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| 1 | Improved survival of porcine acute liver failure by a bioartificial liver device implanted with induced human functional hepatocytes显示文摘 | Xiao-Lei Shi Yimeng Gao YupengYan HuchengMa Lulu Sun Pengyu Huang Xuan Ni Ludi Zhang Xin Zhao Haozhen Ren Dan Hu Yan Zhou Feng Tian Yuan Ji Xin Cheng Guoyu Pan Yi-Tao Ding LijianHui | 2016 | Cell Research2016，26，2： | 31 |
| 2 | Control of aliphatic halogenated DBP precursors with multiple drinking water treatment processes: Formation potential and integrated toxicity显示文摘The comprehensive control efficiency for the formation potentials(FPs) of a range of regulated and unregulated halogenated disinfection by-products(DBPs)(including carbonaceous DBPs(C-DBPs), nitrogenous DBPs(N-DBPs), and iodinated DBPs(I-DBPs)) with the multiple drinking water treatment processes, including pre-ozonation, conventional treatment(coagulation–sedimentation, pre-sand filtration), ozone-biological activated carbon(O_3-BAC) advanced treatment, and post-sand filtration, was investigated. The potential toxic risks of DBPs by combing their FPs and toxicity values were also evaluated.The results showed that the multiple drinking water treatment processes had superior performance in removing organic/inorganic precursors and reducing the formation of a range of halogenated DBPs. Therein, ozonation significantly removed bromide and iodide,and thus reduced the formation of brominated and iodinated DBPs. The removal of organic carbon and nitrogen precursors by the conventional treatment processes was substantially improved by O_3-BAC advanced treatment, and thus prevented the formation of chlorinated C-DBPs and N-DBPs. However, BAC filtration leads to the increased formation of brominated C-DBPs and N-DBPs due to the increase of bromide/DOC and bromide/DON.After the whole multiple treatment processes, the rank order for integrated toxic risk values caused by these halogenated DBPs was haloacetonitriles(HANs)》haloacetamides(HAMs) >haloacetic acids(HAAs) > trihalomethanes(THMs) > halonitromethanes(HNMs) 》I-DBPs(I-HAMs and I-THMs). I-DBPs failed to cause high integrated toxic risk because of their very low FPs. The significant higher integrated toxic risk value caused by HANs than other halogenated DBPs cannot be ignored. | Yimeng Zhang Wenhai Chu Dechang Yao Daqiang Yin | 2017 | Journal of Environmental Sciences2017，29，8： | 15 |
| 3 | A fundamental theorem for eco-environmental surface modelling and its applications显示文摘We propose a fundamental theorem for eco-environmental surface modelling(FTEEM) in order to apply it into the fields of ecology and environmental science more easily after the fundamental theorem for Earth’s surface system modeling(FTESM). The Beijing-Tianjin-Hebei(BTH) region is taken as a case area to conduct empirical studies of algorithms for spatial upscaling, spatial downscaling, spatial interpolation, data fusion and model-data assimilation, which are based on high accuracy surface modelling(HASM), corresponding with corollaries of FTEEM. The case studies demonstrate how eco-environmental surface modelling is substantially improved when both extrinsic and intrinsic information are used along with an appropriate method of HASM. Compared with classic algorithms, the HASM-based algorithm for spatial upscaling reduced the root-meansquare error of the BTH elevation surface by 9 m. The HASM-based algorithm for spatial downscaling reduced the relative error of future scenarios of annual mean temperature by 16%. The HASM-based algorithm for spatial interpolation reduced the relative error of change trend of annual mean precipitation by 0.2%. The HASM-based algorithm for data fusion reduced the relative error of change trend of annual mean temperature by 70%. The HASM-based algorithm for model-data assimilation reduced the relative error of carbon stocks by 40%. We