|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Computed tomography-based radiomics for prediction of neoadjuvant chemotherapy outcomes in locally advanced gastric cancer: A pilot study显示文摘Objective: The standard treatment for patients with locally advanced gastric cancer has relied on perioperative radio-chemotherapy or chemotherapy and surgery. The aim of this study was to investigate the wealth of radiomics for pre-treatment computed tomography(CT) in the prediction of the pathological response of locally advanced gastric cancer with preoperative chemotherapy.Methods: Thirty consecutive patients with CT-staged II/III gastric cancer receiving neoadjuvant chemotherapy were enrolled in this study between December 2014 and March 2017. All patients underwent upper abdominal CT during the unenhanced, late arterial phase(AP) and portal venous phase(PP) before the administration of neoadjuvant chemotherapy. In total, 19,985 radiomics features were extracted in the AP and PP for each patient.Four methods were adopted during feature selection and eight methods were used in the process of building the classifier model. Thirty-two combinations of feature selection and classification methods were examined. Receiver operating characteristic(ROC) curves were used to evaluate the capability of each combination of feature selection and classification method to predict a non-good response(non-GR) based on tumor regression grade(TRG).Results: The mean area under the curve(AUC) ranged from 0.194 to 0.621 in the AP, and from 0.455 to 0.722 in the PP, according to different combinations of feature selection and the classification methods. There was only one cross-combination machine-learning method indicating a relatively higher AUC(>0.600) in the AP, while 12 cross-combination machine-learning methods presented relatively higher AUCs(all >0.600) in the PP. The feature selection method adopted by a filter based on linear discriminant analysis + classifier of random forest achieved a significantly prognostic performance in the PP(AUC, 0.722±0.108; accuracy, 0.793; sensitivity, 0.636; specificity,0.889; Z=2.039; P=0.041).Conclusions: It is possible to predict non-GR after neoadjuvant chemotherapy in locally advanced gastric cancers based on the radiomics of CT. | Zhenhui Li Dafu Zhang Youguo Dai Jian Dong Lin Wu Yajun Li Zixuan Cheng Yingying Ding Zaiyi Liu | 2018 | Chinese Journal of Cancer Research2018，30，4： | 18 |
| 2 | Osteogenic growth peptide enhances the proliferation of bone marrow mesenchymal stem cells from osteoprotegerin-deficient mice by CDK2/cyclin A显示文摘支持骨头形成是在骨质疏松症治疗的基本策略之一,破裂修理。作为骨头形成上的激发器之一, osteogenic 生长肽(OGP ) 在 vitro 并且在 vivo, osteoprotegerin (OPG ) 在被建议了被包含增加造骨细胞的增长和区别。在这研究,我们在骨头髓上评估了 OGP 的效果从在由 3-(4,5-dimethylthiazol-2-yl ) 的 vitro 的 OPG 缺乏的老鼠的间充质的干细胞(MSC )-2,5-diphenyltetrazolium 溴化物试金,碱的磷酸酶(高山) 活动试金,即时聚合酶链反应,和西方的污点分析。结果证明 OGP 刺激了 MSC 增长并且在 mRNA 和蛋白质层次两个都在 MSC 增加了 CDK2 和 cyclin A 的表示。然而, OGP 的 differentiative 效果都没作为高山活动和 Runx2 的表示层次被显示出, Osterix 没被 OGP 显著地增加。我们的学习建议 OGP 可以由刺激 MSC 增长而非区别在 OPG 缺乏的老鼠增加骨头形成,并且可能由触发 CDK2/cyclin 一条小径。 | Qinming Fei Changjun Guo Xiaoya Xu Jianjun Gao Jian Zhang Tongyi Chen Dafu Cui | 2010 | Acta Biochimica et Biophysica Sinica2010，42，11： | 11 |
| 3 | Neural stem cell transplantation in a double-layer collagen membrane with unequal pore sizes for spinal cord injury repair显示文摘A novel double-layer collagen membrane with unequal pore sizes in each layer was designed and tested in this study.The inner,loose layer has about 100-μm-diameter pores,while the outer,compact layer has about 10-μm-diameter pores.In a rat model of incomplete spinal cord injury,a large number of neural stem cells were seeded into the loose layer,which was then adhered to the injured side,and the compact layer was placed against the lateral side.The results showed that the transplantation of neural stem cells in a double-layer collagen membrane with unequal pore sizes promoted the differentiation of neural stem cells,attenuated the pathological lesion,and significantly improved the motor function of the rats with incomplete spinal cord injuries.These experimental findings suggest that the transplantation of neural stem cells in a double-layer collagen membrane with unequal pore sizes is an effective therapeutic strategy to repair an injured spinal cord. | Ning Yuan Wei Tian Lei Sun Runying Yuan Jianfeng Tao Dafu Chen | 2014 | Neural Regeneration Research2014，9，10： | 7 |
