves can be designated as Paliurus sp.The species based on winged fruits,P.mkrocarpa,might represent an ancient intermediate link exclusively known across the P.ramosissimus and P.spina-christi groups,showing a closer affinity to the P.ramosissimus group based on the resemblant smaller fruits with a narrower wing,and to the P.spina-christi group based on the similar wing structure and texture,respectively.Morphological analyses of the present and previous fossil fruit records around the world indicate that diversification of Paliurus had begun in northern transpacific regions by the Late Eocene.The macrofossil records,i.e.,fruits and leaves of Paliurus globally when projected on paleoenvironmental maps in view of changing continental positions through time(from Eocene to Miocene) display that the past distribution of the genus was much wider than the present and belongs to a tropical and warm temperate realm of the Northern Hemisphere.Therefore,the modern restricted disjunction in tropical and warm temperate regions of East Asia and South Europe(even eastwards West Asia) might represent glacial refugia for some of the generic ancient lineages to survive severe cold at least since the terminal Pliocene. | LI Xiangchuan WANG Haofei LENG Qin XIAO Liang GUO Junfeng HE Wenlong | 2014 | Acta Geologica Sinica(English Edition)2014，88，5： | 5 |
| 12 | Theoretical and simulation research of hydrodynamic instabilities in inertial-confinement fusion implosions显示文摘Inertial fusion energy(IFE)has been considered a promising,nearly inexhaustible source of sustainable carbon-free power for the world's energy future.It has long been recognized that the control of hydrodynamic instabilities is of critical importance for ignition and high-gain in the inertial-confinement fusion(ICF)hot-spot ignition scheme.In this mini-review,we summarize the progress of theoretical and simulation research of hydrodynamic instabilities in the ICF central hot-spot implosion in our group over the past decade.In order to obtain sufficient understanding of the growth of hydrodynamic instabilities in ICF,we first decompose the problem into different stages according to the implosion physics processes.The decomposed essential physics processes that are associated with ICF implosions,such as Rayleigh-Taylor instability(RTI),Richtmyer-Meshkov instability(RMI),Kelvin-Helmholtz instability(KHI),convergent geometry effects,as well as perturbation feed-through are reviewed.Analytical models in planar,cylindrical,and spherical geometries have been established to study different physical aspects,including density-gradient,interface-coupling,geometry,and convergent effects.The influence of ablation in the presence of preheating on the RTI has been extensively studied by numerical simulations.The KHI considering the ablation effect has been discussed in detail for the first time.A series of single-mode ablative RTI experiments has been performed on the Shenguang-Ⅱlaser facility.The theoretical and simulation research provides us the physical insights of linear and weakly nonlinear growths,and nonlinear evolutions of the hydrodynamic instabilities in ICF implosions,which has directly supported the research of ICF ignition target design.The ICF hot-spot ignition implosion design that uses several controlling features,based on our current understanding of hydrodynamic instabilities,to address shell implosion stability,has been briefly described,several of which are novel. | LiFeng Wang WenHua Ye XianTu He JunFeng Wu ZhengFeng Fan Chuang Xue HongYu Guo WenYong Miao YongTeng Yuan JiaQin Dong Guo Jia Jing Zhang YingJun Li Jie Liu Min Wang YongKun Ding WeiYan Zhang | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，5： | 4 |
| 13 | Post-fledging dispersal and habitat use of a reintroduced population of the Crested Ibis (Nipponia nippon)显示文摘Background: Knowledge of dispersal movement of birds and their habitat preference during the post-fledging period is fundamental to the understanding of their ecological and evolutionary processes. The Crested Ibis is now being reintroduced to protected sites within its historical range, with the goal of establishing a self-sustaining population that may eventually qualify the species for delisting.Methods: We carried out an ecological study of post-fledging dispersal and habitat use of a reintroduced population of the Crested Ibis(Nipponia nippon) from 2008 to 2012 in Ningshan County, China, by using banding and radio-telemetry methods.Results: In about two weeks(an average of 14.3 days) after fledging, the activities of the fledglings were concentrated in a range of about 100 m around their natal sites, such as the oak-pine forest patches at the edge of open habitats.During this period, fledglings were still partially dependent upon parental care and fed typically on a daily basis.Siblings increasingly became independent by mid-August and then gradually moved away from their natal sites to post-fledging dispersal locations. During the period of the post-fledging dispersal process, most juveniles moving southwest were concentrated at the mean direction(μ = 