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| 1 | Folate receptor-mediated boron-10 containing carbon nanoparticles as potential delivery vehicles for boron neutron capture therapy of nonfunctional pituitary adenomas显示文摘Invasive nonfunctional pituitary adenomas(NFPAs) are difficult to completely resect and often develop tumor recurrence after initial surgery.Currently,no medications are clinically effective in the control of NFPA.Although radiation therapy and radiosurgery are useful to prevent tumor regrowth,they are frequently withheld because of severe complications.Boron neutron capture therapy(BNCT) is a binary radiotherapy that selectively and maximally damages tumor cells without harming the surrounding normal tissue.Folate receptor(FR)-targeted boron-10 containing carbon nanoparticles is a novel boron delivery agent that can be selectively taken up by FR-expressing cells via FR-mediated endocytosis.In this study,FR-targeted boron-10 containing carbon nanoparticles were selectively taken up by NFPAs cells expressing FR but not other types of non-FR expressing pituitary adenomas.After incubation with boron-10 containing carbon nanoparticles and following irradiation with thermal neutrons,the cell viability of NFPAs was significantly decreased,while apoptotic cells were simultaneously increased.However,cells administered the same dose of FR-targeted boron-10 containing carbon nanoparticles without neutron irradiation or received the same neutron irradiation alone did not show significant decrease in cell viability or increase in apoptotic cells.The expression of Bcl-2 was down-regulated and the expression of Bax was up-regulated in NFPAs after treatment with FR-mediated BNCT.In conclusion,FR-targeted boron-10 containing carbon nanoparticles may be an ideal delivery system of boron to NFPAs cells for BNCT.Furthermore,our study also provides a novel insight into therapeutic strategies for invasive NFPA refractory to conventional therapy,while exploring these new applications of BNCT for tumors,especially benign tumors. | DAI CongXin CAI Feng HWANG Kuo Chu ZHOU YongMao ZHANG ZiZhu LIU XiaoHai MA SiHai YANG YaKun YAO Yong FENG Ming BAO XinJie LI GuiLin WEI JunJi JIAO YongHui WEI ZhenQing MA WenBin WANG RenZhi | 2013 | Science China(Life Sciences)2013，56，2： | 8 |
| 2 | Direct observation of metastable face-centered cubic Sb2Te3 crystal显示文摘尽管阶段变化记忆技术在过去的二十年急速地发展了,关键切换材料的认知仍然忽视一个重要成员,以脸为中心的立方的 Sb 2 Te 3 。除了著名平衡六角形的 Sb 2 Te 3 水晶,我们证明亚稳的以脸为中心的立方的 Sb 是 2 Te 3 阶段确实存在。如此的亚稳的晶体包含随机占据 cationic 格子地点的空缺的大集中。以脸为中心对 Sb 2 Te 3, 由空缺聚集伴随了,与 Ge 2 Sb 2 Te 5 合金。我们证明像共有原子价的契约在亚稳的 Sb 2 Te 3 水晶,从理想的反响的特征背离。如果一种合适的做技术被采用,亚稳的 Sb 2 Te 3 阶段能为认识到 reversibly 快速、低精力的阶段变化存储器应用程序是有希望的。我们的学习可以在新奇阶段变化材料的设计提供新卓见进商品化的 Ge-Sb-Te 系统和帮助增加阶段变化存储器设备的表演。 | Yonghui Zheng Mengjiao Xia Yan Cheng Feng Rao Keyuan Ding Weili Liu Yu Jia Zhitang Song Songlin Feng | 2016 | Nano Research2016，9，11： | 5 |
| 3 | The progress on antifouling organic coating: From biocide to biomimetic surface显示文摘The advancement in material science and engineering technology has led to the development of antifouling(AF) coatings which are cheaper, durable, less toxic, and safe to the environment. The use of AF coatings containing tributyltin compounds was prohibited at the beginning of 2003, this necessitated the development of environmentally friendly coatings. The fouling release coating(FRC) lacks biocides and has low surface energy, low elastic modulus with smooth surface properties, hence a better release effect to fouling organisms. Several functional coatings have been recently developed based on fouling release(FR) technology to combat the effects of biofouling. Here, we provide a brief overview of innovative technologies and recent developments based on FRCs, including silicone, modified fluorinated polymer,cross-linked coatings, amphiphilic copolymer coating, hydrogel coatings, and biomimetic coatings. We also highlight the key issues and shortcomings of innovative technologies based on FRCs. This may give new insights into the future development of marine AF coatings. | Xu Han Jianhua Wu Xianhui Zhang Junyou Shi Jiaxin Wei Yang Yang Bo Wu Yonghui Feng | 2021 | Journal of Materials Science & Technology2021，，2： | 2 |