| 4 | Hyaluronic acid facilitates bone repair effects of calcium phosphate cement by accelerating osteogenic expression显示文摘Calcium phosphate cements(CPC)are widely anticipated to be an optimum bone repair substitute due to its satisfied biocompatibility and degradability,suitable to be used in minimally invasive treatment of bone defects.However the clinical application of CPC is still not satisfied by its poor cohesiveness and mechanical properties,in particular its osteoinductivity.Hyaluronic acid reinforced calcium phosphate cements(HA/CPC)showed extroadinary potential not only enhancing the compressive strength of the cements but also significantly increasing its osteoinductivity.In our study,the compressive strength of HA/CPC increased significantly when the cement was added 1%hyaluronic acid(denoted as 1-HA/CPC).In the meantime,hyaluronic acid obviously promoted ALP activity,osteogenic related protein and mRNA expression of hBMSCs(human bone marrow mesenchymal stem cells)in vitro,cement group of HA/CPC with 4%hyaluronic acid adding(denoted as 4-HA/CPC)showed optimal enhancement in hBMSCs differentiation.After being implanted in rat tibial defects,4-HA/CPC group exhibited better bone repair ability and bone growth promoting factors,comparing to pure CPC and 1-HA/CPC groups.The underlying biological mechanism of this stimulation for HA/CPC may be on account of higher osteogenic promoting factors secretion and osteogenic genes expression with hyaluronic acid incorporation.These results indicate that hyaluronic acid is a highly anticipated additive to improve physicochemical properties and osteoinductivity performance of CPCs for minimally invasive healing of bone defects. | Xu Cui Chengcheng Huang Zhizhen Chen Meng Zhang Chunyu Liu Kun Su Jianyun Wang Li Li Renxian Wang Bing Li Dafu Chen Changshun Ruan Deping Wang William W.Lu Haobo Pan | 2021 | Bioactive Materials2021，6，11： | 6 |
| 5 | 3D printed silk-gelatin hydrogel scaffold with different porous structure and cell seeding strategy for cartilage regeneration显示文摘Hydrogel scaffolds are attractive for tissue defect repair and reorganization because of their human tissue-like characteristics.However,most hydrogels offer limited cell growth and tissue formation ability due to their submicron-or nano-sized gel networks,which restrict the supply of oxygen,nutrients and inhibit the proliferation and differentiation of encapsulated cells.In recent years,3D printed hydrogels have shown great potential to overcome this problem by introducing macro-pores within scaffolds.In this study,we fabricated a macroporous hydrogel scaffold through horseradish peroxidase(HRP)-mediated crosslinking of silk fibroin(SF)and tyramine-substituted gelatin(GT)by extrusion-based low-temperature 3D printing.Through physicochemical characterization,we found that this hydrogel has excellent structural stability,suitable mechanical properties,and an adjustable degradation rate,thus satisfying the requirements for cartilage reconstruction.Cell suspension and aggregate seeding methods were developed to assess the inoculation efficiency of the hydrogel.Moreover,the chondrogenic differentiation of stem cells was explored.Stem cells in the hydrogel differentiated into hyaline cartilage when the cell aggregate seeding method was used and into fibrocartilage when the cell suspension was used.Finally,the effect of the hydrogel and stem cells were investigated in a rabbit cartilage defect model.After implantation for 12 and 16 weeks,histological evaluation of the sections was performed.We found that the enzymatic cross-linked and methanol treatment SF5GT15 hydrogel combined with cell aggregates promoted articular cartilage regeneration.In summary,this 3D printed macroporous SF-GT hydrogel combined with stem cell aggregates possesses excellent potential for application in cartilage tissue repair and regeneration. | Qingtao Li Sheng Xu Qi Feng Qiyuan Dai Longtao Yao Yichen Zhang Huichang Gao Hua Dong Dafu Chen Xiaodong Cao | 2021 | Bioactive Materials2021，6，10： | 6 |