propose five theoretical challenges and three application problems of HASM that need to be addressed to improve FTEEM. | Tianxiang YUE Na ZHAO Yu LIU Yifu WANG Bin ZHANG Zhengping DU Zemeng FAN Wenjiao SHI Chuanfa CHEN Mingwei ZHAO Dunjiang SONG Shihai WANG Yinjun SONG Changqing YAN Qiquan LI Xiaofang SUN Lili ZHANG Yongzhong TIAN Wei WANG Ying’an WANG Shengnan MA Hongsheng HUANG Yimin LU Qing WANG Chenliang WANG Yuzhu WANG Ming LU Wei ZHOU Yi LIU Xiaozhe YIN Zong WANG Zhengyi BAO Miaomiao ZHAO Yapeng ZHAO Yimeng JIAO Ufra NASEER Bin FAN Saibo LI Yang YANG John PWILSON | 2020 | Science China Earth Sciences2020，63，8： | 7 |
| 4 | Electrode materials derived from plastic wastes and other industrial wastes for supercapacitors显示文摘The present review not only devotes on the environmental consequences of plastic bag wastes and other industrial wastes observable in the landfills,in the oceans or elsewhere but also gives a new insight idea on conversion of them into worth material,carbon,for the best electrochemical supercapacitor.Transformation of plastic wastes into high-value materials is the incentive for plastic recycling,end-oflife handling case for plastic bag wastes in practice quite limited.The plastic recycling waste for reuse saves energy compared with manufacturing virgin materials.Herein,we identified several synthetic methods to convert plastic waste and other industrial wastes into carbon material for supercapacitor.Different kinds of carbon materials,including nanofiber,nanotube,graphene,mesoporous carbon,etc.,have been derived from plastic waste,and thus give a superior potential for transforming trash into a'gold capacitor'.Finally,conclusions and future trends of high-voltage supercapacitors were made as well as the easy and mass production of high-performance electrode materials for supercapacitors.Our work offers a promising sustainable approach to handle plastic bags,waste,and other industrial wastes and provides a new avenue in supercapacitor applications and other areas. | Wellars Utetiwabo Le Yang Muhammad Khurram Tufail Lei Zhou Renjie Chen Yimeng Lian Wen Yang | 2020 | Chinese Chemical Letters2020，31，6： | 5 |
| 5 | The use of phase-change cooling strategy in proton exchange membrane fuel cells:A numerical study显示文摘Thermal management is considered a critical issue in proton exchange membrane fuel cells(PEMFCs),since it not only influences the cell performance but also impacts PEMFC’s reliability and durability.With the ever-increasing power density of PEMFC,traditional cooling approaches including air cooling and water cooling become difficult to meet the demand for highpower heat dissipation.Therefore,phase-change cooling is proposed for fuel cell application in this work,and the potential advantages are discussed and demonstrated via a mathematical model incorporating phase-change heat transfer.The thermal management performance is evaluated by temperature uniformity,maximum temperature difference,and the cooling capacity to compare the difference between phase-change cooling and traditional methods,which demonstrates that phase-change cooling owns a greatly improved thermal management performance.In addition,a simple method to broaden the operating temperature of phase-change cooling based on one certain coolant is offered,which is pressurizing in the coolant channel to regulate the boiling temperature that could further improve the application feasibility of phase-change cooling strategy in fuel cells. | YAN XiaoHui PENG YiMeng SHEN YuanTing SHEN ShuiYun WEI GuangHua YIN JieWei ZHANG JunLiang | 2021 | Science China(Technological Sciences)2021，64，12： | 4 |