| 4 | Synthetical Numerical Model for Evaluating Blade Fatigue Life of Liquid Corrosion in Steam Turbine显示文摘 | Yonghui Xie Di Zhang Zhenping Feng Bi Sun | 2006 | Key Engineering Materials2006，324，： | 1 |
| 5 | Black garlic (Allium sativum) extracts Enhance the immune system显示文摘 | Danan Wang Yonghui Feng Jun Liu | 2010 | Medicinal and Aromatic Plant Science and Biotechnology2010，，： | 1 |
| 6 | Performance and stability of yield in response to plant density,year and location in maize hybrids of Northwest China显示文摘Identifying desirable genotypes with the best performance in diverse environments is a perpetual aim of plant breeding,and the interaction between genotype and environment(G×E)always plays a key role.This study was conducted to elucidate the genetic behaviour of different hybrid combinations at various densities in diverse environments.According to a line×tester design,32 hybrid combinations were obtained from 16 inbred individuals crossed with two testers and planted at three locations at three density levels(45,000,67,500 and 90,000 plants ha-1)during 2014-2017.Genotype(G),environment(E)and the interaction of genotype and environment(G×E)significantly affected grain yield at different densities.Increasing planting density enhanced grain yield and improved the efficiency of germplasm screening,where the effect of location on grain yield at different densities was larger than that of year and the GCA was larger than the SCA.Finally,four inbred lines(KB102,KB081,KA105,and KB106)with a high GCA,environmental adaptability,and several combinations using them as parents have been approved in ShannXi Province and National of China.In conclusion,the evaluation of combining ability at multiple densities and locations can effectively screen inbred lines and improve breeding efficiency. | Yuan Dong Zhiqian Feng Ting Li Ali Farhan Xiaokang Tian Yonghui Lao Yinxin Duan Leiyong Si Xinghua Zhang Jiquan Xue Shutu Xu | 2022 | Technology in Agronomy2022，2，1： | 1 |
| 7 | Noninvasive identificational diagnosis of diabetic nephropathy and non-diabetic renal disease based on clinical characteristics of Traditional Chinese Medicine symptom pattern and conventional medicine显示文摘OBJECTIVE:To study the clinical characteristics relating to differential diagnosis of diabetic nephropathy(DN) and non-diabetic renal disease(NDRD).METHODS:The subjects were patients with type 2 diabetes mellitus(T2DM) complicated with chronic kidney disease(CKD).Western medical history data and Traditional Chinese Medicine(TCM) symptom pattern were collected,and logistic regression was used to analyze.RESULTS:Blood deficiency pattern [odds ratio(OR) = 2.269,P = 0.017] and Qi stagnation pattern(OR = 1.999,P = 0.041) are independently related to DN.CONCLUSIONS:TCM factors blood deficiency pattern and Qi stagnation pattern are relating to differential diagnosis of DN and NDRD. | QU Yilun CHENG Haimei WANG Qian LI Shuang DUAN Shuwei FENG Zhe LI Weizhen JIANG Shuangshuang YANG Hongtao MAO Yonghui GENG Yanqiu LI Jijun LIU Yuning TIAN Jinzhou LIU Hongfang DONG Zheyi CHEN Xiangmei | 2023 | Journal of Traditional Chinese Medicine2023，43，3： | 1 |
| 8 | An integrated SOM-based multivariate approach for spatio-temporal patterns identification and source apportionment of pollution in complex river network显示文摘 | Yonghui Yang Cuiyu Wang Huaicheng Guo Hu Sheng Feng Zhou | 2012 | Environmental Pollution2012，，： | 1 |
