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| 1 | Analyzing machine learning models to accelerate generation of fundamental materials insights显示文摘Machine learning for materials science envisions the acceleration of basic science research through automated identification of key data relationships to augment human interpretation and gain scientific understanding.A primary role of scientists is extraction of fundamental knowledge from data,and we demonstrate that this extraction can be accelerated using neural networks via analysis of the trained data model itself rather than its application as a prediction tool.Convolutional neural networks excel at modeling complex data relationships in multi-dimensional parameter spaces,such as that mapped by a combinatorial materials science experiment.Measuring a performance metric in a given materials space provides direct information about(locally)optimal materials but not the underlying materials science that gives rise to the variation in performance.By building a model that predicts performance(in this case photoelectrochemical power generation of a solar fuels photoanode)from materials parameters(in this case composition and Raman signal),subsequent analysis of gradients in the trained model reveals key data relationships that are not readily identified by human inspection or traditional statistical analyses.Human interpretation of these key relationships produces the desired fundamental understanding,demonstrating a framework in which machine learning accelerates data interpretation by leveraging the expertize of the human scientist.We also demonstrate the use of neural network gradient analysis to automate prediction of the directions in parameter space,such as the addition of specific alloying elements,that may increase performance by moving beyond the confines of existing data. | Mitsutaro Umehara Helge S.Stein Dan Guevarra Paul F.Newhouse David A.Boyd John M.Gregoire | 2019 | npj Computational Materials2019，，1： | 7 |
| 2 | Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011显示文摘 | Hisanori Umehara Kazuichi Okazaki Yasufumi Masaki Mitsuhiro Kawano Motohisa Yamamoto Takako Saeki Shoko Matsui Tadashi Yoshino Shigeo Nakamura Shigeyuki Kawa Hideaki Hamano Terumi Kamisawa Toru Shimosegawa Akira Shimatsu Seiji Nakamura Tetsuhide Ito Kenji | 2012 | Modern Rheumatology2012，，1： | 4 |
| 3 | A novel clinical entity, IgG4-related disease (IgG4RD): general concept and details显示文摘 | Hisanori Umehara Kazuichi Okazaki Yasufumi Masaki Mitsuhiro Kawano Motohisa Yamamoto Takako Saeki Shoko Matsui Takayuki Sumida Tsuneyo Mimori Yoshiya Tanaka Kazuo Tsubota Tadashi Yoshino Shigeyuki Kawa Ritsuro Suzuki Tsutomu Takegami Naohisa Tomosugi Nozo | 2012 | Modern Rheumatology2012，，1： | 4 |
| 4 | Endoscopic findings can predict the efficacy of leukocytapheresis for steroid-naive patients with moderately active ulcerative colitis显示文摘AIM:To investigate the therapeutic usefulness of leukocytapheresis (LCAP; Cellsoba) in steroid-naive patients with moderately active ulcerative colitis (UC). METHODS: Eighteen steroid-naive patients with moderately active UC received one LCAP session every week for fi ve consecutive weeks. RESULTS: The remission rate 8 weeks after the last LCAP session was 61.1% (11/18). All three patients with deep ulcers showed worsening after LCAP. For the remaining 15 patients, who had erosions or geographic ulcers, the average clinical activity index (CAI) score dropped significantly from 9.4 to 3.8 eight weeks after the last LCAP session (t = 4.89, P = 0.001). The average C-reactive protein (CRP) levels before and after LCAP were 1.2 mg/dL and 1.0 mg/dL, respectively. Of the patients with erosions, geographic ulcers, and deep ulcers, 100% (9/9), 33.3% (2/6), and 0% (0/3) were in remission 8 weeks after the last LCAP session, respectively (χ2 = 7.65, P < 0.005). Forty- eight weeks after the last LCAP session, the remission rates for patients with erosions and geographic ulcers were 44.4% (4/9) and 16.7% (1/6), respectively. Only one patient suffered a mild adverse event after LCAP (nausea). CONCLUSION: LCAP is a useful and safe therapyfor steroid-naive UC patients with moderate disease activity. Moreover, the effi cacy of the treatment can be predicted on the basis of endoscopic fi ndings. | Yasushi Umehara Masatoshi Kudo Masanori Kawasaki | 2008 | World Journal of Gastroenterology2008，14，34： | 2 |