| 6 | Design and optimization of DBR in 980 nm bottom-emitting VCSEL显示文摘According to the theory of DBR,with the P-type DBR as an example,the electrical characteristics and optical reflection of the DBR are analyzed by studying the energy band structure with various graded region widths and doping densities. The width and doping density of graded region are decided through a comparative study. The P-type DBR of 980 nm VCSELs is designed with Al0.9Ga0.1As and Al0.1Ga0.9As selected as the high and low refractive index material for the DBR. The 980 nm bottom VCSELs,which consists of 30 pairs P-type DBR and 28 pairs N-type DBR,are then fabricated. In P-type DBR,the width of graded region is 0.02 μm and the uniformity doping concentration is 2.5×1018cm-3. Its reflectivity is 99.9%. In N-type DBR,the width of graded region is also 0.02 μm and the uniformity doping concen-tration is 2×1018cm-3. Its reflectivity is 99.3%. The I-V curve shows that the series resistance of the device is about 0.05 Ω. According to the theory of DBR,with the P-type DBR as an example,the electri-cal characteristics and optical reflection of the DBR are analyzed by studying the energy band structure with various graded region widths and doping densities. The width and doping density of graded re-gion are decided through a comparative study. The P-type DBR of 980 nm VCSELs is designed,with Al0.9Ga0.1As and Al0.1Ga0.9As selected as the high and low refractive index material for the DBR. The 980 nm bottom VCSELs,which consist of 30 pairs P-type DBR and 28 pairs N-type DBR,are then fabri-cated. In P-type DBR,the width of graded region is 0.02 μm and the uniformity doping concentration is 2.5×1018cm-3. Its reflectivity is 99.9%. In N-type DBR,the width of graded region is also 0.02 μm and the uniformity doping concentration is 2×1018cm-3. Its reflectivity is 99.3%. The I-V curve shows that the series resistance of the device is about 0.05 Ω. | LI Te NING YongQiang HAO ErJuan CUI JinJiang ZHANG Yan LIU GuangYu QIN Li LIU Yun WANG LiJun CUI DaFu XU ZuYan | 2009 | Science in China(Series F)2009，52，7： | 4 |
| 7 | Strontium modulates osteogenic activity of bone cement composed of bioactive borosilicate glass particles by activating Wnt/β-catenin signaling pathway显示文摘There is a need for synthetic grafts to reconstruct large bone defects using minimal invasive surgery.Our previous study showed that incorporation of Sr into bioactive borate glass cement enhanced the osteogenic capacity in vivo.However,the amount of Sr in the cement to provide an optimal combination of physicochemical properties and capacity to stimulate bone regeneration and the underlying molecular mechanism of this stimulation is yet to be determined.In this study,bone cements composed of bioactive borosilicate glass particles substituted with varying amounts of Sr(0 mol%to 12 mol%SrO)were created and evaluated in vitro and in vivo.The setting time of the cement increased with Sr substitution of the glass.Upon immersion in PBS,the cement degraded and converted more slowly to HA(hydroxyapatite)with increasing Sr substitution.The released Sr2+modulated the proliferation,differentiation,and mineralization of hBMSCs(human bone marrow mesenchymal stem cells)in vitro.Osteogenic characteristics were optimally enhanced with cement(designated BG6Sr)composed of particles substituted with 6mol%SrO.When implanted in rabbit femoral condyle defects,BG6Sr cement supported better peri-implant bone formation and bone-implant contact,comparing to cements substituted with 0mol%or 9mol%SrO.The underlying mechanism is involved in the activation of Wnt/β-catenin signaling pathway in osteogenic differentiation of hBMSCs.These results indicate that BG6Sr cement has a promising combination of physicochemical properties and biological performance for minimally invasive healing of bone defects. | Xu Cui Yadong Zhang Jianyun Wang Chengcheng Huang Yudong Wang Hongsheng Yang Wenlong Liu Ting Wang Deping Wang Guocheng Wang Changshun Ruan Dafu Chen William W.Lu Wenhai Huang Mohamed N.Rahaman Haobo Pan | 2020 | Bioactive Materials2020，5，2： | 3 |