| 6 | Construction of molecule-selective mixed matrix membranes with confined mass transfer structure显示文摘Extraordinary mass transfer phenomenon is usually found when the small molecules pass through a confined structure, whose effective size is commensurate with the mean free path of the molecules. Small changes in the confined mass transfer structure(including size, morphology and properties) will lead to significant fluctuations of the mass transfer coefficient. The mass transfer of the penetrant molecules in the dense membranes for pervaporation, gas separation and so on, is located in the scope of confined mass transfer. Incorporating nanofillers into polymer matrix to construct mixed matrix membranes(MMMs) is an effective approach to tune the confined mass transfer structure and enhance the performance of the widely used polymeric membranes. This review focuses on the construction and manipulation of the confined structure in the polymeric membranes via incorporating one-dimensional(1D), two-dimensional(2D) and three-dimensional(3D) fillers.The comparison of the MMMs for pervaporation is summarized, and the research prospective of the MMMs is provided. | Weidong Li Fusheng Pan Yimeng Song Meidi Wang Hongjian Wang Shalik Walker Hong Wu Zhongyi Jiang | 2017 | Chinese Journal of Chemical Engineering2017，25，11： | 3 |
| 7 | Adaptive image enhancement algorithm based on fuzzy entropy and human visual characteristics显示文摘To overcome the shortcomings of the Lee image enhancement algorithm and its improvement based on the logarithmic image processing(LIP) model, this paper proposes what we believe to be an effective image enhancement algorithm. This algorithm introduces fuzzy entropy, makes full use of neighborhood information, fuzzy information and human visual characteristics.To enhance an image, this paper first carries out the reasonable fuzzy-3 partition of its histogram into the dark region, intermediate region and bright region. It then extracts the statistical characteristics of the three regions and adaptively selects the parameter αaccording to the statistical characteristics of the image's gray-scale values. It also adds a useful nonlinear transform, thus increasing the ubiquity of the algorithm. Finally, the causes for the gray-scale value overcorrection that occurs in the traditional image enhancement algorithms are analyzed and their solutions are proposed.The simulation results show that our image enhancement algorithm can effectively suppress the noise of an image, enhance its contrast and visual effect, sharpen its edge and adjust its dynamic range. | WANG Baoping MA Jianjun HAN Zhaoxuan ZHANG Yan FANG Yang GE Yimeng | 2018 | Journal of Systems Engineering and Electronics2018，29，5： | 3 |
| 8 | Optimization of the thermoelectric properties of poly(nickel-ethylenetetrathiolate) synthesized via potentiostatic deposition显示文摘The coordination polymer poly(nickel-ethylenetetrathiolate)(poly(Ni-ett)), formed by nickel(II) and 1,1,2,2-ethenetetrathiolate(ett), is the most promising N-type organic thermoelectric material ever reported; it is synthesized via potentiostatic deposition,and the effect of different applied potentials on the optimal performance of the polymers is investigated. The optimal thermoelectric property of poly(Ni-ett) synthesized at 0.6 V is remarkably greater than that of the polymers synthesized at 1 and 1.6 V, exhibiting a maximum power factor of up to 131.6 μW/mK^2 at 360 K. Furthermore, the structure-property correlation of poly(Ni-ett) is also extensively investigated. X-ray diffraction(XRD) and X-ray photoelectron spectroscopy(XPS) analyses revealed that the larger size of crystalline domains and the higher oxidation state of poly(Ni-ett) synthesized at 0.6 V possibly results in the higher bulk mobility and carrier concentration in the polymer chains, respectively, accounting for the enhanced power factor. | Yuanhui Sun Jiajia Zhang Liyao Liu Yunke Qin Yimeng Sun Wei Xu Daoben Zhu | 2016 | Science China Chemistry2016，59，10： | 3 |
