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| 1 | Cold-Induced CBF–PIF3 Interaction Enhances Freezing Tolerance by Stabilizing the phyB Thermosensor in Arabidopsis显示文摘Growth inhibition and cold-acclimation strategies help plants withstand cold stress,which adversely affects growth and survival.PHYTOCHROME B(phyB)regulates plant growth through perceiving both light and ambient temperature signals.However,the mechanism by which phyB mediates the plant response to cold stress remains elusive.Here,we show that the key transcription factors mediating cold acclimation,C-REPEAT BINDING FACTORs(CBFs),interact with PHYTOCHROME-INTERACTING FACTOR 3(PIF3)under cold stress,thus attenuating the mutually assured destruction of PIF3–phyB.Cold-stabilized phyB acts downstream of CBFs to positively regulate freezing tolerance by modulating the expression of stress-responsive and growth-related genes.Consistent with this,phyB mutants exhibited a freezing-sensitive phenotype,whereas phyB-overexpression transgenic plants displayed enhanced freezing tolerance.Further analysis showed that the PIF1,PIF4,and PIF5 proteins,all of which negatively regulate plant freezing tolerance,were destabilized by cold stress in a phytochrome-dependent manner.Collectively,our study reveals that CBFs–PIF3–phyB serves as an important regulatory module for modulating plant response to cold stress. | Bochen Jiang Yiting Shi Yue Peng Yuxin Jia Yan Yan Xiaojing Dong Hui Li Jie Dong Jigang Li Zhizhong Gong Michael F.Thomashow Shuhua Yang | 2020 | Molecular Plant2020，13，6： | 13 |
| 2 | Hierarchical Manganese Oxide/Carbon Nanocomposites for Supercapacitor Electrodes显示文摘有装载的层次毛孔结构和可控制的 MnO2 的 MnO2/carbon nanocomposites 用一个自我限制的生长方法被综合了。这被 KMnO4 的氧化还原作用反应与包含层次毛孔的牺牲的碳底层完成。唯一的毛孔结构允许 nanocomposites 的合成,悦耳的 MnO2 装载直到 83 wt.% 。nanocomposites 的特定的电容增加了, MnO2 装载;在另一方面,电气化学的阻抗光谱学测量的传导性与增加装载的 MnO2 减少了。装载的 MnO2 的优化与高特定的电容和优秀的率能力导致了 nanocomposites。这个工作提供将为应用的一个大变化便于高效的 supercapacitor 材料的设计和制造的重要基本理解。 | Yiting Peng Zheng Chen Jing Wen Qiangfeng Xiao Ding Weng Shiyu He Hongbin Geng Yunfeng Lu | 2011 | Nano Research2011，4，2： | 8 |
| 3 | Colonization of endophyte Acremonium sp. D212 in Panax notoginseng and rice mediated by auxin and jasmonic acid显示文摘Endophytic fungi can be beneficial to plant growth. However, the molecular mechanisms under-lying colonization of Acremonium spp. remain unclear. In this study, a novel endophytic Acremonium strain was isolated from the buds of Panax notoginseng and named Acremonium sp. D212. The Acremonium sp. D212 could colonize the roots of P. notoginseng, enhance the resistance of P. notoginseng to root rot disease, and promote root growth and saponin bio-synthesis in P. notoginseng. Acremonium sp. D212 could secrete indole-3-acetic acid (IAA) and jasmonic acid (JA), and inoculation with the fungus increased the endogenous levels of IAA and JA in P. noto-ginseng. Colonization of the Acremonium sp. D212 in the roots of the rice line Nipponbare was dependent on the concentration of methyl jasmonate (MeJA) (2–15μmol/L) and 1-naphthalenacetic acid (NAA) (10–20μmol/L). Moreover, the roots of the JA signaling-defective coi1-18 mutant were colonized by Acremonium sp. D212 to a lesser degree than those of the wild-type Nipponbare and miR393b-overexpressing lines, and the colonization was res-cued by MeJA but not by NAA. It suggests that the cross-talk between JA signaling and the auxin biosynthetic pathway plays a crucial role in the colonization of Acremonium sp. D212 in host plants. | Li Han Xuan Zhou Yiting Zhao Shusheng Zhu Lixia Wu Yunlu He Xiangrui Ping Xinqi Lu Wuying Huang Jie Qian Lina Zhang Xi Jiang Dan Zhu Chongyu Luo Saijie Li Qian Dong Qijing Fu Kaiyuan Deng Xin Wang Lei Wang Sheng Peng Jinsong Wu Weimin Li JiǐíFriml Youyong Zhu Xiahong He Yunlong Du | 2020 | Journal of Integrative Plant Biology2020，62，9： | 2 |