| 8 | Beneficial effects of C-peptide on renal morphology in diabetic rats显示文摘学习被承担在 glomerular 上检验 C 肽的效果在有差或中等的 glycemic 的糖尿病的老鼠控制的 streptozotocin (STZ ) 的体积(VGLOM ) , mesangial 矩阵合成,和降级。(差的 glycemic 控制) 系列 1 包括了一些健康老鼠, hyperglycemic 老鼠,糖尿病的对待胰岛素的老鼠和糖尿病的 C-peptide-treated 老鼠。(中等 glycemic 控制) 系列 2 包括了一些健康老鼠,糖尿病的对待胰岛素的老鼠,糖尿病的 insulin-peptide-treated 和 C-peptide-treated 老鼠。在 8 个星期以后,左肾经由轻显微镜学为 VGLOM 和 mesangial 矩阵区域的评估被切除。Mesangial 房间是有教养的因为 48 h 和类型 IV 骨胶原表示和矩阵 metalloproteinase (MMP )-2 表示被 ELISA 和 RTPCR 测量。结果显示在系列 1, C 肽管理在 VGLOM 和 mesangial 矩阵区域压制了导致糖尿病的增加。在系列 2, C 肽管理在 mesangial 矩阵区域在 VGLOM 和更大的减少导致了类似的减少什么时候与胰岛素治疗相比独自一个。而且, C 肽(300 nM ) 完全在在 30 公里葡萄糖媒介有教养的 mesangial 房间禁止了骨胶原 IV mRNA 表示和蛋白质集中的导致葡萄糖的增加。MMP-2 mRNA 表示没被 C 肽影响。在结论,到为 8 个星期的 STZ 糖尿病的老鼠的 C 肽管理导致 mesangial 矩阵的导致糖尿病的扩大的抑制。这效果独立于 glycemic 控制的水平,从 mesangial 的导致糖尿病的过多的形成的抑制的结果打 IV 骨胶原。 | Wei Sun Xin Gao Xiaolong Zhao Dafu Cui Qichang Xia | 2010 | Acta Biochimica et Biophysica Sinica2010，42，12： | 3 |
| 9 | A single-cell transcriptome of mesenchymal stromal cells to fabricate bioactive hydroxyapatite materials for bone regeneration显示文摘The osteogenic microenvironment of bone-repairing materials plays a key role in accelerating bone regeneration but remains incompletely defined,which significantly limits the application of such bioactive materials.Here,the transcriptional landscapes of different osteogenic microenvironments,including three-dimensional(3D)hydroxyapatite(HA)scaffolds and osteogenic medium(OM),for mesenchymal stromal cells(MSCs)in vitro were mapped at single-cell resolution.Our findings suggested that an osteogenic process reminiscent of endochondral ossification occurred in HA scaffolds through sequential activation of osteogenic-related signaling pathways,along with inflammation and angiogenesis,but inhibition of adipogenesis and fibrosis.Moreover,we revealed the mechanism during OM-mediated osteogenesis involves the ZBTB16 and WNT signaling pathways.Heterogeneity of MSCs was also demonstrated.In vitro ossification of LRRC75A+MSCs was shown to have better utilization of WNT-related ossification process,and PCDH10+MSCs with superiority in hydroxyapatite-related osteogenic process.These findings provided further understanding of the cellular activity modulated by OM conditions and HA scaffolds,providing new insights for the improvement of osteogenic biomaterials.This atlas provides a blueprint for research on MSC heterogeneity and the osteogenic microenvironment of HA scaffolds and a database reference for the application of bioactive materials for bone regeneration. | Peng Guo Xizhe Liu Penghui Zhang Zhongyuan He Zhen Li Mauro Alini RGeoff Richards Sibylle Grad Martin J.Stoddart Guangqian Zhou Xuenong Zou Danny Chan Wei Tian Dafu Chen Manman Gao Zhiyu Zhou Shaoyu Liu | 2022 | Bioactive Materials2022，7，3： | 3 |
| 10 | An injectable,self-healing,electroconductive extracellular matrix-based hydrogel for enhancing tissue repair after traumatic spinal cord injury显示文摘Injectable biomaterial-based treatment is a promising strategy to enhance tissue repair after traumatic spinal cord injury(SCI)by bridging cavity spaces.However,there are limited reports of injectable,electroconductive hydrogels with self-healing properties being employed for the treatment of traumatic SCI.Hence,a natural extracellular matrix(ECM)biopolymer(chondroitin sulphate and gelatin)-based hydrogel containing polypyrrole,which imparted electroconductive properties,is developed for traumatic SCI repair.The resulting hydrogels showed mechanical(~928 Pa)and conductive properties(4.49 mS/cm)similar to natural spinal cord tissues.Moreover,the hydrogels exhibited shear-thinning and self-healing abilities,which allows it to be effectively injected into the injury site and to fill the lesion cavity to accelerate the tissue repair