| 9 | A UPLC–MS–MS Method for Quantification of Harpagoside and Cinnamic Acid in Rat Plasma and Its Application to a Pharmacokinetic Study after Oral Administration of Yanyan Tablets显示文摘 | Zhili Xiong Yonghui Fu Jingjing Li Feng Qin Famei Li | 2010 | Chromatographia (-)2010，，1： | 1 |
| 10 | DELAY DIFFERENTIAL EQUATIONS UNDER NONLINEAR IMPULSIVE CONTROL AND APPLICATIONS TO NEURAL NETWORK MODELS显示文摘在这份报纸,延期的一个班有非线性的冲动的控制的微分方程被讨论。基于 nonsmooth 分析,稳定性的标准为有非线性的推动的微分方程在某些条件下面控制的延期被获得。这些标准能被用于一些神经网络模型。在纸的结束,二个例子被提供说明建议结果的可行性和有效性。 | Yong ZHAO Qishao LU Zhaosheng FENG Yonghui XIA | 2012 | Journal of Systems Science & Complexity2012，25，4： | 1 |
| 11 | Liposomal oral DNA vaccine elicts immune response显示文摘 | Danan Wang Jia Xu Yonghui Feng | 2010 | Vaccine2010，，28： | 1 |
| 12 | HYDRAULIC ACTIVE GUIDE ROLLER SYSTEM FOR HIGH-SPEED ELEVATOR BASED ON FUZZY CONTROLLER显示文摘电梯速度的增加引起高速度的电梯的放大颤动。以便减少高速度的电梯的水平颤动,水力的活跃指南压路机系统的一种新类型基于模糊逻辑控制器被开发。首先,水力的指南系统的工作原则被介绍,然后,为有活跃指南压路机系统的电梯笼子的水平颤动的动态模型和水力的系统的数学模型被给。为水力的系统的一个模糊逻辑控制器被设计控制水力的致动器。改进控制表演,为控制器的预览赔偿被提供。最后,模拟和实验被执行验证水力的活跃指南压路机系统和控制策略。模拟和试验性的结果显示水力的活跃指南压路机系统能有效地减少电梯的水平颤动并且与预览赔偿比被动的,和模糊逻辑控制器有更好的效果能给优异控制性能。 | FENG Yonghui ZHANG Jianwu | 2007 | Chinese Journal of Mechanical Engineering2007，20，5： | 1 |
| 13 | Phylogenetic analysis of aerobic anoxygenic phototrophic bacteria and their relatives based on farnesyl pyrophosphate synthase gene显示文摘The study aims to reveal phylogenetic and evolutionary relationship between aerobic anoxygenic phototrophic bacteria(AAnPB) and their relatives,anaerobic anoxygenic phototrophic bacteria(AnAnPB) and nonphototrophic bacteria(NPB,which had high homology of 16S rDNA gene with AAnPB and fell into the same genus),and validate reliability and usefulness of farnesyl pyrophosphate synthase(FPPS) gene for the phylogenetic determination.FPPS genes with our modified primers and 16S rDNA genes with general primers,were amplified and sequenced or retrieved from GenBank database.In contrast to 16S rDNA gene phylogenetic tree,AAnPB were grouped into two clusters and one branch alone with no intermingling with NPB and AnAnPB in the tree constructed on FPPS.One branch of AAnPB,in both trees,was located closer to outgroup species than AnAnPB,which implicated that some AAnPB would be diverged earlier in FPPS evolutionary history than AnAnPB and NPB.Some AAnPB and NPB were closer located in both trees and this suggested that they were the closer relatives than AnAnPB.Combination codon usage in FPPS with phylogenetic analysis,the results indicates that FPPS gene and 16S rRNA gene have similar evolutionary pattern but the former seems to be more reliable and useful in determining the phylogenic and evolutionary relationship between AAnPB and their relatives.This is the first attempt to use a molecular marker beside 16S rRNA gene for studying the phylogeny of AAnPB,and the study may also be helpful in understanding the evolutionary relationship among phototrophic microbes and the trends of photosynthetic genes transfer. | FENG Fuying JIAO Nianzhi DU Hailian ZENG Yonghui | 2010 | Acta Oceanologica Sinica2010，29，5： | 1 |
| 14 | Secure Multigroup Multicast Communication Systems via Intelligent Reflecting Surface显示文摘This paper considers a secure multigroup multicast multiple-input single-output(MISO)communication system aided by an intelligent reflecting surface(IRS).Specifically,we aim to minimize the transmit power at Alice via jointly optimizing the transmit beamformer,artificial noise(AN)vector and phase shifts at the IRS subject to the secrecy rate constraints as well as the unit modulus constraints of IRS phase shifts.To tackle the optimization problem,we first transform it into a