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| 1 | The Chinese Society of Clinical Oncology(CSCO):Clinical guidelines for the diagnosis and treatment of gastric cancer,2021显示文摘There exist differences in the epidemiological characteristics,clinicopathological features,tumor biological characteristics,treatment patterns,and drug selections between gastric cancer patients from the Eastern and Western countries.The Chinese Society of Clinical Oncology(CSCO)has organized a panel of senior experts specializing in all sub-specialties of gastric cancer to compile a clinical guideline for the diagnosis and treatment of gastric cancer since 2016 and renews it annually.Taking into account regional differences,giving full consideration to the accessibility of diagnosis and treatment resources,these experts have conducted expert consensus judgment on relevant evidence and made various grades of recommendations for the clinical diagnosis and treatment of gastric cancer to reflect the value of cancer treatment and meeting health economic indexes in China.The 2021 CSCO Clinical Practice Guidelines for Gastric Cancer covers the diagnosis,treatment,follow-up,and screening of gastric cancer.Based on the 2020 version of the CSCO Chinese Gastric Cancer guidelines,this updated guideline integrates the results ofmajor clinical studies from China and overseas for the past year,focused on the inclusion of research data from the Chinese population for more personalized and clinically relevant recommendations.For the comprehensive treatment of non-metastatic gastric cancer,attentions were paid to neoadjuvant treatment.The value of perioperative chemotherapy is gradually becoming clearer and its recommendation level has been updated.For the comprehensive treatment of metastatic gastric cancer,recommendations for immunotherapy were included,and immune checkpoint inhibitors fromthird-line to the first-line of treatment for different patient groups with detailed notes are provided. | Feng-Hua Wang Xiao-Tian Zhang Yuan-Fang Li Lei Tang Xiu-Juan Qu Jie-Er Ying Jun Zhang Ling-Yu Sun Rong-Bo Lin Hong Qiu Chang Wang Miao-Zhen Qiu Mu-Yan Cai QiWu Hao Liu Wen-Long Guan Ai-Ping Zhou Yu-Jing Zhang Tian-Shu Liu Feng Bi Xiang-Lin Yuan Sheng-Xiang Rao Yan Xin Wei-Qi Sheng Hui-Mian Xu Guo-Xin Li Jia-Fu Ji Zhi-Wei Zhou Han Liang Yan-Qiao Zhang Jing Jin Lin Shen Jin Li Rui-Hua Xu | 2021 | Cancer Communications2021，41，8： | 97 |
| 2 | Erianin,a novel dibenzyl compound in Dendrobium extract,inhibits lung cancer cell growth and migration via calcium/calmodulin-dependent ferroptosis显示文摘Ferroptosis,a novel form of programmed cell death,is characterized by iron-dependent lipid peroxidation and has been shown to be involved in multiple diseases,including cancer.Stimulating ferroptosis in cancer cells may be a potential strategy for cancer therapy.Therefore,ferroptosis-inducing drugs are attracting more attention for cancer treatment.Here,we showed that erianin,a natural product isolated from Dendrobium chrysotoxum Lindl,exerted its anticancer activity by inducing cell death and inhibiting cell migration in lung cancer cells.Subsequently,we demonstrated for the first time that erianin induced ferroptotic cell death in lung cancer cells,which was accompanied by ROS accumulation,lipid peroxidation,and GSH depletion.The ferroptosis inhibitors Fer-1 and Lip-1 but not Z-VAD-FMK,CQ,or necrostatin-1 rescued erianin-induced cell death,indicating that ferroptosis contributed to erianin-induced cell death.Furthermore,we demonstrated that Ca^(2+)/CaM signaling was a critical mediator of erianin-induced ferroptosis and that blockade of this signaling significantly rescued cell death induced by erianin treatment by suppressing ferroptosis.Taken together,our data