| 5 | Update on classification,diagnosis,and management of immunoglobulin G4-related disease显示文摘Immunoglobulin G4-related disease(IgG4-RD)is a newly recognized chronic fibro-inflammatory autoimmune disease,and its recognition has been constantly increasing worldwide over the last few years.A correct and timely recognition,as well as appropriate intervention,is crucial for the treatment of IgG4-RD.For certain subtypes of IgG4-RD,organ-specific criteria are formulated to make the diagnosis more accurate.New biomarkers have emerged in the recent years to aid the disease diagnosis,its prognosis prediction,as well as therapy response monitoring.Although recurrence is very common in IgG4-RD,glucocorticoid is still the first-line treatment for the majority of patients.The factors that affect the likelihood of disease relapse are multifaceted.The selection strategy of various steroid-sparing agents is still being explored.Besides,when patients have special sites involvement leading to severe clinical conditions,surgical operation or interventional therapy should also be considered.An update on classification,diagnosis,and management of IgG4-RD is provided in the current study to fully elucidate the recommended clinical practice of this mysterious disease. | Yu Chen Shaozhe Cai Lingli Dong Hisanori Umehara | 2022 | Chinese Medical Journal2022，，4： | 2 |
| 6 | 显示文摘 | Umehara H Takaya M Terauchi S | 2003 | Surface and Coatings Technology2003，，： | 1 |
| 7 | Mutual separation of two monovalent metal ions by multistage electrodialysis显示文摘 | Takahashi K Umehara K Cruz GPT | 2005 | Chem Eng Sci2005，60，3： | 1 |
| 8 | Plasma exchange- based plasma recycling dialysis system as an artificial liver sup- port显示文摘 | Takahashi K Umehara Y Umehara M | 2008 | Ther Apher Dial2008，12，4： | 1 |
| 9 | The biomechanical effect of postoperative hypolordesis in instrumented lumbar fusion on instrumented and adjacent spinal segments显示文摘 | Umehara S Zindrick MR Patwardhan AG | 2000 | Spine2000，25，13： | 1 |
| 10 | Physical mapping of the rice genome with YAC clones显示文摘 | Kurata N Umehara Y Tanoue H | 1997 | Plant Mol Biol1997，3，12： | 1 |
| 11 | Priming of peripheral monocytes with prolactin (PRL) sensitizes IFN-γ- mediated indoleamine 2,3-dioxygenase (IDO) expression without affecting IFN-;/ signaling显示文摘 | Kawaguchi R Shimokawa T Umehara N | 2008 | J Reprod Immunol2008，77，2： | 1 |
| 12 | Chrome-free surface tueatments for magnesium alloy 显示文摘 | Umehara H Takaya M Terauchi S | 2003 | Surface and Coatings Technology2003，169，2： | 1 |
| 13 | A physical map with yeast artificial chromosome (YAC) clones covering 63% of the 12 rice chromosomes 显示文摘 | Saji S Umehara Y Antonio B A | 2001 | Genome2001，44，： | 1 |
| 14 | Saturation mapping with subclones of YACs: DNA marker production targeting the rice blast disease resistance gene, Pi-b显示文摘 | L. Monna A. Miyao H. S. Zhong M. Yano M. Iwamoto Y. Umehara N. Kurata H. Hayasaka T. Sasaki | 1997 | TAG Theoretical and Applied Genetics1997，，2： | 1 |
| 15 | A new apparatus for finishing large size/large batch silicon nitride (Si3N4) balls for hybrid bearing applications by magnetic float polishing (MFP)显示文摘 | UMEHARA N KIRTANE T GERLICK R | | 0，，02： | 1 |
| 16 | Long-Term Survival After Report Resection of Pulmonary Metastases from Hepatocellular Carcinoma: Report of Two Cases显示文摘 | Toru Nakamura Taizo Kimura Yasuhiko Umehara Kenji Suzuki Kazuya Okamoto Takuya Okumura Sei Morizumi Toshiki Kawabata Akira Komiyama | 2005 | Surgery Today2005，，10： | 1 |
| 17 | Imaging display method for airborne oceanographic LIDAR显示文摘 | Davis J P Keck T Umehara M J | 1990 | SPIE1990，1320，： | 1 |
| 18 | The effect of surface roughness on friction of ceramics sliding in water 显示文摘 | Wong H C Umehara N Kato K | 2001 | Wear2001，218，： | 1 |
| 19 | An investigation of the structure and corrosion resistance of a permanganate conversion coating on AZ 91D magnesiumalloys显示文摘 | Umehara H | 2000 | Journal Japan Institute of Light Metals2000，50，3： | 1 |
| 20 | Chrome- free surface treatments for magnesium alloy 显示文摘 | Umehara H Takaya M Terauchi S | 2003 | Surface and Coatings Technology2003，，： | 1 |
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