semidefinite relaxation(SDR)problem,and then alternately update the transmit beamformer and AN matrix as well as the phase shifts at the IRS.In order to reduce the high computational complexity,we further propose a low-complexity algorithm based on second-order cone programming(SOCP).We decouple the optimization problem into two sub-problems and optimize the transmit beamformer,AN vector and the phase shifts alternately by solving two corresponding SOCP subproblem.Simulation results show that the proposed SDR and SOCP schemes require half or less transmit power than the scheme without IRS,which demonstrates the advantages of introducing IRS and the effectiveness of the proposed methods. | Weiping Shi Jiayu Li Guiyang Xia Yuntian Wang Xiaobo Zhou Yonghui Zhang Feng Shu | 2021 | China Communications2021，18，3： | 1 |
| 15 | Hydrothermal synthesis of hierarchical SnO_(2)nanomaterials for high-efficiency detection of pesticide residue显示文摘Acephate pesticide contamination in agricultural production has caused serious human health problems.Metal oxide semiconductor(MOS)gas sensor can be used as a portable and promising alternative tool for efficiently detection of acephate.In this study,hierarchical assembled SnO_(2)nanosphere,SnO_(2)hollow nanosphere and SnO_2 nanoflower were synthesized respectively as high efficiency sensing materials to build rapid and selective acephate pesticide residues sensors.The morphologies of different SnO_(2)3 D nanostructures were characterized by various material characterization technology.The sensitive performance test results of the 3 D SnO_(2)nanomaterials towards acephate show that hollow nanosphere SnO_(2)based sensor displayed preferable sensitivity,selectivity,and rapid response(9 s)properties toward acephate at the optimal working temperature(300℃).This SnO_(2)hollow nanosphere based gas sensor represents a useful tool for simple and highly effective monitoring of acephate pesticide residues in food and environment.According to the characterization results,particularly Brunauer-Emmett-Teller(BET)and Ultraviolet-Visible Spectroscopy(UV-vis),the obvious and fast response can be attributed to the mesoporous hollow nanosphere structure and appropriate band gap of SnO_2 hollow nanosphere. | Haijie Cai Xiaopeng Qiao Meilian Chen Dongsheng Feng Abdulaziz AAlghamdi Fahad A.Alharthi Yingjie Pan Yong Zhao Yongheng Zhu Yonghui Deng | 2021 | Chinese Chemical Letters2021，32，4： | 1 |
| 16 | Stochastic stability of Markovian switching genetic regulatory networks显示文摘 | Sun Yonghui Feng Gang Cao Jinde | 2009 | Physics Letters A2009，20，： | 1 |
| 17 | Eupalinolide B inhibits hepatic carcinoma by inducing ferroptosis and ROS-ER-JNK pathway显示文摘Primary hepatic carcinoma is a common malignant tumor.The classic molecular targeted drug sorafenib is costly and is only effective for some patients.Therefore,it is of great clinical significance to search for new molecular targeted drugs.Eupalinolide B(EB)from Eupatorium lindleyanum DC.is used to treat chronic tracheitis in clinical practice.However,the role of EB in hepatic carcinoma is unknown.In this study,we first measure the effect of EB on tumor growth in a xenograft model and PDX model.The cell proliferation and migration are also detected in human hepatocarcinoma cell lines(SMMC-7721 and HCCLM3).Then,we investigate cell cycle,cell apoptosis,cell necrosis,cell autophagy,and ferroptosis by flow cytometry,western blot analysis and electron microscopy.The results demonstrate that EB exerts anti-proliferative activity in hepatic carcinoma by blocking cell cycle arrest at S phase and inducing ferroptosis mediated by endoplasmic reticulum(ER)stress,as well as HO-1 activation.When HO-1 is inhibited,EB-induced cell death and ER protein expression are rescued.The