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| 1 | 亚太地区胃食管反流病的处理共识:更新版显示文摘背景与目的:自从2004年亚太地区胃食管反流病(GERD)共识发表以来,更多关于GERD流行病学和处理的文献资料相继出现。有必要对这些资料进行循证综述,对共识作出更新。方法:由多学科专家组应用德尔菲(Delphi)法制定共识条文,提呈相关资料,并对证据质量、推荐力度和共识水平进行分级。结果:亚洲GERD发生率日益增加。其危险因素包括老年、男性、种族、家族史、社会经济地位高、体重指数增加和吸烟。对于有典型症状而无报警症状的患者,对质子泵抑制剂(PPI)试验有症状应答具有诊断意义。如PPI试验失败,停止治疗后pH监测结果阴性可排除GERD。窄带成像、胶囊内镜检查和无线pH监测的作用尚未明确。亚洲诊断策略的制定须考虑到并存的胃癌和消化性溃疡。减轻体质量和抬高床头可改善反流症状。PPIs是最有效的内科治疗手段。对于非糜烂性反流病(NERD)患者,按需治疗较为适宜。有慢性咳嗽、喉炎和典型GERD症状的患者在排除非GERD病因后,应予PPI每天两次治疗。如有经验丰富的外科医师,GERD患者可行胃底折叠术。除临床试验外,GERD不应采用内镜治疗。结论:新的诊断方法和内镜治疗的作用有待进一步研究阐明。亚洲GERD诊断策略的制定须考虑到并存的胃癌和消化性溃疡。PPIs仍为治疗的基石。 | Kwong Ming Fock Nicholas J Talley Ronnie Fass Khean Lee Goh Peter Katelaris Richard Hunt Michio Hongo Tiing Leong Ang Gerald Holtmann Sanjay Nandurkar San Ren Lin Benjamin CY Wong Francis KL Chan Abdul Aziz Rani Young-Tae Bak Jose Sollano Khek Yu Ho Sathoporn Manatsathit 钱本余 | 2008 | 胃肠病学2008，13，7： | 21 |
| 2 | Rapid measurement of indocyanine green retention by pulse spectrophotometry: a validation study in 70 patients with Child-Pugh A cirrhosis before hepatectomy for hepatocellular carcinoma显示文摘BACKGROUND: The indocyanine green (ICG) retention test is the most popular liver function test for selecting patients for major hepatectomy. Traditionally, it is done using spectrophotometry with serial blood sampling. The newly- developed pulse spectrophotometry is a faster alternative, but its accuracy on Child-Pugh A cirrhotic patients undergoing hepatectomy for hepatocellular carcinoma has not been well documented. This study aimed to assess the accuracy of the LiMON , one of the pulse spectrophotometry systems, in measuring preoperative ICG retention in these patients and to devise an easy formula for conversion of the results so that they can be compared with classical literature records where ICG retention was measured by the traditional method. METHODS: We measured the liver function of 70 Child-Pugh A cirrhotic patients before hepatectomy for hepatocellular carcinoma from September 2008 to January 2009. ICG retention at 15 minutes measured by traditional spectrophotometry (ICGR15) was compared with ICG retention at 15 minutes measured by the LiMON (ICGR15(L)). RESULTS: The median ICGR15 was 14.7% (5.6%-32%) and the median ICGR15(L) was 10.4% (1.2%-28%). The mean difference between them was -4.3606. There was a strong correlation between ICGR15 and ICGR15(L) (correlation coefficient, 0.844; 95% confidence interval, 0.762-0.899). The following formula was devised: ICGR15=1.16×ICGR15(L)+2.73.CONCLUSIONS: The LiMON provides a fast and repeatable way to measure ICG retention at 15 minutes, but with constant underestimation of the real value. Therefore, when comparing results obtained by traditional spectrophotometry and the LiMON, adjustment of results from the latter is necessary, and this can be done with a simple mathematical calculation using the above formula. | Tan To Cheung See Ching Chan Kenneth SH Chok Albert CY Chan Wan Ching Yu Ronnie TP Poon Chung Mau Lo Sheung Tat Fan | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，3： | 8 |
| 3 | Loss of the vitamin D receptor in human breast and prostate cancers strongly induces cell apoptosis through downregulation of Wnt/β-catenin signaling显示文摘Vitamin D co-regulates cell proliferation, differentiation and apoptosis in numerous tissues, including cancers. The known anti-proliferative and pro-apoptotic actions of the active metabolite of vitamin D,1,25-dihydroxy-vitamin D [1,25(OH)2 D] are mediated through binding to the vitamin D receptor(VDR). Here,we report on the unexpected finding that stable knockdown of VDR expression in the human breast and prostate cancer cell lines, MDA-MB-231 and PC3, strongly induces cell apoptosis and inhibits cell proliferation in vitro. Implantation of these VDR knockdown cells into the mammary fat pad(MDA-MB-231),subcutaneously(PC3) or intra-tibially(both cell lines) in immune-incompetent nude mice resulted in reduced tumor growth associated with increased apoptosis and reduced cell proliferation compared with controls.These growth-retarding effects of VDR knockdown occur in the presence and absence of vitamin D and are independent of whether cells were grown in bone or soft tissues. Transcriptome analysis of VDR knockdown and non-target control cell lines