| 9 | Improving Baculovirus Transduction of Mammalian Cells by Incorporation of Thogotovirus Glycoproteins显示文摘Baculovirus can transduce a wide range of mammalian cells and is considered a promising gene therapy vector. However,the low transduction efficiency of baculovirus into many mammalian cells limits its practical application. Co-expressing heterologous viral glycoproteins(GPs), such as vesicular stomatitis virus G protein(VSV G), with baculovirus native envelope protein GP64 is one of the feasible strategies for improving virus transduction. Tick-borne thogotoviruses infect mammals and their GPs share sequence/structure homology and common evolutionary origins with baculovirus GP64.Herein, we tested whether thogotovirus GPs could facilitate the entry of the prototype baculovirus Autographa californica multiple multiple nucleopolyhedrovirus(AcMNPV) into mammalian cells. The gp genes of two thogotoviruses, Thogoto virus and Dhori virus, were inserted into the AcMNPV genome. Both GPs were properly expressed and incorporated into the envelope of the recombinant AcMNPVs. The transduction rates of recombinant AcMNPVs expressing the two thogotovirus GPs increased for approximately 4–12 fold compared to the wild type AcMNPV in six of the 12 tested mammalian cell lines. It seemed that thogotovirus GPs provide the recombinant AcMNPVs with different cell tropisms and showed better performance in several mammalian cells compared to VSV G incorporated AcMNPV. Further studies showed that the improved transduction was a result of augmented virus-endosome fusion and endosome escaping, rather than increased cell binding or internalization. We found the AcMNPV envelope protein GP64-mediated fusion was enhanced by the thogotovirus GPs at relatively higher p H conditions. Therefore, the thogotovirus GPs represent novel candidates to improve baculovirus-based gene delivery vectors. | Liangbo Hu Yimeng Li Fei Deng Zhihong Hu Hualin Wang Manli Wang | 2019 | Virologica Sinica2019，34，4： | 3 |
| 10 | Objective assessment of bradykinesia in Parkinson’s disease using evolutionary algorithms:clinical validation显示文摘Background:There is an urgent need for developing objective,effective and convenient measurements to help clinicians accurately identify bradykinesia.The purpose of this study is to evaluate the accuracy of an objective approach assessing bradykinesia in finger tapping(FT)that uses evolutionary algorithms(EAs)and explore whether it can be used to identify early stage Parkinson’s disease(PD).Methods:One hundred and seven PD,41 essential tremor(ET)patients and 49 normal controls(NC)were recruited.Participants performed a standard FT task with two electromagnetic tracking sensors attached to the thumb and index finger.Readings from the sensors were transmitted to a tablet computer and subsequently analyzed by using EAs.The output from the device(referred to as'PD-Monitor')scaled from−1 to+1(where higher scores indicate greater severity of bradykinesia).Meanwhile,the bradykinesia was rated clinically using the Movement Disorder Society-Sponsored Revision of the Unified Parkinson’s Disease Rating Scale(MDS-UPDRS)FT item.Results:With an increasing MDS-UPDRS FT score,the PD-Monitor score from the same hand side increased correspondingly.PD-Monitor score correlated well with MDS-UPDRS FT score(right side:r=0.819,P=0.000;left side:r=0.783,P=0.000).Moreover,PD-Monitor scores in 97 PD patients with MDS-UPDRS FT bradykinesia and each PD subgroup(FT bradykinesia scored from 1 to 3)were all higher than that in NC.Receiver operating characteristic(ROC)curves revealed that PD-Monitor FT scores could detect different severity of bradykinesia with high accuracy(≥89.7%)in the right dominant hand.Furthermore,PD-Monitor scores could discriminate early stage PD from NC,with area under the ROC curve greater than or equal to 0.899.Additionally,ET without bradykinesia could be differentiated from PD by PD-Monitor scores.A positive correlation of PD-Monitor scores with modified Hoehn and Yahr stage was found in the left hand sides.Conclusions:Our study demonstrated that a simple to use device employing classifiers derived from EAs could not only be used to accurately measure different severity of bradykinesia in PD,but also had the potential to differentiate early stage PD from normality. | Chao Gao Stephen Smith Michael Lones Stuart Jamieson Jane Alty Jeremy Cosgrove Pingchen Zhang Jin Liu Yimeng Chen Juanjuan Du Shishuang Cui Haiyan Zhou Shengdi Chen | 2018 | Translational Neurodegeneration2018，7，1： | 3 |