of traumatic SCI.In vitro,electroconductive ECM hydrogels promoted neuronal differentiation,enhanced axon outgrowth,and inhibited astrocyte differentiation.The electroconductive ECM hydrogel activated endogenous neural stem cell neurogenesis in vivo(n=6),and induced myelinated axon regeneration into the lesion site via activation of the PI3K/AKT and MEK/ERK pathways,thereby achieving significant locomotor function restoration in rats with spinal cord injury(p<0.001,compared to SCI group).Overall,the injectable self-healing electroconductive ECM-based hydrogels developed in this study are ideal biomaterials for treatment of traumatic SCI. | Yian Luo Lei Fan Can Liu Huiquan Wen Shihuan Wang Pengfei Guan Dafu Chen Chengyun Ning Lei Zhou Guoxin Tan | 2022 | Bioactive Materials2022，7，1： | 2 |
| 11 | Design and evaluation of a novel sub-scaffold dental implant system based on the osteoinduction of micro-nano bioactive glass显示文摘Alveolar ridge atrophy brings great challenges for endosteal implantation due to the lack of adequate vertical bone mass to hold the implants.To overcome this limitation,we developed a novel dental implant design:sub-scaffold dental implant system(SDIS),which is composed of a metal implant and a micro-nano bioactive glass scaffold.This implant system can be directly implanted under mucous membranes without adding any biomolecules or destroying the alveolar ridge.To evaluate the performance of the novel implant system in vivo,SDISs were implanted into the subepicranial aponeurosis space of Sprague–Dawley rats.After 6 weeks,the SDIS and surrounding tissues were collected and analysed by micro-CT,scanning electron microscopy and histology.Our results showed that SDISs implanted into the sub-epicranial aponeurosis had integrated with the skull without any mobility and could stably support a denture.Moreover,this design achieved alveolar ridge augmentation,as active osteogenesis could be observed outside the cortical bone.Considering that the microenvironment of the sub-epicranial aponeurosis space is similar to that of the alveolar ridge,SDISs have great potential for clinical applications in the treatment of atrophic alveolar ridges.The study was approved by the Animal Care Committee of Guangdong Pharmaceutical University(approval No.2017370). | Fujian Zhao Zhen Yang Lu Liu Dafu Chen Longquan Shao Xiaofeng Chen | 2020 | Biomaterials Translational2020，1，1： | 2 |
| 12 | A New View of the Initiation and Propagation in Anionic Polymerization显示文摘这个工作证实开始和 anionic 聚合的繁殖机制的新看法以前求婚了,基于在自我的帮助下的苯乙烯和甲基苯乙烯的 anionic 体积聚合的调查设计了 microflow 设备并且由 GPC 并且在 situ 7Li NMR 描绘了。趋于形成聚集 hexameric 的结构并且弄平基于前者形成巨大的聚集的结构,被发现那 n-BuLi。开始者的这些聚集能直接开始 anionic 聚合并且形成 supramolecule 聚集。supramolecule 聚集不可避免地堵住了单体的散开到离子对并且导致了一个静止变换的平台。然后,集成者完全被分裂进相等的聚集二进制代码的种类,并且聚合在结束前很快再继续。Tetrahydrofuran (THF ) 充当了电子捐赠者,它能把电子云推到李阳离子并且做相当松开并且便于单体插入在里面的活跃种类的聚集的戒指。因此,小 THF 能极大地支持 anionic 聚合。然而, THF 的进一步的增加可能堵住在离子对和减少之间的隧道繁殖率。活跃种类的聚集的结构仅仅在 anionic 聚合期间取决于在聚合前被形成的开始者聚集,这也被发现。 | Anna Zheng Bo Chen Dihang Hu Yong Guan Dafu Wei Shuzhao Li Dandan Ji | 2013 | Chinese Journal of Chemistry2013，31，3： | 2 |
| 13 | Effect of cyclic mechanical loading on immunoinflammatory microenvironment in biofabricating hydroxyapatite scaffold for bone regeneration显示文摘It has been proven that the mechanical microenvironment can impact the differentiation of mesenchymal stem cells(MSCs).However,the effect of mechanical stimuli in biofabricating hydroxyapatite scaffolds on the inflammatory response of MSCs remains unclear.This study aimed to investigate the effect of mechanical loading on the inflammatory response of MSCs seeded on scaffolds.Cyclic mechanical loading was applied to biofabricate the cell-scaffold composite for 15 min/day over 7,14,or 21 days.At the predetermined time points,culture supernatant was collected for inflammatory mediator detection,and gene expression was analyzed by qRT-PCR.The results showed that the expression of inflammatory mediators(IL1B and IL8)was downregulated(p<0.05)and the expression of ALP(p<0.01)and COL1A1(p<0.05)was upregulated under mechanical loading.The cell-scaffold