254.6°, ? = 70.5°) with a mean dispersal distance of 5.1 km.It took an average of 56.4 days to disperse from the natal territory to the first wintering area. Also, forging habitats for juvenile ibis varied with time and local conditions. For example, paddy fields were used most frequently among all habitat types, while shallow rivers just from August to October. Masson pine(Pinus massoniana) was often regarded as the roosting tree species preferred by the Crested Ibis, with the highest utilization rate among all the roosting habitat types. The juveniles of the wild population dispersed four times as far as that of the reintroduced population, but the overall pattern of post-fledging dispersal is similar for the reintroduced and wild populations.Conclusions: Our results are very useful for us to predict the distance and direction of dispersal under various landscape conditions in other released sites. The project is a good example for reintroducing endangered species to their former ranges, and will be valuable for the protection of reintroduced populations of this critically and other endangered species. | Zhiping Huo Junfeng Guo Xia Li Xiaoping Yu | 2014 | Chinese Birds2014，，1： | 4 |
| 14 | Safety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial显示文摘Recent evidence suggests that CD147 serves as a novel receptor for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection.Blocking CD147 via anti-CD147 antibody could suppress the in vitro SARS-CoV-2 replication.Meplazumab is a humanized anti-CD147 IgG_(2) monoclonal antibody,which may effectively prevent SARS-CoV-2 infection in coronavirus disease 2019(COVID-19)patients.Here,we conducted a randomized,double-blinded,placebo-controlled phase 1 trial to evaluate the safety,tolerability,and pharmacokinetics of meplazumab in healthy subjects,and an open-labeled,concurrent controlled add-on exploratory phase 2 study to determine the efficacy in COVID-19 patients.In phase 1 study,59 subjects were enrolled and assigned to eight cohorts,and no serious treatment-emergent adverse event(TEAE)or TEAE grade≥3 was observed.The serum and peripheral blood Cmax and area under the curve showed non-linear pharmacokinetic characteristics.No obvious relation between the incidence or titer of positive anti-drug antibody and dosage was observed in each cohort.The biodistribution study indicated that meplazumab reached lung tissue and maintained>14 days stable with the lung tissue/cardiac blood-pool ratio ranging from 0.41 to 0.32.In the exploratory phase 2 study,17 COVID-19 patients were enrolled,and 11 hospitalized patients were involved as concurrent control.The meplazumab treatment significantly improved the discharged(P=0.005)and case severity(P=0.021),and reduced the time to virus negative(P=0.045)in comparison to the control group.These results show a sound safety and tolerance of meplazumab in healthy volunteers and suggest that meplazumab could accelerate the recovery of patients from COVID-19 pneumonia with a favorable safety profile. | Huijie Bian Zhao-Hui Zheng Ding Wei Aidong Wen Zheng Zhang Jian-Qi Lian Wen-Zhen Kang Chun-Qiu Hao Jing Wang Rong-Hua Xie Ke Dong Jie-Lai Xia Jin-Lin Miao Wen Kang Guoquan Li Di Zhang Mingru Zhang Xiu-Xuan Sun Likun Ding Kui Zhang Junfeng Jia Jin Ding Zhiqin Li Yanyan Jia Lin-Na Liu Zhe Zhang Zhao-Wei Gao Hong Du Na Yao Qing Wang Ke Wang Jie-Jie Geng Bin Wang Ting Guo Ruo Chen Yu-Meng Zhu Li-Juan Wang Qian He Rui-Rui Yao Ying Shi Xiang-Min Yang Jian-Sheng Zhou Yi-Nan Ma Ya-Tao Wang Xue Liang Fei Huo Zhe Wang Yang Zhang Xu Yang Ye Zhang Lu-Hua Gao Ling Wang Xiao-Chun Chen Hao Tang Shuang-Shuang Liu Qing-Yi Wang Zhi-Nan Chen Ping Zhu | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 2 |
| 15 | Pathogenesis and Immunogenicity of an Avian H9N2 Influenza Virus Isolated from Human显示文摘Objective To investigate the pathogenesis and immunogenicity of H9N2 influenza virus A/Guangzhou/333/99 (a reassortant of G1 and G9 viruses isolated from a female patient in 1999) in a mouse model of infection.Methods Mice were infected with increasing virus titers.Viral load in the lungs and trachea was determined by EID50 assay.Pulmonary histopathology was assessed by hematoxylin‐eosin staining.Anti‐HI antibody titers and T‐cell responses to viral HA were determined by ELISPOT and confirmed by flow cytometry.Results Mice presented a mild syndrome after intranasal infection with A/Guangzhou/333/99 (H9N2) influenza virus.Virus was detected in the trachea and lungs of mice harvested on days 3,6,and 9 post‐infection.A T‐cell response to viral HA was detected on day 6 and H9 HA‐specific CD 4+ T‐cells predominated.Seroconversion was detected after 14 days and antibody persisted for at least 28 weeks.Conclusion Our results suggest that H9N2 (A/Guangzhou/333/99) can replicate in the murine respiratory tract without prior adaptation,and both humoral and cell‐mediated immunity play an important role in the immune response. | LIU LiQi Li Zi ZHOU JianFang ZHU Yun DONG Jie ZHAO Xiang GUO JunFeng SHU YueLong | 2011 | Biomedical and Environmental Sciences2011，24，5： | 2 |
