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| 1 | A novel clinical entity, IgG4-related disease (IgG4RD): general concept and details显示文摘 | Hisanori Umehara Kazuichi Okazaki Yasufumi Masaki Mitsuhiro Kawano Motohisa Yamamoto Takako Saeki Shoko Matsui Takayuki Sumida Tsuneyo Mimori Yoshiya Tanaka Kazuo Tsubota Tadashi Yoshino Shigeyuki Kawa Ritsuro Suzuki Tsutomu Takegami Naohisa Tomosugi Nozo | 2012 | Modern Rheumatology2012，，1： | 4 |
| 2 | Intragastric surgery using laparoscopy and oral endoscopy for gastric submucosal tumors显示文摘We review the techniques and outcomes of the intragastric resection for gastric submucosal tumors(GSTs) using laparoscope and oral endoscope. In the literature, the mean operation time, intraoperative blood loss, pathological size of the tumor and postoperative hospital stay were 134 min, minimal, 31 mm and 6.4 d, respectively. There were no particular perioperative complications during the follow-up period(mean: 121.3 mo). Intragastric surgery using laparoscopy and oral endoscopy can be considerably beneficial for patients with GSTs locating in the upper third of the stomach between 2-5 cm in diameter and < 8 cm2 in crosssectional area and located in the upper third of the stomach. | Nobumi Tagaya Teppei Tatsuoka Yawara Kubota Masayuki Takegami Nana Sugamata Kazuyuki Saito Takashi Okuyama Yoshitake Sugamata Masatoshi Oya | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，1： | 2 |
| 3 | Osteogenic protein-1 is most effective in stimulating nucleus pulposus and annulus fibrosus cells to repair their matrix after chondmitinase ABC-induced in vitro chemonucleolysis显示文摘 | Takegami K An HS Kumano F | 2005 | Spine J2005，5，3： | 1 |
| 4 | Characterization and E protein expression of mutant strains during persistent infection of KN73 cells with Japanese encephalitis virus显示文摘 | Feng GH Takegami T Zhao GZ | 2002 | Chin Med J2002，115，9： | 1 |
| 5 | Osteogenic protein-1 enhances matrix replenishment by intervertebral disc cells previously exposed to interleukin-l显示文摘 | Takegami K Thonar EJ An HS | 2002 | Spine2002，27，12： | 1 |
| 6 | Determination of macrolide antibiotics in meat and fish by liquid chromatography electrospray mass spectrometry显示文摘 | Horie M Takegami H Toya K | 2003 | Anal Chim Acta2003，492，12： | 1 |
| 7 | Intradiscal administration of osteogenic protein-1 increases intervertebral disc height and proteoglycan content in the nucleus pulposus in normal adolescent rabbits显示文摘 | An HS Takegami K Kamada H | 2005 | Spine2005，30，1： | 1 |
| 8 | A novel hyperthermia treatment for bone metastases using mag- netic materials 显示文摘 | Matsumine A Takegami K Asanuma K | 2011 | International Journal of Clinical On- coloty2011，16，2： | 1 |
| 9 | RECK modulates Notch signaling during cortical neurogenesis by regulating ADAMlO activi- ty显示文摘 | Muraguchi T Takegami Y Ohtsuka T | 2007 | Nat Neurosci2007，10，7： | 1 |