suggest that the natural product erianin exerts its anticancer effects by inducing Ca^(2+)/CaMdependent ferroptosis and inhibiting cell migration,and erianin will hopefully serve as a prospective compound for lung cancer treatment. | Peng Chen Qibiao Wu Jiao Feng Lili Yan Yitian Sun Shuiping Liu Yu Xiang Mingming Zhang Ting Pan Xiaying Chen Ting Duan Lijuan Zhai Bingtao Zhai Wengang Wang Ruonan Zhang Bi Chen Xuemeng Han Yicong Li Liuxi Chen Ying Liu Xingxing Huang Ting Jin Wenzheng Zhang Hong Luo Xiaohui Chen Yongqiang Li Qiujie Li Guohua Li Qin Zhang Lvjia Zhuo Zuyi Yang Huifen Tang Tian Xie Xiaoping Ouyang Xinbing Sui | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 42 |
| 3 | Multiple methods of surgical treatment combined with primary IOL implantation on traumatic lens subluxation/dislocation in patients with secondary glaucoma显示文摘AIM:To describe clinical findings and complications from cases of traumatic lens subluxation/dislocation in patients with secondary glaucoma,and discuss the multiple treating methods of operation combined with primary intraocular lens(IOL)implantation.METHODS:Non-comparativeretrospectiveobservational case series.Participants:30 cases(30 eyes)of lens subluxation/dislocation in patients with secondary glaucoma were investigated which accepted the surgical treatment by author in the Ophthalmology of Xi'an No.4Hospital from 2007 to 2011.According to the different situations of lens subluxation/dislocation,various surgical procedures were performed such as crystalline lens phacoemulsification,crystalline lens phacoemulsification combined anterior vitrectomy,intracapsular cataract extraction combined anterior vitrectomy,lensectomy combined anterior vitrectomy though peripheral transparent cornea incision,pars plana lensectomy combined pars plana vitrectomy,and intravitreal cavity crystalline lens phacofragmentation combined pars plana vitrectomy.And whether to implement trabeculectomy depended on the different situations of secondary glaucoma.The posterior chamber intraocular lenses(PC-IOLs)were implanted in the capsular-bag or trassclerally sutured in the sulus decided by whether the capsular were present.Main outcome measures:visual acuity,intraocular pressure,the situation of intraocular lens and complications after the operations.RESULTS:The follow-up time was 11-36mo(21.4±7.13).Postoperative visual acuity of all eyes were improved;28 cases maintained IOP below 21 mm Hg;2cases had slightly IOL subluxation,4 cases had slightlytilted lens optical area;1 case had postoperative choroidal detachment;4 cases had postoperative corneal edema more than 1wk,but eventually recovered transparent;2 cases had mild postoperative vitreous hemorrhage,and absorbed 4wk later.There was no postoperative retinal detachment,IOL dislocation,and endophthalmitis.CONCLUSION:To take early treatment of traumatic lens subluxation/dislocation in patients with secondary glaucoma by individual surgical plan based on the different eye conditions would be safe and effective,which can effectively control the intraocular pressure and restore some vision. | Rui Wang Chun-Chao Bi Chun-Ling Lei Wen-Tao Sun Shan-Shan Wang Xiao-Juan Dong | 2014 | International Journal of Ophthalmology(English edition)2014，7，2： | 26 |
| 4 | Postharvest Chitosan Treatment Induces Resistance in Potato Against Fusarium sulphureum显示文摘The effects of chitosan treatment and inoculation on dry rot in tubers and slices of potato were studied. The results showed that chitosan treatment significantly reduced the lesion diameter of potato inoculated with Fusarium sulphureum. The treatment at 0.25% showed the best effect. Chitosan at 0.25% increased the activities of peroxidase and polyphenoloxidase,and the contents of flavonoid compounds and lignin in tissues. Increased activities of β-1,3-glucanase,and phenylalanine ammonialyase were observed,but there were no significant differences between the treated and the control. These findings suggested that the effects of chitosan could be associated with the induced resistance against Fusarium dry rot in potato. | SUN Xiao-juan BI Yang LI Yong-cai HAN Rui-feng GE Yong-hong | 2008 | Agricultural Sciences in China2008，7，5： | 25 |