| 11 | Prognostic Value of Serum LP-PLA2 and hs-CRP in Unstable Atherosclerotic Plaques显示文摘 | Yimeng Du Fengtao Wei Zhaoqiang Dong Junni Liu Weidong Jiang Qinghua Lu | 2011 | Clinical and Experimental Hypertension2011，，2： | 3 |
| 12 | Pattern transition and sluggish cracking of colloidal droplet deposition with polymer additives显示文摘Drying of colloidal droplets often develops versatile depositions.We study the drying deposition of both colloidal droplets containing silica nanoparticles and the silica colloidal droplets with polyethylene oxide(PEO) additives.We focus on the effect of polymer additives on the deposition formation and the cracking dynamics by using in-situ microscope observation.With PEO additives,a transition from ring-like deposition to uniform deposition is observed,and the cracking dynamics is greatly reduced.The PEO additives enhance the adsorption of particles at the air-water interface,thus forming the network structure at the interface which blocks the outward capillary flow.This contributes to the uniform deposition.Meanwhile,the multi-distribution of the aggregates size enhances the non-homogeneity of the drying film and consequently results in multi-nucleation of cracks.This reduces the stress accumulation that drives the crack propagation and may be responsible for the sluggish cracking dynamics. | ZHANG YongJian LIU ZhengTang ZANG DuYang QIAN YiMeng LIN KeJun | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，9： | 2 |
| 13 | Two Dimension C_3N_4/MoS_2 Nanocomposites with Enhanced Photocatalytic Hydrogen Evolution under Visible Light Irradiation显示文摘MoS_2-decorated C_3N_4(C_3N_4/MoS_2) nanosheets hybrid photocatalysts were prepared by a simple sonication-impregnation method. Face-to-face lamellar heterojunctions were well established between two dimension(2D) C_3N_4 and MoS_2 nanosheets. The effects of MoS_2 content on the light absorption, charge transfer and photocatalytic activity of the hybrid samples were investigated. Characterization results show that MoS_2 nanosheets are well anchored on the face of C_3N_4 nanosheets and the composites have well dispersed layered morphology. After loading with MoS_2, the light absorption of composites was much improved, especially in visible-light region. The photocatalytic activities of C_3N_4/MoS_2 samples were evaluated based on the H_2 evolution under visible light irradiation(λ > 400 nm). When the loading amount of MoS_2 was increased to 5 wt%, the highest H_2 evolution rate(274 μmol·g^(-1)·h^(-1)) was obtained. Compared with samples obtained from direct impregnation method, sonication pretreatment is favorable for the formation of 2D layered heterojuctions and thus improve the photocatalytic activity. Slightly deactivation of C_3N_4/MoS_2 composites could be observed when recycled due to the mild photocorrosion of MoS_2. Based on the band alignments of C_3N_4 and MoS_2, a possible photocatalytic mechanism was discussed, where MoS_2 could efficiently promote the separation of the photogenerated carriers of C_3N_4. | 崔言娟 YANG Chuanfeng TANG Sheng ZHAO Yimeng CHEN Fangyan | 2019 | Journal of Wuhan University of Technology(Materials Science)2019，34，1： | 2 |