demonstrated that loss of the VDR was associated with significant attenuation in the Wnt/β-catenin signaling pathway. In particular, cytoplasmic and nuclear β-catenin protein levels were reduced with a corresponding downregulation of downstream genes such as Axin2, Cyclin D1,interleukin-6(IL-6), and IL-8. Stabilization of β-catenin using the GSK-3β inhibitor BIO partly reversed the growth-retarding effects of VDR knockdown. Our results indicate that the unliganded VDR possesses hitherto unknown functions to promote breast and prostate cancer growth, which appear to be operational not only within but also outside the bone environment. These novel functions contrast with the known anti-proliferative nuclear actions of the liganded VDR and may represent targets for new diagnostic and therapeutic approaches in breast and prostate cancer. | Yu Zheng Trupti Trivedi Ruby CY Lin Colette Fong-Yee Rick Nolte Jeline Manibo Yunzhao Chen Musharraf Hossain Konstantin Horas Colin Dunstan Hong Zhou Markus J Seibel | 2017 | Bone Research2017，5，3： | 4 |
| 4 | Outcome of Pulmonary Multidrug-Resistant Tuberculosis: a 6-yr Follow-up Study显示文摘 | Chiang CY Enarson DA Yu MC Bai KJ Huang RM Hsu CJ Suo J Lin TP | 2006 | Eur Respir J2006，28，5： | 1 |
| 5 | The sweet potato sporamin promoter confers high- level phytase expression and improves organic phosphorus acquisition and tuber yield of transgenic potato 显示文摘 | Hong YF Liu CY Cheng KJ Hour AL Chan MT Tseng TH Chert KY Shaw JF Yu SM | 2008 | Plant Mol Biol2008，67，： | 1 |
| 6 | Highly pathogenic avian influ- enza A virus H5N1 NS1 protein induces caspase-dependent apop- tosis in human alveolar basal epithelial cells显示文摘 | Zhang CY Yu T Zhou XW | 2010 | Virol J2010，7，51： | 1 |
| 7 | 18F-FDG PET/CT-based gross tumor volume definition for radiotherapy in head and neck cancer: a correlation study between suitable uptake value threshold and tu- mor parameters显示文摘 | Kao CH Hsieh TC Yu CY | 2010 | Radiat Oncol2010，5，： | 1 |
| 8 | The 3D scanner for measuring body surface area: a simplified calculation in the Chinese adult 显示文摘 | Yu CY Lo YH Chiou WK | 2003 | Appl Ergon2003，34，3： | 1 |
| 9 | Modified technique of per- cutaneous posterior columnar screw insertion and neutralization plate for complex acetabular fractures 显示文摘 | Yu YH Tseng 1C Su CY | 2011 | J Trauma2011，71，1： | 1 |
| 10 | Radiofrequency ablation after transar-terial embolization as therapy for patients with unresectable hepatocellular carcinoma显示文摘 | Liao GS Yu CY Shih ML | 2008 | Eur J Surg Oncol2008，34，1： | 1 |
| 11 | Amyloidosis cutis dyschromica: four cases from two families显示文摘 | Huang WH Wu CY Yu CP | 2009 | Int J Dermatol2009，48，5： | 1 |
| 12 | Positive correlations of Oct-4 and Nanog in oral cancer stem-like cells and high-grade oralsquamous cell carcinoma 显示文摘 | Chiou SH Yu CC Huang CY | 2008 | Clin Cancer Res2008，14，13： | 1 |
| 13 | Radiographic and clinical results of posterior dynamic stabilization for the treatment of multisegrnent degenerative disc disease with a minimum follow-up of 3 years显示文摘 | Yu SW Yen CY Wu CH | 2012 | Arch Orthop Trauma Surg2012，132，5： | 1 |
| 14 | The relationship between coronary artery disease and abnormal glucose regulation in China:The China Heart Survey显示文摘 | Hu DY Pan CY Yu JM | 2006 | Eur Heart J2006，27，： | 1 |
| 15 | Assessment of visual function in chronic progressive external ohthalmoplegia 显示文摘 | Yu Wai Man CY Smith T | 2006 | Eye2006，20，5： | 1 |
| 16 | MR imaging of CS involvement by pituitary adenomas 显示文摘 | Scotti G Yu CY Dillon WP | 1988 | Am J Roentgenol1988，151，： | 1 |
| 17 | Cerebrovascular disease in Hong Kong Chinese显示文摘 | Huang CY Chan FL Yu YL | 1990 | Stroke1990，21，2： | 1 |
| 18 | Change of serum growth factors in infants with isolated ventricular defect undergoing surgical repair显示文摘 | Tsai TP Yu JM Wu YL Huang CY Chen FL | 2002 | Ann Whorac Surg2002，73，6： | 1 |
| 19 | Positive correlations of Oct-4 and Nanog in oral cancer stem-like cells and high-grade oral squamous cell carcinoma显示文摘 | Chiou SH Yu CC Huang CY | | 0，，： | 1 |
| 20 | Radiographic and clinical results of posterior dynamic stabilization for the treatment of multisegment degenerative disc disease with a minimum follow-up of 3 years显示文摘 | Yu SW Yen CY Wu CH | 2012 | Arch Orthop Trauma Surg2012，132，5： | 1 |
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