| 5 | Baicalin induces ferroptosis in bladder cancer cells by downregulating FTH1显示文摘Ferroptosis is a non-apoptotic regulated cell death caused by iron accumulation and subsequent lipid peroxidation.Currently,the therapeutic role of ferroptosis on cancer is gaining increasing interest.Baicalin an active component in Scutellaria baicalensis Georgi with anticancer potential various cancer types;however,the effects of baicalein on bladder cancer and the underlying molecular mechanisms remain largely unknown.In the study,we investigated the effect of baicalin on bladder cancer cells5637 and KU-19-19.As a result,we show baicalin exerted its anticancer activity by inducing apoptosis and cell death in bladder cancer cells.Subsequently,we for the first time demonstrate baicalin-induced ferroptotic cell death in vitro and in vivo,accompanied by reactive oxygen species(ROS) accumulation and intracellular chelate iron enrichment.The ferroptosis inhibitor deferoxamine but not necrostatin-1,chloroquine(CQ),N-acetyl-L-cysteine,L-glutathione reduced,or carbobenzoxy-valyl-alanyl-aspartyl-[O-methyl]-fluoromethylketone(Z-VAD-FMK) rescued baicalin-induced cell death,indicating ferroptosis contributed to baicalin-induced cell death.Mechanistically,we show that ferritin heavy chain1(FTH1) was a key determinant for baicalin-induced ferroptosis.Overexpression of FTH1 abrogated the anticancer effects of baicalin in both 5637 and KU19-19 cells.Taken together,our data for the first time suggest that the natural product baicalin exerts its anticancer activity by inducing FTH1-dependent ferroptosis,which will hopefully provide a prospective compound for bladder cancer treatment. | Na Kong Xiaying Chen Jiao Feng Ting Duan Shuiping Liu Xueni Sun Peng Chen Ting Pan Lili Yan Ting Jin Yu Xiang Quan Gao Chengyong Wen Weirui Ma Wencheng Liu Mingming Zhang Zuyi Yang Wengang Wang Ruonan Zhang Bi Chen Tian Xie Xinbing Sui Wei Tao | 2021 | Acta Pharmaceutica Sinica B2021，11，12： | 23 |
| 6 | The ChinaMAP analytics of deep whole genome sequences in 10,588 individuals显示文摘Metabolic diseases are the most common and rapidly growing health issues worldwide.The massive population-based human genetics is crucial for the precise prevention and intervention of metabolic disorders.The China Metabolic Analytics Project(ChinaMAP)is based on cohort studies across diverse regions and ethnic groups with metabolic phenotypic data in China.Here,we describe the centralized analysis of the deep whole genome sequencing data and the genetic bases of metabolic traits in 10,588 individuals from the ChinaMAP.The frequency spectrum of variants,population structure,pathogenic variants and novel genomic characteristics were analyzed.The individual genetic evaluations of Mendelian diseases,nutrition and drug metabolism,and traits of blood glucose and BMI were integrated.Our study establishes a large-scale and deep resource for the genetics of East Asians and provides opportunities for novel genetic discoveries of metabolic characteristics and disorders. | Yanan Cao Lin Li Min Xu Zhimin Feng Xiaohui Sun Jieli Lu Yu Xu Peina Du Tiange Wang Ruying Hu Zhen Ye Lixin Shi Xulei Tang Li Yan Zhengnan Gao Gang Chen Yinfei Zhang Lulu Chen Guang Ning Yufang Bi Weiqing Wang The ChinaMAP Consortium | 2020 | Cell Research2020，30，9： | 20 |