composites biofabricated with or without mechanical loading were freeze-dried to prepare extracellular matrix-based scaffolds(ECM-based scaffolds).Murine macrophages were seeded on the ECM-based scaffolds to evaluate their polarization.The ECM-based scaffolds that were biofabricated with mechanical loading before freeze-drying enhanced the expression of M2 polarization-related biomarkers(Arginase 1 and Mrc1,p<0.05)of macrophages in vitro and increased bone volume/total volume ratio in vivo.Overall,these findings demonstrated that mechanical loading could dually modulate the inflammatory responses and osteogenic differentiation of MSCs.Besides,the ECM-based scaffolds that were biofabricated with mechanical loading before freeze-drying facilitated the M2 polarization of macrophages in vitro and bone regeneration in vivo.Mechanical loading may be a promising biofabrication strategy for bone biomaterials. | Penghui Zhang Xizhe Liu Peng Guo Xianlong Li Zhongyuan He Zhen Li Martin J.Stoddart Sibylle Grad Wei Tian Dafu Chen Xuenong Zou Zhiyu Zhou Shaoyu Liu | 2021 | Bioactive Materials2021，6，10： | 2 |
| 14 | STUDY OF CAPILLARY ELECTROPHORESIS ON MICROCHIP BASED ON MEMS显示文摘Using a standard photolithographical procedure, chemical wet etching and thermal diffusion bonding technology, a chemical analysis device for Capillary Electrophoresis(CE) has been microfabricated on a planar glass substrate with a cross-column geometry. The channels on the microchip substrate are about 50μm deep and 150μm wide. By employing amino acids derived from 2,4-DiNitroFluoroBenzen (DNFB) on CE chip channels, the sample manipulating system is studied based on the principle of electrodynamics. | Wang Ming Li Wei Han Jinghong Cui Dafu (State Key Lab. of Transducer Tech., Inst. of Electron., Chinese Academy of Sci., Beijing 100080) | 2002 | Journal of Electronics(China)2002，19，4： | 1 |
| 15 | Fabrication and Charac- terization of A Double-Heater Based MEMS Thermal Flow Sensor 显示文摘 | Sun Jianhai Cui Dafu Zhang Lulu | 2013 | Sensors and Actuators A2013，193，： | 1 |
| 16 | Phase transition behavior of BaTiO3 thin films using high-temperature X-ray diffraction显示文摘 | Li Chunling Chen Zhenghao Cui Dafu | 1999 | Journal of Applied Physics1999，86，： | 1 |
| 17 | Improving Foamability of Polypropylene by Grafting Modification显示文摘 | LIU Chunsheng WEI Dafu ZHENG Anna | 2006 | Journal of Applied Polymer Science2006，101，6： | 1 |
| 18 | Experimental study of signal-to-noise ratio of stochastic resonance systems显示文摘 | G Dechun H Gang W Xiaodong Y Chunyan Q Guangrong L Rong and D Dafu | 1992 | Phys Rev A1992，46，： | 1 |
| 19 | 显示文摘 | Zheng Anna Yah Xue Wei Dafu | 2013 | Materials Science and Engineering2013，33，1： | 1 |
| 20 | Review:A Survey of Single Gimbal Control Moment Gyroscope forAgile Spacecraft Attitude Control显示文摘Agile attitude maneuver is a basic requirement for next generation imaging spacecraft and Control Moment Gyroscope (CMG) is an effective candidate for large space station and agile spacecraft attitude control because of its torque amplification capability. This paper provides a thorough survey of Single Gimbal Control Moment Gyroscope (SGCMG) in terms of configuration,evaluation,modeling,singularity analysis and steering logic,etc. For specific space missions,CMGs are logically mounted into different particular arrays which can be chosen by the proposed evaluation methods. From the dynamic model we find a tough inverse mapping problem which suffers the inherent geometric singularity. Different techniques and theories then are applied for singularity analysis and CMG steering logics design. The pyramid CMG cluster and singular robust logics are proven to be able to enhance the agility of spacecraft. Above work forms a systematic framework of SGCMG for agile spacecraft control with lots of illustrative examples,tables and figures,and will evoke further investigation for future missions. | Yunhua Wu Feng Han Bing Hua Zhiming Chen Dafu Xu Linlin Ge | 2018 | Journal of Harbin Institute of Technology(New Series)2018，25，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员