| 16 | Mechanism and kinetics for scavenging superoxide anion by progesterone显示文摘The chemical reaction of progesterone with su-peroxide anion O2- in 0.1 mol/L NaHCO3 medium is studied by polarography. Differing from the indirect inhibition of O2- generation by synthesized glucocorticoids in mecha-nism, the function that progesterone scavenges O2- is as-cribed to that O2- directly oxidizes the C =C double bond conjugated with the carbonyl moiety of progesterone mole-cule to a free radical, and then is reduced to H2O2. The result obtained in this work gives new evidence for biomedical research. The equation of rate constant of the oxidization reaction is deduced, and the apparent rate constant obtained is308 L·mol-1·s-1. | SONG Junfeng SHAO Yong GUO Wei | 2001 | Chinese Science Bulletin2001，46，2： | 2 |
| 17 | Genetic causes of oil-rich and oil-poor reservoirs: Implications from two Cenozoic basins in the eastern North China Craton显示文摘The Bohai Bay and Hehuai(southern North China) rift basins in the eastern part of the North China Craton are southnorth-adjacent. They have shown synchronous evolutionary processes, and possess generally identical superficial and shallow structural characteristics as well as similar basin areas. However, there is a large difference in the richness of oil resources between the two basins. The Bohai Bay Basin has extremely abundant oil reserves, while commercial oil reserves have not been found in the Hehuai Basin. The deep tectonic structures, magmatic activities, and modern and paleo-geothermal fields of the two basins are significantly different. Compared with the Hehuai Basin, the Bohai Bay Basin has a thinner crust and more complex structure with multiple low-velocity layers. It is also characterized by intense magmatic activity, high modern and paleogeothermal fields, frequent seismic activity, and active deep interactions, small effective elastic thickness of the isotropic lithosphere, and shorter balanced transformation wavelength of the lithosphere with a high likelihood of local compensation. The Hehuai Basin has a simple deep structure and homogeneous crustal composition, with a high likelihood of regional compensation. The characteristics of the deep structures mentioned above are generally similar to those of the southern part of the stable Ordos Basin, except for the smaller crust thickness. This indicates the presence of differences in Mesozoic destruction between the southern and northern zones in the eastern part of the North China Craton. The northern zone was subjected to significant destruction, while the southern zone was subjected to modifications, primarily in the form of local changes in the structures and/or properties of the crust or lithospheric mantle, with the overall structure and stability of the craton kept intact. The formation of high-quality source rock is primarily influenced by the abnormal flourishment of organisms in water bodies during the syndepositional period, and is also strongly associated with the high geothermal setting of basins and nutrients from hydrothermal solutions and volcanoes. In other words, it is mainly controlled by deep processes and deep-major fault activity. The differences in the deep structures and modern and paleo geothermal fields of the two basins correspond to the difference in richness of oil resources, suggesting that there is an important internal or causal relationship between the two aspects. This viewpoint coincides with the conditions and environments required for the development of high-quality source rock in hydrocarbon-rich basins(sags)in China and other countries, and is evidenced by the modern lake basin of the East African Rift. A new hydrocarbon generation model is proposed in this work: petroleum is a comprehensive product of the integration of bioenergy, thermal energy, and other related energies(such as chemical and kinetic energy) and their interactions; the degree of richness of petroleum is generally controlled by the regional tectonic structure, thermal environment, and deep processes; nonmarine basins or depressions with abundant resources are closely related to active deep processes, intense exchange of material between the deep and shallow layers, participation of external hydrocarbons, and energy integration and conversion. | Chiyang LIU Lei HUANG Dongdong ZHANG Junfeng ZHAO Yu DENG Pei GUO Yijian HUANG &Jianqiang WANG | 2018 | Science China Earth Sciences2018，61，12： | 2 |