| 4 | Structural Characteristics and their Significance for Hydrocarbon Accumulation in the Northern Slope of the Central Sichuan Paleo-uplift显示文摘Based on 2D and 3D seismic data,the latest drilling data and field outcrop data of the northern slope of the Central Sichuan paleo-uplift,the structural analysis method is used to analyze unconformity development characteristics and fault characteristics during the key structural transformation period,discussing the influence of the structural characteristics on the hydrocarbon accumulation of deep carbonate rocks.The results show that:(1)The two key unconformities of the Tongwan and Caledonian periods were primarily developed in deep carbonate rocks.Firstly,Tongwan’s unconformities are characterized by regional disconformities between the second and third members of the Dengying Formation,the top formation of the Sinian and the lower Cambrian,strips of which zigzag through the north and south sides of the study area.Secondly,the Caledonian unconformity is characterized by a regional unconformable contact between the lower Permian and the ower Paleozoic strata.From NE to SW,the age of the strata,which were subject to erosion,changes from new to old,the denudation distribution showing as a nose-shaped structure which inclines towards the ENE.(2)Boundary fault and transtensional strike-slip faults developed in the Sinian to Paleozoic strata.In profile,there are three types of structural styles:steep and erect,flower structures,’Y’and reversed’Y’type faults.In plane view,the Sinian developed extensional boundary faults extending in an almost NS direction,strike-slip faults developing and extending linearly in approximately EW,WNW and NE strikes in the Cambrian,with characteristically more in the south and less in the north.(3)The faults in the northern slope show obvious zonal deformations in transverse view as well as significant stages and stratified activity in a longitudinal direction.Among them,the activity of faults in the Sinian was the strongest,followed by the activity in the Cambrian period,the activity intensity of faults in the Permian period being the weakest.This fault activity can be divided into four periods:Sinian,Cambrian-Permian,the early Indosinian period and the late Indosinian-Himalayan period,the transtensional strikeslip faults being the products of oblique extensions of pre-existing weak zones in the Xingkai and Emei taphrogenesis,with a particular inheritance in the main faults.(4)Combined with hydrocarbon accumulation factors,it is considered that the epigenetic karstification of the Tongwan and Caledonian unconformities in the northern slope controlled the formation and distribution of carbonate karst reservoirs over a large area,also acting as a good pathway for oil and gas migration.The extensional faults developed at the margin of the NS trending rift,controlling the sag-platform sedimentary pattern in the Dengying Formation of the Sinian.Strike-slip faults in NE,WNW and ENE directions may control the microgeomorphological pattern inside the platform and intensify the differential distribution of grain beach facies.The multi-stage hereditary activity of strike-slip faults not only improved the porosity and permeability of the reservoirs,but also acted as the main channel of oil and gas migration,providing favorable conditions for the development of the current multi-layer gasbearing scenario in the northern slope of the Central Sichuan Basin. | TIAN Xingwang LIU Guangdi LUO Bing YANG Yu WEN Long ZHANG Benjian CHEN Xiao SU Guiping SONG Zezhang PENG Hanlin ZHOU Gang YAN Wei YANG Dailin WANG Yunlong SUN Yiting DOU Shuang | 2022 | Acta Geologica Sinica(English Edition)2022，96，4： | 2 |
| 5 | Fluorofenidone Attenuates Inflammation by Inhibiting the NF-кB Pathway显示文摘 | Ling Huang Fangfang Zhang Yiting Tang Jiao Qin Yu Peng Lin Wu Fang Wang Qiongjing Yuan Zhangzhe Peng Jishi Liu Jie Meng Lijian Tao | 2014 | The American Journal of the Medical Sciences2014，，1： | 1 |
| 6 | 4350<ce:hsp sp='0.25'/>W quasi-continuous-wave operation of a diode face-pumped ceramic Nd: YAG slab laser显示文摘 | Junchi Chen Jiang Li Jialin Xu Wenbin Liu Yong Bo Xiqi Feng Yiting Xu Dongliang Jiang Zhongzheng Chen Yubai Pan Yading Guo Biao Yan Chang Guo Lei Yuan Hongtao Yuan Yanyong Lin Yunsheng Xiao Qinjun Peng Wenqiang Lei Dafu Cui Zuyan Xu | 2014 | Optics and Laser Technology2014，，： | 1 |
| 7 | DNA Dumbbell and Chameleon Silver Nanoclusters for miRNA Logic Operations显示文摘Multiplex miRNA analysis is a fundamental issue for exploring a complex biological system and early diagnosis of miRNA-related diseases.Herein,we have developed a series of novel logic gates for miRNA analysis coupling DNA nanostructures and chameleon silver nanoclusters(AgNCs).DNA dumbbell structures are firstly designed with two independent nucleation sequences for AgNCs at the 5′and 3′ends,respectively.By introducing different miRNA inputs,separations of two AgNCs are controlled and the fluorescence property of AgNCs changes.By studying the ratiometric fluorescence responses,sensitive and selective analysis of multiple miRNAs can be achieved.The present work provides powerful tools for miRNA diagnostics and may also guide future DNA nanostructure-based logic gates. | Yiting Jiang Peng Miao | 2020 | Research2020，，1： | 0 |