| 10 | 丙型肝炎病毒非结构蛋白NS_3与端粒酶活性(英文)显示文摘目的 研究丙型肝炎病毒非结构区 3(HCVNS3)蛋白对端粒酶活性的影响 ,以探讨HCVNS3蛋白在HCV致癌中的作用。方法 利用HCVNS3真核细胞表达质粒pRcHCNS3 5 '(表达HCVNS3N端多肽 )和pRcHCNS3 3'(表达HCVNS3C端多肽 )转染NIH3T3细胞 ;采用S P免疫组化方法检测转染的NIH3T3细胞中HCVNS3蛋白表达 ,并通过端粒酶活性原位检测法、TRAP PCR和端粒酶PCRELISA技术分别检测转染前后NIH3T3细胞端粒酶活性的变化。结果 HCVNS3表达质粒pRcHCNS3 5 '或pRcHCNS3 3'转染的NIH3T3细胞均表达HCVNS3蛋白 ,HCVNS3蛋白阳性信号均位于细胞浆中 ,并以前者表达的阳性信号为强 ;质粒pRcHCNS3 5 '转染的NIH3T3细胞端粒酶活性最强 (P<0 0 1) ,质粒pRcHCNS3 3'转染的细胞次之 (P <0 0 5 ) ,空白质粒pRcCMV转染细胞和未转染NIH3T3细胞最弱 (P<0 0 5 ) ;HCVNS3蛋白的表达水平和端粒酶活性强度之间具有显著相关性 (P <0 0 1) ;采用端粒酶活性原位检测方法和端粒酶PCRELISA技术检测结果具有较好的一致性。结论 HCVNS3蛋白可能是通过内源性机制激活细胞端粒酶导致宿主细胞恶性转化 ;HCVNS3蛋白N端多肽对宿主细胞端粒酶的激活作用强于C端多肽 ;进一步证实端粒酶活性原位检测法是一种适合于病理形态与功能研究的有效技术。 | 冯德云 程瑞雪 欧阳小明 郑晖 Tsutomu Takegami | 2002 | Chinese Medical Journal2002，，4： | 1 |
| 11 | Recombinant osteogenic protein-1 upregulates extracellular matrix metabolism by rabbit annulus fibrosus and nucleus pulposus cells cultured in alginate beads显示文摘 | Masuda K Takegami K An H | 2003 | J Orthop Res2003，21，5： | 1 |
| 12 | Molecular characterization of the Japanese encephalitis virus representative immunotype strain JaGAr 01显示文摘 | Mangada MNM Takegami T | 1999 | Virus Res1999，59，1： | 1 |
| 13 | Chemical structure of tar-sand bitumens by 13C and 1H NMR spectroscopy method显示文摘 | Suzuki T I Y Takegami Y Watanahe Y | 1982 | Fuel1982，61，4： | 1 |
| 14 | Use of a microbubble agent to increase the effects of high intensity focused ultrasound on liver tissue显示文摘 | Keneko Y Maruyama T Takegami K | 2005 | Eur Radiol2005，15，7： | 1 |
| 15 | Molecular,characterization of the Japanese encephalitis virus representative immunotype strain JaGAr 01显示文摘 | Mangada MNM Takegami T | 1999 | Virus Res1999，59，1： | 1 |
| 16 | Lessons Learned About Technology Transfer 显示文摘 | Rogers E M Takegami S Jing Y | 2001 | Technovation2001，，4： | 1 |
| 17 | Pervaporation of ethanol/water mixtures using novel hydrophobic membranes containing polydimethylsiloxane显示文摘 | Takegami S Yamada H Tsujii S | 1992 | J Membr Sci1992，75，12： | 1 |
| 18 | Dynamic activity-induced manganese-dependent contrast magnetic resonance imaging (DAIM MRI)显示文摘 | Aoki I Tanaka C Takegami T | 2002 | Magn Reson Med2002，48，6： | 1 |
| 19 | Osteogenic protein- 1 is most effective in stimulating nucleus pulposus and an- nulus fibrosus cells to repair their matrix after chondroitinase ABC-induced in vitro chemonucleolysis显示文摘 | Takegami K An HS Kumano F | 2005 | Spine J2005，5，3： | 1 |
| 20 | Osteogenic protein-1 is most effective in stimulating nucleus pulposus and annulus fibrosus cells to repair their matrix after chondroitinase ABC-induced in vitro chemonucleolysis显示文摘 | Takegami K An HS Kumano F | 2005 | Spine J2005，5，： | 1 |
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