| 7 | Chemotherapy-induced intestinal inflammatory responses are mediated by exosome secretion of double-strand DNA via AIM2 inflammasome activation显示文摘化疗经常被知道导致严重的胃肠的道毒性,但是内在的机制仍然保持不清楚。这研究作为一个代表性的代理人认为广泛地应用的细胞毒素的代理人是 irinotecan (CPT-11 ) 并且证明治疗从说明混合物的限制剂量的肠的毒性的肠导致双海滨 DNA 的巨大的版本。明确地,通过 exosome 分泌物释放的 self-DNA 进入天生的有免疫力的房间的 cytosol 并且激活 AIM2 (在黑瘤 2 不在) inflammasome。这导致成熟 IL-1 和 IL-18 分泌物并且导致肠的 mucositis 和迟了发作的腹泻。有趣地,在 AIM2 缺乏的老鼠或由象镇静药那样的一个药理学禁止者,没有影响 CPT-11 的 anticancer 功效, AIM2 发信号的废除显著地减少导致药的腹泻的发生。这些调查结果提供化疗怎么触发引起肠的毒性的天生的有免疫力的回答的机械学的卓见,并且揭示维持反瘤效果,但是围绕联系不利煽动性的反应的新化疗政体。 | Lian, Qiaoshi Xu, Jun Yan, Shanshan Huang, Min Ding, Honghua Sun, Xiaoyu Bi, Aiwei Ding, Jian Sun, Bing Geng, Meiyu | 2017 | Cell Research2017，27，6： | 18 |
| 8 | Predictive role of interleukin-6 and CAT score in mechanical ventilation in patients with chronic obstructive pulmonary disease at the acute exacerbation stage in the emergency department显示文摘BACKGROUND:The study aimed to evaluate the predictive role of interleukin-6(IL-6)and chronic obstructive pulmonary disease(COPD)assessment test(CAT)score in mechanical ventilation(MV)in COPD patients at the acute exacerbation stage in the emergency department(ED).METHODS:For a one-year period,among adult patients in the ED who met the criteria of acute exacerbation of COPD,158 who received MV within 48 hours after admission were compared to 294 who didn't require MV within the same period after admission.IL-6 level and CAT score were compared between the two groups.The predicted value of IL-6 and CAT score was assessed by logistic regression analysis and a receiver operating characteristic(ROC)curve.RESULTS:The IL-6 and CAT scores in the 158 MV patients were much higher than those without.IL-6 and CAT scores were independent predictors of MV within 48 hours using logistic regression analysis(IL-6:odds ratio[OR]1.053,95%confidence interval[CI]1.039–1.067,P<0.001;CAT score:OR 1.122,95%CI 1.086–1.159,P<0.001).The combination of IL-6 and CAT scores(area under ROC curve[AUC]0.826,95%CI 0.786–0.866,P<0.001)improved the accuracy of predicting MV within 48 hours when compared with IL-6(AUC 0.752,95%CI 0.703–0.800,P<0.001)and CAT scores alone(AUC 0.739,95%CI 0.692–0.786,P<0.001).The sensitivity and specificity were 69.6%,74.1%,75.32%and 63.6%,respectively.CONCLUSION:The combined of IL-6 and CAT scores is useful for evaluating the risk of COPD patients at acute exacerbation in ED,and can provide a predictive value for MV or not within 48 hours. | Wei Bi Yan Sun Lin-qin Ma Cai-jun Wu | 2020 | World Journal of Emergency Medicine2020，11，2： | 17 |
| 9 | Preservation of the continence function after intersphincteric resection using a prolapsing technique in the patients with low rectal cancer and its clinical prognosis显示文摘肿瘤的 intersphincteric 切除术的技术与 coloanal 吻合相结合的背景被用来为病人避免永久结肠开口术,直肠的癌症定位了 < 从肛门边缘的 5 厘米。针对用 prolapsing technique.Methods 在 intersphincteric 切除术以后与更低的直肠的癌症估计剩余直肠和病人的临床的预后的克制功能的保藏的这研究这研究与下列包括标准包括了病人:(1 ) 在远侧的边缘以内的直肠的癌症和肿瘤的病理学的证据由外科手术前的内视镜的检查从肛门定位了 5 厘米或更少;(2 ) 不由也的渗入的 MRI 证实外部括约肌, puborectalis 或提肌肌肉;(3 ) 病人与与 well-to-moderate 区别显示出肿瘤的外科手术前的活体检视为 intersphincteric 切除术和更低的 coloanal 吻合是合格的。从 2000 年 1 月,到 6 月 2004,23 日,有低直肠的癌症的病人在这研究被包括。我们使用了标准 abdominoperineal 途径与内部括约肌的 mesorectum 和总数或部分的切除执行肿瘤的激进的切除术。病人为对剩余直肠的功能的评价被跟随,在 operations.Results 以后的癌症复发,从肛门边缘的中部的肿瘤距离是 4.5 (范围 3.5-5.0 ) 厘米和吝啬的远侧的外科的边缘 1.6 (范围 1.0-2.0 ) 厘米。癌症被分类进舞台我(30.4%) ,舞台(47.8%) ,和舞台(21.7%) 根据 TNM 分类。在外科的切除术和 2 个病人(8.7%) 在 coloanal 吻合的地点开发了 anastomotic 苛评的以后的阶段以后,二个病人开发了 anastomotic 管。中部的后续时期是 31.5 个月(范围 12-54 ) , 2 个病人(8.7%) 开发了本地复发。三死亡与远侧的机关转移被联系。二十个病人(87.0%) 维持了胜任在外科以后控制固体或液体凳子和屁克制的能力。在这些病人之中, 2 个病人能控制稳固的凳子并且偶尔失去液体凳子的克制。并且仅仅 1 个病人(4.4%) 在手术以后与稳固的凳子然而并非液体的好克制保留了部分直肠功能。在外科是 13.1,4.7,3.1,2.9,和 3.2 时间 / 天以后,每 3, 6, 12, 24 和 36 个月的天平均澄清的时间。在 intersphincteric 切除术和这个变化在后续的时期期间留下了以后,肛门压力计大小在休息时间期间显示出压力的减少。最大值挤压压力在外科以后在起始的减少以后被改进。在外科以后的更多的剩余直肠功能可以被低直肠癌症的 intersphincteric 切除术保存的结论。同时这种技术在外科以后与很少手术后的复杂并发症和低肿瘤复发是安全的。 | DAI Yong JIANG Jin-bo BI Dong-song JIN Zu-tao SUN Jing-zhong HU San-yuan | 2008 | Chinese Medical Journal2008，，20： | 16 |