| 8 | Immunometabolism:a new dimension in immunotherapy resistance显示文摘Immune checkpoint inhibitors(ICIs)have demonstrated unparalleled clinical responses and revolutionized the paradigm of tumor treatment,while substantial patients remain unresponsive or develop resistance to ICIs as a single agent,which is traceable to cellular metabolic dysfunction.Although dysregulated metabolism has long been adjudged as a hallmark of tumor,it is now increasingly accepted that metabolic reprogramming is not exclusive to tumor cells but is also characteristic of immunocytes.Correspondingly,people used to pay more attention to the effect of tumor cell metabolism on immunocytes,but in practice immunocytes interact intimately with their own metabolic function in a way that has never been realized before during their activation and differentiation,which opens up a whole new frontier called immunometabolism.The metabolic intervention for tumor-infiltrating immunocytes could offer fresh opportunities to break the resistance and ameliorate existing ICI immunotherapy,whose crux might be to ascertain synergistic combinations of metabolic intervention with ICIs to reap synergic benefits and facilitate an adjusted anti-tumor immune response.Herein,we elaborate potential mechanisms underlying immunotherapy resistance from a novel dimension of metabolic reprogramming in diverse tumor-infiltrating immunocytes,and related metabolic intervention in the hope of offering a reference for targeting metabolic vulnerabilities to circumvent immunotherapeutic resistance. | Chaoyue Xiao Wei Xiong Yiting Xu Ji’an Zou Yue Zeng Junqi Liu Yurong Peng Chunhong Hu Fang Wu | 2023 | Frontiers of Medicine2023，17，4： | 0 |
| 9 | Superelastic Radiative Cooling Metafabric for Comfortable Epidermal Electrophysiological Monitoring显示文摘Epidermal electronics with superb passive-cooling capabilities are of great value for both daytime outdoor dressing comfort and low-carbon economy. Herein, a multifunctional and skinattachable electronic is rationally developed on a porous all-elastomer metafabric for efficient passive daytime radiative cooling(PDRC) and human electrophysiological monitoring. The cooling characteristics are realized through the homogeneous impregnation of polytetrafluoroethylene microparticles in the styrene–ethylene–butylene–styrene fibers, and the rational regulation of microporosity in SEBS/PTFE metafabrics, thus synergistically backscatter ultraviolet–visible–near-infrared light(maximum reflectance over 98.0%) to minimize heat absorption while efficiently emit human-body midinfrared radiation to the sky. As a result, the developed PDRC metafabric achieves approximately 17℃ cooling effects in an outdoor daytime environment and completely retains its passive cooling performance even under 50% stretching. Further, high-fidelity electrophysiological monitoring capability is also implemented in the breathable and skin-conformal metafabric through liquid metal printing, enabling the accurate acquisition of human electrocardiograph, surface electromyogram, and electroencephalograph signals for comfortable and lengthy health regulation. Hence, the fabricated superelastic PDRC metafabric opens a new avenue for the development of body-comfortable electronics and low-carbon wearing technologies. | Jiancheng Dong Yidong Peng Yiting Zhang Yujia Chai Jiayan Long Yuxi Zhang Yan Zhao Yunpeng Huang Tianxi Liu | 2023 | Nano-Micro Letters2023，15，10： | 0 |
| 10 | An ultra-fast and highly efficient multiple proteases digestion strategy using graphene-oxide-based immobilized protease reagents显示文摘Highly efficient and rapid proteolytic digestion of proteins into peptides is a crucial step in shotgun-based proteome-analysis strategy.Tandem digestion by two or more proteases is demonstrated to be helpful for increasing digestion efficiency and decreasing missed cleavages,which results in more peptides that are compatible with mass-spectrometry analysis.Compared to conventional solution digestion,immobilized protease digestion has the obvious advantages of short digestion time,no self-proteolysis,and reusability.We proposed a multiple-immobilized proteases-digestion strategy that combines the advantages of the two digestion strategies mentioned above.Graphene-oxide(GO)-based immobilized trypsin and endoproteinase Glu-C were prepared by covalently