| 14 | Harmonious World and Neo-idealism显示文摘Chinese leaders have time and again talked about the wish to build a'harmonious world.'The authors believe that this can be seen as a new attempt to deal with world affairs using the doctrine of idealism or neo-idealism.Unlike the failed idealism of the early years in last century, the authors believe that this time neo-idealism has a fairly good chance of succeeding due to changes of the international environment. | Liu Liping Zhang Yimeng* *Professor are editors of Contemporary International Relations. Ma Zongshi | 2009 | Contemporary International Relations2009，19，A02： | 2 |
| 15 | Musk secretion in muskrats(Ondatra zibethicus L.):association with lipid and cholesterol metabolism-related pathways显示文摘Male muskrats(Ondatra zibethicus L.)secrete musk from their scent glands during musk secretion season.Musk plays an important role as a communication pheromone during the breeding season.In this study,gas chromatography–mass spectrometry(GC–MS)was used to analyze the main components of musk.The GC–MS results after methyl esterification showed that 71.55%of the musk is composed of fatty acids.The other components of muskrat musk include cholesterol(9.31%)and other organics.Transcriptome comparison between musk secretion and non-secretion seasons showed significant changes in the scent glands for 53 genes involved in fatty acid and cholesterol synthesis and metabolism regulatory pathways,which include fatty acid biosynthesis,elongation,and metabolism;steroid biosynthesis;steroid hormone biosynthesis pathways.A reverse transcription–polymerase chain reaction analysis confirmed these detected changes.Overall,our results indicated that lipid synthesis and metabolism play important roles in musk compound synthesis by providing energy for musk production,and the produced musk provides a mechanism for male muskrats to communicate with females during the breeding season. | TIANXIANG ZHANG MEISHAN ZHANG MINGHUI SHI WEIJIANG JIN SHUMIAO ZHANG MENGYUAN FAN YIMENG LI YUPING MENG XUELIN TIAN SHUQIANG LIU DEFU HU | 2021 | BIOCELL2021，45，2： | 2 |
| 16 | Influence of the Axial Position of the Guide Vane on the Fluctuations of Pressure in a Nuclear Pump显示文摘The influence of the axial mount position of the guide vane on the pressure fluctuation in a nuclear pump(AP1000)is investigated.The characteristics of the three-dimensional flow inside the nuclear pump are analyzed by means of numerical simulation.Results indicate that when the axial relative distance between the guide vane and the pumping chamber is reduced,in conditions of“small flow,”the efficiency of the pump increases,the pressure inside the pumping chamber decreases,while the losses related to the guide vane grow.Under large flow conditions,as the efficiency of the pump decreases,the losses for the guide vane and the pumping chamber increase.The pressure fluctuation in the annular pumping chamber is basically determined by the rotation frequency and the blade passing frequency.The magnitude of these fluctuations is affected by the guide vane axial position.In particular,the smallest possible amplitude is obtained when the outlet central plane of the guide vane coincides with the outlet axis of the pumping chamber. | Xiaorui Cheng Yimeng Jiang Min Li Shuyan Zhang | 2020 | Fluid Dynamics & Materials Processing2020，16，5： | 2 |
| 17 | Scientific Outlook on Development and China's Foreign Policy显示文摘More than half a century has passed since the founding of the People's Republic of China.There have been successes as well as failures in China's policies and practices at home and abroad.The failures are stepping stones for success;lessons drawn from errors lead to truth. Chinese leader Hu Jintao recently spoke about'Scientific Outlook on Development,'a summary of past history and an important guiding principle for China's economic and social development both now and in future.The authors believe that this is a major development in China's strategic thinking following Deng Xiaoping's'Reform and Opening Up'and Jiang Zemin's'Three Representatives'and that it should be upheld and applied to foreign policy decision making. | Zhang Yimeng Liu Liping | 2008 | Contemporary International Relations2008，18，6： | 2 |