| 10 | Electroacupuncture preconditioning protects against focal cerebral ischemia/reperfusion injury via suppression of dynamin-related protein 1显示文摘Electroacupuncture preconditioning at acupoint Baihui(GV20) can reduce focal cerebral ischemia/reperfusion injury. However, the precise protective mechanism remains unknown. Mitochondrial fission mediated by dynamin-related protein 1(Drp1) can trigger neuronal apoptosis following cerebral ischemia/reperfusion injury. Herein, we examined the hypothesis that electroacupuncture pretreatment can regulate Drp1, and thus inhibit mitochondrial fission to provide cerebral protection. Rat models of focal cerebral ischemia/reperfusion injury were established by middle cerebral artery occlusion at 24 hours after 5 consecutive days of preconditioning with electroacupuncture at GV20(depth 2 mm, intensity 1 m A, frequency 2/15 Hz, for 30 minutes, once a day). Neurological function was assessed using the Longa neurological deficit score. Pathological changes in the ischemic penumbra on the injury side were assessed by hematoxylin-eosin staining. Cellular apoptosis in the ischemic penumbra on the injury side was assessed by terminal deoxyribonucleotidyl transferase-mediated d UTP-digoxigenin nick end labeling staining. Mitochondrial ultrastructure in the ischemic penumbra on the injury side was assessed by transmission electron microscopy. Drp1 and cytochrome c expression in the ischemic penumbra on the injury side were assessed by western blot assay. Results showed that electroacupuncture preconditioning decreased expression of total and mitochondrial Drp1, decreased expression of total and cytosolic cytochrome c, maintained mitochondrial morphology and reduced the proportion of apoptotic cells in the ischemic penumbra on the injury side, with associated improvements in neurological function. These data suggest that electroacupuncture preconditioning-induced neuronal protection involves inhibition of the expression and translocation of Drp1. | Gao-feng Zhang Pei Yang Zeng Yin Huai-long Chen Fu-guo Ma Bin Wang Li-xin Sun Yan-lin Bi Fei Shi Ming-shan Wang | 2018 | Neural Regeneration Research2018，13，1： | 16 |
| 11 | Assessment on environmental quality of heavy metals in agricultural soils of Chongming Island, Shanghai City显示文摘重金属的环境质量( Pb , Cd , Cr ,同样 Hg )在 Chongming 的农业表面土壤,岛被国家、本地、职业的标准基于大规模调查估计在哪个从蔬菜的 28 件样品阴谋,来自稻地的 65 件样品和来自西瓜地的 9 件样品从整个岛区域被收集。结果证明 Pb 的平均集中, Cd, Cr,并且 Hg 是 21.6 mg ???? | SUN Chao BI Chunjuan CHEN Zhenlou WANG Dongqi ZHANG Cui SUN Yuedi YU Zhongjie ZHOU Dong | 2010 | Journal of Geographical Sciences2010，20，1： | 14 |
| 12 | Responses of Saline Soil Properties and Cotton Growth to Different Organic Amendments显示文摘Application of organic waste to saline alkaline soils is considered to be a good practice for soil remediation. The effects of applying different organic amendments(e.g., cattle dung, vermicompost, biofertilizer) and earthworm inoculations(Eisenia fetida) on saline soils and cotton growth were investigated during 1 year of cotton cultivation. Compared to the control(applied with inorganic NPK fertilizer), applying organic amendments improved soil physicochemical properties. Biofertilizer application improved available nutrient content, reduced short-term soil electrical conductivity, and produced the highest cotton yield, whereas cattle dung and vermicompost applications resulted in higher soil organic matter content. Application of organic amendments