attaching them onto the GO surface.The prepared GO-trypsin and GO-Glu-C were successfully applied in standard protein digestion and multiple immobilized proteases digestion of total proteins of Thermoanaerobacter tengcongensis.Compared to 12-hour solution digestion using trypsin or Glu-C,14%and 7%improvement were obtained,respectively,in the sequence coverage of BSA by one-minute digestion using GO-trypsin and GO-Glu-C.Multiple immobilized-proteases digestion of the total proteins of Thermoanaerobacter tengcongensis showed 24.3%and 48.7%enhancement in the numbers of identified proteins than was obtained using GO-trypsin or GO-Glu-C alone.The ultra-fast and highly efficient digestion can be contributed to the high loading capacity of protease on GO,which leads to fewer missed cleavages and more complete digestion.As a result,improved protein identification and sequence coverage can be expected. | BAI HaiHong PAN YiTing REN XiaoJun HAO FeiRan DENG ShanShan FAN Chao YAN Hui SHEN BingQuan MA Lin TIAN Fang PENG Bo DENG YuLin QIN WeiJie QIAN XiaoHong | 2014 | Science China Chemistry2014，57，5： | 0 |
| 11 | Temporal and spatial variation characteristics of extreme precipitation on the Loess Plateau of China facing the precipitation process显示文摘The preceding and succeeding precipitation(PSP)often act together with extreme precipitation(EP),in turn,causing floods,which is an objective component that is often overlooked with regard to summer flood hazards in the arid region of Northwest China.In this study,event-based extreme precipitation(EEP)was defined as continuous precipitation that includes at least one day of EP.We analyzed the spatiotemporal variation characteristics of four EEP types(front EEP,late EEP,balanced EEP,and single day EEP)across the Loess Plateau(LP)based on data acquired from 87 meteorological stations from 1960 to 2019.Precipitation on the LP basically maintained a spatial pattern of'low in the northwest region and high in the southeast region',and EP over the last 10 a increased significantly.The cumulative precipitation percentage of single day EEP was 34%and was dominant for 60 a,while the cumulative precipitation percentage of front,late,and balanced EEP types associated with PSP accounted for 66%,which confirms to the connotation of EEP.The cumulative frequencies of front and late EEP types were 23%and 21%,respectively,while the cumulative frequency of balanced EEP had the lowest value at only 13%.Moreover,global warming could lead to more single day EEP across the LP,and continuous EEP could increase in the northwestern region and decrease in the eastern region in the future.The concept of process-oriented EP could facilitate further exploration of disaster-causing processes associated with different types of EP,and provide a theoretical basis for deriving precipitation disaster chains and construction of disaster cluster characteristics. | ZHANG Yixin LI Peng XU Guoce MIN Zhiqiang LI Qingshun LI Zhanbin WANG Bin CHEN Yiting | 2023 | Journal of Arid Land2023，15，4： | 0 |
| 12 | Research progress on chemical composition, pharmacological effects of Forsythia suspensa (Thunb.) Vahl and predictive analysis on Q-marker显示文摘Lianqiao(Forsythia suspensa(Thunb.)Vahl,Abbreviated as“F.suspensa”below)is traditional Chinese medicine in China,widely distributed all over the country and also highly rich in resources.The Northwest Territories is a genuine producing area.There are many chemical components in F.suspensa,including lignans,phenylethanolic glycosides,flavonoids,C6-C2 natural alcohols and their glycosides,phenolic acids,terpenes and volatile oils.Among them,lignans and phenylethanolic glycosides are the main active components.Based on the review of chemical components or constituents and main pharmacological activities,according to the definition of quality marker,the components of quality marker of F.suspensa were predicted and analyzed from the aspects of plant genetics and chemical composition,traditional efficacy,traditional medicine,new efficacy,blood entering composition,measurable composition,effective composition in different compatibility,and the influence of storage conditions of extract.Further research on its medicinal active ingredients will provide scientific basis for the evaluation of F.suspensa quality. | Hui Peng Peng Lu Yiting Liu Chuanxin Liu Yanquan Gao EbukaOlisaemeka Nwafor Yuelin Zhang Zhidong Liu | 2020 | TMR Modern Herbal Medicine2020，3，2： | 0 |
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