| 18 | High-efficiency green micro-LEDs with GaN tunnel junctions grown hybrid by PA-MBE and MOCVD显示文摘We fabricated p-i-n tunnel junction(TJ)contacts for hole injection on c-plane green micro-light-emitting diodes(micro-LEDs)by a hybrid growth approach using plasma-assisted molecular beam epitaxy(PA-MBE)and metal–organic chemical vapor deposition(MOCVD).The TJ was formed by an MBE-grown ultra-thin unintentionally doped In Ga N polarization layer and an n^(++)∕n^(+)-GaN layer on the activated p^(++)-Ga N layer prepared by MOCVD.This hybrid growth approach allowed for the realization of a steep doping interface and ultrathin depletion width for efficient inter-band tunneling.Compared to standard micro-LEDs,the TJ micro-LEDs showed a reduced device resistance,enhanced electroluminescence intensity,and a reduced efficiency droop.The size-independent J-V characteristics indicate that TJ could serve as an excellent current spreading layer.All these results demonstrated that hybrid TJ contacts contributed to the realization of high-performance micro-LEDs with long emission wavelengths. | YAOZHENG WU BIN LIU FEIFAN XU YIMENG SANG TAO TAO ZILI XIE KE WANG XIANGQIAN XIU PENG CHEN DUNJUN CHEN HAI LU RONG ZHANG YOUDOU ZHENG | 2021 | Photonics Research2021，9，9： | 2 |
| 19 | Baf60b-mediated ATM-p53 activation blocks cell identity conversion by sensing chromatin opening显示文摘由系特定的抄写因素的表示的系变换是改变那的 epigenetic 的进程有低效率。一个房间由抵抗系变换的机制大部分是未知的。使用肝特定的抄写因素 Foxa3, Hnf1 和 Gata4 (3TF ) 在老鼠成纤维细胞导致肝的变换,我们证明 3TF 导致了 ATM-p53 小径的强壮的激活,它导致了增长拘捕和房间死亡,和它进一步阻止了肝的变换。尤其是, ATM 激活,独立于 DNA 损坏,对染色质在肝的变换期间开作出回应。由在肝的变换期间描绘早分子的事件,我们发现了那 Baf60b,改变建筑群的 SWI/SNF 染色质的一个成员,连接染色质洞到由便于 ATM 招募到肝的基因 loci 的一块面板的开的染色质区域的 ATM 激活。这些调查结果由在察觉到揭示 ATM-p53 小径的功能使细胞的回答清楚些到系变换染色质洞。 | Shuyi Ji Linying Zhu Yimeng Gao Xiaoran Zhang Yupeng Yan Jin Cen Rongxia Li Rong Zeng Lujian Liao Chunhui Hou Yawei Gao Shaorong Gao Gang Wei Lijian Hui | 2017 | Cell Research2017，27，5： | 2 |
| 20 | Cobalt protoporphyrin-induced nano-self-assembly for CT imaging,magnetic-guidance,and antioxidative protection of stem cells in pulmonary fibrosis treatment显示文摘Mesenchymal stem cells(MSCs)transplantation is a promising approach for pulmonary fibrosis(PF),however it is impeded by several persistent challenges,including the lack of long-term tracking,low retention,and poor survival of MSCs,as well as the low labeling efficiency of nanoprobes.Herein,a cobalt protoporphyrin IX(CoPP)aggregation-induced strategy is applied to develop a multifunctional nano-self-assembly(ASCP)by combining gold nanoparticle(AuNPs),superparamagnetic iron oxide nanoparticles(SPIONs),and CoPP through a facile solvent evaporation-driven approach.Since no additional carrier materials are employed during the synthesis,high loading efficiency of active ingredients and excellent biocompatibility are achieved.Additionally,facile modification of the ASCPs with bicyclo[6.1.0]nonyne(BCN)groups(named as ASCP-BCN)enables them to effectively label MSCs through bioorthogonal chemistry.The obtained ASCP-BCN could not only help to track MSCs with AuNP-based computed tomography(CT)imaging,but also achieve an SPIONs-assisted magnetic field based improvement in the MSCs retention in lungs as well as promoted the survival of MSCs via the sustained release of CoPP.The in vivo results demonstrated that the labeled MSCs improved the lung functions and alle-viated the fibrosis symptoms in a bleomycin–induced PF mouse model.Collectively,a novel ASCP-BCN multi-functional nanoagent was developed to bioorthogonally-label MSCs with a high efficiency,presenting a promising potential in the high-efficient MSC therapy for PF. | Yimeng Shu Ming Ma Xiaoxia Pan Muhammad Shafiq Huizhu Yu Hangrong Chen | 2023 | Bioactive Materials2023，，3： | 2 |
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