| 18 | Kernel position effects of grain morphological characteristics by X-ray micro-computed tomography (μCT)显示文摘Grain size and shape are important factors for yield and quality.The difference in grain phenotypic characteristics in the same maize hybrid is related to its position in the ear.This study aimed to clarify the distribution characteristics of grain morphological characteristics in the ear and to provide guidance for research of grain phenotype and kernel position effects.Three maize hybrids were used in the experiment,namely,Denghai 618(DH618),KX3564,and Xianyu 335(XY335),and the kernel number per row were 40,40,and 36,respectively.The X-rayμCT was applied to obtain five kernel morphological indicators,including grain length,width,thickness,volume,surface area.Grain sphericity,length-width ratio,specific surface area,and volume coefficient were further calculated.The results showed that there were three types of maize ear morphological indicators trends:grain length,width,volume,and surface area were parabolic;thickness and sphericity were inverted parabolic;length-to-width ratio and specific surface area were irregular.The volume coefficient of grain at different parts of the ear,namely the relation coefficient between grain volume and grain length,width,and thickness,was determined.The average value of the middle grains morphological indicators of the ear was taken to select kernels representing stable characteristics of the variety.Within the range of 5%deviation from the morphological mean value of the middle grains of the ear,the grains in the middle part accounted for 26.39%of the total ear,about 10 grains extending from the 14th grain at the base of the ear to the top.Within the range of 10%deviation,the middle accounted for 47.22%,about 18 grains extending from the 12th grain at the base of the ear to the top.This study found that grain morphological indicators were greatly different at different positions of the maize ear,and showed different change rules as extend from the base to the top of the ear.Therefore,there were different grain volume coefficients at different positions of maize ear.And the representative sampling range on maize ear was determined based on the comprehensive analysis of different morphological indexes variation of grain. | Xuebo Yin Junfeng Hou Bo Ming Ying Zhang Xinyu Guo Shang Gao Keru Wang Peng Hou Shaokun Li Ruizhi Xie | 2021 | International Journal of Agricultural and Biological Engineering2021，14，2： | 2 |
| 19 | Influence of proximity to the Qinghai-Tibet highway and railway on variations of soil heavy metal concentrations and bacterial community diversity on the Tibetan Plateau显示文摘An understanding of soil microbial communities is crucial in roadside soil environmental assessments.The 16S rRNA se quencing of a stressed microbial community in soil adjacent to the Qinghai-Tibet Highway(QTH)revealed that the accu mulation of heavy metals(over about 10 years)has affected the diversity of bacterial abundance and microbial community structure.The proximity of a sampling site to the QTH/Qinghai-Tibet Railway(QTR),which is effectively a measure of the density of human engineering,was the dominant factor influencing bacterial community diversity.The diversity of bacterial communities shows that 16S rRNA gene abundance decreased in relation to proximity to the QTH and QTR in both alpine wetland and meadow areas.The dominant phyla across all samples were Actinobacteria and Proteobacteria.The concentration of Cr and Cd in the soil were positively correlated with proximity to the QTH and QTR(MC/WC sam pling sites),and Ni,Co,and V were positively correlated with proximity to the QTH and QTR(MA/WA sampling sites).The results presented in this study provide an insight into the relationships among heavy metals and soil microbial commu nities,and have important implications for assessing and predicting the impacts of human-induced activities from the QTH and QTR in such an extreme and fragile environment. | Xia Zhao JunFeng Wang Yun Wang Xiang Lu ShaoFang Liu YuBao Zhang ZhiHong Guo ZhongKui Xie RuoYu Wang | 2019 | Research in Cold and Arid Regions2019，11，6： | 2 |
| 20 | Pressureless crystallization of glass toward scintillating composite with high crystallinity for radiation detection显示文摘The construction of scintillating ceramics is of great technological importance for various fundamental applications, including medical diagnostic, security inspection, resource exploration and particle physics. The chief challenge is the facile and scalable synthesis of scintillating ceramics with the desirable combination of pore-free, reliable mechanical properties and excellent scintillating performance. Here we present a pressureless glass crystallization strategy for the construction of scintillating composite with high crystallinity. The fabricated scintillating composites are featured by small optical turbidity, excellent mechanical properties, and efficient scintillating luminescence with the scintillating light yield of 15,000 pH/MeV and about 2.46 times higher than that of the commercial BGO single crystal. Moreover, the scintillating composite derived radiation detector device is successfully elaborated. The practical application for monitoring gamma ray is demonstrated and the precision of the device is less than that of the tolerable deviation of 30%. Our results suggest an innovative approach for expanding the category of scintillating material candidates, pointing to practical application in the field of radiation detection. | Junzhou Tang Shichao Lv Ziyu Lin Guanxin Du Manyun Tang Xu Feng Junpeng Guo Xiang Li Junfeng Chen Lei Wei Jianrong Qiu Shifeng Zhou | 2022 | Journal of Materials Science & Technology2022，，34： | 2 |
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