significantly increased soil microbial biomass carbon during the flowering period, which sharply declined at harvest. This was especially true for the biofertilizer treatment,which also exhibited lower nematode abundance compared with the other organic materials. Earthworm inoculation following cattle dung application failed to significantly change soil physicochemical properties when compared to the treatments without earthworm inoculation. Results suggest that biofertilizer application to saline soil would improve soil nutrient status in the short-term, whereas cattle dung application would improve soil organic matter content and increase soil organism abundance to a greater extent. However,different strategies might be required for long-term saline soil remediation. | WU Yupeng LI Yufei ZHANG Yi BI Yanmeng SUN Zhenjun | 2018 | Pedosphere2018，28，3： | 13 |
| 13 | Antifungal Activity of Chitosan on Fusarium sulphureum in Relation to Dry Rot of Potato Tuber显示文摘The antifungal activity of chitosan on Fusarium sulphureum in relation to the inhibitory effect on dry rot of potato tuber was investigated. The results showed spore germination and mycelial growth of F. sulphureum were inhibited by chitosan treatment and the inhibitory effect was highly correlated with chitosan concentration used in this study. Morphological changes such as intertwisting hyphal, distortion, and swelling with excessive branching were observed by scanning electron microscopy (SEM) observation. Transmission electron microscopy (TEM) observation further indicated the ultrastructural alterations of hyphae. These changes included abnormal distribution of cytoplasma, non-membraneous inclusion bodies assembling in cytoplasm, considerable thickening of the hyphal cellular walls, and very frequent septation with malformed septa. Application of chitosan at higher concentration caused serious damage to fungal hyphae, including cellular membrane disorganisation, cell wall disruption, and breaking of inner cytoplast. New hyphae (daughter hyphae) inside the collapsed hyphal cells was often detected in the cytoplasm of chitosan-treated hyphae. In vivo tests showed that chitosan treatment at 0.5 or 1% effectively controlled the dry rot of potato tuber inoculated with a spore suspension of F. sulphureum. However, the chitosan treatment at 1% caused phytotoxicity to potato tuber. This study suggests that the use of chitosan could be a promising handling as a natural fungicide to partially substitute for the synthetic fungicides in potato tuber. | LI Yong-cai SUN Xiao-juan BI Yang GE Yong-hong WANG Yi | 2009 | Agricultural Sciences in China2009，8，5： | 13 |
| 14 | Phosphorus oxoanion-intercalated layered double hydroxides for high-performance oxygen evolution显示文摘合理设计和为氧进化反应(OER ) 的有效、划算的电极的控制制造为探讨崭新的精力危机是批评的。有特定的夹层阴离子的镍铁分层的双氢氧化物(NiFe-LDHs )( 即磷酸盐,亚磷酸盐,和次磷酸盐) 被一个一起沉淀方法制作并且作为氧进化 electrocatalysts 调查了。磷 oxoanion 的置闰在一个碱的答案提高了 OER 活动;最佳的表演(即, 215 mV, 37.7 mV/dec 的一个小 Tafel 斜坡,和稳定的电气化学的行为的一个低发作潜力) 与设置次磷酸盐的 NiFe-LDH 催化剂被完成,在传统的设置碳酸盐的 NiFe-LDH 上的示威戏剧的改进以活动和耐久性。这提高的表演被归因于在设置的磷的 oxoanions 和分享边的瞬间 6 之间的相互作用(M = Ni, Fe ) 层,它修改表面 Ni 地点的电子结构。这个概念应该为更有效的基于 LDH 的氧进化 electrocatalysts 的设计是鼓舞人心的。 | Ma Luo Zhao Cai Cheng Wang Yongmin Bi Li Qian Yongchao Hao Li Li Yun Kuang Yaping Li Xiaodong Lei Ziyang HUO Wen Liu Hailiang Wang Xiaoming Sun Xue Duan | 2017 | Nano Research2017，10，5： | 12 |