migration-related mechanism consists of activation of the ROS-ER-JNK signaling pathway and is not connected to ferroptosis.In summary,we first discover that EB inhibits cell proliferation and migration in hepatic carcinoma,and thus EB is a promising anti-tumor compound that can be used for hepatic carcinoma. | Yonghui Zhang Haoyang Zhang Jinage Mu Meiyue Han Zhihao Cao Feng Dong Tingting Wang Lian Pan Wujing Luo Jiaxin Li Huan Liu Lishan Jin Wenxuan Ding Yong Wei Xuesong Deng Dan Liu Xiuzhen He Yi Pang Xiao Mu Zhongjun Wu Dilong Chen | 2022 | Acta Biochimica et Biophysica Sinica2022，54，7： | 1 |
| 18 | Acidic catalysis of microporous polyoxometalate H_3PW_(12)O_(40)/SiO_2 in acetal reaction between benzaldehyde and ethylene glycol | YANG Yulin, GUO Yihang, WANG Yonghui, HU Changwen, WANG Enbo and FENG Shouhua( Institute of Polyoxometalate Chemistry, Faculty of Chemistry, Northeast Normal University, Changchun 130024, China State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, Jilin University, Changchun 130023, China) | 2002 | Progress in Natural Science:Materials International2002，12，2： | 0 |
| 19 | Current-limiting Characteristics of a Modified Flux-coupling Type Superconducting Fault Current Limiter and Its Effects on the Transient Stability of a Multi-machine Power System显示文摘A modified flux-coupling type superconducting fault current limiter(SFCL)is proposed here for suppressing fault currents.The modified SFCL consists of a coupling transformer,an yttrium barium copper oxide(YBCO)pancake coil,and a controlled switch.By flexibly adjusting the controlled switch’s contact states based on the system operational conditions,the coupling transformer’s primary inductance as well as the YBCO coil’s normal-state resistance are incorporated into the main system for current limitation.Because the modified SFCL has the advantages of resistive and inductive SFCLs,it may improve the power system’s transient behavior.Hence,the SFCL’s effect on the transient stability of a multi-machine power system was also theoretically investigated.Further,simulations were conducted for accessing the SFCL’s performance characteristics under different fault conditions.The results show that using the proposed SFCL can effectively restrain the increased fault current and improve the bus voltage sag;meanwhile,the imitated multi-machine system’s power-angle oscillation can be obviously reduced. | Yonghui He Langheng Cao Feng Zheng | 2021 | Chinese Journal of Electrical Engineering2021，7，2： | 0 |
| 20 | Porous 2D CuO nanosheets for efficient triethylamine detection at low temperature显示文摘The freshness of seafood can be judged by detecting the concentration of triethylamine(TEA). In this work, 2D Cu O porous nanosheets(Cu O PNs) were prepared by a graphene oxide template method and their particle sizes were regulated by changing the calcination temperature. Their structure, morphology and gas sensing performances were investigated by various characterization methods. The response(Rg/Ra) of the gas sensor based on Cu O PNs calcined at 700oC was as high as 440-100 ppm TEA at the operating temperature of 40 ℃. The detection limit was as low as 0.25 ppm. In addition, the gas sensor has good selectivity and stability. The excellent TEA sensitivity is mainly resulted from the appropriate particle size and loose porous framework. This work not only paves the way to explore the novel low temperature TEA gas sensors, but also provides deep insight on improving the structure and properties of gas sensitive materials by controlling the calcination temperature. | Feng Wang Haoran Zhong Zhenlu Chen Ding Wang Zhuangchai Lai Yonghui Deng Xianying Wang | 2023 | Chinese Chemical Letters2023，34，2： | 0 |
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