| 15 | Clinical characteristics and effectiveness of antiviral agents in hospitalized children with infectious mononucleosis in China:A multicenter retrospective study显示文摘Importance:The clinical characteristics of infectious mononucleosis(IM)in Chinese children have not been evaluated in multicenter studies,and the effectiveness of antiviral treatment are controversial.Objective:To investigate the clinical characteristics of Chinese children with IM and current status of antiviral therapy for affected patients.Methods:Hospitalized patients with IM were enrolled between 2018 and 2020 in five children’s hospitals in China.The clinical characteristics were compared among four age groups:<3 years,3-<6 years,6-<10 years,and≥10 years.The clinical characteristics of IM and effectiveness of antiviral therapy were compared among patients receiving acyclovir(ACV),ganciclovir(GCV),and no antiviral therapy(i.e.,non-antiviral group).Results:In total,499 patients were analyzed;most patients were 3-<6 years of age.The most common symptoms and signs included fever(100%),lymphadenopathy(98.6%),pharyngitis(86.4%),eyelid edema(76.8%),and snoring(72.9%).There were significant differences in rash,hepatomegaly,and liver dysfunction among the four age groups.Patients aged<3 years had a lower incidence of liver dysfunction and a higher incidence of rash.Among the 499 patients,50.1%were treated with GCV,26.3%were treated with ACV,and 23.6%received no antiviral therapy.Compared with the non-antiviral group,patients in the ACV and GCV groups had longer durations of fever(P<0.001).There were no significant differences in the incidences of complications among the three treatment groups.Interpretation:The incidence of IM in Chinese children peaked at 3-<6 years of age.Clinical features of IM varied according to age.Patients receiving antiviral therapy exhibited more serious clinical manifestations than did patients without antiviral therapy.The effectiveness of antiviral therapy for IM requires further analysis. | Huili Hu Huiling Deng Jing Bi Yi Xu Shuangjie Li Yue Xie Xinrong Sun Dongmeng Wang Xufang Li Wenxian Ouyang Bing Hu Yufeng Zhang He Tang Chunxiao Fang Hui Zhang Lingyun Guo Chen Wang Tianyi Wang Fengxia Yang Tao Jiang Zhengde Xie Gang Liu | 2021 | Pediatric Investigation2021，5，3： | 12 |
| 16 | Atmospheric Deposition-Carried Pb, Zn, and Cd from a Zinc Smelter and Their Effect on Soil Microorganisms显示文摘Dust emissions from smelters, as a major contributor to heavy metal contamination in soils, could severely influence soil quality. Downwind surface soils within 1.5 km of a zinc smelter, which was active for 10 years but ceased in 2000, in Magu Town, Guizhou Province, China were selected to examine Pb, Zn, and Cd concentrations and their fractionation along a distance gradient from a zinc smelter, and to study the possible e?ects of Pb, Zn, and Cd accumulation on soil microorganisms by comparing with a reference soil located at a downwind distance of 10 km from the zinc smelter. Soils within 1.5 km of the zinc smelter accumulated high levels of heavy metals Zn (508 mg kg-1), Pb (95.6 mg kg-1), and Cd (5.98 mg kg-1) with low ratios of Zn/Cd (59.1-115) and Pb/Cd (12.4-23.4). Composite pollution indices (CPIs) of surface soils (2.52-15.2) were 3 to 13 times higher than the reference soils. In metal accumulated soils, exchangeable plus carbonate-bound fractions accounted for more than 10% of the total Zn, Pb, and Cd. The saturation degree of metals (SDM) in soils within 1.5 km of the smelter (averaging 1.25) was six times higher than that of the reference soils (0.209). A smaller soil microbial biomass was found more frequently in metal accumulated soils (85.1-438 μg C g-1) than in reference soils (497 μg C g-1), and a negative correlation (P < 0.01) of soil microbial biomass carbon to organic carbon ratio (Cmic/Corg) with SDM was observed. Microbial consumption of carbon sources was more rapid in contaminated soils than in reference soils, and a shift in the substrate utilization pattern was apparent and was negatively correlated with SDM (R = -0.773, P < 0.01). Consequently, dust deposited Pb, Zn, and Cd in soils from zinc smelting were readily mobilized, and were detrimental to soil quality mainly in respect of microbial biomass. | YANG Yuan-Gen2, JIN Zhi-Sheng, BI Xiang-Yang, LI Fei-Li, SUN Li, LIU Jie and FU Zhi-You Institute of Geochemistry, Chinese Academy of Sciences, Guiyang 550002 (China) | 2009 | Pedosphere2009，19，4： | 11 |
| 17 | Relationship between linguistic functions and cognitive functions in a clinical study of Chinese patients with post-stroke aphasia显示文摘 | YU Zeng-zhi JIANG Shu-jun BI Sheng LI Jun LEI Di SUN Li-ling | 2013 | Chinese Medical Journal2013，，7： | 10 |
| 18 | IL-10-Producing Type 1 Regulatory T Cells and Allergy显示文摘As an important subset of regulatory T(Treg) cells,IL-10-producing type 1 regulatory T cells(Tr1) ,have some different features to thymic-derived naturally occurring CD4+CD25+Foxp3+ Treg cells(nTreg cells) . Similar to nTreg cells,Tr1 also play important roles in the control of allergic inflammation in several ways. There is a fine balance between Tr1 and Th2 responses in healthy subjects. Skewing of allergic-specific effctor T cells to a Tr1 phenotype appears to be a critical event in successful allergen-specific immunotherapy and glucocorticoids and β2-agonists treatment. Tr1 suppress Th2 cells and effector cells of allergic inflammation,such as eosinophils,mast cells,basophils,through producing IL-10,and perhaps TGF-β. Understanding of Tr1 may be helpful in developing new strategies for treatment of allergic diseases. | Kui Wu Yutian Bi Kun Sun Changzheng Wang | 2007 | Cellular & Molecular Immunology2007，4，4： | 9 |
| 19 | A 2-way cross-over,open-labeled trial to compare efficacy and safety of insulin Aspart and Novolin R delivered with CSII in 21 Chinese diabetic patients显示文摘背景下的吸收被胰岛素 Aspart 的 monomeric 符合构造加速,它向好 glycemic 控制提供低血糖症和更少的身体重量增加的更低的风险。在我们调查了的现在的学习,快速行动的人的胰岛素类似物(胰岛素 Aspart )的功效和安全与类型 1 或类型 2 糖尿病与连续下的胰岛素注入( CSII )交付了进 21 个病人的中国糖尿病的 patients.Methods Atotal 为2方法转线路被招募,开标签的试用,然后使随机化组织 A ( n=10 ,与胰岛素 Aspart 对待)或组 B ( n=11 ,与 Novolin 对待 R )。胰岛素 Aspart 和 Novolin R 被 CSII 管理。毛状的葡萄糖集中在 8 个次点被测量,餐前、饭后,上床时间(10 下午) ,午夜(2 是) 每天,在 treatment.Results 期间,平均毛状的葡萄糖介绍因为日子更好比在组 B (P0.01 ) 在组 A 被控制。血葡萄糖层次更好特别地在早餐前比在组 B 在组 A 被控制((6. | BI Yu-fang ZHAO Lie-bin LI Xiao-ying WANG Wei-qing SUN Shou-yue CHEN Yu-hong HONG Jie SU Ting-wei LIU Jian-min NING Guang | 2007 | Chinese Medical Journal2007，，19： | 9 |
| 20 | Soft–strong supporting mechanism of gob-side entry retaining in deep coal seams threatened by rockburst显示文摘When gob-side entry retaining is implemented in deep coal seams threatened by rockburst, the cementbased supporting body beside roadway will bear greater roof pressure and strong impact load. Then the supporting body may easily deform and fail because of its low strength in the early stage. This paper established the roadside support mechanical model of gob-side entry retaining. Based on this model,we proposed and used the soft–strong supporting body as roadside support in the gob-side entry retaining. In the early stage of roof movement, the soft–strong supporting body has a better compressibility, which can not only relieve roof pressure and strong impact load, but also reduce the supporting resistance and prevent the supporting body from being crushed. In the later stage, with the increase of the strength of the supporting body, it can better support the overlying roof. The numerical simulation results and industrial test show that the soft–strong supporting body as roadside support can be better applied into the gob-side entry retaining in deep coal seams threatened by rockburst. | Ning Jianguo Wang Jun Liu Xuesheng Qian Kun Sun Bi | 2014 | International Journal of Mining Science and Technology2014，24，6： | 9 |
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